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Information on EC 1.8.7.3 - ferredoxin:CoB-CoM heterodisulfide reductase

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IUBMB Comments
HdrABC is an enzyme complex that is found in most methanogens and catalyses the reduction of the CoB-CoM heterodisulfide back to CoB and CoM. HdrA contains a FAD cofactor that acts as the entry point for electrons, which are transferred via HdrC to the HdrB catalytic subunit. One form of the enzyme from Methanosarcina acetivorans (HdrA2B2C2) can also catalyse EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase. cf. EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
Reaction Schemes
2
oxidized ferredoxin [iron-sulfur] cluster
+
+
=
2
reduced ferredoxin [iron-sulfur] cluster
+
+
2
Synonyms
CoB-S-S-CoM reductase, Coenzyme B-Coenzyme M heterodisulfide reductase, hdrA1B1C1, hdrA2B2C2, HdrABC, HdrB, HdrB2, HdrB2C2, heterodisulfide reductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM = 2 reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + 2 H+
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