Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 1.7.1.13 - preQ1 synthase and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC1.7.1.13

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

The reaction occurs in the reverse direction. This enzyme catalyses one of the early steps in the synthesis of queuosine (Q-tRNA), and is followed by the action of EC 2.4.2.29, tRNA-guanosine34 transglycosylase. Queuosine is found in the wobble position of tRNAGUN in Eukarya and Bacteria and is thought to be involved in translational modulation. The enzyme is not a GTP cyclohydrolase, as was thought previously based on sequence-homology studies.

The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The enzyme appears in selected viruses and cellular organisms

Synonyms
nitrile reductase, 7-cyano-7-deazaguanine reductase, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
queuine synthase
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
queuosine biosynthesis I (de novo)
SYSTEMATIC NAME
IUBMB Comments
7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase
The reaction occurs in the reverse direction. This enzyme catalyses one of the early steps in the synthesis of queuosine (Q-tRNA), and is followed by the action of EC 2.4.2.29, tRNA-guanosine34 transglycosylase. Queuosine is found in the wobble position of tRNAGUN in Eukarya and Bacteria [2] and is thought to be involved in translational modulation. The enzyme is not a GTP cyclohydrolase, as was thought previously based on sequence-homology studies.
Highest Expressing Human Cell Lines
Cell Line Links Gene Links
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A069QED5_PSEAI
276
0
30820
TrEMBL
-
A0A3M5EKN9_PSEAI
300
0
33309
TrEMBL
Secretory Pathway (Reliability: 2)
A0A4V8DPG7_PSEAI
276
0
30867
TrEMBL
-
A0A643ELI0_PSEAI
276
0
30820
TrEMBL
-
A0A6A9JUL5_PSEAI
276
0
30800
TrEMBL
-
A0A6B0IP80_PSEAI
276
0
30839
TrEMBL
-
A0ABD7JXZ1_PSEAI
276
0
30931
TrEMBL
Secretory Pathway (Reliability: 3)