Disease on EC 1.6.5.6 - p-benzoquinone reductase (NADPH)
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DISEASE 
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down syndrome and Alzheimer's disease.
Asthma
Vasoactive Intestinal Peptide Knockout (VIP KO) mouse model of sulfite-sensitive asthma: up-regulation of novel lung carbonyl reductase.
Breast Neoplasms
Carbonyl reductase and NADPH cytochrome P450 reductase activities in human tumoral versus normal tissues.
Breast Neoplasms
Reduction of doxorubicin and oracin and induction of carbonyl reductase in human breast carcinoma MCF-7 cells.
Breast Neoplasms
[Assessment of the concentrations of carbonylated proteins and carbonyl reductase enzyme in mexican women with breast cancer: A pilot study].
Carcinogenesis
Candidate gene and mechanism investigations in congenital obstructive nephropathy based on bioinformatics analysis.
Carcinoma
Increased resistance of tumor cells to daunorubicin after transfection of cDNAs coding for anthracycline inactivating enzymes.
Carcinoma
Suppression of carbonyl reductase expression enhances malignant behaviour in uterine cervical squamous cell carcinoma: Carbonyl reductase predicts prognosis and lymph node metastasis.
Carcinoma
Tumor-related protein, the squamous cell carcinoma antigen binds to the intracellular protein carbonyl reductase.
Carcinoma, Hepatocellular
Decreased expression of the human carbonyl reductase 2 gene HCR2 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Decreased expression of the peroxisomal bifunctional enzyme and carbonyl reductase in human hepatocellular carcinomas.
Carcinoma, Ovarian Epithelial
Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer.
Carcinoma, Squamous Cell
Suppression of carbonyl reductase expression enhances malignant behaviour in uterine cervical squamous cell carcinoma: Carbonyl reductase predicts prognosis and lymph node metastasis.
Carcinoma, Squamous Cell
Tumor-related protein, the squamous cell carcinoma antigen binds to the intracellular protein carbonyl reductase.
Cardiomyopathies
Anthracycline-Related Cardiomyopathy After Childhood Cancer: Role of Polymorphisms in Carbonyl Reductase Genes--A report From the Children's Oncology Group.
Cardiotoxicity
Flavonoids as protectors against doxorubicin cardiotoxicity: role of iron chelation, antioxidant activity and inhibition of carbonyl reductase.
Cardiotoxicity
Human carbonyl reductase overexpression in the heart advances the development of doxorubicin-induced cardiotoxicity in transgenic mice.
Cardiotoxicity
Modeling the metabolism of idarubicin to idarubicinol in rat heart: effect of rutin and phenobarbital.
Cardiotoxicity
Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1.
Cardiotoxicity
Single-nucleotide polymorphisms in aldo-keto and carbonyl reductase genes are not associated with acute cardiotoxicity after daunorubicin chemotherapy.
Down Syndrome
Human carbonyl reductase (CBR) localized to band 21q22.1 by high-resolution fluorescence in situ hybridization displays gene dosage effects in trisomy 21 cells.
Down Syndrome
Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down syndrome and Alzheimer's disease.
Fatty Liver
A novel NAD(P)H-dependent carbonyl reductase specifically expressed in the thyroidectomized chicken fatty liver: catalytic properties and crystal structure.
Fatty Liver
Expression, purification, crystallization and preliminary X-ray analysis of NAD(P)H-dependent carbonyl reductase specifically expressed in thyroidectomized chicken fatty liver.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Glucose-6-phosphate dehydrogenase deficiency severely restricts the biotransformation of daunorubicin in human erythrocytes.
Glucosephosphate Dehydrogenase Deficiency
Glucose-6-phosphate dehydrogenase deficiency severely restricts the biotransformation of daunorubicin in human erythrocytes.
Kidney Failure, Chronic
Downregulation of Hepatic Carbonyl Reductase Type 1 in End-Stage Renal Disease.
Leukemia
Protection against daunorubicin cytotoxicity by expression of a cloned human carbonyl reductase cDNA in K562 leukemia cells.
Lung Neoplasms
Carbonyl reductase expression and its clinical significance in non-small-cell lung cancer.
Lymphatic Metastasis
Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer.
Lymphatic Metastasis
Suppression of carbonyl reductase expression enhances malignant behaviour in uterine cervical squamous cell carcinoma: Carbonyl reductase predicts prognosis and lymph node metastasis.
Neoplasm Metastasis
Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer.
Neoplasm Metastasis
Suppression of carbonyl reductase expression enhances malignant behaviour in uterine cervical squamous cell carcinoma: Carbonyl reductase predicts prognosis and lymph node metastasis.
Neoplasm Metastasis
Towards a lung adenocarcinoma proteome map: studies with SP-C/c-raf transgenic mice.
Neoplasms
Anthracycline-Related Cardiomyopathy After Childhood Cancer: Role of Polymorphisms in Carbonyl Reductase Genes--A report From the Children's Oncology Group.
Neoplasms
Carbonyl reductase and NADPH cytochrome P450 reductase activities in human tumoral versus normal tissues.
Neoplasms
Carbonyl reductase inactivation may contribute to mouse lung tumor promotion by electrophilic metabolites of butylated hydroxytoluene: protein alkylation in vivo and in vitro.
Neoplasms
CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients.
Neoplasms
Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice.
Neoplasms
Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancer.
Neoplasms
Malignant ovarian tumors with induced expression of carbonyl reductase show spontaneous regression.
Neoplasms
Protection against daunorubicin cytotoxicity by expression of a cloned human carbonyl reductase cDNA in K562 leukemia cells.
Neoplasms
Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat.
Neoplasms
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
Neoplasms
Towards a lung adenocarcinoma proteome map: studies with SP-C/c-raf transgenic mice.
Ovarian Neoplasms
Malignant ovarian tumors with induced expression of carbonyl reductase show spontaneous regression.
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