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IUBMB Comments The enzyme, found in plants and cyanobacteria, is involved in the biosynthesis of phylloquinone (vitamin K1
Synonyms
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NAD(P)H dehydrogenase C1
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NADPH quinone dehydrogenase
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ndbB
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NDC1
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demethylphylloquinone + NADPH + H+ = demethylphylloquinol + NADP+
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MetaCyc
phylloquinol biosynthesis
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demethylphylloquinone:NADPH oxidoreductase
The enzyme, found in plants and cyanobacteria, is involved in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is a type II NADPH dehydrogenase and requires a flavine adenine dinucleotide cofactor.
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decyl prenylquinone + NADH + H+
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Substrates: -
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demethylphylloquinone + NADPH + H+
demethylphylloquinol + NADP+
menadione + NADPH + H+
menadiol + NADP+
demethylphylloquinone + NADPH + H+
demethylphylloquinol + NADP+
Substrates: -
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demethylphylloquinone + NADPH + H+
demethylphylloquinol + NADP+
Substrates: i.e. 2-phytyl-1,4-naphthoquinone
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demethylphylloquinone + NADPH + H+
demethylphylloquinol + NADP+
Substrates: i.e. 2-phythyl-1,4-naphthoquinone
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demethylphylloquinone + NADPH + H+
demethylphylloquinol + NADP+
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Substrates: -
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menadione + NADPH + H+
menadiol + NADP+
Substrates: -
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menadione + NADPH + H+
menadiol + NADP+
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Substrates: -
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demethylphylloquinone + NADPH + H+
demethylphylloquinol + NADP+
demethylphylloquinone + NADPH + H+
demethylphylloquinol + NADP+
Substrates: -
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demethylphylloquinone + NADPH + H+
demethylphylloquinol + NADP+
Substrates: i.e. 2-phytyl-1,4-naphthoquinone
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demethylphylloquinone + NADPH + H+
demethylphylloquinol + NADP+
Substrates: i.e. 2-phythyl-1,4-naphthoquinone
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demethylphylloquinone + NADPH + H+
demethylphylloquinol + NADP+
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Substrates: -
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FAD
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NADPH
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dicumarol
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Neuroinflammatory Diseases
Gedunin Inhibits Oligomeric A?1-42-Induced Microglia Activation Via Modulation of Nrf2-NF-?B Signaling.
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0.0024
menadione
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pH 7.5, 30°C, recombinant enzyme
0.02
menadione
pH 7.5, 30°C, recombinant enzyme
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0.44
menadione
pH 7.5, 30°C, recombinant enzyme
3.2
menadione
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pH 7.5, 30°C, recombinant enzyme
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0.0013 - 0.0055
dicumarol
0.0013
dicumarol
substrate menadione and NADPH
0.0055
dicumarol
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substrate menadione and NADPH
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SwissProt
brenda
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brenda
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brenda
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brenda
chloroplast lipid droplet
brenda
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brenda
Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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malfunction
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enzyme deletion mutants display increased photosensitivity to high light
malfunction
enzyme deletion mutants display increased photosensitivity to high light
metabolism
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the enzyme performs the penultimate step in the biosynthesis of vitamin K1
metabolism
the enzyme performs the penultimate step in the biosynthesis of vitamin K1
metabolism
the enzyme is required for normal plastochromanol-8 accumulation and is essential for vitamin K1 production
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Ni-NTA His-Bind resin column chromatography
Ni-NTA His-Bind resin column chromatography
Ni-NTA His-Bind resin column chromatography
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expressed in Escherichia coli BL21 Star (DE3) pLysS cells
expressed in Nicotiana benthamiana
expressed in Escherichia coli BL21 Star (DE3) pLysS cells
expressed in Escherichia coli BL21 Star (DE3) pLysS cells
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Kim, H.U.; Kim, E.-H.; Lee, K.-R.; Jung, S.-J.; Roh, K.H.; Kim, J.-B.
Plastoglobule in chloroplast and its role in prenylquinone metabolism
J. Plant Biotechnol.
40
125-134
2013
Arabidopsis thaliana (Q8GXR9)
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brenda
Fatihi, A.; Latimer, S.; Schmollinger, S.; Block, A.; Dussault, P.H.; Vermaas, W.F.; Merchant, S.S.; Basset, G.J.
A dedicated type II NADPH dehydrogenase performs the penultimate step in the biosynthesis of vitamin K1 in Synechocystis and Arabidopsis
Plant Cell
27
1730-1741
2015
Arabidopsis thaliana (Q8GXR9), Arabidopsis thaliana, Synechocystis sp.
brenda
Eugeni Piller, L.; Besagni, C.; Ksas, B.; Rumeau, D.; Brehelin, C.; Glauser, G.; Kessler, F.; Havaux, M.
Chloroplast lipid droplet type II NAD(P)H quinone oxidoreductase is essential for prenylquinone metabolism and vitamin K1 accumulation
Proc. Natl. Acad. Sci. USA
108
14354-14359
2011
Arabidopsis thaliana (Q8GXR9)
brenda
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