Disease on EC 1.6.5.10 - NADPH dehydrogenase (quinone)

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DISEASE
TITLE OF PUBLICATION
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Abscess
Adaptive immune defects against glycoantigens in chronic granulomatous disease via dysregulated nitric oxide production.
Aspergillus nidulans infection in a patient with chronic granulomatous disease.
Acidosis
Microglial voltage-gated proton channel Hv1 in ischemic stroke.
Possible mechanism(s) of arachidonic acid-induced intracellular acidosis in rat cardiac myocytes.
Acute Coronary Syndrome
Is there a clinical role for oxidative stress biomarkers in atherosclerotic diseases?
Acute Kidney Injury
CYBA Gene Polymorphisms and Adverse Outcomes in Acute Kidney Injury: A Prospective Cohort Study.
NADPH oxidase p22phox and catalase gene variants are associated with biomarkers of oxidative stress and adverse outcomes in acute renal failure.
Short chain fatty acid, acetate ameliorates sepsis-induced acute kidney injury by inhibition of NADPH oxidase signaling in T cells.
TGF-?-mediated NADPH oxidase 4-dependent oxidative stress promotes colistin-induced acute kidney injury.
Acute Lung Injury
Acute lung injury leads to depression-like symptoms through upregulation of neutrophilic and neuronal NADPH oxidase signaling in a murine model.
Animal models of oxidant lung injury.
Effect of the NADPH oxidase inhibitor apocynin on septic lung injury in guinea pigs.
In Vivo evidence of free radical generation in the mouse lung after exposure to Pseudomonas Aeruginosa bacterium: An ESR spin-trapping investigation.
In vivo lipid-derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDS.
Inhibition of NADPH oxidase prevents acute lung injury in obese rats following severe trauma.
NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury.
Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases.
Propofol alleviates acute lung injury following orthotopic autologous liver transplantation in rats via inhibition of the NADPH oxidase pathway.
Protection against LPS-induced acute lung injury by a mechanism-based inhibitor of NADPH oxidase (type 2).
Regulation of innate immunity by NADPH oxidase.
Adenocarcinoma
Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S.
Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis.
Bile acid receptor TGR5, NADPH Oxidase NOX5-S and CREB Mediate Bile Acid-Induced DNA Damage In Barrett's Esophageal Adenocarcinoma Cells.
Bile acid reflux contributes to development of esophageal adenocarcinoma via activation of phosphatidylinositol-specific phospholipase Cgamma2 and NADPH oxidase NOX5-S.
cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells.
Decreased NADPH oxidase expression and antioxidant activity in cachectic skeletal muscle.
Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase.
NADPH Oxidase Activation in Pancreatic Cancer Cells Is Mediated through Akt-dependent Up-regulation of p22phox.
NADPH Oxidase NOX5-S and NF-?B1 Mediate Acid-Induced Microsomal Prostaglandin Synthase-1 (Mpges1) Expression in Barrett's Esophageal Adenocarcinoma (EA) Cells.
NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's esophageal adenocarcinoma cells.
Rho Kinase ROCK2 Mediates Acid-Induced NADPH Oxidase NOX5-S Expression in Human Esophageal Adenocarcinoma Cells.
Role Of Intracellular Calcium And NADPH Oxidase NOX5-S In Acid-Induced DNA Damage In Barrett's cells and Barrett's Esophageal Adenocarcinoma Cells.
Role of Rac1 in regulation of NOX5-S function in Barrett's esophageal adenocarcinoma cells.
STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells.
Adenocarcinoma of Lung
HIF-1alpha signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells.
Adenoma, Pleomorphic
Binding of pleomorphic adenoma gene-like 2 to the tumor necrosis factor (TNF)-alpha-responsive region of the NCF2 promoter regulates p67(phox) expression and NADPH oxidase activity.
Adenomyosis
Involvement of NADPH oxidase and NF-?B activation in CXCL1 induction by vascular endothelial growth factor in human endometrial epithelial cells of patients with adenomyosis.
Adrenoleukodystrophy
Oxidative imbalance in nonstimulated X-adrenoleukodystrophy-derived lymphoblasts.
Aggressive Periodontitis
NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis: a case-control association study.
Respiratory burst of neutrophils in diabetic patients with periodontal disease.
Agranulocytosis
Involvement of Myeloperoxidase and NADPH Oxidase in the Covalent Binding of Amodiaquine and Clozapine to Neutrophils: Implications for Drug-Induced Agranulocytosis.
AIDS Dementia Complex
Cooperative induction of CXCL10 involves NADPH oxidase: Implications for HIV dementia.
Albuminuria
A Salt-Induced Reno-Cerebral Reflex Activates Renin-Angiotensin Systems and Promotes CKD Progression.
Accumulation of advanced oxidation protein products induces podocyte apoptosis and deletion through NADPH-dependent mechanisms.
Advanced oxidation protein products decrease expression of nephrin and podocin in podocytes via ROS-dependent activation of p38 MAPK.
Albuminuria, expression of nicotinamide adenine dinucleotide phosphate oxidase and monocyte chemoattractant protein-1 in the renal tubules of hypertensive Dahl salt-sensitive rats.
Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension.
Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment.
Calcium channel blocker enhances beneficial effects of an angiotensin II AT1 receptor blocker against cerebrovascular-renal injury in type 2 diabetic mice.
Candesartan reduced advanced glycation end-products accumulation and diminished nitro-oxidative stress in type 2 diabetic KK/Ta mice.
Cardiac myocyte-derived follistatin-like 1 prevents renal injury in a subtotal nephrectomy model.
Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury.
Exacerbation of albuminuria and renal fibrosis in subtotal renal ablation model of adiponectin-knockout mice.
Hypoglycaemic, antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits.
Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.
NADPH oxidase-mediated triggering of inflammasome activation in mouse podocytes and glomeruli during hyperhomocysteinemia.
RAGE-Aptamer Blocks the Development and Progression of Experimental Diabetic Nephropathy.
Selective albuminuria via podocyte albumin transport in puromycin nephrotic rats is attenuated by an inhibitor of NADPH oxidase.
The mTOR promotes oxidative stress-induced apoptosis of mesangial cells in diabetic nephropathy.
Theobromine increases NAD?/Sirt-1 activity and protects the kidney under diabetic conditions.
Alkalosis
Extracellular alkalosis activates ERK mitogen-activated protein kinase of vascular smooth muscle cells through NADPH-mediated formation of reactive oxygen species.
Alveolitis, Extrinsic Allergic
Role of NADPH oxidase in host defense against aspergillosis.
Alzheimer Disease
Activation of NADPH oxidase in Alzheimer's disease brains.
AGEs Induce Cell Death via Oxidative and Endoplasmic Reticulum Stresses in Both Human SH-SY5Y Neuroblastoma Cells and Rat Cortical Neurons.
Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants.
Amyloid ? induces microglia to phagocytose neurons via activation of protein kinase Cs and NADPH oxidase.
Apocynin administration does not improve behavioral and neuropathological deficits in a transgenic mouse model of Alzheimer's disease.
beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease.
Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer A? Peptides.
Chronic apocynin treatment attenuates beta amyloid plaque size and microglial number in hAPP(751)(SL) mice.
Design of dual inhibitors of ROCK-I and NOX2 as potential leads for the treatment of neuroinflammation associated with various neurological diseases including autism spectrum disorder.
Motor coordination and synaptic plasticity deficits are associated with increased cerebellar activity of NADPH oxidase, CAMKII, and PKC at preplaque stage in the TgCRND8 mouse model of Alzheimer's disease.
NADPH oxidase as a therapeutic target in Alzheimer's disease.
Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease.
NOX activity is increased in mild cognitive impairment.
Oligomeric A?-induced microglial activation is possibly mediated by NADPH oxidase.
Targeting NADPH Oxidase and Phospholipases A(2) in Alzheimer's Disease.
The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease.
The role of secretory phospholipase A2 in the central nervous system and neurological diseases.
The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases.
Amyotrophic Lateral Sclerosis
The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice.
The NADPH oxidase pathway is dysregulated by the P2X7 receptor in the SOD1-G93A microglia model of amyotrophic lateral sclerosis.
Anaplasmosis
Commentary: adaptive immunity in the absence of innate immune responses? The un-Tolled truth of the silent invaders.
Androgen-Insensitivity Syndrome
A2A AR deficiency leads to impaired tracheal relaxation via NADPH oxidase pathway in allergic mice.
Anemia
Activity of neutrophil NADPH oxidase in iron-deficient anemia.
Anemia, Sickle Cell
Endothelin-1 Contributes to the Progression of Renal Injury in Sickle Cell Disease via Reactive Oxygen Species.
Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease.
Modulation of redox pathways in neutrophils from sickle cell disease patients.
Raised neutrophil phospholipase A2 activity and defective priming of NADPH oxidase and phospholipase A2 in sickle cell disease.
Up-regulation of NADPH oxidase components and increased production of interferon-gamma by leukocytes from sickle cell disease patients.
Aneurysm
Inhibition of reactive oxygen species attenuates aneurysm formation in a murine model.
Mechanisms of oxidative stress in human aortic aneurysms - Association with clinical risk factors for atherosclerosis and disease severity.
Angina Pectoris
Suppressing NADPH oxidase-dependent oxidative stress in the vasculature with nitric oxide donors.
Aortic Aneurysm
Redox stress in Marfan syndrome: Dissecting the role of the NADPH oxidase NOX4 in aortic aneurysm.
Aortic Aneurysm, Abdominal
Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.
NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice.
Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice.
Aortic Aneurysm, Thoracic
Pleiotropic effects of ARB in vascular metabolism--focusing on atherosclerosis-based cardiovascular disease.
Aortic Coarctation
Effects of aortic coarctation on aortic antioxidant enzymes and NADPH oxidase protein expression.
Arteriovenous Fistula
p47phox-dependent NADPH oxidase regulates flow-induced vascular remodeling.
Arthritis
Advanced intercross line mapping suggests that ncf1 (ean6) regulates severity in an animal model of guillain-barre syndrome.
Antiinflammatory effects of NADPH oxidase inhibitors.
Arthritis suppression by NADPH activation operates through an interferon-beta pathway.
Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models.
Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1.
Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in mice.
Modulation of inflammatory arthritis by inhibition of poly(ADP ribose) polymerase.
Positional identification of Ncf1 as a gene that regulates arthritis severity in rats.
Reactive Oxygen Species Regulate Innate But Not Adaptive Inflammation in ZAP70-Mutated SKG Arthritic Mice.
Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies.
Suppression of inflammatory arthritis by simultaneous inhibition of nitric oxide synthase and NADPH oxidase.
Arthritis, Experimental
Synergistic effects of thalidomide and poly (ADP-ribose) polymerase inhibition on type II collagen-induced arthritis in mice.
Arthritis, Rheumatoid
Activation of neutrophil reactive-oxidant production by synovial fluid from patients with inflammatory joint disease. Soluble and insoluble immunoglobulin aggregates activate different pathways in primed and unprimed cells.
Bb2Bb3 regulation of murine Lyme arthritis is distinct from Ncf1 and independent of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase.
Hydrogen Peroxide As an Immunological Transmitter Regulating Autoreactive T Cells.
NADPH oxidase priming and p47phox phosphorylation in neutrophils from synovial fluid of patients with rheumatoid arthritis and spondylarthropathy.
Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: regulation by interleukin-1beta and tumour necrosis factor-alpha.
Aspergillosis
Corticosteroids block autophagy protein recruitment in Aspergillus fumigatus phagosomes via targeting dectin-1/Syk kinase signaling.
NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.
NADPH oxidase regulates efficacy of vaccination in aspergillosis.
Role of NADPH oxidase in host defense against aspergillosis.
[Contribution of neutrophils to Aspergillus infection]
Asthma
A2A AR deficiency leads to impaired tracheal relaxation via NADPH oxidase pathway in allergic mice.
Anti-inflammatory effects of apocynin, an inhibitor of NADPH oxidase, in airway inflammation.
Deficiency of gp91phox Inhibits Allergic Airway Inflammation.
Defining the molecular role of gp91phox in the immune manifestation of acute allergic asthma using a preclinical murine model.
Haplotype Analysis of the NADPH Oxidase p22 Gene in Patients with Bronchial Asthma.
Increased Expression of p22phox Mediates Airway Hyperresponsiveness in an Experimental Model of Asthma.
NADPH oxidase 4 over-expression is associated with epithelial ciliary dysfunction in neutrophilic asthma.
Nitric oxide-mediated activation of NADPH oxidase by salbutamol during acute asthma in children.
Nonhematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally induced asthma.
Role of T cells in a gp91phox knockout murine model of acute allergic asthma.
Three novel mutations in CYBA among 22 Iranians with Chronic granulomatous disease.
[Association of C242T and A640G polymorphisms in the gene for p22phox subunit of NADPH oxidase with the risk of bronchial asthma: a pilot study]
[Oxygen and the superoxide anion. Modulation of NADPH oxidase?]
Astrocytoma
Nox2-based NADPH oxidase mediates HIV-1 Tat-induced up-regulation of VCAM-1/ICAM-1 and subsequent monocyte adhesion in human astrocytes.
Atherosclerosis
A central role for the endothelial NADPH oxidase in atherosclerosis.
A Drosophila model for the screening of bioavailable NADPH oxidase inhibitors and antioxidants.
A variant of p22(phox), involved in generation of reactive oxygen species in the vessel wall, is associated with progression of coronary atherosclerosis.
Active principle of kimchi, 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid, retards fatty streak formation at aortic sinus of apolipoprotein E knockout mice.
Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone.
Ambient Particulates Alter Vascular Function through Induction of Reactive Oxygen and Nitrogen Species.
Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice.
Antioxidative potential of fluvastatin via the inhibition of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity.
Assessment of atherosclerosis in chronic granulomatous disease.
C/EBP transcription factors regulate NADPH oxidase in human aortic smooth muscle cells.
C242T polymorphism of NADPH oxidase p22 PHOX gene and ischemic cerebrovascular disease in the Japanese population.
Clinical Application of NOX Activity and Other Oxidative Biomarkers in Cardiovascular Disease: A Critical Review.
Differential vascular functions of Nox family NADPH oxidases.
Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability and early atherosclerotic plaque formation in ApoE-/- mice.
Effects of dietary sodium on reactive oxygen species formation and endothelial dysfunction in low-density lipoprotein receptor-deficient mice on high-fat diet.
Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase.
Epigallocatechin-3-gallate Regulates NADPH Oxidase Expression in Human Umbilical Vein Endothelial Cells.
Expression of p22-phox and gp91-phox, essential components of NADPH oxidase, increases after myocardial infarction.
Galectin-3, a biomarker linking oxidative stress and inflammation with the clinical outcomes of patients with atherothrombosis.
High glucose downregulates the number of caveolae in monocytes through oxidative stress from NADPH oxidase: implications for atherosclerosis.
Homocysteine stimulates phosphorylation of NADPH oxidase p47phox and p67phox subunits in monocytes via protein kinase Cbeta activation.
Identification of a functional leukocyte-type NADPH oxidase in human endothelial cells :a potential atherogenic source of reactive oxygen species.
Impaired superoxide production due to a deficiency in phagocyte NADPH oxidase fails to inhibit atherosclerosis in mice.
Increased myocardial NADPH oxidase activity in human heart failure.
Increased phagocytic NADPH oxidase activity associates with coronary artery calcification in asymptomatic men.
Inhibition of human neutrophil reactive oxygen species production and p67phox translocation by cigarette smoke extract.
Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis.
Inhibition of NADPH oxidase by vaspin may prevent progression of atherosclerosis.
Interaction of hyperlipidemia and reactive oxygen species: Insights from the lipid-raft platform.
Is leptin involved in phagocytic NADPH oxidase overactivity in obesity? Potential clinical implications.
Is there a clinical role for oxidative stress biomarkers in atherosclerotic diseases?
Letter by violi et Al regarding article, "molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition".
Lutein Prevents High Fat Diet-Induced Atherosclerosis in ApoE-Deficient Mice by Inhibiting NADPH Oxidase and Increasing PPAR Expression.
Modulation of oxidized-LDL receptor-1 (LOX1) contributes to the antiatherosclerosis effect of oleanolic acid.
Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition.
NADPH oxidase in endothelial cells: impact on atherosclerosis.
NADPH oxidase-dependent superoxide production is associated with carotid intima-media thickness in subjects free of clinical atherosclerotic disease.
NADPH oxidases regulate CD44 and hyaluronic acid expression in thrombin-treated vascular smooth muscle cells and in atherosclerosis.
Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells.
Novel isoforms of NADPH oxidase in vascular physiology and pathophysiology.
Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries.
Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models.
NOX2-dependent regulation of inflammation.
NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease.
Out, damned dot: studies of the NADPH oxidase in atherosclerosis.
Oxidative stress, NADPH oxidases, and arteries.
Oxyradical stress increases the biosynthesis of 2-arachidonoylglycerol: involvement of NADPH oxidase.
Oxyradical Stress, Endocannabinoids, and Atherosclerosis.
p-Cresyl sulfate is associated with carotid arteriosclerosis in hemodialysis patients and promotes atherogenesis in apoE-/- mice.
Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome.
Phagocytic NADPH oxidase-dependent superoxide production stimulates matrix metalloproteinase-9: implications for human atherosclerosis.
Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune-inflammatory responses in diabetic Apoe(-/-) mice.
Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis.
Pleiotropic effects of ARB in vascular metabolism--focusing on atherosclerosis-based cardiovascular disease.
Polymorphisms of the NADPH oxidase P22PHOX gene in a Caucasian population with intracranial aneurysms.
Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase.
Prolonged exposure to LPS increases iron, heme, and p22phox levels and NADPH oxidase activity in human aortic endothelial cells: inhibition by desferrioxamine.
Quercetin attenuates high fat diet-induced atherosclerosis in apolipoprotein E knockout mice: A critical role of NADPH oxidase.
Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling.
Reactive oxygen species in the cerebral circulation: physiological roles and therapeutic implications for hypertension and stroke.
Reduced atherosclerotic burden in subjects with genetically determined low oxidative stress.
Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells.
Regulation of superoxide anion production by NADPH oxidase in monocytes/macrophages: contributions to atherosclerosis.
Role for Nox1 NADPH oxidase in atherosclerosis.
Role of NADPH oxidase in atherosclerosis.
Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis.
S-Glutathionylation Reshapes Our Understanding of Endothelial Nitric Oxide Synthase Uncoupling and Nitric Oxide/Reactive Oxygen Species-Mediated Signaling.
S100A12 in Vascular Smooth Muscle Accelerates Vascular Calcification in Apolipoprotein E-Null Mice by Activating an Osteogenic Gene Regulatory Program.
S17834, a new inhibitor of cell adhesion and atherosclerosis that targets nadph oxidase.
Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration.
Superoxide dismutase mimetic M40403 improves endothelial function in apolipoprotein(E)-deficient mice.
Suppressing NADPH oxidase-dependent oxidative stress in the vasculature with nitric oxide donors.
The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension.
The clinical research for Ganoderan's effect on preventing and treating cerebral arteriosclerosis through inhibiting NADPH oxidizing enzyme expression.
The Renin Angiotensin aldosterone system in hypertension: roles of insulin resistance and oxidative stress.
The role of NADPH oxidase in vascular disease--hypertension, atherosclerosis & stroke.
The role of oxidative stress and NADPH oxidase in the pathogenesis of atherosclerosis.
The role of the methoxyphenol apocynin, a vascular NADPH oxidase inhibitor, as a chemopreventative agent in the potential treatment of cardiovascular diseases.
Thioredoxin attenuates oxidized low-density lipoprotein induced oxidative stress in human umbilical vein endothelial cells by reducing NADPH oxidase activity.
Thioredoxin-1/peroxiredoxin-1 as sensors of oxidative stress mediated by NADPH oxidase activity in atherosclerosis.
Tyrosine kinase-mediated activation of NADPH oxidase enhances proliferative capacity of diabetic vascular smooth muscle cells.
[Modulation by some fatty acids of protein kinase C-dependent NADPH oxidase in human adherent monocyte: mechanism of action, possible implication in atherogenesis]
[NADPH oxidase activity does not affect cellular cholesterol loading in vascular smooth muscle cells.]
[Oxygen and the superoxide anion. Modulation of NADPH oxidase?]
[Research progress of Chinese herbs inhibiting NADPH oxidase].
Atrial Fibrillation
Apocynin: a potent NADPH oxidase inhibitor for the management of atrial fibrillation.
Atrial myocardial nox2 containing NADPH oxidase activity contribution to oxidative stress in mitral regurgitation: potential mechanism for atrial remodeling.
Different behaviour of NOX2 activation in patients with paroxysmal/persistent or permanent atrial fibrillation.
NADPH oxidase 4 induces cardiac arrhythmic phenotype in zebrafish.
Oxidative stress in atrial fibrillation: an emerging role of NADPH oxidase.
The More Effective Treatment of Atrial Fibrillation Applying the Natural Compounds; as NADPH Oxidase and Ion Channel Inhibitors.
Autoimmune Diseases
NADPH oxidase is required for neutrophil-dependent autoantibody-induced tissue damage.
Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice.
Oxygen radical production and severity of the Guillain--Barré syndrome.
Bacteremia
NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium.
Bacterial Infections
A Localized Pseudomonas syringae Infection Triggers Systemic Clock Responses in Arabidopsis.
Altered Pattern of Nave and Memory B cells and B1 Cells in Patients with Chronic Granulomatous Disease.
Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity.
Evasion of Legionella pneumophila from the bactericidal system by reactive oxygen species (ROS) in macrophages.
NADPH oxidase but not myeloperoxidase protects lymphopenic mice from spontaneous infections.
NADPH oxidases: an overview from structure to innate immunity-associated pathologies.
Partial correction of neutrophil dysfunction by oral galactose therapy in glycogen storage disease type Ib.
Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidase.
Polymorphonuclear leukocyte-mediated cell and tissue injury: oxygen metabolites and their relations to human disease.
Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense.
The metabolic and phagocytic activities of leukocytes from patients receiving corticosteroid and radiation therapy, and patients with bacterial infections.
[Chronic-granulomatous disease.]
[Studies on relationships between the inhibition of human neutrophil NADPH oxidase by anti-inflammatory drugs and development of bacterial infections]
Barrett Esophagus
NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's esophageal adenocarcinoma cells.
STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells.
Blast Crisis
Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia.
Bone Resorption
Osteoclastic superoxide production and bone resorption: stimulation and inhibition by modulators of NADPH oxidase.
Brain Edema
Administration of pigment epithelium-derived factor (PEDF) inhibits cold injury-induced brain edema in mice.
Attenuation of brain edema and spatial learning de?cits by the inhibition of NADPH oxidase activity using apocynin following diffuse traumatic brain injury in rats.
NADPH oxidase inhibition improves neurological outcomes in surgically-induced brain injury.
Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke.
Brain Injuries
Ca(2+)/Calmodulin-Dependent Protein Kinase II Contributes to Hypoxic Ischemic Cell Death in Neonatal Hippocampal Slice Cultures.
Cellular and temporal expression of NADPH oxidase (NOX) isotypes after brain injury.
CK2 is a novel negative regulator of NADPH oxidase and a neuroprotectant in mice after cerebral ischemia.
Deletion of NADPH oxidase 4 reduces severity of traumatic brain injury.
Excess salt causes cerebral neuronal apoptosis and inflammation in stroke-prone hypertensive rats through angiotensin II-induced NADPH oxidase activation.
Hyperbaric oxygen suppresses NADPH oxidase in a rat subarachnoid hemorrhage model.
Increased NADPH oxidase-derived superoxide is involved in the neuronal cell death induced by hypoxia-ischemia in neonatal hippocampal slice cultures.
Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase.
Mechanisms regulating superoxide generation in experimental models of phenylketonuria: An essential role of NADPH oxidase.
Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats.
NADPH oxidase in brain injury and neurodegenerative disorders.
NADPH oxidase inhibition improves neurological outcomes in surgically-induced brain injury.
NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke.
Neuroprotective effect of hyperbaric oxygen in a rat model of subarachnoid hemorrhage.
NOX2 inhibition with apocynin worsens stroke outcome in aged rats.
Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice.
Role of NADPH oxidase in the brain injury of intracerebral hemorrhage.
Status epilepticus results in persistent overproduction of reactive oxygen species, inhibition of which is neuroprotective.
Brain Injuries, Traumatic
Activation of mGluR5 and Inhibition of NADPH Oxidase Improves Functional Recovery after Traumatic Brain Injury.
Attenuation of brain edema and spatial learning de?cits by the inhibition of NADPH oxidase activity using apocynin following diffuse traumatic brain injury in rats.
Critical role of NADPH oxidase in neuronal oxidative damage and microglia activation following traumatic brain injury.
Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.
NADPH oxidase in brain injury and neurodegenerative disorders.
NADPH oxidase inhibition improves neurological outcome in experimental traumatic brain injury.
Prevention of traumatic brain injury-induced neuronal death by inhibition of NADPH oxidase activation.
The NADPH oxidase NOX2 mediates loss of parvalbumin interneurons in traumatic brain injury: human autoptic immunohistochemical evidence.
Traumatic brain injury and NADPH oxidase: a deep relationship.
Brain Ischemia
Acute NADPH oxidase activation potentiates cerebrovascular permeability response to bradykinin in ischemia-reperfusion.
Alpha-Lipoic Acid Attenuates Cerebral Ischemia and Reperfusion Injury via Insulin Receptor and PI3K/Akt-Dependent Inhibition of NADPH Oxidase.
CK2 is a novel negative regulator of NADPH oxidase and a neuroprotectant in mice after cerebral ischemia.
Effect of the NADPH oxidase inhibitor apocynin on ischemia-reperfusion hippocampus injury in rat brain.
Inhibition of gp91(phox) contributes towards normobaric hyperoxia afforded neuroprotection in focal cerebral ischemia.
mGluR1 antagonist decreased NADPH oxidase activity and superoxide production after transient focal cerebral ischemia.
Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats.
NADPH oxidase mediates striatal neuronal injury after transient global cerebral ischemia.
NADPH oxidase-mediated oxidative damage to proteins in the postsynaptic density after transient cerebral ischemia and reperfusion.
Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia.
Oral phycocyanobilin may diminish the pathogenicity of activated brain microglia in neurodegenerative disorders.
Oxidative Stress and NAD(+) in Ischemic Brain Injury: Current Advances and Future Perspectives.
Phospholipase A(2), reactive oxygen species, and lipid peroxidation in cerebral ischemia.
Release of mitochondrial apoptogenic factors and cell death are mediated by CK2 and NADPH oxidase.
Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat.
Suppression of the inflammatory response by diphenyleneiodonium after transient focal cerebral ischemia.
The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases.
Breast Neoplasms
Breast cancer: role of polymorphisms in biotransformation enzymes.
Metastatic breast carcinoma induces vascular endothelial dysfunction in Balb-c mice: Role of the tumor necrosis factor-? and NADPH oxidase.
NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis.
Polymorphisms in oxidative stress-related genes and postmenopausal breast cancer risk.
Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway.
Redox-modulating agents target NOX2-dependent IKK? oncogenic kinase expression and proliferation in human breast cancer cell lines.
Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells.
Bronchiolitis
Anti-inflammatory action of erythromycin. Its inhibitory effect on neutrophil NADPH oxidase activity.
Burkitt Lymphoma
The NADPH oxidase inhibitor imipramine-blue in the treatment of burkitt lymphoma.
Carcinogenesis
Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis.
Association between NADPH oxidase (NOX) and lung cancer: a systematic review and meta-analysis.
Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1-5 and Superoxide Dismutase 1-3 Signal Transduction Pathways.
Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancer prevention.
NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium.
NADPH oxidase biology and the regulation of tyrosine kinase receptor signaling and cancer drug cytotoxicity.
NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy.
NADPH oxidase NOX4 supports renal tumorigenesis by promoting the expression and nuclear accumulation of HIF2?.
NADPH Oxidases and Their Roles in Skin Homeostasis and Carcinogenesis.
ROS signaling by NADPH oxidase 5 modulates the proliferation and survival of prostate carcinoma cells.
Suppressive effects of the NADPH oxidase inhibitor apocynin on intestinal tumorigenesis in obese KK-A(y) and Apc mutant Min mice.
Targeting NOX, INOS and COX-2 in inflammatory cells: Chemoprevention using food phytochemicals.
The NADPH oxidase inhibitor apocynin inhibits UVB-induced skin carcinogenesis.
Understanding the biology of reactive oxygen species and their link to cancer: NADPH oxidases as novel pharmacological targets.
Carcinoma
ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals.
HaCaT keratinocytes overexpressing the S100 proteins S100A8 and S100A9 show increased NADPH oxidase and NF-kappaB activities.
miR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo.
NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation.
NADPH oxidase and uncoupled nitric oxide synthase are major sources of reactive oxygen species in oral squamous cell carcinoma. Potential implications for immune regulation in high oxidative stress conditions.
NADPH-oxidase and a hydrogen peroxide-sensitive K+ channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines.
NOX2 (gp91 phox) is a predominant O2 sensor in a human airway chemoreceptor cell line: biochemical, molecular and electrophysiological evidence.
ROS generation via NOX4 and its utility in the cytological diagnosis of urothelial carcinoma of the urinary bladder.
TG-interacting factor-induced superoxide production from NADPH oxidase contributes to the migration/invasion of urothelial carcinoma.
[Interaction of polymorphisms of PPAR-?2 gene -C34G and NADPH oxidase subunit p22phox gene -C242T with Helicobacter pylori infection in esophageal squamous cell carcinoma].
Carcinoma, Hepatocellular
Divergent pathways for TNF and C(2)-ceramide toxicity in HTC hepatoma cells.
Fluvastatin attenuates hepatic steatosis-induced fibrogenesis in rats through inhibiting paracrine effect of hepatocyte on hepatic stellate cells.
Mechanism of apoptosis induced by apigenin in HepG2 human hepatoma cells: involvement of reactive oxygen species generated by NADPH oxidase.
NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy.
NADPH oxidase NOX1 controls autocrine growth of liver tumor cells through up-regulation of the epidermal growth factor receptor pathway.
Role of reactive oxygen species generated by NADPH oxidase in the mechanism of activation of K(+)-Cl(-)-cotransport by N-ethylmaleimide in HepG2 human hepatoma cells.
Carcinoma, Non-Small-Cell Lung
NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer.
Carcinoma, Squamous Cell
Increased level of the p67phox subunit of NADPH oxidase by 4HPR in head and neck squamous carcinoma cells.
miR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo.
NADPH oxidase and uncoupled nitric oxide synthase are major sources of reactive oxygen species in oral squamous cell carcinoma. Potential implications for immune regulation in high oxidative stress conditions.
Cardio-Renal Syndrome
Chronic Kidney Disease and Disproportionally Increased Cardiovascular Damage: Does Oxidative Stress Explain the Burden?
Cardiomegaly
3,3',4',5,7-Pentamethylquercetin reduces angiotensin II-induced cardiac hypertrophy and apoptosis in rats.
Activation of NADPH oxidase during progression of cardiac hypertrophy to failure.
Administration of rosmarinic acid reduces cardiopathology and blood pressure through inhibition of p22phox NADPH oxidase in fructose-fed hypertensive rats.
Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase.
Apocynin attenuates pressure overload-induced cardiac hypertrophy in rats by reducing levels of reactive oxygen species.
Apocynin prevents isoproterenol-induced cardiac hypertrophy in rat.
Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1-7 in experimental heart failure in angiotensin-converting enzyme 2-null mice.
Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy.
Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1.
Differential involvement of various sources of reactive oxygen species in thyroxin-induced hemodynamic changes and contractile dysfunction of the heart and diaphragm muscles.
Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis.
Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats.
Impaired endothelial regulation of ventricular relaxation in cardiac hypertrophy: role of reactive oxygen species and NADPH oxidase.
NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure.
Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy.
Olmesartan inhibits cardiac hypertrophy in mice overexpressing renin independently of blood pressure: its beneficial effects on ACE2/Ang(1-7)/Mas axis and NADPH oxidase expression.
Pathogenesis of target organ damage in hypertension: role of mitochondrial oxidative stress.
Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice.
Polydatin prevents angiotensin II-induced cardiac hypertrophy and myocardial superoxide generation.
Proteomic profiling reveals comprehensive insights into adrenergic receptor-mediated hypertrophy in neonatal rat cardiomyocytes.
Puerarin Suppresses Angiotensin II-Induced Cardiac Hypertrophy by Inhibiting NADPH Oxidase Activation and Oxidative Stress-Triggered AP-1 Signaling Pathways.
Requirement of Rac1 in the development of cardiac hypertrophy.
Resveratrol ameliorates cardiac oxidative stress in diabetes through deacetylation of NFkB-p65 and histone 3.
Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice.
Stachydrine Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Suppressing Autophagy.
Statins and the myocardium.
The antioxidant tempol inhibits cardiac hypertrophy in the insulin-resistant GLUT4-deficient mouse in vivo.
Vascular but not cardiac remodeling is associated with superoxide production in angiotensin II hypertension.
[Oxidative stress and calcium/calmodulin-dependent protein kinase II contribute to the development of sustained ? adrenergic receptor-stimulated cardiac hypertrophy in rats].
Cardiomyopathies
Hemin decreases cardiac oxidative stress and fibrosis in a rat model of systemic hypertension via PI3K/Akt signaling.
NecroX-7 prevents oxidative stress-induced cardiomyopathy by inhibition of NADPH oxidase activity in rats.
Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment.
Phosphoinositide 3-kinase (p110?) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction.
Ramipril restores PPAR?/? and PPAR? expressions and reduces cardiac NADPH oxidase but fails to restore cardiac function and accompanied myosin heavy chain ratio shift in severe anthracycline-induced cardiomyopathy in rat.
Role of alpha1-adrenoreceptors in cocaine-induced NADPH oxidase expression and cardiac dysfunction.
Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110?) signaling.
Cardiomyopathy, Dilated
Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47phox NADPH oxidase subunit.
Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment.
Cardiotoxicity
17?-estradiol protects against doxorubicin-induced cardiotoxicity in male Sprague-Dawley rats by regulating NADPH oxidase and apoptosis genes.
Association of anthracycline-related cardiac histological lesions with NADPH oxidase functional polymorphisms.
Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma.
Chronic cocaine-induced cardiac oxidative stress and mitogen-activated protein kinase activation: the role of Nox2 oxidase.
Corrigendum to "Exploring the protective role of apocynin, a specific NADPH oxidase inhibitor, in cisplatin-induced cardiotoxicity in rats" [Chem. Biol. Interact. 207 (2014) 58-66].
Exploring the protective role of apocynin, a specific NADPH oxidase inhibitor, in cisplatin-induced cardiotoxicity in rats.
Nox2 NADPH Oxidase Promotes Pathologic Cardiac Remodeling Associated with Doxorubicin Chemotherapy.
p-Cresyl sulfate aggravates cardiac dysfunction associated with chronic kidney disease by enhancing apoptosis of cardiomyocytes.
Rac1 signalling mediates doxorubicin-induced cardiotoxicity through both reactive oxygen species-dependent and -independent pathways.
Cardiovascular Diseases
Acute inhibition of superoxide formation and Rac1 activation by nitric oxide and iloprost in human vascular smooth muscle cells in response to the thromboxane A2 analogue, U46619.
Angiotensin-Generated Reactive Oxygen Species in Brain and Pathogenesis of Cardiovascular Diseases.
Assessment of atherosclerosis in chronic granulomatous disease.
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets.
Current status of NADPH oxidase research in cardiovascular pharmacology.
CYBA gene variants as biomarkers for coronary artery disease.
D1-Like Receptors Regulate NADPH Oxidase Activity and Subunit Expression in Lipid Raft Microdomains of Renal Proximal Tubule Cells.
Dysfunctional endothelial progenitor cells in cardiovascular diseases: role of NADPH oxidase.
Endothelins and NADPH oxidases in the cardiovascular system.
Epigallocatechin-3-gallate Regulates NADPH Oxidase Expression in Human Umbilical Vein Endothelial Cells.
Mitochondrial reactive oxygen species and calcium uptake regulate activation of phagocytic NADPH oxidase.
NADPH oxidase 1 mediates upregulation of thromboxane A(2) synthase in human vascular smooth muscle cells: Inhibition with iloprost.
NADPH oxidase CYBA polymorphisms, oxidative stress and cardiovascular diseases.
NADPH oxidase-mediated oxidative stress: genetic studies of the p22(phox) gene in hypertension.
NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies.
NADPH oxidases in the vasculature: molecular features, roles in disease and pharmacological inhibition.
NADPH oxidases of the brain: distribution, regulation, and function.
Nicotinamide adenine dinucleotide phosphate oxidase: a promiscuous therapeutic target for cardiovascular drugs?
Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models.
Oxidative stress and vascular remodelling.
p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels.
Pharmacology down under in 2005--focus on targets.
Procyanidins from grape pomace are suitable inhibitors of human endothelial NADPH oxidase.
Reactive oxygen species and endothelial activation.
Recent development in the effects of statins on cardiovascular disease through Rac1 and NADPH oxidase.
Redox signaling in angiogenesis: role of NADPH oxidase.
Relation between development of cardiovascular disease and the C242T CYBA polymorphism of the NADPH oxidase in ESRD patients.
Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain.
Role of Nox inhibitors plumbagin, ML090 and gp91ds-tat peptide on homocysteine thiolactone induced blood vessel dysfunction.
Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia.
Suppression of oxidative stress in the endothelium and vascular wall.
The C242T CYBA polymorphism as a major determinant of NADPH oxidase activity in patients with cardiovascular disease.
The endothelin receptor antagonist CPU0213 is more effective than aminoguanidine to attenuate isoproterenol-induced vascular abnormality by suppressing overexpression of NADPH Oxidas, ETA, ETB, and MMP9 in the vasculature.
The role of the methoxyphenol apocynin, a vascular NADPH oxidase inhibitor, as a chemopreventative agent in the potential treatment of cardiovascular diseases.
Upregulation of intermediate-conductance Ca2+-activated K+ channels (KCNN4) in porcine coronary smooth muscle requires NADPH oxidase 5 (NOX5).
Carotid Artery Diseases
Association of the C242T polymorphism in the NADPH oxidase p22 phox gene with carotid atherosclerosis in Slovenian patients with type 2 diabetes.
Carotid Stenosis
Attenuation of Brain Damage and Cognitive Impairment by Direct Renin Inhibition in Mice With Chronic Cerebral Hypoperfusion.
Phagocytic NADPH oxidase-dependent superoxide production stimulates matrix metalloproteinase-9: implications for human atherosclerosis.
Central Nervous System Diseases
Control of JNK for an activation of NADPH oxidase in LPS-stimulated BV2 microglia.
NADPH oxidases - molecular understanding finally reaching the clinical level?
NOX Inhibitors as a Therapeutic Strategy for Stroke and Neurodegenerative Disease.
Cerebral Hemorrhage
Role of NADPH oxidase in the brain injury of intracerebral hemorrhage.
Cerebral Infarction
Apocynin attenuates cerebral infarction after transient focal ischaemia in rats.
Cerebral Small Vessel Diseases
NADPH oxidase polymorphisms in cerebral small vessel disease.
Cerebrovascular Disorders
Association between NADPH oxidase p22(phox) C242T polymorphism and ischemic cerebrovascular disease: a meta-analysis.
C242T polymorphism of NADPH oxidase p22 PHOX gene and ischemic cerebrovascular disease in the Japanese population.
NADPH oxidase in stroke and cerebrovascular disease.
NADPH oxidase p22phox C242T polymorphism and ischemic cerebrovascular disease: an updated meta-analysis.
Polymorphisms of the NADPH oxidase P22PHOX gene in a Caucasian population with intracranial aneurysms.
The role of oxidative stress and NADPH oxidase in cerebrovascular disease.
The role of secretory phospholipase A2 in the central nervous system and neurological diseases.
[Stroke and renin-angiotensin system]
Chagas Disease
NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas disease.
Ovarian dual oxidase (Duox) activity is essential for insect eggshell hardening and waterproofing.
Chediak-Higashi Syndrome
Defective priming of the phagocyte oxidative burst in a child with recurrent intracellular infections.
Cholangiocarcinoma
Free radicals enzymatically triggered by Clonorchis sinensis excretory-secretory products cause NF-?B-mediated inflammation in human cholangiocarcinoma cells.
Cholera
Activation of the superoxide-generating NADPH oxidase of macrophages by sodium dodecyl sulfate in a soluble cell-free system: evidence for involvement of a G protein.
Concanavalin A stimulation of O2 consumption in electropermeabilized neutrophils via a pertussis toxin-insensitive G protein.
Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride. Evidence for participation of a pertussis and cholera toxin-insensitive G protein.
Subcellular distribution and membrane association of human neutrophil substrates for ADP-ribosylation by pertussis toxin and cholera toxin.
Choriocarcinoma
Expression of NADPH oxidase isoform 1 (Nox1) in human placenta: involvement in preeclampsia.
Choroidal Neovascularization
Breaking barriers: insight into the pathogenesis of neovascular age-related macular degeneration.
The role of vascular endothelial growth factor-induced activation of NADPH oxidase in choroidal endothelial cells and choroidal neovascularization.
Coinfection
Nox2-derived oxidative stress results in inefficacy of antibiotics against post-influenza S. aureus pneumonia.
Trichinella spiralis infection affects p47(phox) protein expression in guinea-pig alveolar macrophages.
Colitis
A Model of Salmonella Colitis with Features of Diarrhea in SLC11A1 Wild-Type Mice.
NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium.
Protective action of NADPH oxidase inhibitors and role of NADPH oxidase in pathogenesis of colon inflammation in mice.
Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide.
Colitis, Ulcerative
Apocynin Suppresses Lipopolysaccharide-Induced Inflammatory Responses Through the Inhibition of MAP Kinase Signaling Pathway in RAW264.7 Cells.
Influence of NADPH oxidase on inflammatory response in primary intestinal epithelial cells in patients with ulcerative colitis.
NADPH oxidase p22phox gene expression in ulcerative colitis.
No association between a genetic variant of the p22PHOX component of NADPH oxidase C242T and ulcerative colitis.
Colonic Neoplasms
Defective IL-23/IL-17 Axis Protects p47phox-/- Mice from Colon Cancer.
Effects of iodonium-class flavin dehydrogenase inhibitors on growth, reactive oxygen production, cell cycle progression, NADPH oxidase 1 levels, and gene expression in human colon cancer cells and xenografts.
Epidermal growth factor stimulates nuclear factor-?B activation and heme oxygenase-1 expression via c-Src, NADPH oxidase, PI3K, and Akt in human colon cancer cells.
IGF-1 induces expression of zinc-finger protein 143 in colon cancer cells through phosphatidylinositide 3-kinase and reactive oxygen species.
Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells.
NADPH oxidase is involved in protein kinase CKII down-regulation-mediated senescence through elevation of the level of reactive oxygen species in human colon cancer cells.
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
NADPH oxidase subunit, gp91(phox) homologue, preferentially expressed in human colon epithelial cells.
NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7.
Colorectal Neoplasms
15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity.
Suppressive effects of the NADPH oxidase inhibitor apocynin on intestinal tumorigenesis in obese KK-A(y) and Apc mutant Min mice.
Coma
Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
A novel and unusual case of chronic granulomatous disease in a child with a homozygous 36-bp deletion in the CYBA gene (A22(0)) leading to the activation of a cryptic splice site in intron 4.
Different unequal cross-over events between NCF1 and its pseudogenes in autosomal p47(phox)-deficient chronic granulomatous disease.
Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease.
Rare Duplication or Deletion of Exons 6, 7 and 8 in CYBB Leading to X-Linked Chronic Granulomatous Disease in Two Patients from Different Families.
Corneal Neovascularization
NADPH oxidase 2 plays a role in experimental corneal neovascularization.
Coronary Artery Disease
C242T polymorphism of NADPH oxidase p22 PHOX gene and ischemic cerebrovascular disease in the Japanese population.
C242T polymorphism of NADPH oxidase p22phox and recurrence of cardiovascular events in coronary artery disease.
C242T polymorphism of NADPH oxidase p22phox gene reduces the risk of coronary artery disease in a random sample of Egyptian population.
Endothelin-1 increases superoxide production in human coronary artery bypass grafts.
NADPH oxidase activation played a critical role in the oxidative stress process in stable coronary artery disease.
Relationship between NADPH oxidase p22phox C242T, PARP-1 Val762Ala polymorphisms, angiographically verified coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus.
Relationship of the C242T p22phox gene polymorphism to angiographic coronary artery disease and endothelial function.
Roles of NADPH oxidase and mitochondria in flow-induced vasodilation of human adipose arterioles: ROS-induced ROS release in coronary artery disease.
The effect of p22-PHOX (CYBA) polymorphisms on premature coronary artery disease (? 40 years of age).
[Role of NADPH oxidase in endothelial cell dysfunction induced by endothelial microparticles]
Coronary Disease
p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels.
Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin-Potential for Preventing or Slowing the Progression of Diabetic Complications.
Coxsackievirus Infections
Superoxide Production by NADPH Oxidase Intensifies Macrophage Antiviral Responses during Diabetogenic Coxsackievirus Infection.
Crohn Disease
Escherichia coli LF82 differentially regulates ROS production and mucin expression in intestinal epithelial T84 cells: implication of NOX1.
NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2.
Subtractive screening reveals up-regulation of NADPH oxidase expression in Crohn's disease intestinal macrophages.
cystathionine beta-synthase deficiency
Cystathionine beta synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver.
Cystic Fibrosis
Defective protein kinase C-mediated actions in cystic fibrosis neutrophils.
Delayed association of the NADPH oxidase complex with macrophage vacuoles containing the opportunistic pathogen Burkholderia cenocepacia.
Dysregulation in lung immunity - the protective and pathologic Th17 response in infection.
Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented by
Small interfering peptide (siP) for in vivo examination of the developing lung interactonome.
The role of chloride anion and CFTR in killing of Pseudomonas aeruginosa by normal and CF neutrophils.
Dehydration
A novel rice C2H2-type zinc finger protein, ZFP36, is a key player involved in abscisic acid-induced antioxidant defence and oxidative stress tolerance in rice.
Abscisic acid mediated differential growth responses of root and shoot of Vigna radiata (L.) Wilczek seedlings under water stress.
Drought-stimulated activity of plasma membrane nicotinamide adenine dinucleotide phosphate oxidase and its catalytic properties in rice.
Mechanical wounding-induced laticifer differentiation in rubber tree: An indicative role of dehydration, hydrogen peroxide, and jasmonates.
Delirium
Involvement of the NADPH Oxidase NOX2-Derived Brain Oxidative Stress in an Unusual Fatal Case of Cocaine-Related Neurotoxicity Associated With Excited Delirium Syndrome.
The role of the NADPH oxidase derived brain oxidative stress in the cocaine-related death associated with excited delirium: A literature review.
Dementia, Vascular
Pitavastatin and 4'-hydroxy-3'-methoxyacetophenone (HMAP) reduce cognitive dysfunction in vascular dementia during experimental diabetes.
Demyelinating Diseases
Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage.
Dental Caries
Deciphering of the Dual oxidase (Nox family) gene from kuruma shrimp, Marsupenaeus japonicus: full-length cDNA cloning and characterization.
Dermatitis
Severe Dermatitis Associated with Spontaneous Staphylococcus xylosus Infection in Rag(-/-)Tpl2(-/-) Mice.
Diabetes Complications
Kinin Receptors in Vascular Biology and Pathology.
NOX enzymes and diabetic complications.
Diabetes Mellitus
Apocynin influence on oxidative stress and cardiac remodeling of spontaneously hypertensive rats with diabetes mellitus.
Association of the -262C/T polymorphism in the catalase gene promoter and the C242T polymorphism of the NADPH oxidase P22phox gene with essential arterial hypertension in patients with diabetes mellitus type 2.
Augmented NADPH oxidase activity and p22phox expression in monocytes underlie oxidative stress of patients with type 2 diabetes mellitus.
Correction of aberrant NADPH oxidase activity in blood derived mononuclear cells from type II diabetes mellitus patients by a naturally fermented papaya preparation.
Deletion of p47 ( phox ) attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse.
Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4.
Monocyte NADPH oxidase subunit p22(phox) and inducible hemeoxygenase-1 gene expressions are increased in type II diabetic patients: relationship with oxidative stress.
NADPH oxidases in the kidney.
Pharmacological Prevention of eNOS Uncoupling.
Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase.
Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling.
Relationship between NADPH oxidase p22phox C242T, PARP-1 Val762Ala polymorphisms, angiographically verified coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus.
Selective Rac-1 inhibition protects from diabetes-induced vascular injury.
The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70in pancreatic islet function, dysfunction and diabetes.
[Genetic risk factors for ischemic cerebrovascular disease--analysis on fifteen candidate prothrombotic gene polymorphisms in the Japanese population]
Diabetes Mellitus, Type 1
Allelic variations in the CYBA gene of NADPH oxidase and risk of kidney complications in patients with type 1 diabetes.
Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes.
Deletion of p47 ( phox ) attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse.
NADPH oxidase and PKC contribute to increased Na transport by the thick ascending limb during type 1 diabetes.
NADPH oxidases in the kidney.
Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes.
Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes.
Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice.
The interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats.
The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy.
Diabetes Mellitus, Type 2
Association of the -262C/T polymorphism in the catalase gene promoter and the C242T polymorphism of the NADPH oxidase P22phox gene with essential arterial hypertension in patients with diabetes mellitus type 2.
Association of the C242T polymorphism in the NADPH oxidase p22 phox gene with carotid atherosclerosis in Slovenian patients with type 2 diabetes.
Augmented NADPH oxidase activity and p22phox expression in monocytes underlie oxidative stress of patients with type 2 diabetes mellitus.
Differential gene expression of NADPH oxidase (p22phox) and hemoxygenase-1 in patients with Type 2 diabetes and microangiopathy.
Monocyte NADPH oxidase subunit p22(phox) and inducible hemeoxygenase-1 gene expressions are increased in type II diabetic patients: relationship with oxidative stress.
NADPH oxidase inhibitor, apocynin, restores the impaired endothelial-dependent and -independent responses and scavenges superoxide anion in rats with type 2 diabetes complicated by NO dysfunction.
Relationship between NADPH oxidase p22phox C242T, PARP-1 Val762Ala polymorphisms, angiographically verified coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus.
Short-term intravenous insulin infusion is associated with reduced expression of NADPH oxidase p47(phox) subunit in monocytes from type 2 diabetes patients.
The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice.
Tyrosine kinase-mediated activation of NADPH oxidase enhances proliferative capacity of diabetic vascular smooth muscle cells.
Unacylated ghrelin rescues endothelial progenitor cell function in individuals with type 2 diabetes.
Diabetic Angiopathies
Blockade of chronic high glucose-induced endothelial apoptosis by Sasa borealis bamboo extract.
Blockade of Renin-Angiotensin System Attenuates Advanced Glycation End Products-Mediated Signaling Pathways.
Resveratrol Protects Vascular Endothelial Cells from High Glucose-Induced Apoptosis through Inhibition of NADPH Oxidase Activation-Driven Oxidative Stress.
Vascular Dysfunction in Streptozotocin-Induced Experimental Diabetes Strictly Depends on Insulin Deficiency.
Diabetic Cardiomyopathies
AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase.
Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy.
Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes.
Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK.
Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme.
Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes.
Phosphoinositide 3-kinase (p110?) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction.
Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110?) signaling.
Diabetic Nephropathies
A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis.
Allelic variations in the CYBA gene of NADPH oxidase and risk of kidney complications in patients with type 1 diabetes.
Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue.
Chronic Running Exercise Alleviates Early Progression of Nephropathy with Upregulation of Nitric Oxide Synthases and Suppression of Glycation in Zucker Diabetic Rats.
Comment on: Thallas-Bonke et al. (2008) Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway: Diabetes 57:460-469, 2008.
Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney - implications in type 2 diabetic nephropathy.
Effects of NADPH oxidase inhibitor in diabetic nephropathy.
Effects of NADPH oxidase inhibitor on diabetic nephropathy in OLETF rats: the role of reducing oxidative stress in its protective property.
Ethyl pyruvate ameliorates albuminuria and glomerular injury in the animal model of diabetic nephropathy.
Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy.
Glycated albumin activates NADPH oxidase in rat mesangial cells through up-regulation of p47phox.
Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway.
Inhibition of renal gluconeogenesis contributes to hypoglycaemic action of NADPH oxidase inhibitor, apocynin.
Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury.
Melatonin nephroprotective action in Zucker diabetic fatty rats involves its inhibitory effect on NADPH oxidase.
Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease.
Microarray analysis of multiple candidate genes and associated plasma proteins for nephropathy secondary to type 2 diabetes among Chinese individuals.
mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes.
NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation.
NADPH Oxidase Nox5 Accelerates Renal Injury in Diabetic Nephropathy.
NADPH oxidase p22phox C242T polymorphism is associated with macroalbuminuria in diabetic patients: A meta-analysis.
Normalizing NADPH Oxidase Contributes to Attenuating Diabetic Nephropathy by the Dual Endothelin Receptor Antagonist CPU0213 in Rats.
Preservation of kidney function with combined inhibition of NADPH oxidase and angiotensin-converting enzyme in diabetic nephropathy.
Reactive oxygen species and oxidative stress.
Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental diabetic nephropathy.
Regulation of transforming growth factor beta 1 gene expression by dihydropteridine reductase in kidney 293T cells.
Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of type 2 diabetes.
ROS generation by nonphagocytic NADPH oxidase: potential relevance in diabetic nephropathy.
Schizandrin prevents damage of murine mesangial cells via blocking NADPH oxidase-induced ROS signaling in high glucose.
Suppressing renal NADPH oxidase to treat diabetic nephropathy.
Targeting of Rho kinase ameliorates impairment of diabetic endothelial function in intrarenal artery.
The mTOR promotes oxidative stress-induced apoptosis of mesangial cells in diabetic nephropathy.
The role of adrenomedullin in the renal NADPH oxidase and (pro)renin in diabetic mice.
The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy.
Diabetic Neuropathies
Curcumin ameliorated diabetic neuropathy partially by inhibition of NADPH oxidase mediating oxidative stress in the spinal cord.
Diabetic Retinopathy
A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase.
Activation of nicotinamide adenine dinucleotide phosphate (reduced form) oxidase by advanced glycation end products links oxidative stress to altered retinal vascular endothelial growth factor expression.
Diabetic retinopathy and transcriptional regulation of a small molecular weight G-Protein, Rac1.
NADPH Oxidase versus Mitochondria-Derived ROS in Glucose-Induced Apoptosis of Pericytes in Early Diabetic Retinopathy.
Pigment epithelium-derived factor inhibits advanced glycation end products-induced retinal vascular permeability.
Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids.
Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy.
Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy.
Disorders of Excessive Somnolence
NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea.
Duodenal Ulcer
Genetic variant of the p22PHOX component of NADPH oxidase C242T and the incidence of gastric cancer in Japan.
Dyslipidemias
Simvastatin Attenuates Oxidative Stress, NF-?B Activation, and Artery Calcification in LDLR-/- Mice Fed with High Fat Diet via Down-regulation of Tumor Necrosis Factor-? and TNF Receptor 1.
Ectodermal Dysplasia
Essential role of nuclear factor-kappaB for NADPH oxidase activity in normal and anhidrotic ectodermal dysplasia leukocytes.
Nuclear factor-{kappa}B is not essential for NADPH oxidase activity in neutrophils from anhidrotic ectodermal dysplasia patients.
Ehrlichiosis
Anaplasma phagocytophilum modulates gp91phox gene expression through altered interferon regulatory factor 1 and PU.1 levels and binding of CCAAT displacement protein.
Essential role for humoral immunity during Ehrlichia infection in immunocompetent mice.
Encephalitis
NADPH oxidase is involved in post-ischemic brain inflammation.
Encephalomyelitis
A leading role for NADPH oxidase in an in-vitro study of experimental autoimmune encephalomyelitis.
Advanced intercross line mapping suggests that ncf1 (ean6) regulates severity in an animal model of guillain-barre syndrome.
Experimental autoimmune encephalomyelitis and age-related correlations of NADPH oxidase, MMP-9, and cell adhesion molecules: The increased disease severity and blood-brain barrier permeability in middle-aged mice.
Expression and activation of matrix metalloproteinase-9 and NADPH oxidase in tissues and plasma of experimental autoimmune encephalomyelitis in mice.
Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice.
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.
Superoxide prevents nitric oxide-mediated suppression of helper T lymphocytes: decreased autoimmune encephalomyelitis in nicotinamide adenine dinucleotide phosphate oxidase knockout mice.
Encephalomyelitis, Autoimmune, Experimental
A leading role for NADPH oxidase in an in-vitro study of experimental autoimmune encephalomyelitis.
Experimental autoimmune encephalomyelitis and age-related correlations of NADPH oxidase, MMP-9, and cell adhesion molecules: The increased disease severity and blood-brain barrier permeability in middle-aged mice.
Expression and activation of matrix metalloproteinase-9 and NADPH oxidase in tissues and plasma of experimental autoimmune encephalomyelitis in mice.
Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice.
Superoxide prevents nitric oxide-mediated suppression of helper T lymphocytes: decreased autoimmune encephalomyelitis in nicotinamide adenine dinucleotide phosphate oxidase knockout mice.
Endometrial Neoplasms
?-Terthienylmethanol, isolated from Eclipta prostrata, induces apoptosis by generating reactive oxygen species via NADPH oxidase in human endometrial cancer cells.
Endogenous production of reactive oxygen species by the NADPH oxidase complexes is a determinant of ?-glutamyltransferase expression.
Endotoxemia
Effect of natural antioxidants and apocynin on LPS-induced endotoxemia in rabbit.
Role of NADPH oxidase in retinal vascular inflammation.
Eosinophilia
Nonhematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally induced asthma.
Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba).
Epilepsy
NADPH oxidase activation and 4-hydroxy-2-nonenal/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy.
Reactive oxygen species generated by NADPH oxidase are involved in neurodegeneration in the pilocarpine model of temporal lobe epilepsy.
Status epilepticus results in persistent overproduction of reactive oxygen species, inhibition of which is neuroprotective.
Epilepsy, Temporal Lobe
Reactive oxygen species generated by NADPH oxidase are involved in neurodegeneration in the pilocarpine model of temporal lobe epilepsy.
Erectile Dysfunction
Comparison of sildenafil with strontium fructose diphosphate in improving erectile dysfunction against upregulated cavernosal NADPH oxidase, protein kinase C?, and endothelin system in diabetic rats.
Constitutive NOS uncoupling and NADPH oxidase upregulation in the penis of type 2 diabetic men with erectile dysfunction.
Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits.
NADPH Oxidase Activation: A Mechanism of Erectile Dysfunction in a Rat Model of Sleep Apnea.
NADPH oxidase activation: a mechanism of hypertension-associated erectile dysfunction.
NADPH oxidase: recent evidence for its role in erectile dysfunction.
Reactive oxygen species and erectile dysfunction: possible role of NADPH oxidase.
Sildenafil inhibits the up-regulation of phosphodiesterase type 5 elicited with nicotine and tumour necrosis factor-alpha in cavernosal vascular smooth muscle cells: mediation by superoxide.
Smoking and erectile dysfunction: the role of NADPH oxidase.
Superoxide Anion Production by NADPH Oxidase Plays a Major Role in Erectile Dysfunction in Middle-Aged Rats: Prevention by Antioxidant Therapy.
The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2.
[NADPH oxidase and male erectile dysfunction]
Esophageal Squamous Cell Carcinoma
[Interaction of polymorphisms of PPAR-?2 gene -C34G and NADPH oxidase subunit p22phox gene -C242T with Helicobacter pylori infection in esophageal squamous cell carcinoma].
Essential Hypertension
Hemizygosity at the NCF1 Gene in Patients with Williams-Beuren Syndrome Decreases Their Risk of Hypertension.
NADPH oxidase, superoxide overproduction and nitric oxide bioavailability in essential hypertension.
Regulation of the superoxide-forming NADPH oxidase of human neutrophils is not altered in essential hypertension.
The C242T CYBA polymorphism of NADPH oxidase is associated with essential hypertension.
Fatty Liver
Apocynin administration prevents the changes induced by a fructose-rich diet on rat liver metabolism and the antioxidant system.
NADPH oxidase is not an essential mediator of oxidative stress or liver injury in murine MCD diet-induced steatohepatitis.
The Presence of p47phox in Liver Parenchymal Cells is a Key Mediator in the Pathogenesis of Alcoholic Liver Steatosis.
Fetal Alcohol Spectrum Disorders
The role of NADPH oxidase in a mouse model of fetal alcohol syndrome.
Fibrosarcoma
Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-alpha-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain.
Superoxide plays critical roles in electrotaxis of fibrosarcoma cells via activation of ERK and reorganization of cytoskeleton.
Fragile X Syndrome
Design of dual inhibitors of ROCK-I and NOX2 as potential leads for the treatment of neuroinflammation associated with various neurological diseases including autism spectrum disorder.
Galactosemias
Impaired NADPH oxidase activity in peripheral blood lymphocytes of galactosemia patients.
Gastritis
Association of polymorphism of the p22PHOX component of NADPH oxidase in gastroduodenal diseases in Japan.
Gastrointestinal Neoplasms
Dual Oxidase2 and pancreatic adenocarcinoma: IFN-?-mediated dual oxidase2 overexpression results in H2O2-induced, ERKassociated up-regulation of HIF-1? and VEGF-A.
Genetic Diseases, Inborn
Interferon gamma-1b. A review of its pharmacology and therapeutic potential in chronic granulomatous disease.
Molecular analysis of X-linked chronic granulomatous disease in five unrelated Korean patients.
Rapid determination of chimerism status using dihydrorhodamine assay in a patient with X-linked chronic granulomatous disease following hematopoietic stem cell transplantation.
Renal transplantation in a patient with chronic granulomatous disease: case report.
Successful renal transplantation in patients with chronic granulomatous disease.
The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs.
Virulence of catalase-deficient aspergillus nidulans in p47(phox)-/- mice. Implications for fungal pathogenicity and host defense in chronic granulomatous disease.
[Chronic granulomatous disease: pathogenesis and therapy of associated fungal infections].
Gilbert Disease
NAPDH oxidase mediates glucolipotoxicity-induced beta cell dysfunction - Clinical implications.
Glioblastoma
Lentivirus-mediated Nox4 shRNA invasion and angiogenesis and enhances radiosensitivity in human glioblastoma.
NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme.
NADPH oxidase subunit 4-mediated reactive oxygen species contribute to cycling hypoxia-promoted tumor progression in glioblastoma multiforme.
Nox4 redox regulation of PTP1B contributes to the proliferation and migration of glioblastoma cells by modulating tyrosine phosphorylation of coronin-1C.
Glioma
An oxidative stress mechanism of shikonin in human glioma cells.
Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival.
Mechanisms of tumor necrosis factor-alpha-induced interleukin-6 synthesis in glioma cells.
Nicotine- and tar-free cigarette smoke extract induces cell injury via intracellular Ca2+-dependent subtype-specific protein kinase C activation.
Glomerulonephritis
Addition of the Antioxidant Probucol to Angiotensin II Type I Receptor Antagonist Arrests Progressive Mesangioproliferative Glomerulonephritis in the Rat.
Peroxisome proliferator-activated receptor alpha protects against glomerulonephritis induced by long-term exposure to the plasticizer di-(2-ethylhexyl)phthalate.
Polymorphisms in NADPH oxidase CYBA gene modify the risk of ESRD in patients with chronic glomerulonephritis.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Association of glucose-6-phosphate dehydrogenase deficiency and X-linked chronic granulomatous disease in a child with anemia and recurrent infections.
Expanding the clinical and genetic spectrum of G6PD deficiency: The occurrence of BCGitis and novel missense mutation.
Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II.
Glucosephosphate Dehydrogenase Deficiency
Association of glucose-6-phosphate dehydrogenase deficiency and X-linked chronic granulomatous disease in a child with anemia and recurrent infections.
Expanding the clinical and genetic spectrum of G6PD deficiency: The occurrence of BCGitis and novel missense mutation.
Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II.
Glycogen Storage Disease
NADPH oxidase activity and chemotaxis by neutrophils in two patients with glycogen storage disease type Ib treated with recombinant human granulocyte-monocyte colony-stimulating factor.
Goiter
A Novel Missense Mutation (I26M) in DUOXA2 Causing Congenital Goiter Hypothyroidism Impairs NADPH Oxidase Activity but Not Protein Expression.
Ca(2+)/nicotinamide adenine dinucleotide phosphate-dependent H(2)O(2) generation is inhibited by iodide in human thyroids.
Granuloma
Adaptive immune defects against glycoantigens in chronic granulomatous disease via dysregulated nitric oxide production.
Aspergillus nidulans infection in a patient with chronic granulomatous disease.
Bacillus calmette-guerin infection in NADPH oxidase deficiency: defective mycobacterial sequestration and granuloma formation.
Chronic granulomatous disease.
Genetic, biochemical, and clinical features of chronic granulomatous disease.
Induction of Pulmonary Granuloma Formation by Propionibacterium acnes is regulated by MyD88 and Nox2.
Safety and effectiveness of long-term interferon gamma therapy in patients with chronic granulomatous disease.
Granulomatous Disease, Chronic
A 1.1-kb duplication in the p67-phox gene causes chronic granulomatous disease.
A founder effect for p47(phox)Trp193Ter chronic granulomatous disease in Kavkazi Jews.
A functional NADPH oxidase prevents caspase involvement in the clearance of phagocytic neutrophils.
A mutation located at the 5' splice junction sequence of intron 3 in the p67phox gene causes the lack of p67phox mRNA in a patient with chronic granulomatous disease.
A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity.
A novel and unusual case of chronic granulomatous disease in a child with a homozygous 36-bp deletion in the CYBA gene (A22(0)) leading to the activation of a cryptic splice site in intron 4.
A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation.
A Review of Chronic Granulomatous Disease.
A Role for NADPH Oxidase in Antigen Presentation.
A simple approach for the analysis of intracellular movement of oxidant-producing intracellular compartments in living human neutrophils.
A variant of chronic granulomatous disease: deficient oxidative metabolism due to a low-affinity NADPH oxidase.
Abnormal activation of H+ conductance in NADPH oxidase-defective neutrophils.
Activation of H+ conductance in neutrophils requires assembly of components of the respiratory burst oxidase but not its redox function.
Activation of NADPH oxidase required for macrophage-mediated oxidation of low-density lipoprotein.
Activation of the small GTPase rap1 in human neutrophils.
Adaptive immune defects against glycoantigens in chronic granulomatous disease via dysregulated nitric oxide production.
Adenosine A(2A) receptor activation limits chronic granulomatous disease-induced hyperinflammation.
Altered Pattern of Nave and Memory B cells and B1 Cells in Patients with Chronic Granulomatous Disease.
An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD.
Analysis of Chronic Granulomatous Disease in the Kavkazi Population in Israel Reveals Phenotypic Heterogeneity in Patients with the Same NCF1 mutation (c.579G>A).
Aspergillus nidulans infection in chronic granulomatous disease.
Assessment of the contribution of the cytochrome b moiety of the NADPH oxidase to the transmembrane H+ conductance of leukocytes.
Association of glucose-6-phosphate dehydrogenase deficiency and X-linked chronic granulomatous disease in a child with anemia and recurrent infections.
Autosomal recessive chronic granulomatous disease with absence of the 67-kD cytosolic NADPH oxidase component: identification of mutation and detection of carriers.
beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease.
Bioluminescence imaging of NADPH oxidase activity in different animal models.
Catalase negative Staphylococcus aureus retain virulence in mouse model of chronic granulomatous disease.
CD40/CD40L expression in leukocytes from chronic granulomatous disease patients.
Cell-free assays: the reductionist approach to the study of NADPH oxidase assembly, or "all you wanted to know about cell-free assays but did not dare to ask".
Cell-free NADPH oxidase activation assays: "in vitro veritas".
Characterization of nitric oxide consumption pathways by normal, chronic granulomatous disease and myeloperoxidase-deficient human neutrophils.
Characterization of six novel mutations in the CYBB gene leading to different sub-types of X-linked chronic granulomatous disease.
Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoic acid.
Chronic granulomatous disease due to granulocytes with abnormal NADPH oxidase activity and deficient cytochrome-b.
Chronic Granulomatous Disease Due to Neutrophil Cytosolic Factor (NCF2) Gene Mutations in Three Unrelated Families.
Chronic granulomatous disease, the McLeod phenotype and the contiguous gene deletion syndrome-a review.
Chronic granulomatous disease.
Chronic Granulomatous Disease.
Chronic Granulomatous Disease: A 25-Year Patient Registry Based on a Multistep Diagnostic Procedure, from the Referral Center for Primary Immunodeficiencies in Greece.
Chronic granulomatous disease: Clinical, molecular, and therapeutic aspects.
Chronic granulomatous disease: towards gene therapy.
Chronic granulomatous disease: why an inflammatory disease?
Clinical and molecular features of 38 children with chronic granulomatous disease in mainland china.
Clinical Manifestations of Disease in X-Linked Carriers of Chronic Granulomatous Disease.
Clinical, Functional and Genetic Analysis of Twenty-Four Patients with Chronic Granulomatous Disease - Identification of Eight Novel Mutations in CYBB and NCF2 Genes.
Clinical, Immunological, and Molecular Findings of Patients with p47(phox) Defect Chronic Granulomatous Disease (CGD) in Indian Families.
Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.
Complementation of NADPH oxidase in p67-phox-deficient CGD patients p67-phox/p40-phox interaction.
Conventional versus interferon-gamma therapy in chronic granulomatous disease.
Copy number variations due to large genomic deletion in x-linked chronic granulomatous disease.
Coregulation of NADPH oxidase activation and phosphorylation of a 48-kD protein(s) by a cytosolic factor defective in autosomal recessive chronic granulomatous disease.
Cytochrome b558-negative, autosomal recessive chronic granulomatous disease: two new mutations in the cytochrome b558 light chain of the NADPH oxidase (p22-phox).
Cytokine-mediated induction of MHC class II in human neutrophils is dependent on NADPH oxidase activity.
Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils.
Decreased neural precursor cell pool in NADPH oxidase 2-deficiency: From mouse brain to neural differentiation of patient derived iPSC.
Defective priming of the phagocyte oxidative burst in a child with recurrent intracellular infections.
Deficiency of NADPH oxidase activity in chronic granulomatous disease.
Deficiency of p67phox, p47phox or gp91phox in chronic granulomatous disease does not impair leucocyte chemotaxis or motility.
Delineation of the phagocyte NADPH oxidase through studies of chronic granulomatous diseases of childhood.
Derivation and Functional Analysis of Patient Specific Induced Pluripotent Stem Cells as an In Vitro Model of Chronic Granulomatous Disease.
Detection of gp91-phox precursor protein in B-cell lines from patients with X-linked chronic granulomatous disease as an indicator for mutations impairing cytochrome b558 biosynthesis.
Detection of non-DeltaGT NCF-1 mutations in chronic granulomatous disease.
Different unequal cross-over events between NCF1 and its pseudogenes in autosomal p47(phox)-deficient chronic granulomatous disease.
Differential expression and regulation of hsp70 and hsp90 by phorbol esters and heat shock.
Diverse stimuli engage different neutrophil extracellular trap pathways.
Dysregulation in lung immunity - the protective and pathologic Th17 response in infection.
Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease.
Effects of platinum and palladium ions on the production and reactivity of neutrophil-derived reactive oxygen species.
Enhanced cutaneous inflammatory reactions to Aspergillus fumigatus in a murine model of chronic granulomatous disease.
Enterobacter cloacae pyomyositis complicating chronic granulomatous disease and review of gram-negative bacilli pyomyositis.
Fas and FasL expression in leukocytes from chronic granulomatous disease patients.
Flow cytometric analysis of the granulocyte respiratory burst: a comparison study of fluorescent probes.
Functional analysis of NADPH oxidase in granulocytic cells expressing a delta488-497 gp91(phox) deletion mutant.
Functional analysis of two-amino acid substitutions in gp91 phox in a patient with X-linked flavocytochrome b558-positive chronic granulomatous disease by means of transgenic PLB-985 cells.
Functional Restoration of gp91phox-Oxidase Activity by BAC Transgenesis and Gene Targeting in X-linked Chronic Granulomatous Disease iPSCs.
Gene transfer to primary chronic granulomatous disease monocytes.
Generation of X-CGD cells for vector evaluation from healthy donor CD34(+) HSCs by shRNA-mediated knock down of gp91(phox).
Genetic studies of three Japanese patients with p22-phox-deficient chronic granulomatous disease: detection of a possible common mutant CYBA allele in Japan and a genotype-phenotype correlation in these patients.
Genetic variants of chronic granulomatous disease: prevalence of deficiencies of two cytosolic components of the NADPH oxidase system.
Genetic, biochemical, and clinical features of chronic granulomatous disease.
Genetical analysis of all Danish patients diagnosed with chronic granulomatous disease.
Granulocyte colony-stimulating factor prior to nonmyeloablative irradiation decreases murine host hematopoietic stem cell function and increases engraftment of donor marrow cells.
Haploidentical stem cell transplantation in a boy with chronic granulomatous disease.
Haploinsufficiency of NADPH Oxidase Subunit Neutrophil Cytosolic Factor 2 Is Sufficient to Accelerate Full-Blown Lupus in NZM 2328 Mice.
Human polymorphonuclear leukocytes inhibit Aspergillus fumigatus conidial growth by lactoferrin-mediated iron depletion.
Hyper-responsive Toll-like receptor 7 and 9 activation in NADPH oxidase-deficient B lymphoblasts.
Hypochlorous acid regulates neutrophil extracellular trap release in humans.
Identification of a thermolabile component of the human neutrophil NADPH oxidase. A model for chronic granulomatous disease caused by deficiency of the p67-phox cytosolic component.
Identification of the defective NADPH-oxidase component in chronic granulomatous disease: a study of 57 European families.
Impaired macrophage function following bacterial stimulation in chronic granulomatous disease.
Infections associated with chronic granulomatous disease: linking genetics to phenotypic expression.
Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease.
Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt.
Interferon gamma-1b. A review of its pharmacology and therapeutic potential in chronic granulomatous disease.
Interferon-gamma improves splicing efficiency of CYBB gene transcripts in an interferon-responsive variant of chronic granulomatous disease due to a splice site consensus region mutation.
Intracellular generation of superoxide by the phagocyte NADPH oxidase: How, where, and what for?
Intractable colitis associated with chronic granulomatous disease in a young girl.
Intrapulmonary Mycobacterium avium infection as the first manifestation of chronic granulomatous disease.
Invasive aspergillosis in chronic granulomatous disease.
Investigation into the relationship between calyculin A-mediated potentiation of NADPH oxidase activity and inhibition of store-operated uptake of calcium by human neutrophils.
Involvement of a functional NADPH oxidase in neutrophils and macrophages during programmed cell clearance: implications for chronic granulomatous disease.
Involvement of p40phox in activation of phagocyte NADPH oxidase through association of its carboxyl-terminal, but not its amino-terminal, with p67phox.
IRE1? mediates PKR activation in response to Chlamydia trachomatis infection.
Killing of Mycobacterium tuberculosis by neutrophils: a nonoxidative process.
Lentivirus-mediated gene transfer of gp91phox corrects chronic granulomatous disease (CGD) phenotype in human X-CGD cells.
Lessons about the pathogenesis and management of aspergillosis from studies in chronic granulomatous disease.
Leukotriene B4 metabolism in neutrophils of patients with chronic granulomatous disease: phorbol myristate acetate decreases endogenous leukotriene B4 via NADPH oxidase-dependent mechanism.
Long polymerase chain reaction-based fluorescence in situ hybridization analysis of female carriers of X-linked chronic granulomatous disease deletions.
Long-term high-level reconstitution of NADPH oxidase activity in murine X-linked chronic granulomatous disease using a bicistronic vector expressing gp91phox and a Delta LNGFR cell surface marker.
Missense mutations in the gp91-phox gene encoding cytochrome b558 in patients with cytochrome b positive and negative X-linked chronic granulomatous disease.
Molecular analysis of X-linked chronic granulomatous disease in five unrelated Korean patients.
Molecular Basis of Autosomal Recessive Chronic Granulomatous Disease in Iran.
Molecular characterization of a large cohort of patients with Chronic Granulomatous Disease and identification of novel CYBB mutations: An Italian multicenter study.
Molecular diagnosis of X-linked chronic granulomatous disease in Iran.
Molecular dynamics study on the ligand recognition by tandem SH3 domains of p47phox, regulating NADPH oxidase activity.
Molecular quality control machinery contributes to the leukocyte NADPH oxidase deficiency in chronic granulomatous disease.
Monocyte- and Macrophage-Targeted NADPH Oxidase Mediates Antifungal Host Defense and Regulation of Acute Inflammation in Mice.
Mutation at histidine 338 of gp91(phox) depletes FAD and affects expression of cytochrome b558 of the human NADPH oxidase.
NADPH Oxidase 1 and Its Derived Reactive Oxygen Species Mediated Tissue Injury and Repair.
NADPH oxidase activity and cytochrome b558 content of human Epstein-Barr-virus-transformed B lymphocytes correlate with expression of genes encoding components of the oxidase system.
NADPH oxidase deficiency in X-linked chronic granulomatous disease.
NADPH Oxidase Deficiency: A Multisystem Approach.
NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium.
NADPH oxidase involvement in the pathology of Helicobacter pylori infection.
NADPH oxidase is not essential for low density lipoprotein oxidation by human monocyte-derived macrophages.
NADPH oxidase is not required for spontaneous and Staphylococcus aureus-induced apoptosis of monocytes.
NADPH oxidase limits innate immune responses in the lungs in mice.
NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.
Neutrophil extracellular trap cell death requires both autophagy and superoxide generation.
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease.
Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice.
Nicotinamide-adenine dinucleotide phosphate oxidase assembly and activation in EBV-transformed B lymphoblastoid cell lines of normal and chronic granulomatous disease patients.
Novel cell death program leads to neutrophil extracellular traps.
Ocular manifestations in chronic granulomatous disease in Saudi Arabia.
Osteomyelitis due to Aspergillus spp. in patients with chronic granulomatous disease: comparison of Aspergillus nidulans and Aspergillus fumigatus.
Oxidant-mediated phosphatidylserine exposure and macrophage uptake of activated neutrophils: possible impairment in chronic granulomatous disease.
p40phox: the last NADPH oxidase subunit.
P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.
p47phox-deficient immune microenvironment signals dysregulate naive T-cell apoptosis.
Persistence of the Bacterial Pathogen Granulibacter bethesdensis in Chronic Granulomatous Disease Monocytes and Macrophages Lacking a Functional NADPH Oxidase.
Phagocytic NADPH oxidase and its role in chronic granulomatous disease.
Phorbol myristate acetate induced oxidation of 2',7'-dichlorofluorescin by neutrophils from patients with chronic granulomatous disease.
PI(3)P-p40phox binding regulates NADPH oxidase activation in mouse macrophages and magnitude of inflammatory responses in vivo.
Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba).
Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease.
PPAR{gamma} activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease.
Preservation of complement-induced lung injury in mice with deficiency of NADPH oxidase.
Protein delivery by Pseudomonas type III secretion system: Ex vivo complementation of p67(phox)-deficient chronic granulomatous disease.
Pulmonary computed tomography scan findings in chronic granulomatous disease.
Pyocyanin-enhanced neutrophil extracellular trap formation requires the NADPH oxidase.
Rapid Detection of Intracellular p47phox and p67phox by Flow Cytometry; Useful Screening Tests for Chronic Granulomatous Disease.
Rapid determination of chimerism status using dihydrorhodamine assay in a patient with X-linked chronic granulomatous disease following hematopoietic stem cell transplantation.
Rapid whole-blood flow cytometry assay for diagnosis of chronic granulomatous disease.
Rare Duplication or Deletion of Exons 6, 7 and 8 in CYBB Leading to X-Linked Chronic Granulomatous Disease in Two Patients from Different Families.
Recent advances in chronic granulomatous disease.
Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease.
Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease.
Reconstitution of NADPH oxidase activity in human X-linked chronic granulomatous disease myeloid cells after stable gene transfer using a recombinant adeno-associated virus 2 vector.
Redox regulation of beta2-integrin CD11b/CD18 activation.
Regulation of innate immunity by NADPH oxidase.
Regulation of NADPH oxidase activity in phagocytes: relationship between FAD/NADPH binding and oxidase complex assembly.
Renal transplantation in a patient with chronic granulomatous disease: case report.
Residual NADPH oxidase activity and isolated lung involvement in x-linked chronic granulomatous disease.
Residual NADPH oxidase and survival in chronic granulomatous disease.
Respiratory complications after haematopoietic stem cell transplantation in a patient with chronic granulomatous disease.
Restoration of superoxide generation to a chronic granulomatous disease-derived B-cell line by retrovirus mediated gene transfer.
Retroviral-mediated gene transfer and nonmyeloablative conditioning: studies in a murine X-linked chronic granulomatous disease model.
Role of Flow Cytometry in the Diagnosis of Chronic Granulomatous Disease: the Egyptian Experience.
Role of NADPH oxidase in host defense against aspergillosis.
Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense.
Role of p47phox in antigen-presenting cell-mediated regulation of humoral immunity in mice.
Safety and effectiveness of long-term interferon gamma therapy in patients with chronic granulomatous disease.
Severe glucose-6-phosphate dehydrogenase deficiency leads to susceptibility to infection and absent NETosis.
Study of nave and memory cells in a cohort of Egyptian chronic granulomatous disease patients.
Successful immune reconstitution by means of hematopoietic stem cell transplantation in a Colombian patient with chronic granulomatous disease.
Successful renal transplantation in patients with chronic granulomatous disease.
Sulfite stimulates NADPH oxidase of human neutrophils to produce active oxygen radicals via protein kinase C and Ca2+/calmodulin pathways.
Synaptic plasticity deficits and mild memory impairments in mouse models of chronic granulomatous disease.
Targeted gene addition in human CD34(+) hematopoietic cells for correction of X-linked chronic granulomatous disease.
Thapsigargin and flavin adenine dinucleotide ex vivo treatment rescues trafficking-defective gp91phox in chronic granulomatous disease leukocytes.
The active N-terminal region of p67phox. Structure at 1.8 A resolution and biochemical characterizations of the A128V mutant implicated in chronic granulomatous disease.
The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex.
The management of chronic granulomatous disease.
The NADPH oxidase and chronic granulomatous disease.
The NADPH oxidase: lessons from chronic granulomatous disease neutrophils.
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor.
The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs.
The relationship between alloimmunization and posttransfusion granulocyte survival: experience in a chronic granulomatous disease cohort.
The role of reactive oxygen species (ROS) in the effector mechanisms of human antimycobacterial immunity.
The search for a genetic defect in Polish patients with chronic granulomatous disease.
The three CYBA variants (rs4673, rs1049254 and rs1049255) are benign: new evidence from a patient with CGD.
Transducible form of p47phox and p67phox compensate for defective NADPH oxidase activity in neutrophils of patients with chronic granulomatous disease.
Tumor necrosis factor and immune interferon synergistically induce cytochrome b-245 heavy-chain gene expression and nicotinamide-adenine dinucleotide phosphate hydrogenase oxidase in human leukemic myeloid cells.
Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67(phox).
Two x-linked chronic granulomatous disease patients with unusual NADPH oxidase properties.
Undiagnosed Chronic Granulomatous Disease, Burkholderia cepacia complex Pneumonia, and Acquired Hemophagocytic Lymphohistiocytosis: A Deadly Association.
Variant of X-Linked Chronic Granulomatous Disease Revealed by a Severe Burkholderia cepacia Invasive Infection in an Infant.
Vav proteins control MyD88-dependent oxidative burst.
Virulence of catalase-deficient aspergillus nidulans in p47(phox)-/- mice. Implications for fungal pathogenicity and host defense in chronic granulomatous disease.
X-linked chronic granulomatous disease secondary to skewed X chromosome inactivation in a female with a novel CYBB mutation and late presentation.
X-linked chronic granulomatous disease: correction of NADPH oxidase defect by retrovirus-mediated expression of gp91-phox.
X-linked chronic granulomatous disease: first report of mutations in patients of Argentina.
X-Linked Chronic Granulomatous Disease: First Report of Mutations in Patients of Argentina.
Xanthine oxidase contributes to host defense against Burkholderia cepacia in the p47(phox-/-) mouse model of chronic granulomatous disease.
[A report of a family with chronic granulomatous disease with a gp91phox disorder]
[Activation mechanism of neutrophil NADPH oxidase complex--molecular pathology of chronic granulomatous disease]
[Chronic granulomatous disease (CGD): dysfunction of the neutrophil granulocyte NADPH-oxidase enzyme system]
[Chronic granulomatous disease recognised in 42-years-old patient.]
[Chronic granulomatous disease: pathogenesis and therapy of associated fungal infections].
[Chronic granulomatous disease]
[Clinical, genetic and molecular characterization of the X-linked chronic granulomatous disease: A case report of a new splicing mutation].
[Contribution of neutrophils to Aspergillus infection]
[Multifocal osteomyelitis as the first manifestation of chronic granulomatous disease]
[Prenatal diagnosis and novel mutation in X-linked chronic granulomatous disease.]
[Progress of leukocyte research]
[The X+ chronic granulomatous disease as a fabulous model to study the NADPH oxidase complex activation]
gtp cyclohydrolase i deficiency
High-cholesterol Diet Augments Endothelial Dysfunction via Elevated Oxidative Stress and Reduced BH(4) in Ins2(Akita) Mice, an Autosomal Dominant Mutant Type 1 Diabetic Model.
Hearing Loss
NOX3 NADPH Oxidase Couples Transient Receptor Potential Vanilloid 1 to STAT1-Mediated Inflammation and Hearing Loss.
Transtympanic Administration of Short Interfering (si)RNA for the NOX3 Isoform of NADPH Oxidase Protects Against Cisplatin-Induced Hearing Loss in the Rat.
Hearing Loss, Noise-Induced
Noise-induced changes in expression levels of NADPH oxidases in the cochlea.
Heart Diseases
Association of phagocytic NADPH oxidase activity with hypertensive heart disease: a role for cardiotrophin-1?
Increased myocardial NADPH oxidase activity in human heart failure.
Recent Insights into the Biological Functions of Sestrins in Health and Disease.
Redox signaling in angiogenesis: role of NADPH oxidase.
Heart Failure
Activation of NADPH oxidase during progression of cardiac hypertrophy to failure.
Alternative Splicing of NOX4 in the Failing Human Heart.
Cardiomyocyte-specific overexpression of an active form of Rac predisposes the heart to increased myocardial stunning and ischemia-reperfusion injury.
CPU228, a derivative of dofetilide, relieves cardiac dysfunction by normalizing FKBP12.6, NADPH oxidase and protein kinase C epsilon in the myocardium.
Diaphragm Abnormalities in Patients with End-Stage Heart Failure: NADPH Oxidase Upregulation and Protein Oxidation.
Enhanced ROS production by NADPH oxidase is correlated to changes in antioxidant enzyme activity in human heart failure.
Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47phox NADPH oxidase subunit.
Enhanced TNF alpha and oxidative stress in patients with heart failure: effect of TNF alpha on platelet O2- production.
Exercise training decreases NADPH oxidase activity and restores skeletal muscle mass in heart failure rats.
Glucose-6-phosphate dehydrogenase: a novel therapeutic target in cardiovascular diseases.
Increased myocardial NADPH oxidase activity in human heart failure.
Influence of N- acetylcysteine on oxidative stress in slow-twitch soleus muscle of heart failure rats.
Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction.
Inhibition of NADPH oxidase up-regulates connexin 43 and ameliorates electrical remodeling in rabbits with heart failure.
Leptin, endothelin, NADPH oxidase, and heart failure.
NADPH oxidase and cardiac failure.
NADPH oxidase and heart failure.
NADPH oxidase hyperactivity induces plantaris atrophy in heart failure rats.
NADPH oxidase inhibition ameliorates cardiac dysfunction in rabbits with heart failure.
NADPH oxidase is involved in angiotensin II-induced apoptosis in H9C2 cardiac muscle cells: Effects of apocynin.
NADPH oxidase-dependent redox signaling in human heart failure: relationship between the left and right ventricle.
NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure.
NADPH oxidase/ROS-dependent PYK2 activation is involved in TNF-?-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells.
Oxidized CaMKII: a "heart stopper" for the sinus node?
Parsing the role of NADPH oxidase enzymes and reactive oxygen species in heart failure.
Rac-1 as a new therapeutic target in cerebro- and cardio-vascular diseases.
Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury.
Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells.
Response: Leptin, Endothelin, NADPH Oxidase, and Heart Failure.
Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.
S-Glutathionylation Reshapes Our Understanding of Endothelial Nitric Oxide Synthase Uncoupling and Nitric Oxide/Reactive Oxygen Species-Mediated Signaling.
[Correlation between left ventricular mass index and NADPH oxidase p22phox in patients with non-valvular chronic heart failure].
[Effects of NADPH oxidase inhibition on cardiac function and myocardial calcium regulatory proteins in rabbits with heart failure]
Heart Rupture
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
Hematologic Diseases
Generation of X-CGD cells for vector evaluation from healthy donor CD34(+) HSCs by shRNA-mediated knock down of gp91(phox).
Hemochromatosis
Potential thrombophilic mutations/polymorphisms in patients with no flow-limiting stenosis after myocardial infarction.
Hepatic Encephalopathy
Elevated dopamine induces minimal hepatic encephalopathy by activation of astrocytic NADPH oxidase and astrocytic protein tyrosine nitration.
Hepatitis
Histamine dihydrochloride protects against early alcohol-induced liver injury in a rat model.
NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.
Hepatitis C
Nonstructural 3 protein of hepatitis C virus triggers an oxidative burst in human monocytes via activation of NADPH oxidase.
Hepatitis C, Chronic
Effects of Losartan on Hepatic Expression of Non-phagocytic NADPH Oxidase and Fibrogenic Genes in Patients with Chronic Hepatitis C.
Hepatitis, Alcoholic
Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase.
Hepatoblastoma
Atrial natriuretic peptide induces cell death in human hepatoblastoma (HepG2) through the involvement of NADPH oxidase.
HIV Infections
NADPH oxidase drives cytokine and neurotoxin release from microglia and macrophages in response to HIV-Tat.
[Analysis of p22-phox and p47-phox subcellular localization and distribution in neutrophils from human immunodeficiency virus (HIV) infected patients].
Hodgkin Disease
Hodgkin-Reed-Sternberg cells in classical Hodgkin lymphoma show alterations of genes encoding the NADPH oxidase complex and impaired reactive oxygen species synthesis capacity.
Homocystinuria
Cystathionine beta synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver.
Huntington Disease
Acute exposure to chlorpyrifos caused NADPH oxidase mediated oxidative stress and neurotoxicity in a striatal cell model of Huntington's disease.
Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease.
Retracted: Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease.
Hyperaldosteronism
Aldosterone increases kidney tubule cell oxidants through calcium-mediated activation of NADPH oxidase and nitric oxide synthase.
Hyperalgesia
Argan Oil as an Effective Nutri-Therapeutic Agent in Metabolic Syndrome: A Preclinical Study.
Oral phycocyanobilin may diminish the pathogenicity of activated brain microglia in neurodegenerative disorders.
Reactive oxygen species derived from NOX1/NADPH oxidase enhance inflammatory pain.
Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats.
Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance.
Superoxide anion-induced pain and inflammation depends on TNF?/TNFR1 signaling in mice.
The connection of monocytes and reactive oxygen species in pain.
Hyperargininemia
High concentration of L-arginine suppresses nitric oxide synthase activity and produces reactive oxygen species in NB9 human neuroblastoma cells.
Hypercholesterolemia
Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia.
CD40 ligand enhances monocyte tissue factor expression and thrombin generation via oxidative stress in patients with hypercholesterolemia.
Cerebral microvascular responses to hypercholesterolemia: roles of NADPH oxidase and P-selectin.
Impaired superoxide production due to a deficiency in phagocyte NADPH oxidase fails to inhibit atherosclerosis in mice.
LDL are oxidatively modified by platelets via GP91(phox) and accumulate in human monocytes.
Persistence of the nitric oxide pathway in the aorta of hypercholesterolemic apolipoprotein-E-deficient mice.
Pharmacological Prevention of eNOS Uncoupling.
Suppressing renal NADPH oxidase to treat diabetic nephropathy.
Hyperemia
Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals.
Hyperglycemia
?3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia.
?3-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na+-K+ pump in hyperglycemia induced by insulin receptor blockade.
Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes.
Acetylcholine-induced relaxation of rabbit basilar artery in vitro is rapidly reduced by reactive oxygen species in acute hyperglycemia: role of NADPH oxidase.
Adjuvant strategies for prevention of glomerulosclerosis.
AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes.
Angiotensin-(1-7) prevents diabetes-induced attenuation in PPAR-gamma and catalase activities.
Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice.
Curcumin ameliorated diabetic neuropathy partially by inhibition of NADPH oxidase mediating oxidative stress in the spinal cord.
Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis.
Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice.
Glucose and NADPH oxidase drive neuronal superoxide formation in stroke.
High glucose-induced oxidative stress inhibits Na+/glucose cotransporter activity in renal proximal tubule cells.
Hyperglycemia-Mediated Oxidative Stress Increases Pulmonary Vascular Permeability.
Lack of p47(phox) in Akita Diabetic Mice Is Associated with Interstitial Pneumonia, Fibrosis, and Oral Inflammation.
NADPH oxidase activation by hyperglycemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1.
NADPH Oxidase Activity in Cerebral Arterioles Is a Key Mediator of Cerebral Small Vessel Disease-Implications for Prevention.
Neonatal hyperglycemia induces oxidative stress in the rat brain: the role of pentose phosphate pathway enzymes and NADPH oxidase.
NOX enzymes and diabetic complications.
Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase.
Prorenin receptor (PRR)-mediated NADPH oxidase (Nox) signaling regulates VEGF synthesis under hyperglycemic condition in ARPE-19 cells.
Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental diabetic nephropathy.
Role of reactive oxygen species in the renal fibrosis.
Short-term intravenous insulin infusion is associated with reduced expression of NADPH oxidase p47(phox) subunit in monocytes from type 2 diabetes patients.
Spironolactone improves nephropathy by enhancing glucose-6-phosphate dehydrogenase activity and reducing oxidative stress in diabetic hypertensive rat.
Studying neuroprotective effect of Atorvastatin as a small molecule drug on high glucose-induced neurotoxicity in undifferentiated PC12 cells: role of NADPH oxidase.
[Research progress of Chinese herbs inhibiting NADPH oxidase].
Hyperhomocysteinemia
Acid sphingomyelinase gene deficiency ameliorates the hyperhomocysteinemia-induced glomerular injury in mice.
Epithelial-to-mesenchymal transition in podocytes mediated by activation of NADPH oxidase in hyperhomocysteinemia.
Folic acid supplementation inhibits NADPH oxidase-mediated superoxide anion production in the kidney.
Homocysteine stimulates NADPH oxidase-mediated superoxide production leading to endothelial dysfunction in rats.
Hyperhomocysteinemia, a cardiac metabolic disease: role of nitric oxide and the p22phox subunit of NADPH oxidase.
Hyperinsulinism
Hyperinsulinemia-induced vascular smooth muscle cell (VSMC) migration and proliferation is mediated by converging mechanisms of mitochondrial dysfunction and oxidative stress.
Nox2 contributes to hyperinsulinemia-induced redox imbalance and impaired vascular function.
Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome.
Hyperlipidemias
Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology.
Increased oxidative stress in obesity and its impact on metabolic syndrome.
Involvement of NADPH oxidases and non-muscle myosin light chain in senescence of endothelial progenitor cells in hyperlipidemia.
Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells.
Superoxide dismutase mimetic M40403 improves endothelial function in apolipoprotein(E)-deficient mice.
[Genetic risk factors for ischemic cerebrovascular disease--analysis on fifteen candidate prothrombotic gene polymorphisms in the Japanese population]
Hyperoxaluria
Apocynin-treatment reverses hyperoxaluria induced changes in NADPH oxidase system expression in rat kidneys: a transcriptional study.
Ayurvedic medicine and NADPH oxidase: a possible approach to the prevention of ESRD in hyperoxaluria.
Design and characterization of apocynin loaded PLGA nanoparticles and their in vivo efficacy in hyperoxaluric rats.
Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-L-proline-induced hyperoxaluria in the male Sprague-Dawley rats.
Role of mitochondria and NADPH oxidase derived reactive oxygen species in hyperoxaluria induced nephrolithiasis: therapeutic intervention with combinatorial therapy of N-acetyl cysteine and Apocynin.
Hypersensitivity
Advanced Oxidative Protein Products Cause Pain Hypersensitivity in Rats by Inducing Dorsal Root Ganglion Neurons Apoptosis via NADPH Oxidase 4/c-Jun N-terminal Kinase Pathways.
Chronic granulomatous disease.
Modulation of chronic hypoxia-induced chemoreceptor hypersensitivity by NADPH oxidase subunits in rat carotid body.
NADPH Oxidase-Derived ROS Induced by Chronic Intermittent Hypoxia Mediates Hypersensitivity of Lung Vagal C Fibers in Rats.
Oxidative stress and alpha(1)-adrenoceptor-mediated stimulation of the Cl(-)/HCO(3)(-) exchanger in immortalized SHR proximal tubular epithelial cells.
ROS-mediated vascular homeostatic control of root-to-shoot soil Na delivery in Arabidopsis.
Three novel mutations in CYBA among 22 Iranians with Chronic granulomatous disease.
Hypertension
"Angiotensin II memory" contributes to the development of hypertension and vascular injury via activation of NADPH oxidase.
A Drosophila model for the screening of bioavailable NADPH oxidase inhibitors and antioxidants.
A novel CYBA variant, the -675A/T polymorphism, is associated with essential hypertension.
A Synthetic Peptide from Transforming Growth Factor-?1 Type III Receptor Inhibits NADPH Oxidase and Prevents Oxidative Stress in the Kidney of Spontaneously Hypertensive Rats.
ACE2-Mediated Reduction of Oxidative Stress in the Central Nervous System Is Associated with Improvement of Autonomic Function.
Activation of vascular p38MAPK by mechanical stretch is independent of c-Src and NADPH oxidase: influence of hypertension and angiotensin II.
Adjuvant strategies for prevention of glomerulosclerosis.
Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase.
Alterations in the subcellular distribution of NADPH oxidase p47(phox) in hypothalamic paraventricular neurons following slow pressor Angiotensin II hypertension in female mice with accelerated ovarian failure.
Angiotensin Converting Enzyme 2 antagonizes Ang II-induced pressor response and NADPH oxidase activation in WKY rats and in SHR model.
Angiotensin II induces p67phox mRNA expression and NADPH oxidase superoxide generation in rabbit aortic adventitial fibroblasts.
Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase.
Angiotensin-(1-7) prevents diabetes-induced attenuation in PPAR-gamma and catalase activities.
Angiotensin-induced defects in renal oxygenation: role of oxidative stress.
Antioxidant effect of imperatorin from Angelica dahurica in hypertension via inhibiting NADPH oxidase activation and MAPK pathway.
Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR.
Apocynin activity in spontaneously hypertensive rats (SHR): preliminary studies in vivo.
Apocynin Ameliorates Cadmium-Induced Hypertension Through Elevation of Endothelium Nitric Oxide Synthase.
Apocynin attenuates oxidative stress and hypertension in young spontaneously hypertensive rats independent of ADMA/NO pathway.
Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension.
Aspirin suppresses cardiac fibroblast proliferation and collagen formation through downregulation of angiotensin type 1 receptor transcription.
Association of the -262C/T polymorphism in the catalase gene promoter and the C242T polymorphism of the NADPH oxidase P22phox gene with essential arterial hypertension in patients with diabetes mellitus type 2.
Associations of NADPH oxidase-related genes with blood pressure changes and incident hypertension: The GenSalt Study.
C242T polymorphism of the NADPH oxidase p22PHOX gene and its association with endothelial dysfunction in asymptomatic individuals with essential systemic hypertension.
Central interactions of aldosterone and angiotensin II in aldosterone- and angiotensin II-induced hypertension.
Chronic alcohol-induced oxidative endothelial injury relates to angiotensin II levels in the rat.
D1-Like Receptors Regulate NADPH Oxidase Activity and Subunit Expression in Lipid Raft Microdomains of Renal Proximal Tubule Cells.
Dexamethasone upregulates Nox1 expression in vascular smooth muscle cells.
Differential regulation of NADPH oxidase in sympathetic and sensory Ganglia in deoxycorticosterone acetate salt hypertension.
Effect of apocynin treatment on renal expression of COX-2, NOS1, and renin in Wistar-Kyoto and spontaneously hypertensive rats.
Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice.
Effect of NADPH oxidase inhibitor apocynin on the expression of hypoxia-induced factor-1? and endothelin-1 in rat carotid body exposed to chronic intermittent hypoxia.
Effects of aortic coarctation on aortic antioxidant enzymes and NADPH oxidase protein expression.
Effects of continuous ingestion of hesperidin and glucosyl hesperidin on vascular gene expression in spontaneously hypertensive rats.
Elevated peripheral blood mononuclear cell-derived superoxide production in healthy young black men.
Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice.
Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats.
Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms.
Endothelins and NADPH oxidases in the cardiovascular system.
Enhanced platelet release of superoxide anion in systemic hypertension: role of AT1 receptors.
EPA:DHA 6:1 prevents angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase- and COX-derived oxidative stress.
Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension.
Erratum to: Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction.
Exaggerated vasomotor response to ANG II in rats with fetal programming of hypertension associated with exposure to a low-protein diet during gestation.
Exercise training, NADPH oxidase p22phox gene polymorphisms, and hypertension.
Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats.
Functional and genetic characterization of two extremely rare cases of Williams-Beuren syndrome associated with chronic granulomatous disease.
Functional effect of the p22phox -930A/G polymorphism on p22phox expression and NADPH oxidase activity in hypertension.
G allele of the -930A>G polymorphism of the CYBA gene is associated with insulin resistance in obese subjects.
Garcinia mangostana pericarp extract protects against oxidative stress and cardiovascular remodeling via suppression of p47(phox) and iNOS in nitric oxide deficient rats.
Genetic polymorphisms of oxidative and antioxidant enzymes and arsenic-related hypertension.
Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II.
Hemin decreases cardiac oxidative stress and fibrosis in a rat model of systemic hypertension via PI3K/Akt signaling.
Hemizygosity at the NCF1 Gene in Patients with Williams-Beuren Syndrome Decreases Their Risk of Hypertension.
High Salt Intake Delayed Angiotensin II-Induced Hypertension in Mice With a Genetic Variant of NADPH Oxidase.
Immune activation caused by vascular oxidation promotes fibrosis and hypertension.
Impact of androgen-induced oxidative stress on hypertension in male SHR.
Increased free radical production in hypertension due to increased expression of the NADPH oxidase subunit p22(phox) in lymphoblast cell lines.
Increased myocardial NADPH oxidase activity in human heart failure.
Increased NADPH oxidase activity mediates spontaneous aortic tone in genetically hypertensive rats.
Interleukin-10 Released by CD4+CD25+ Natural Regulatory T Cells Improves Microvascular Endothelial Function Through Inhibition of NADPH Oxidase Activity in Hypertensive Mice.
L-arginine reverses p47phox and gp91phox expression induced by high salt in Dahl rats.
Low-dose dextromethorphan, a NADPH oxidase inhibitor, reduces blood pressure and enhances vascular protection in experimental hypertension.
Lysozyme M-Positive Monocytes Mediate Angiotensin II-Induced Arterial Hypertension and Vascular Dysfunction.
MAPK pathway activation by chronic lead-exposure increases vascular reactivity through oxidative stress/cyclooxygenase-2-dependent pathways.
Marinobufagenin and cyclic strain may activate endothelial NADPH oxidase, contributing to the adverse impact of salty diets on vascular and cerebral health.
Membrane Trafficking of NADPH Oxidase p47phox in Paraventricular Hypothalamic Neurons Parallels Local Free Radical Production in Angiotensin II Slow-Pressor Hypertension.
Mitochondrial Thioredoxin: novel regulator for NADPH oxidase and angiotensin II-induced hypertension.
NADPH Oxidase Activity in Cerebral Arterioles Is a Key Mediator of Cerebral Small Vessel Disease-Implications for Prevention.
NADPH oxidase contributes to renal damage and dysfunction in Dahl salt-sensitive hypertension.
NADPH oxidase in the renal medulla causes oxidative stress and contributes to salt-sensitive hypertension in Dahl S rats.
NADPH oxidase in the renal microvasculature is a primary target for blood pressure-lowering effects by inorganic nitrate and nitrite.
NADPH oxidase inhibition attenuates oxidative stress but not hypertension produced by chronic ET-1.
NADPH Oxidase Plays a Role on Ethanol-Induced Hypertension and Reactive Oxygen Species Generation in the Vasculature.
NADPH oxidase-derived superoxide augments endothelin-1-induced venoconstriction in mineralocorticoid hypertension.
NADPH oxidase-mediated oxidative stress: genetic studies of the p22(phox) gene in hypertension.
NADPH oxidase: its potential role in promotion of pulmonary arterial hypertension.
NADPH Oxidases and Measurement of Reactive Oxygen Species.
NADPH oxidases in the kidney.
Nebivolol improves insulin sensitivity in the TGR(Ren2)27 rat.
Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats.
Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease.
New roles for old pathways? A circuitous relationship between reactive oxygen species and cyclo-oxygenase in hypertension.
Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II-mediated hypertension.
Nitric oxide, oxidative stress and vascular endothelium in health and hypertension.
Non-muscle myosin light chain promotes endothelial progenitor cells senescence and dysfunction in pulmonary hypertensive rats through up-regulation of NADPH oxidase.
Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models.
Nox2 deficiency prevents hypertension-induced vascular dysfunction and hypertrophy in cerebral arterioles.
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension.
Oxidative stress and endothelial dysfunction in hypertension.
Oxidative stress and hypertension.
Oxidative stress contributes to sex differences in angiotensin II-mediated hypertension in spontaneously hypertensive rats.
Oxidative stress, NADPH oxidases, and arteries.
Oxidized CaMKII: a "heart stopper" for the sinus node?
Oxygen availability limits renal NADPH-dependent superoxide production.
Pathogenesis of target organ damage in hypertension: role of mitochondrial oxidative stress.
Pharmacological Prevention of eNOS Uncoupling.
Polyphenols restore endothelial function in DOCA-salt hypertension: role of endothelin-1 and NADPH oxidase.
Protein disulfide isomerase expression increases in resistance arteries during hypertension development. Effects on Nox1 NADPH oxidase signaling.
PVN adenovirus-siRNA injections silencing either NOX2 or NOX4 attenuate aldosterone/NaCl-induced hypertension in mice.
Reactive oxygen species and glucocorticoid-induced hypertension.
Reactive oxygen species in the cerebral circulation: physiological roles and therapeutic implications for hypertension and stroke.
Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase.
Redox mechanisms of the beneficial effects of heme oxygenase in hypertension.
Reduced NOS3 phosphorylation mediates reduced NO/cGMP signaling in mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats.
Regression of glomerular and tubulointerstitial injuries by dietary salt reduction with combination therapy of angiotensin II receptor blocker and calcium channel blocker in Dahl salt-sensitive rats.
Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells.
Regulation of T-cell function by endogenously produced angiotensin II.
Relative contributions of mitochondria and NADPH oxidase to deoxycorticosterone acetate-salt hypertension in mice.
Renal molecular mechanisms underlying altered Na+ handling and genesis of hypertension during adulthood in prenatally undernourished rats.
Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in angiotensin II-dependent chronic hypertension.
Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain.
Resveratrol Inhibition of Rac1-Derived Reactive Oxygen Species by AMPK Decreases Blood Pressure in a Fructose-Induced Rat Model of Hypertension.
Resveratrol Regulates Blood Pressure by Enhancing AMPK Signaling to Downregulate a Rac1-Derived NADPH Oxidase in the Central Nervous System.
Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.
RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response.
Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction.
Role of extracellular superoxide dismutase in the mouse angiotensin slow pressor response.
Role of gp91phox-containing NADPH oxidase in the deoxycorticosterone acetate-salt-induced hypertension.
Role of macula densa neuronal nitric oxide synthase in renal diseases.
Role of reactive oxygen species in chronic hypoxia-induced pulmonary hypertension and vascular remodeling.
Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction.
S-Glutathionylation Reshapes Our Understanding of Endothelial Nitric Oxide Synthase Uncoupling and Nitric Oxide/Reactive Oxygen Species-Mediated Signaling.
Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration.
Sex differences in angiotensin signaling in bulbospinal neurons in the rat rostral ventrolateral medulla.
Sex differences in maternal gestational hypertension-induced sensitization of angiotensin II hypertension in rat offspring: the protective effect of estrogen.
Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension.
Superoxide anion is elevated in sympathetic neurons in DOCA-salt hypertension via activation of NADPH oxidase.
Superoxide dismutase, catalase, glutathione peroxidase and NADPH oxidase in lead-induced hypertension.
SY 17-2 INFLAMMATION, IMMUNITY AND HYPERTENSION.
Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in obesity-induced hypertension.
Targeting reactive oxygen species in hypertension.
The C242T CYBA polymorphism of NADPH oxidase is associated with essential hypertension.
The effects of novokinin, an AT2 agonist, on blood pressure, vascular responses, and levels of ADMA, NADPH oxidase, and Rho kinase in hypertension induced by NOS inhibition and salt.
The elevated blood pressure of human GRK4gamma A142V transgenic mice is not associated with increased ROS production.
The polymorphonuclear leukocyte contributes to the development of hypertension in the Sabra rat.
The protective effect of Apocynin on Cyclosporine A-induced hypertension and nephrotoxicity in rats.
The shift in the "paradigm" of the pharmacology of hypertension.
Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension.
TMEM16A Contributes to Endothelial Dysfunction by Facilitating Nox2 NADPH Oxidase-Derived Reactive Oxygen Species Generation in Hypertension.
Tumor necrosis factor-alpha: a possible priming agent for the polymorphonuclear leukocyte-reduced nicotinamide-adenine dinucleotide phosphate oxidase in hypertension.
Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling.
Vaccarin alleviates hypertension and nephropathy in renovascular hypertensive rats.
[Effect of NADPH oxidase activity inhibitor apocynin on blood pressure in rats exposed to chronic intermittent hypoxia and the possible mechanisms]
[Genetic risk factors for ischemic cerebrovascular disease--analysis on fifteen candidate prothrombotic gene polymorphisms in the Japanese population]
[Influence of polymorphism's of endothelial nitric oxide synthase gene and polymorphism of NADPH oxidase gene on development of complications of arterial hypertension]
[Research progress of Chinese herbs inhibiting NADPH oxidase].
Hypertension, Pregnancy-Induced
Uncoupled endothelial nitric oxide synthase and oxidative stress in a rat model of pregnancy-induced hypertension.
Hypertension, Pulmonary
Control of vascular smooth muscle function by Src-family kinases and reactive oxygen species in health and disease.
Cross-Talk between NADPH Oxidase and Autophagy in Pulmonary Artery Endothelial Cells with Intrauterine Persistent Pulmonary Hypertension.
Cyclic stretch stimulates mitochondrial reactive oxygen species and Nox4 signaling in pulmonary artery smooth muscle cells.
Hypoxia induces K(v) channel current inhibition by increased NADPH oxidase-derived reactive oxygen species.
Hypoxic pulmonary hypertension: role of superoxide and NADPH oxidase (gp91phox).
Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase.
Increased p22(phox)/Nox4 Expression Is Involved in Remodeling Through Hydrogen Peroxide Signaling in Experimental Persistent Pulmonary Hypertension of the Newborn.
Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidase.
Increased Superoxide Production Contributes to the Impaired Angiogenesis of Fetal Pulmonary Arteries with In Utero Pulmonary Hypertension.
Perinatal changes in superoxide generation in the ovine lung: Alterations associated with increased pulmonary blood flow.
Reactive oxygen species and RhoA signaling in vascular smooth muscle: role in chronic hypoxia-induced pulmonary hypertension.
Reactive oxygen species from NADPH oxidase contribute to altered pulmonary vascular responses in piglets with chronic hypoxia-induced pulmonary hypertension.
Rosiglitazone Attenuates Chronic Hypoxia-induced Pulmonary Hypertension in a Mouse Model.
Statins ameliorate pulmonary hypertension secondary to left ventricular dysfunction through the Rho-kinase pathway and NADPH oxidase.
The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice.
Hypertension, Renovascular
gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension.
Hyperthyroidism
Superoxide radical generation, NADPH oxidase activity, and cytochrome P-450 content of rat liver microsomal fractions in an experimental hyperthyroid state: relation to lipid peroxidation.
Hypoglycemia
Control of Insulin Secretion by Production of Reactive Oxygen Species: Study Performed in Pancreatic Islets from Fed and 48-Hour Fasted Wistar Rats.
Hypoglycemia, functional brain failure, and brain death.
Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.
Hypothyroidism
A Novel Missense Mutation (I26M) in DUOXA2 Causing Congenital Goiter Hypothyroidism Impairs NADPH Oxidase Activity but Not Protein Expression.
Idiopathic Pulmonary Fibrosis
First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis.
NADPH oxidase inhibitors: a patent review.
[Increased expression of NADPH oxidase p47-PHOX and p67-PHOX factor in idiopathic pulmonary fibrosis]
Immune System Diseases
Recent Insights into the Biological Functions of Sestrins in Health and Disease.
[Multifocal osteomyelitis as the first manifestation of chronic granulomatous disease]
Infarction, Middle Cerebral Artery
Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase.
Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke.
Normobaric hyperoxia protects the blood brain barrier through inhibiting Nox2 containing NADPH oxidase in ischemic stroke.
NOX2 inhibition with apocynin worsens stroke outcome in aged rats.
Infection
A 1.1-kb duplication in the p67-phox gene causes chronic granulomatous disease.
A novel missense mutation in the NADPH binding domain of CYBB abolishes the NADPH oxidase activity in a male patient with increased susceptibility to infections.
A Phaseolus vulgaris NADPH Oxidase Gene Is Required For Root Infection By Rhizobia.
A Role for NADPH Oxidase in Antigen Presentation.
Acid sphingomyelinase amplifies redox signaling in Pseudomonas aeruginosa-induced macrophage apoptosis.
Activation of NADPH oxidase is essential, but not sufficient, in controlling intracellular multiplication of Burkholderia pseudomallei in primary human monocytes.
Adaptive immune defects against glycoantigens in chronic granulomatous disease via dysregulated nitric oxide production.
Adenosine A(2A) receptor activation limits chronic granulomatous disease-induced hyperinflammation.
Aluminum uptake and disease resistance in Nicotiana rustica leaves.
Analysis of Chronic Granulomatous Disease in the Kavkazi Population in Israel Reveals Phenotypic Heterogeneity in Patients with the Same NCF1 mutation (c.579G>A).
Anaplasma phagocytophilum Dihydrolipoamide Dehydrogenase 1 Affects Host-Derived Immunopathology during Microbial Colonization.
Anaplasma phagocytophilum modulates gp91phox gene expression through altered interferon regulatory factor 1 and PU.1 levels and binding of CCAAT displacement protein.
Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection.
Aspergillus nidulans infection in a patient with chronic granulomatous disease.
Association of glucose-6-phosphate dehydrogenase deficiency and X-linked chronic granulomatous disease in a child with anemia and recurrent infections.
Attenuated Salmonella typhimurium htrA mutants cause fatal infections in mice deficient in NADPH oxidase and destroy NADPH oxidase-deficient macrophage monolayers.
Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation.
Bacillus calmette-guerin infection in NADPH oxidase deficiency: defective mycobacterial sequestration and granuloma formation.
Beta-glucan is a fungal determinant for adhesion-dependent human neutrophil functions.
Bioluminescence imaging of NADPH oxidase activity in different animal models.
Both inducible nitric oxide synthase and NADPH oxidase contribute to the control of virulent phase I Coxiella burnetii infections.
Caveolin-1 serves as a negative effector in senescent human gingival fibroblasts during Fusobacterium nucleatum infection.
Changes in the superoxide anion generating capacity and respiratory burst enzymes of peripheral blood monocytes of monkeys during acute Plasmodium knowlesi infection.
Chronic granulomatous disease, the McLeod phenotype and the contiguous gene deletion syndrome-a review.
Chronic granulomatous disease.
Chronic granulomatous disease: towards gene therapy.
Combined proteomic and transcriptomic analysis of the response of Bacillus anthracis to oxidative stress.
Commentary: adaptive immunity in the absence of innate immune responses? The un-Tolled truth of the silent invaders.
Cytokines, signaling pathways, and effector molecules required for the control of Leishmania (Viannia) braziliensis in mice.
Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity.
Deciphering of the Dual oxidase (Nox family) gene from kuruma shrimp, Marsupenaeus japonicus: full-length cDNA cloning and characterization.
Dectin-1 Activation during Leishmania amazonensis Phagocytosis Prompts Syk-Dependent Reactive Oxygen Species Production To Trigger Inflammasome Assembly and Restriction of Parasite Replication.
Dectin-1 Compromises Innate Responses and Host Resistance against Neospora caninum Infection.
Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase.
Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection.
Delayed association of the NADPH oxidase complex with macrophage vacuoles containing the opportunistic pathogen Burkholderia cenocepacia.
Delineation of the phagocyte NADPH oxidase through studies of chronic granulomatous diseases of childhood.
Diphenyleneiodonium Inhibits Apoptotic Cell Death of Gastric Epithelial Cells Infected with Helicobacter pylori in a Korean Isolate.
Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury.
Dual oxidase 2 and glutathione peroxidase gene expression are elevated in hyperimmunised sheep challenged with Haemonchus contortus.
Effects of Anaplasma phagocytophilum on host cell ferritin mRNA and protein levels.
Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domains.
Electron and proton transport by NADPH oxidases.
EmrA1 membrane fusion protein of Francisella tularensis?LVS is required for resistance to oxidative stress, intramacrophage survival and virulence in mice.
Endogenous mechanisms of reactive oxygen species (ROS) generation.
Enterobacter cloacae pyomyositis complicating chronic granulomatous disease and review of gram-negative bacilli pyomyositis.
Expanding the clinical and genetic spectrum of G6PD deficiency: The occurrence of BCGitis and novel missense mutation.
Expression of NADPH oxidase-dependent resistance to listeriosis in mice occurs during the first 6 to 12 hours of liver infection.
Functional interplay between Arabidopsis NADPH oxidases and heterotrimeric G protein.
Functional Restoration of gp91phox-Oxidase Activity by BAC Transgenesis and Gene Targeting in X-linked Chronic Granulomatous Disease iPSCs.
Genetic and epigenetic damage induced by reactive nitrogen species: implications in carcinogenesis.
Identification of DUOX1-dependent redox signaling through protein S-glutathionylation in airway epithelial cells.
Identification of the defective NADPH-oxidase component in chronic granulomatous disease: a study of 57 European families.
Impaired host defense against Sporothrix schenckii in mice with chronic granulomatous disease.
In vitro Staphylococcus aureus-induced oxidative stress in mice murine peritoneal macrophages: a duration-dependent approach.
In vitro time-dependent vancomycin-resistant Staphylococcus aureus-induced free radical generation and status of antioxidant enzymes in murine peritoneal macrophage.
Inflammation-Enhanced Drug-Induced Liver Injury.
Influenza Infection Suppresses NADPH Oxidase-Dependent Phagocytic Bacterial Clearance and Enhances Susceptibility to Secondary Methicillin-Resistant Staphylococcus aureus Infection.
Inhibitory Effects of Antioxidant Reagent in Reactive Oxygen Species Generation and Penetration of Appressoria of Alternaria alternata Japanese Pear Pathotype
Inhibitory effects of antioxidant reagent in reactive oxygen species generation and penetration of appressoria of Alternaria alternata Japanese pear pathotype.
Inositol-Requiring Enzyme 1-Dependent Activation of AMPK Promotes Brucella abortus Intracellular Growth.
Interactions between the components of the human NADPH oxidase: a review about the intrigues in the phox family.
Leishmania amazonensis amastigotes highly express a tryparedoxin peroxidase isoform that increases parasite resistance to macrophage antimicrobial defenses and Fosters parasite virulence.
Leishmania donovani: superoxide dismutase level in infected macrophages.
Lipopolysaccharide primes the respiratory burst of Atlantic salmon SHK-1 cells through protein kinase C-mediated phosphorylation of p47phox.
Listeriolysin O suppresses phospholipase C-mediated activation of the microbicidal NADPH oxidase to promote Listeria monocytogenes infection.
Live attenuated S. Typhimurium vaccine with improved safety in immuno-compromised mice.
Localization of the Dual Oxidase BLI-3 and Characterization of Its NADPH Oxidase Domain during Infection of Caenorhabditis elegans.
Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation.
May Dietary Supplementation Augment Respiratory Burst in Wound-site Inflammatory Cells?
MicroRNA-217 suppresses homocysteine-induced proliferation and migration of vascular smooth muscle cells via N-methyl-D-aspartic acid receptor inhibition.
Mitochondrial ROS potentiates indirect activation of the AIM2 inflammasome.
Molecular basis of phosphorylation-induced activation of the NADPH oxidase.
Molecular cloning and sequencing of Japanese pufferfish (Takifugu rubripes) NADPH oxidase cDNAs.
Mycobacterial infection induces higher interleukin-1? and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase.
NADPH oxidase but not myeloperoxidase protects lymphopenic mice from spontaneous infections.
NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis.
NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium.
NADPH oxidase depletion in neutrophils from patients with cirrhosis and restoration via toll-like receptor 7/8 activation.
NADPH oxidase in human lung fibroblasts.
NADPH oxidase involvement in the pathology of Helicobacter pylori infection.
NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.
NADPH oxidases regulate septin-mediated cytoskeletal remodeling during plant infection by the rice blast fungus.
Neutrophil NADPH oxidase activity in chronic myeloproliferative and myelodysplastic diseases by microscopic and photometric assays.
Neutrophil pyroptosis mediates pathology of P. aeruginosa lung infection in the absence of the NADPH oxidase NOX2.
Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice.
Nicotinamide effects oxidative burst activity of neutrophils in patients with poorly controlled type 2 diabetes mellitus.
Nonstructural 3 protein of hepatitis C virus triggers an oxidative burst in human monocytes via activation of NADPH oxidase.
NOX1/2 activation in human gingival fibroblasts by Fusobacterium nucleatum facilitates attachment of Porphyromonas gingivalis.
Oxidase activity in cord blood neutrophils: a balance between increased membrane associated cytochrome b558 and deficient cytosolic components.
p47phox-deficient immune microenvironment signals dysregulate naive T-cell apoptosis.
Pathology of a mouse model of x-linked chronic granulomatous disease.
Peptide inhibition of p22phox and Rubicon interaction as a therapeutic strategy for septic shock.
Phosphoinositol 3-phosphate acts as a timer for reactive oxygen species production in the phagosome.
Physiological roles of voltage-gated proton channels in leukocytes.
PI(3)P-p40phox binding regulates NADPH oxidase activation in mouse macrophages and magnitude of inflammatory responses in vivo.
Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba).
Potential dengue virus-triggered apoptotic pathway in human neuroblastoma cells: arachidonic acid, superoxide anion, and NF-kappaB are sequentially involved.
PPAR{gamma} activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease.
Production of free radical species during Eimeria maxima infections in chickens.
Production of reactive oxygen species is turned on and rapidly shut down in epithelial cells infected with Chlamydia trachomatis.
Protein disulfide isomerase (PDI) associates with NADPH oxidase and is required for phagocytosis of Leishmania chagasi promastigotes by macrophages.
Pulmonary computed tomography scan findings in chronic granulomatous disease.
Rac1 disrupts p67phox/p40phox binding: a novel role for Rac in NADPH oxidase activation.
Reactive Oxygen Species-Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis.
Regulation of alveolar macrophage p40phox: hierarchy of activating kinases and their inhibition by PGE2.
Regulation of protein kinase CKII by direct interaction with the C-terminal region of p47(phox).
Residual NADPH oxidase activity and isolated lung involvement in x-linked chronic granulomatous disease.
Restoration of superoxide generation to a chronic granulomatous disease-derived B-cell line by retrovirus mediated gene transfer.
Role of inducible nitric oxide synthase and NADPH oxidase in early control of Burkholderia pseudomallei infection in mice.
Role of NOX Proteins in Pseudomonas aeruginosa Induced Lung Inflammation and Permeability.
Role of oxidative stress in infectious diseases. A review.
Role of superoxide and reactive nitrogen intermediates in Rhodnius prolixus (Reduviidae)/Trypanosoma rangeli interactions.
Safety and effectiveness of long-term interferon gamma therapy in patients with chronic granulomatous disease.
Salmonella pathogenicity island 2-encoded type III secretion system mediates exclusion of NADPH oxidase assembly from the phagosomal membrane.
Silencing of the Rac1 GTPase MtROP9 in Medicago truncatula stimulates early mycorrhizal and oomycete root colonizations but negatively affects rhizobial infection.
Small-angle X-ray scattering reveals an extended organization for the autoinhibitory resting state of the p47(phox) modular protein.
Spontaneous Staphylococcus xylosus Infection in Mice Deficient in NADPH Oxidase and Comparison with Other Laboratory Mouse Strains.
Structure of the TPR domain of p67phox in complex with Rac.GTP.
Superoxide production by plant homologues of the gp91(phox) NADPH oxidase. Modulation of activity by calcium and by tobacco mosaic virus infection.
T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus.
The active N-terminal region of p67phox. Structure at 1.8 A resolution and biochemical characterizations of the A128V mutant implicated in chronic granulomatous disease.
The complex roles of NADPH oxidases in fungal infection.
The effect of captopril on the expression of MMP-9 and the prognosis of neurological function in herpes simplex encephalitis mice.
The human NADPH oxidase: primary and secondary defects impairing the respiratory burst function and the microbicidal ability of phagocytes.
The NADPH oxidase and chronic granulomatous disease.
The NADPH oxidase AoNoxA in Arthrobotrys oligospora functions as an initial factor in the infection of Caenorhabditis elegans.
The O-2 Generating NADPH Oxidase of Phagocytes: Structure and Methods of Detection
The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.
The role of NADH-NADPH oxidase activity in the leukocyte function of burned patients.
Transcriptome analysis of hybrid tilapia (Oreochromis spp.) with Streptococcus agalactiae infection identifies Toll-like receptor pathway-mediated induction of NADPH oxidase complex and piscidins as primary immune-related responses.
Trichinella spiralis infection affects p47(phox) protein expression in guinea-pig alveolar macrophages.
Trypanosoma cruzi Needs a Signal Provided by Reactive Oxygen Species to Infect Macrophages.
Upregulation of cannabinoid receptor-1 and fibrotic activation of mouse hepatic stellate cells during Schistosoma J. infection: Role of NADPH oxidase.
Variable correction of host defense following gene transfer and bone marrow transplantation in murine X-linked chronic granulomatous disease.
Virulent Shigella flexneri causes damage to mitochondria and triggers necrosis in infected human monocyte-derived macrophages.
[Chronic granulomatous disease]
[Effects of respiratory tract infections and antibiotic therapy on NADPH oxidase activity]
[Interaction of polymorphisms of PPAR-?2 gene -C34G and NADPH oxidase subunit p22phox gene -C242T with Helicobacter pylori infection in esophageal squamous cell carcinoma].
[Molecular aspects of chronic granulomatous disease. "the NADPH oxidase complex"]
[The NADPH oxidase activity of pea seedling roots in rhizobial infection depending on abiotic and biotic factors]
Inflammatory Bowel Diseases
Association between a multi-locus genetic risk score and inflammatory bowel disease.
Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease.
In vivo treatment with the herbal phenylethanoid acteoside ameliorates intestinal inflammation in dextran sulphate sodium-induced colitis.
NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2.
Role of NADPH oxidase in host defense against aspergillosis.
Influenza, Human
Influenza Infection Suppresses NADPH Oxidase-Dependent Phagocytic Bacterial Clearance and Enhances Susceptibility to Secondary Methicillin-Resistant Staphylococcus aureus Infection.
Inhibition of Nox2 oxidase activity ameliorates influenza A virus-induced lung inflammation.
NADPH Oxidase 1 Is Associated with Altered Host Survival and T Cell Phenotypes after Influenza A Virus Infection in Mice.
NADPH oxidases as novel pharmacologic targets against influenza A virus infection.
Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress.
Practical strategies for targeting NF-kappaB and NADPH oxidase may improve survival during lethal influenza epidemics.
Superoxide anion production in influenza protein-activated NADPH oxidase of human polymorphonuclear leukocytes.
Insulin Resistance
(-)-Epicatechin and its metabolites prevent palmitate-induced NADPH oxidase upregulation, oxidative stress and insulin resistance in HepG2 cells.
(-)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress.
Administration of rosmarinic acid reduces cardiopathology and blood pressure through inhibition of p22phox NADPH oxidase in fructose-fed hypertensive rats.
Advanced oxidation protein products induce inflammatory response and insulin resistance in cultured adipocytes via induction of endoplasmic reticulum stress.
Angiotensin II-induced skeletal muscle insulin resistance mediated by NF-kappaB activation via NADPH oxidase.
Antioxidant treatment prevents the development of fructose-induced abdominal adipose tissue dysfunction.
Argan Oil as an Effective Nutri-Therapeutic Agent in Metabolic Syndrome: A Preclinical Study.
Beneficial effects of argan oil on blood pressure, insulin resistance, and oxidative stress in rat.
Differential effect of amylin on endothelial-dependent vasodilation in mesenteric arteries from control and insulin resistant rats.
Effect of pioglitazone on insulin resistance in fructose-drinking rats correlates with AGEs/RAGE inhibition and block of NADPH oxidase and NF kappa B activation.
Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats.
FFA-induced hepatic insulin resistance in vivo is mediated by PKC?, NADPH oxidase, and oxidative stress.
Garlic and onion attenuates vascular inflammation and oxidative stress in fructose-fed rats.
Insulin resistance determines phagocytic nicotinamide adenine dinucleotide phosphate oxidase overactivation in metabolic syndrome patients.
Involvement of oxidative stress and NADPH oxidase activation in the development of cardiovascular complications in a model of insulin resistance, the fructose-fed rat.
Kinin Receptors in Vascular Biology and Pathology.
L-Arginine supplementation improves insulin sensitivity and beta cell function in the offspring of diabetic rats through AKT and PDX-1 activation.
Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat.
Mice lacking NOX2 are hyperphagic and store fat preferentially in the liver.
NADPH oxidase activation by hyperglycemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1.
NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat.
Nebivolol improves insulin sensitivity in the TGR(Ren2)27 rat.
Nox2 contributes to hyperinsulinemia-induced redox imbalance and impaired vascular function.
Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance-Related Endothelial Cell Dysfunction.
Renin inhibition attenuates insulin resistance, oxidative stress, and pancreatic remodeling in the transgenic ren2 rat.
Sleep fragmentation promotes NADPH oxidase 2-mediated adipose tissue inflammation leading to insulin resistance in mice.
The antioxidant tempol inhibits cardiac hypertrophy in the insulin-resistant GLUT4-deficient mouse in vivo.
The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways.
The Renin Angiotensin aldosterone system in hypertension: roles of insulin resistance and oxidative stress.
Intervertebral Disc Degeneration
Sparstolonin B prevents lumbar intervertebral disc degeneration through toll like receptor 4, NADPH oxidase activation and the protein kinase B signaling pathway.
Intracranial Aneurysm
Polymorphisms of the NADPH oxidase P22PHOX gene in a Caucasian population with intracranial aneurysms.
Intracranial Arteriosclerosis
Omega-3 fatty acid supplement reduces activation of NADPH oxidase in intracranial atherosclerosis stenosis.
Invasive Pulmonary Aspergillosis
Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent.
Restoration of NET formation by gene therapy in CGD controls aspergillosis.
Iron Overload
Chronic iron overload induces functional and structural vascular changes in small resistance arteries via NADPH oxidase-dependent O2(-) production.
Ischemic Attack, Transient
Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke.
Kidney Calculi
NADPH oxidase as a therapeutic target for oxalate induced injury in kidneys.
Kidney Diseases
A Synthetic Peptide from Transforming Growth Factor-?1 Type III Receptor Inhibits NADPH Oxidase and Prevents Oxidative Stress in the Kidney of Spontaneously Hypertensive Rats.
Asymmetric dimethylarginine and reactive oxygen species: unwelcome twin visitors to the cardiovascular and kidney disease tables.
NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation.
NADPH oxidase in the kidney: a Janus in determining cell fate.
Recent Insights into the Biological Functions of Sestrins in Health and Disease.
Role of NADPH oxidase-mediated reactive oxygen species in podocyte injury.
Kidney Failure, Chronic
Ayurvedic medicine and NADPH oxidase: a possible approach to the prevention of ESRD in hyperoxaluria.
Depressed phagocytosis in hemodialyzed patients: in vivo and in vitro mechanisms.
Polymorphisms in NADPH oxidase CYBA gene modify the risk of ESRD in patients with chronic glomerulonephritis.
Relation between development of cardiovascular disease and the C242T CYBA polymorphism of the NADPH oxidase in ESRD patients.
[Effects of Jianpi Qinghua Recipe on angiotensin II/NADPH oxidase pathway in 5/6 nephrectomized rats].
Kidney Neoplasms
Nox4 inhibition enhances the cytotoxicity of cisplatin in human renal cancer cells.
Leiomyoma
Reactive Oxygen Species Mediate Mitogenic Growth Factor Signaling Pathways in Human Leiomyoma Smooth Muscle Cells.
Leukemia
15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity.
Bifidobacterium breve - HT-29 cell line interaction: modulation of TNF-? induced gene expression.
Development of the superoxide-generating system during differentiation of the HL-60 human promyelocytic leukemia cell line.
Glucocorticoid-induced apoptotic pathways in eosinophils: comparison with glucocorticoid-sensitive leukemia cells.
Induction of cytosolic activation factor for NADPH oxidase in differentiated HL-60 leukemia cells.
Isolation and characterization of a variant HL60 cell line defective in the activation of the NADPH oxidase by phorbol myristate acetate.
NADPH oxidase-mediated generation of reactive oxygen species is critically required for survival of undifferentiated human promyelocytic leukemia cell line HL-60.
Pigment epithelium-derived factor (PEDF) inhibits survival and proliferation of VEGF-exposed multiple myeloma cells through its anti-oxidative properties.
PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase.
Progression and inflammation of human myeloid leukemia induced by ambient PM2.5 exposure.
Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells.
Selenium suppresses leukemia through the action of endogenous eicosanoids.
The role of Rac2-NADPH oxidase-ROS in human leukemia HL-60 cell apoptosis induced by diallyl disulfide.
Transcriptional activation of the gp91phox NADPH oxidase subunit by TPA in HL-60 cells.
Tumor necrosis factor and immune interferon synergistically induce cytochrome b-245 heavy-chain gene expression and nicotinamide-adenine dinucleotide phosphate hydrogenase oxidase in human leukemic myeloid cells.
Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia.
Studies on granulocyte functions in patients with chronic myeloid leukemia.
Leukemia, Myeloid
Pharmacological targeting of ROS reaction network in myeloid leukemia cells monitored by ultra-weak photon emission.
Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells.
Leukemia, Myeloid, Acute
Impact of NADPH oxidase functional polymorphisms in acute myeloid leukemia induction chemotherapy.
Leukemia, Promyelocytic, Acute
PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase.
Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.
Leukocyte-Adhesion Deficiency Syndrome
Defective priming of the phagocyte oxidative burst in a child with recurrent intracellular infections.
Leukostasis
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis.
Liver Abscess
Autosomal recessive chronic granulomatous disease with absence of the 67-kD cytosolic NADPH oxidase component: identification of mutation and detection of carriers.
Liver Cirrhosis
Effects of Losartan on Hepatic Expression of Non-phagocytic NADPH Oxidase and Fibrogenic Genes in Patients with Chronic Hepatitis C.
NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development.
NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis.
Nicotinamide adenine dinucleotide phosphate oxidase (nox) in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent.
NOX in liver fibrosis.
Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo.
Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice.
Liver Diseases
Hepatitis C Viral Proteins induce NADPH Oxidase 4 (Nox4) in a TGF{beta}-dependent manner: A new contributor of HCV-induced oxidative stress.
The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease.
[Effects of sequoyitol on expression of NADPH oxidase subunits p22 phox and p47 phox in rats with type 2 diabetic liver disease].
Liver Diseases, Alcoholic
Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex.
[NADPH oxidase in the pathogenesis of alcoholic liver diseases]
Liver Neoplasms
The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-?-induced apoptosis of liver tumor cells.
The NADPH oxidase NOX4 inhibits hepatocyte proliferation and liver cancer progression.
Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer.
Lung Diseases
Recent Insights into the Biological Functions of Sestrins in Health and Disease.
Regulation of NADPH Oxidase in Vascular Endothelium: The Role of Phospholipases, Protein Kinases, and Cytoskeletal Proteins.
Lung Injury
Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.
Aprotinin attenuated ischemia-reperfusion injury in an isolated rat lung model after 18-hours preservation.
Dynamin 2 and c-Abl are novel regulators of hyperoxia-mediated NADPH oxidase activation and ROS production in caveolin-enriched microdomains of the endothelium.
Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury.
Effect of the NADPH oxidase inhibitor apocynin on ischemia-reperfusion lung injury.
Effect of the NADPH oxidase inhibitor apocynin on septic lung injury in guinea pigs.
In Vivo evidence of free radical generation in the mouse lung after exposure to Pseudomonas Aeruginosa bacterium: An ESR spin-trapping investigation.
Inhibition of the phospholipase A2 activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia.
Is Nox4 a key regulator of the activated state of fibroblasts in systemic sclerosis?
Ischemia-reperfusion lung injury is prevented by apocynin, a novel inhibitor of leukocyte NADPH oxidase.
NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice.
Novel role for non-muscle MLCK in hyperoxia-induced recruitment of cytoskeletal proteins, NADPH oxidase activation and reactive oxygen species generation in lung endothelium.
Preservation of complement-induced lung injury in mice with deficiency of NADPH oxidase.
Protection against LPS-induced acute lung injury by a mechanism-based inhibitor of NADPH oxidase (type 2).
Regulation of NADPH Oxidase in Vascular Endothelium: The Role of Phospholipases, Protein Kinases, and Cytoskeletal Proteins.
Lung Neoplasms
Association between NADPH oxidase (NOX) and lung cancer: a systematic review and meta-analysis.
C609T Polymorphism of NADPH Quinone Oxidoreductase 1 Correlates Clinical Hematological Toxicities in Lung Cancer Patients Treated with Amrubicin.
Dual inhibition of NOX2 and receptor tyrosine kinase by BJ-1301 enhances anticancer therapy efficacy via suppression of autocrine stimulatory factors in lung cancer.
Glutathione S-transferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of P16(INK4a) and O(6)-methylguanine-DNA methyltransferase in sputum.
Grape seed proanthocyanidins inhibit cigarette smoke condensate-induced lung cancer cell migration through inhibition of NADPH oxidase and reduction in the binding of p22(phox) and p47(phox) proteins.
Inhibition of NADPH oxidase protects against metastasis of human lung cancer by decreasing microRNA-21.
Lack of association between NADPH quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and lung cancer: a case-control study and a meta-analysis.
NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer.
Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases.
Tight junction protein 1 is regulated by Transforming growth factor ? and contributes to cell motility in NSCLC cells.
Lupus Erythematosus, Systemic
207 Structural basis of the effect of systemic lupus erythematosus (SLE)-associated mutations on the activity of NADPH oxidase.
Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations.
Haploinsufficiency of NADPH Oxidase Subunit Neutrophil Cytosolic Factor 2 Is Sufficient to Accelerate Full-Blown Lupus in NZM 2328 Mice.
Lupus and proliferative nephritis are PAD4 independent in murine models.
NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus.
Lupus Nephritis
NADPH oxidase and nitric oxide synthase-dependent superoxide production is increased in proliferative lupus nephritis.
Lyme Disease
Bb2Bb3 regulation of murine Lyme arthritis is distinct from Ncf1 and independent of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase.
Lymphohistiocytosis, Hemophagocytic
Undiagnosed Chronic Granulomatous Disease, Burkholderia cepacia complex Pneumonia, and Acquired Hemophagocytic Lymphohistiocytosis: A Deadly Association.
Lymphoma
NOX4/ROS mediate ethanol?induced apoptosis via MAPK signal pathway in L?02 cells.
Regression of Diffuse B-cell Lymphoma of the Leg with Intralesional Gentian Violet.
The NADPH oxidase NOX5 protects against apoptosis in ALK-positive anaplastic large-cell lymphoma cell lines.
Vaccarin alleviates hypertension and nephropathy in renovascular hypertensive rats.
Lymphoma, B-Cell
Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma.
Influence of Delphinidin-3-glucoside on Oxidized Low-Density Lipoprotein-Induced Oxidative Stress and Apoptosis in Cultured Endothelial Cells.
Vaccarin alleviates hypertension and nephropathy in renovascular hypertensive rats.
Lymphoma, Large-Cell, Anaplastic
The NADPH oxidase NOX5 protects against apoptosis in ALK-positive anaplastic large-cell lymphoma cell lines.
Malaria
Characterization of a candidate locus for malaria susceptibility in human populations: a (TA)n microsatellite in the promoter region of the CYBB gene, the gp91 phox subunit of the NADPH oxidase.
DNA phasing by TA dinucleotide microsatellite length determines in vitro and in vivo expression of the gp91phox subunit of NADPH oxidase and mediates protection against severe malaria.
Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections.
Malnutrition
Long-term effects of intrauterine malnutrition on vascular function in female offspring: implications of oxidative stress.
NADPH oxidase and enhanced superoxide generation in intrauterine undernourished rats: involvement of the renin-angiotensin system.
Marfan Syndrome
Redox stress in Marfan syndrome: Dissecting the role of the NADPH oxidase NOX4 in aortic aneurysm.
Mastitis
Cloning and sequencing of the bovine flavocytochrome b subunit proteins, gp91-phox and p22-phox: comparison with other known flavocytochrome b sequences.
The role of NADPH oxidase in taurine attenuation of Streptococcus uberis-induced mastitis in rats.
Melanoma
Interleukin-8 (IL-8), melanoma growth-stimulatory activity, and neutrophil-activating peptide selectively mediate priming of the neutrophil NADPH oxidase through the type A or type B IL-8 receptor.
Metabolic utilization of exogenous pyruvate by mutant p53(R175H) human melanoma cells promotes survival under glucose depletion.
Proopiomelanocortin gene delivery induces apoptosis in melanoma through NADPH oxidase 4-mediated ROS generation.
Redox modulation of FAK controls melanoma survival--role of NOX4.
Regression of Diffuse B-cell Lymphoma of the Leg with Intralesional Gentian Violet.
Melanoma, Experimental
Inhibition of NADPH oxidase activity promotes differentiation of B16 melanoma cells.
Melioidosis
Role of inducible nitric oxide synthase and NADPH oxidase in early control of Burkholderia pseudomallei infection in mice.
Memory Disorders
Attenuation of Brain Damage and Cognitive Impairment by Direct Renin Inhibition in Mice With Chronic Cerebral Hypoperfusion.
Protective effect of resveratrol against chronic intermittent hypoxia-induced spatial memory deficits, hippocampal oxidative DNA damage and increased p47Phox NADPH oxidase expression in young rats.
Meningitis, Pneumococcal
Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase.
Mesothelioma
Diarachidonoylphosphoethanolamine induces apoptosis of malignant pleural mesothelioma cells through a Trx/ASK1/p38 MAPK pathway.
Metabolic Diseases
Genetic Deletion of NADPH Oxidase 1 Rescues Microvascular Function in Mice With Metabolic Disease.
Hyperhomocysteinemia, a cardiac metabolic disease: role of nitric oxide and the p22phox subunit of NADPH oxidase.
Metabolic Syndrome
Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats.
Emerging Role of Oxidative Stress in Metabolic Syndrome and Cardiovascular Diseases: Important Role of Rac/NADPH Oxidase.
G allele of the -930A>G polymorphism of the CYBA gene is associated with insulin resistance in obese subjects.
High fructose consumption combined with low dietary magnesium intake may increase the incidence of the metabolic syndrome by inducing inflammation.
Hyperglycemia-Mediated Oxidative Stress Increases Pulmonary Vascular Permeability.
NADPH Oxidase Activity in Cerebral Arterioles Is a Key Mediator of Cerebral Small Vessel Disease-Implications for Prevention.
Neovascular deterioration, impaired NADPH oxidase and inflammatory cytokine expression in adipose-derived multipotent cells from subjects with metabolic syndrome.
Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome.
Renin inhibition improves metabolic syndrome, and reduces angiotensin II levels and oxidative stress in visceral fat tissues in fructose-fed rats.
Mitral Valve Insufficiency
Atrial myocardial nox2 containing NADPH oxidase activity contribution to oxidative stress in mitral regurgitation: potential mechanism for atrial remodeling.
Mucositis
Potential role of the NADPH oxidase NOX1 in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice.
Multiple Myeloma
Pigment epithelium-derived factor (PEDF) inhibits survival and proliferation of VEGF-exposed multiple myeloma cells through its anti-oxidative properties.
Multiple Sclerosis
Erratum: Persistent activation of microglia and NADPH oxidase drive hippocampal dysfunction in experimental multiple sclerosis.
Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice.
Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage.
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury.
Muscle Cramp
Neutrophil antimicrobial defense against Staphylococcus aureus is mediated by phagolysosomal but not extracellular trap-associated cathelicidin.
Muscular Atrophy
Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy.
Muscular Dystrophies
Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy.
Elevation of the level of thiobarbituric acid-reactive products in hindleg skeletal muscle of dystrophic mice, but non-elevation in tongue muscle.
Mycoses
Characterization of the defense transcriptome responsive to Fusarium oxysporum-infection in Arabidopsis using RNA-seq.
Chronic granulomatous disease.
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.
Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease.
Fas and FasL expression in leukocytes from chronic granulomatous disease patients.
Genetic, biochemical, and clinical features of chronic granulomatous disease.
Impaired macrophage function following bacterial stimulation in chronic granulomatous disease.
Intractable colitis associated with chronic granulomatous disease in a young girl.
Monocyte- and Macrophage-Targeted NADPH Oxidase Mediates Antifungal Host Defense and Regulation of Acute Inflammation in Mice.
NADPH oxidase limits innate immune responses in the lungs in mice.
PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation.
Regulation of innate immunity by NADPH oxidase.
Respiratory complications after haematopoietic stem cell transplantation in a patient with chronic granulomatous disease.
Role of NADPH oxidase in host defense against aspergillosis.
Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense.
Severe glucose-6-phosphate dehydrogenase deficiency leads to susceptibility to infection and absent NETosis.
The complex roles of NADPH oxidases in fungal infection.
The search for a genetic defect in Polish patients with chronic granulomatous disease.
Xanthine oxidase contributes to host defense against Burkholderia cepacia in the p47(phox-/-) mouse model of chronic granulomatous disease.
[Chronic granulomatous disease (CGD): dysfunction of the neutrophil granulocyte NADPH-oxidase enzyme system]
[Contribution of neutrophils to Aspergillus infection]
myeloperoxidase deficiency
Identification of a subgroup of myelodysplastic patients with a neutrophil stimulation-signalling defect.
Myeloproliferative Disorders
Increased reactive oxygen species production and p47phox phosphorylation in neutrophils from myeloproliferative disorders patients with JAK2 (V617F) mutation.
Neutrophil NADPH oxidase activity in chronic myeloproliferative and myelodysplastic diseases by microscopic and photometric assays.
Myocardial Infarction
Activation of NADPH oxidase mediates increased endoplasmic reticulum stress and left ventricular remodeling after myocardial infarction in rabbits.
Angiotensin-converting enzyme and p22(phox) polymorphisms and the risk of coronary heart disease in a low-risk Spanish population.
Cardiomyocyte-specific overexpression of an active form of Rac predisposes the heart to increased myocardial stunning and ischemia-reperfusion injury.
Differential effects of NADPH oxidase and xanthine oxidase inhibition on sympathetic reinnervation in postinfarct rat hearts.
Exercise preconditioning of myocardial infarct size in dogs is triggered by calcium.
Expression of p22-phox and gp91-phox, essential components of NADPH oxidase, increases after myocardial infarction.
Influence of N- acetylcysteine on oxidative stress in slow-twitch soleus muscle of heart failure rats.
Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction.
Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction.
Left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91(PHOX).
Mechanisms for suppressing NADPH oxidase in the vascular wall.
Nitrite confers protection against myocardial infarction: Role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels.
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
Rac-1 as a new therapeutic target in cerebro- and cardio-vascular diseases.
Relationship between NADPH oxidase p22phox C242T, PARP-1 Val762Ala polymorphisms, angiographically verified coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus.
Suppression of oxidative stress in the endothelium and vascular wall.
Myocardial Ischemia
Effects of apocynin, an NADPH oxidase inhibitor, on levels of ADMA, MPO, iNOS and TLR4 induced by myocardial ischemia reperfusion.
Role of NADPH oxidase and xanthine oxidase in mediating inducible VT/VF and triggered activity in a canine model of myocardial ischemia.
Myocardial Reperfusion Injury
Zinc pyrithione salvages reperfusion injury by inhibiting NADPH oxidase activation in cardiomyocytes.
Myocarditis
A P2X7 receptor antagonist attenuates experimental autoimmune myocarditis via suppressed myocardial CD4(+) T and macrophage infiltration and NADPH oxidase 2/4 expression in mice.
NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas disease.
nad(p)h oxidase (h2o2-forming) deficiency
A mutation located at the 5' splice junction sequence of intron 3 in the p67phox gene causes the lack of p67phox mRNA in a patient with chronic granulomatous disease.
Peroxynitrite-dependent activation of protein phosphatase type 2A mediates microvascular endothelial barrier dysfunction.
Sulfite stimulates NADPH oxidase of human neutrophils to produce active oxygen radicals via protein kinase C and Ca2+/calmodulin pathways.
nadph dehydrogenase (quinone) deficiency
Bacillus calmette-guerin infection in NADPH oxidase deficiency: defective mycobacterial sequestration and granuloma formation.
Cardiac oxidative stress and remodeling following infarction: role of NADPH oxidase.
Conventional versus interferon-gamma therapy in chronic granulomatous disease.
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.
Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration.
Does NADPH oxidase deficiency cause artery dilatation in humans?
Earlier onset of neutrophil-mediated inflammation in the ultraviolet-exposed skin of mice deficient in myeloperoxidase and NADPH oxidase.
Genetic Phagocyte NADPH Oxidase Deficiency Enhances Nonviable Candida albicans-Induced Inflammation in Mouse Lungs.
Intractable colitis associated with chronic granulomatous disease in a young girl.
Low-density lipoprotein modification by normal, myeloperoxidase-deficient and NADPH oxidase-deficient granulocytes and the impact of redox active transition metal ions.
Molecular analysis of X-linked chronic granulomatous disease in five unrelated Korean patients.
Molecular quality control machinery contributes to the leukocyte NADPH oxidase deficiency in chronic granulomatous disease.
NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating the IL-1?/G-CSF axis.
NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice.
NADPH oxidase deficiency in X-linked chronic granulomatous disease.
NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.
NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis.
NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs.
NADPH Oxidase Deficiency: A Multisystem Approach.
NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium.
NADPH oxidases regulate CD44 and hyaluronic acid expression in thrombin-treated vascular smooth muscle cells and in atherosclerosis.
Nox2-containing NADPH oxidase deficiency confers protection from hindlimb ischemia in conditions of increased oxidative stress.
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.
Potency of antileukoprotease and alpha 1-antitrypsin to inhibit degradation of fibrinogen by adherent polymorphonuclear leukocytes from normal subjects and patients with chronic granulomatous disease.
Respiratory control in neonatal mice with NADPH oxidase deficiency.
Severe glucose-6-phosphate dehydrogenase deficiency leads to susceptibility to infection and absent NETosis.
The three CYBA variants (rs4673, rs1049254 and rs1049255) are benign: new evidence from a patient with CGD.
[Contribution of neutrophils to Aspergillus infection]
Nasal Polyps
Overexpression of the superoxide anion and NADPH oxidase isoforms 1 and 4 (NOX1 and NOX4) in allergic nasal mucosa.
Neoplasm Metastasis
Adenosine A(3) receptor suppresses prostate cancer metastasis by inhibiting NADPH oxidase activity.
Inhibition of NADPH oxidase protects against metastasis of human lung cancer by decreasing microRNA-21.
NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer.
Suppression of NADPH Oxidase Activity May Slow the Expansion of Osteolytic Bone Metastases.
Neoplasms
(-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance.
17beta-estradiol inhibits NADPH oxidase activity through the regulation of p47phox mRNA and protein expression in THP-1 cells.
4-fluoro-2-methoxyphenol, an apocynin analog with enhanced inhibitory effect on leukocyte oxidant production and phagocytosis.
A nonpolar blueberry fraction blunts NADPH oxidase activation in neuronal cells exposed to tumor necrosis factor-?.
A two-phase strategy for treatment of oxidant-dependent cancers.
Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo.
Acetylcholinesterase inhibitors attenuate atherogenesis in apolipoprotein E-knockout mice.
Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents.
Activation of microglial cells by ceruloplasmin.
Activation of primary human monocytes by the oxidized form of alpha1-antitrypsin.
Activation of the respiratory burst enzyme from human neutrophils in a cell-free system. Evidence for a soluble cofactor.
Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-? and lipopolysaccharide in human pancreatic cancer cell lines.
Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells: role of p47phox phosphorylation and binding to TRAF4.
Adenosine A(3) receptor suppresses prostate cancer metastasis by inhibiting NADPH oxidase activity.
Aiding and abetting roles of NOX oxidases in cellular transformation.
Aldosterone-induced inflammation in the rat heart : role of oxidative stress.
Annexin peptide Ac2-26 suppresses TNF?-induced inflammatory responses via inhibition of Rac1-dependent NADPH oxidase in human endothelial cells.
Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components.
Anti-inflammatory effect of interleukin-10 on human neutrophil respiratory burst involves inhibition of GM-CSF-induced p47PHOX phosphorylation through a decrease in ERK1/2 activity.
Anti-inflammatory effects of dimemorfan on inflammatory cells and LPS-induced endotoxin shock in mice.
Anti-inflammatory therapies for atherosclerosis.
Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor.
Attenuation of aortic injury by ursolic acid through RAGE-Nox-NF?B pathway in streptozocin-induced diabetic rats.
Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy.
beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease.
Binding of pleomorphic adenoma gene-like 2 to the tumor necrosis factor (TNF)-alpha-responsive region of the NCF2 promoter regulates p67(phox) expression and NADPH oxidase activity.
BK channels in innate immune functions of neutrophils and macrophages.
Carbon ion beams induce hepatoma cell death by NADPH oxidase-mediated mitochondrial damage.
Cellular crosstalk between TNF-?, NADPH oxidase, PKC?2, and C2GNT in human leukocytes.
Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research.
Could nanoparticles that mimic the NADPH oxidase be used to kill tumor cells?
Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors.
Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3.
Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin kinase to induce reactive oxygen species-mediated apoptotic cell death.
Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling.
Demonstration of reversible priming of human neutrophils using platelet-activating factor.
Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein ? Signaling.
Development of a PET radiotracer for non-invasive imaging of the reactive oxygen species, superoxide, in vivo.
Differential Effects of CORM-2 and CORM-401 in Murine Intestinal Epithelial MODE-K Cells under Oxidative Stress.
Differential sensitivity of the tyrosyl radical of mouse ribonucleotide reductase to nitric oxide and peroxynitrite.
Differential upregulation of Nox homologues of NADPH oxidase by tumor necrosis factor-alpha in human aortic smooth muscle and embryonic kidney cells.
Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat.
Dual Oxidase2 and pancreatic adenocarcinoma: IFN-?-mediated dual oxidase2 overexpression results in H2O2-induced, ERKassociated up-regulation of HIF-1? and VEGF-A.
Effects of paricalcitol and enalapril on atherosclerotic injury in mouse aortas.
Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase.
Escaping Anoikis through ROS: ANGPTL4 Controls Integrin Signaling through Nox1.
Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha.
Ethanol metabolism by a transplantable hepatocellular carcinoma. Role of microsomes and mitochondria.
Exacerbation of albuminuria and renal fibrosis in subtotal renal ablation model of adiponectin-knockout mice.
Exploring the protective role of apocynin, a specific NADPH oxidase inhibitor, in cisplatin-induced cardiotoxicity in rats.
Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues.
Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase.
Gangliosides activate microglia via protein kinase C and NADPH oxidase.
Granulocyte activity in patients with cancer and healthy subjects.
Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes.
Histamine promotes the development of monocyte-derived dendritic cells and reduces tumor growth by targeting the myeloid NADPH oxidase.
Hypoxia-Induced Signaling Promotes Prostate Cancer Progression: Exosomes Role as Messenger of Hypoxic Response in Tumor Microenvironment.
Imaging neutrophil activation: analysis of the translocation and utilization of NAD(P)H-associated autofluorescence during antibody-dependent target oxidation.
Imaging the Impact of Nox4 in Cycling Hypoxia-mediated U87 Glioblastoma Invasion and Infiltration.
Increasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular Ascorbate.
Induction of hepatoma carcinoma cell apoptosis through activation of the JNK-nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-ROS self-driven death signal circuit.
Inhibition of NADPH oxidase protects against metastasis of human lung cancer by decreasing microRNA-21.
Inhibition of nuclear factor erythroid 2-related factor 2 exacerbates HIV-1 gp120-induced oxidative and inflammatory response: role in HIV associated neurocognitive disorder.
Inhibition of Protein Kinase C ?(2) Prevents Tumor Necrosis Factor-?-Induced Apoptosis and Oxidative Stress in Endothelial Cells: The Role of NADPH Oxidase Subunits.
Insulin mediated DNA damage in mammalian colon cells and human lymphocytes in vitro.
Interferon gamma/NADPH oxidase defense system in immunity and cancer.
Intracellular expression of ROS-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues.
Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species.
Leptin induces ROS via NOX5 in healthy and neoplastic mammary epithelial cells.
Loss of NADPH quinone oxidoreductase in the prostate and enhanced serum levels of cytokine-induced neutrophil chemoattractant 2alpha in hormone-stimulated noble rats: potential role in prostatic intraepithelial neoplasia development.
Magnolia officinalis Reverses Alcoholic Fatty Liver by Inhibiting the Maturation of Sterol Regulatory Element-Binding Protein-1c.
Metastatic breast carcinoma induces vascular endothelial dysfunction in Balb-c mice: Role of the tumor necrosis factor-? and NADPH oxidase.
Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancer prevention.
Modulation of myocardial injury and collagen deposition following ischaemia-reperfusion by linagliptin and liraglutide, and both together.
Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-?B.
Molecular mechanisms of felodipine suppressing atherosclerosis in high-cholesterol-diet apolipoprotein e-knockout mice.
Molecular mechanisms of irbesartan suppressing atherosclerosis in high cholesterol-diet apolipoprotein E knock-out mice.
Molecular mechanisms underlying chronic inflammation-associated cancers.
Muscle dysfunction associated with adjuvant-induced arthritis is prevented by antioxidant treatment.
Myeloid-derived suppressor cells modulate immune responses independently of NADPH oxidase in the ovarian tumor microenvironment in mice.
N-Adamantyl-4-Methylthiazol-2-Amine Attenuates Glutamate-Induced Oxidative Stress and Inflammation in the Brain.
NAD in skin: therapeutic approaches for niacin.
NADPH accumulation is responsible for apoptosis in breast cancer cells induced by fatty acid synthase inhibition.
NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer.
NADPH Oxidase Activation Contributes to Heavy Ion Irradiation-Induced Cell Death.
NADPH oxidase and uncoupled nitric oxide synthase are major sources of reactive oxygen species in oral squamous cell carcinoma. Potential implications for immune regulation in high oxidative stress conditions.
NADPH oxidase as a therapeutic target in Alzheimer's disease.
NADPH oxidase biology and the regulation of tyrosine kinase receptor signaling and cancer drug cytotoxicity.
NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat.
NADPH oxidase drives cytokine and neurotoxin release from microglia and macrophages in response to HIV-Tat.
NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy.
NADPH oxidase NOX1 controls autocrine growth of liver tumor cells through up-regulation of the epidermal growth factor receptor pathway.
NADPH Oxidase NOX4 Is a Critical Mediator of BRAF(V600E)-Induced Downregulation of the Sodium/Iodide Symporter in Papillary Thyroid Carcinomas.
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
NADPH oxidase priming and p47phox phosphorylation in neutrophils from synovial fluid of patients with rheumatoid arthritis and spondylarthropathy.
NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme.
NADPH oxidase subunit 4-mediated reactive oxygen species contribute to cycling hypoxia-promoted tumor progression in glioblastoma multiforme.
NADPH oxidase subunit p22(phox)-mediated reactive oxygen species contribute to angiogenesis and tumor growth through AKT and ERK1/2 signaling pathways in prostate cancer.
NADPH OXIDASES AS REGULATORS OF TUMOR ANGIOGENESIS: CURRENT AND EMERGING CONCEPTS.
Neuroinflammation and its modulation by flavonoids.
Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-?: the role of PKC-?2 and NADPH oxidase.
NO modulates NADPH oxidase function via heme oxygenase-1 in human endothelial cells.
Nox2 and Nox4 mediate tumor necrosis factor-alpha-induced ventricular remodeling in mice.
NOX2-dependent regulation of inflammation.
NOX5-L can stimulate proliferation and apoptosis depending on its levels and cellular context, determining cancer cell susceptibility to cisplatin.
Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4.
Paeonol attenuates advanced oxidation protein product-induced oxidative stress injury in THP-1 macrophages.
Panaxydol induces apoptosis through an increased intracellular calcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species.
Pattern of expression of immune-relevant genes in the gonad of a teleost, the gilthead seabream (Sparus aurata L.).
Pharmacology down under in 2005--focus on targets.
Phytochemical Inhibition of Multidrug Resistance Protein-1 as a Therapeutic Strategy for Hemangioendothelioma.
Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress.
PKC? activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells.
PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells.
Priming of NADPH oxidase by tumor necrosis factor alpha in patients with inflammatory and autoimmune rheumatic diseases.
Protective effects of apocynin nitrone on acute lung injury induced by lipopolysaccharide in rats.
Raised neutrophil phospholipase A2 activity and defective priming of NADPH oxidase and phospholipase A2 in sickle cell disease.
Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy.
Reconstituted high-density lipoprotein suppresses leukocyte NADPH oxidase activation by disrupting lipid rafts.
Redox signaling at invasive microdomains in cancer cells.
Redox-mediated angiogenesis in the hypoxic joint of inflammatory arthritis.
Reduced NADPH oxidase type 2 activity mediates sleep fragmentation-induced effects on TC1 tumors in mice.
Regression of Diffuse B-cell Lymphoma of the Leg with Intralesional Gentian Violet.
Riboflavin kinase couples TNF receptor 1 to NADPH oxidase.
RNAi-mediated silencing of NOX4 inhibited the invasion of gastric cancer cells through JAK2/STAT3 signaling.
Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells.
Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-alpha and lipopolysaccharide.
Role of reactive oxygen species in the renal fibrosis.
ROS and energy metabolism in cancer cells: alliance for fast growth.
ROS generation via NOX4 and its utility in the cytological diagnosis of urothelial carcinoma of the urinary bladder.
ROS mediates interferon gamma induced phosphorylation of Src, through the Raf/ERK pathway, in MCF-7 human breast cancer cell line.
Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration.
Signaling at the Crossroads: Matrix-Derived Proteoglycan and Reactive Oxygen Species Signaling.
Signaling by reactive oxygen and nitrogen species in skin diseases.
STAT5A-mediated NOX5-L expression promotes the proliferation and metastasis of breast cancer cells.
Subclinical inflammation/oxidation as revealed by altered gene expression profiles in subjects with impaired glucose tolerance and Type 2 diabetes patients.
Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: regulation by interleukin-1beta and tumour necrosis factor-alpha.
Suppression of NADPH Oxidase Activity May Slow the Expansion of Osteolytic Bone Metastases.
Targeting the Warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest.
Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation.
The effect of IFN-gamma and TNF-alpha on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells.
The effect of IFN-gamma and TNF-alpha on the NADPH oxidase system of human colostrum macrophages, blood monocytes, and THP-1 cells.
The Human NADPH Oxidase, Nox4, Regulates Cytoskeletal Organization in Two Cancer Cell Lines, HepG2 and SH-SY5Y.
The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance.
The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-?-induced apoptosis of liver tumor cells.
The NADPH Oxidase Nox4 mediates tumour angiogenesis.
The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination.
The NADPH oxidase of human polymorphonuclear leukocytes. Evidence for regulation by multiple signals.
The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin.
The neutrophil as a cellular source of chemokines.
The prolyl isomerase Pin1 acts as a novel molecular switch for TNF{alpha}-induced priming of the NADPH oxidase in human neutrophils.
Thiol chemistry in peroxidase catalysis and redox signaling.
TNF-?/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells.
Transcriptional regulation of NOX genes express ion in human breast adenocarcinoma MCF-7 cells is modulated by adaptor protein Ruk/CIN 85.
Treadmill exercise produces neuroprotective effects in a murine model of Parkinson's disease by regulating the TLR2/MyD88/NF-?B signaling pathway.
Tuberin regulates reactive oxygen species in renal proximal cells, kidney from rodents, and kidney from patients with tuberous sclerosis complex.
Tumor necrosis factor alpha activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells.
Tumor necrosis factor and immune interferon synergistically induce cytochrome b-245 heavy-chain gene expression and nicotinamide-adenine dinucleotide phosphate hydrogenase oxidase in human leukemic myeloid cells.
Tumor necrosis factor triggers redistribution to a Triton X-100-insoluble, cytoskeletal fraction of beta 2 integrins, NADPH oxidase components, tyrosine phosphorylated proteins, and the protein tyrosine kinase p58fgr in human neutrophils adherent to fibrinogen.
Tumor necrosis factor-?-induced nuclear factor-kappaB activation in human cardiomyocytes is mediated by NADPH oxidase.
Tumor necrosis factor-alpha: a possible priming agent for the polymorphonuclear leukocyte-reduced nicotinamide-adenine dinucleotide phosphate oxidase in hypertension.
Tumor promoter TPA stimulates MMP-9 secretion from human keratinocytes by activation of superoxide-producing NADPH oxidase.
Tumor-associated macrophages favor C26 murine colon carcinoma cell proliferation in an oxidative stress-dependent manner.
Understanding the biology of reactive oxygen species and their link to cancer: NADPH oxidases as novel pharmacological targets.
Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity.
Vaccarin alleviates hypertension and nephropathy in renovascular hypertensive rats.
[Dynamic analysis of modification of peripheral neutrophils functional activity and its regulation during tumor growth in vivo]
[ROS and NADPH oxidase: key regulators of tumor vascularisation].
Nephrolithiasis
Effects of apocynin and losartan treatment on renal oxidative stress in a rat model of calcium oxalate nephrolithiasis.
Role of mitochondria and NADPH oxidase derived reactive oxygen species in hyperoxaluria induced nephrolithiasis: therapeutic intervention with combinatorial therapy of N-acetyl cysteine and Apocynin.
The selective NADPH oxidase inhibitor apocynin has potential prophylactic effects on melamine-related nephrolithiasis in vitro and in vivo.
Nephrosis
NADPH oxidase-derived ROS contributes to upregulation of TRPC6 expression in puromycin aminonucleoside-induced podocyte injury.
Nervous System Diseases
NADPH oxidase in brain injury and neurodegenerative disorders.
Testosterone induces neuroprotection from oxidative stress. Effects on catalase activity and 3-nitro-L-tyrosine incorporation into alpha-tubulin in a mouse neuroblastoma cell line.
Neuralgia
A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.
NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain.
Neuroblastoma
A key role for the microglial NADPH oxidase in APP-dependent killing of neurons.
Ceramide kinase regulates TNF?-stimulated NADPH oxidase activity and eicosanoid biosynthesis in neuroblastoma cells.
HaRas activates the NADPH oxidase complex in human neuroblastoma cells via extracellular signal-regulated kinase 1/2 pathway.
Interferon-? counter-regulates its own pro-apoptotic action by activating p38 MAPK signalling in human SH-SY5Y neuroblastoma cells.
NADPH oxidase mediates the oxygen-glucose deprivation/reperfusion-induced increase in the tyrosine phosphorylation of the N-methyl-D-aspartate receptor NR2A subunit in retinoic acid differentiated SH-SY5Y Cells.
PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation.
Rac1-NADPH oxidase-regulated generation of reactive oxygen species mediates glutamate-induced apoptosis in SH-SY5Y human neuroblastoma cells.
Reactive oxygen species regulate the levels of dual oxidase (Duox1-2) in human neuroblastoma cells.
Rotenone induces neurotoxicity through Rac1-dependent activation of NADPH oxidase in SHSY-5Y cells.
Neurodegenerative Diseases
AGEs Induce Cell Death via Oxidative and Endoplasmic Reticulum Stresses in Both Human SH-SY5Y Neuroblastoma Cells and Rat Cortical Neurons.
Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration.
NADPH oxidase in brain injury and neurodegenerative disorders.
NADPH oxidase produces reactive oxygen species and maintains survival of rat astrocytes.
NADPH oxidases: novel therapeutic targets for neurodegenerative diseases.
NOX1/NADPH oxidase negatively regulates nerve growth factor-induced neurite outgrowth.
NOX2-dependent regulation of inflammation.
Phospholipases A2 and neural membrane dynamics: implications for Alzheimer's disease.
Rotenone induces neurotoxicity through Rac1-dependent activation of NADPH oxidase in SHSY-5Y cells.
Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases.
The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases.
Thioxanthenes, chlorprothixene and flupentixol inhibit proton currents in BV2 microglial cells.
Neurogenic Inflammation
Combination of Wu Lin San and Shan Zha ameliorates substance P-induced hyperactive bladder via the inhibition of neutrophil NADPH oxidase activity.
Neutropenia
Beta-glucan is a fungal determinant for adhesion-dependent human neutrophil functions.
Human polymorphonuclear leukocytes inhibit Aspergillus fumigatus conidial growth by lactoferrin-mediated iron depletion.
Non-alcoholic Fatty Liver Disease
HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease.
Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis.
NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment.
The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease.
[Interaction of polymorphisms of monocyte chemoattractant protein-1 receptor CCR2 gene 190A/G, nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox gene C242T and cigarette smoking increases the risk of nonalcoholic fatty liver disease].
Obesity
Adverse cognitive effects of high-fat diet in a murine model of sleep apnea are mediated by NADPH oxidase activity.
Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch.
Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity.
Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity.
Exercise training protects against atherosclerotic risk factors through vascular NADPH oxidase, extracellular signal-regulated kinase 1/2 and stress-activated protein kinase/c-Jun N-terminal kinase downregulation in obese rats.
Folic acid supplementation attenuates high fat diet induced hepatic oxidative stress via regulation of NADPH oxidase.
Ingested capsaicinoids can prevent low-fat-high-carbohydrate diet and high-fat diet-induced obesity by regulating the NADPH oxidase and Nrf2 pathways.
Is leptin involved in phagocytic NADPH oxidase overactivity in obesity? Potential clinical implications.
Microvascular Endothelial Dysfunction in Sedentary, Obese Humans Is Mediated by NADPH Oxidase: Influence of Exercise Training.
Myeloid-specific deletion of NOX2 prevents the metabolic and neurologic consequences of high fat diet.
NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet.
Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole.
Rac1 is a possible link between obesity and oxidative stress in Chinese overweight adolescents.
Systemic upregulation of NADPH oxidase in diet-induced obesity in rats.
[Roles of glucose-6-phosphate dehydrogenase in obesity induced by high fat diet].
Ocular Hypertension
Investigations into Hypoxia and Oxidative Stress at the Optic Nerve Head in a Rat Model of Glaucoma.
Opportunistic Infections
Haploinsufficiency of NADPH Oxidase Subunit Neutrophil Cytosolic Factor 2 Is Sufficient to Accelerate Full-Blown Lupus in NZM 2328 Mice.
Osteoarthritis
Age-related NADPH Oxidase (arNOX) Activity Correlated with Cartilage Degradation and Bony Changes in Age-related Osteoarthritis.
The anti-inflammatory effects of apocynin, inhibitor of NADPH oxidase, contrasting hyaluronic acid on articular cartilage during the development of osteoarthritis in a rabbit model.
Osteoarthritis, Knee
Age-related NADPH Oxidase (arNOX) Activity Correlated with Cartilage Degradation and Bony Changes in Age-related Osteoarthritis.
Association of NADPH oxidase p22phox gene C242T, A640G and -930A/G polymorphisms with primary knee osteoarthritis in the Greek population.
Corrigendum to "The Overexpression of NALP3 Inflammasome in Knee Osteoarthritis Is Associated with Synovial Membrane Prolidase and NADPH Oxidase 2".
Osteolysis
Suppression of NADPH Oxidase Activity May Slow the Expansion of Osteolytic Bone Metastases.
Osteoporosis
A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase.
Osteosarcoma
A possible involvement of plasma membrane NAD(P)H oxidase in the switch mechanism of the cell death mode from apoptosis to necrosis in menadione-induced cell injury.
Ovarian Neoplasms
Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor.
Pancreatic Neoplasms
Dual Oxidase2 and pancreatic adenocarcinoma: IFN-?-mediated dual oxidase2 overexpression results in H2O2-induced, ERKassociated up-regulation of HIF-1? and VEGF-A.
Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase.
Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells.
NADPH Oxidase Activation in Pancreatic Cancer Cells Is Mediated through Akt-dependent Up-regulation of p22phox.
NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox.
NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases.
Nox4-derived ROS signaling contributes to TGF-?-induced epithelial-mesenchymal transition in pancreatic cancer cells.
Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer.
Pancreatitis
NADPH oxidase mediates interleukin-6 expression in cerulein-stimulated pancreatic acinar cells.
Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis.
Potential role of NADPH oxidase in pathogenesis of pancreatitis.
Potential role of NADPH oxidase-mediated activation of Jak2/Stat3 and mitogen-activated protein kinases and expression of TGF-?1 in the pathophysiology of acute pancreatitis.
Pancreatitis, Alcoholic
Association Analyses of Genetic Polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR With Chronic Alcoholic Pancreatitis in Japan.
Parasitemia
Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections.
Suppression of Plasmodium chabaudi parasitemia is independent of the action of reactive oxygen intermediates and/or nitric oxide.
Parkinson Disease
Angiotensin AT2 receptor stimulation inhibits activation of NADPH oxidase and ameliorates oxidative stress in rotenone model of Parkinson's disease in CATH.a cells.
Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson's Disease Model.
Chronic dichlorvos exposure: microglial activation, proinflammatory cytokines and damage to nigrostriatal dopaminergic system.
Complement receptor 3 mediates NADPH oxidase activation and dopaminergic neurodegeneration through a Src-Erk-dependent pathway.
Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease.
Integrin CD11b mediates ?-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway.
Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration.
NADPH Oxidase 1-Mediated Oxidative Stress Leads to Dopamine Neuron Death in Parkinson's Disease.
NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson's disease.
Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase.
Oral Treatment with the NADPH Oxidase Antagonist Apocynin Mitigates Clinical and Pathological Features of Parkinsonism in the MPTP marmoset Model.
Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease models.
Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease.
Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases.
Tanshinone IIA prevents the loss of nigrostriatal dopaminergic neurons by inhibiting NADPH oxidase and iNOS in the MPTP model of Parkinson's disease.
Parkinsonian Disorders
Oral Treatment with the NADPH Oxidase Antagonist Apocynin Mitigates Clinical and Pathological Features of Parkinsonism in the MPTP marmoset Model.
Periodontitis
NADPH Oxidase Contributes to Resistance against Aggregatibacter actinomycetemcomitans-Induced Periodontitis in Mice.
Peripheral Arterial Disease
Low-density lipoprotein apheresis for haemodialysis patients with peripheral arterial disease reduces reactive oxygen species production via suppression of NADPH oxidase gene expression in leucocytes.
Peritoneal Fibrosis
NADPH oxidase-dependent formation of reactive oxygen species contributes to angiotensin II-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cells.
Peritonitis
An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD.
HMGB1 induces neutrophil dysfunction in experimental sepsis and in patients who survive septic shock.
NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A.
Peroxisomal Disorders
Very long chain fatty acids activate NADPH oxidase in human dermal fibroblasts.
Phenylketonurias
Mechanisms regulating superoxide generation in experimental models of phenylketonuria: An essential role of NADPH oxidase.
Pheochromocytoma
Essential role of Rac1/NADPH oxidase in nerve growth factor induction of TRPV1 expression.
Photosensitivity Disorders
Inhibition of neutrophil superoxide generation by hypericin, an antiretroviral agent.
Plant Diseases
RACK1 Functions in Rice Innate Immunity by Interacting with the Rac1 Immune Complex.
Pneumonia
Bioluminescence imaging of NADPH oxidase activity in different animal models.
Blockade of class IA phosphoinositide 3-kinase in neutrophils prevents NADPH oxidase activation- and adhesion-dependent inflammation.
Dynamin 2 and c-Abl are novel regulators of hyperoxia-mediated NADPH oxidase activation and ROS production in caveolin-enriched microdomains of the endothelium.
Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation.
Francisella tularensis directly interacts with the endothelium and recruits neutrophils with a blunted inflammatory phenotype.
Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice.
Genetic Phagocyte NADPH Oxidase Deficiency Enhances Nonviable Candida albicans-Induced Inflammation in Mouse Lungs.
Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes.
Inhibition of Nox2 oxidase activity ameliorates influenza A virus-induced lung inflammation.
Inhibition of the p