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EC Tree
IUBMB Comments Contains a cytidylyl molybdenum cofactor . The enzyme, which participates in the nicotine degradation pathway, has been characterized from the soil bacterium Arthrobacter nicotinovorans [1,2].
The expected taxonomic range for this enzyme is: Bacteria, Archaea
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PNO
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1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + acceptor + H2O = 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + reduced acceptor
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1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one:acceptor 6-oxidoreductase (hydroxylating)
Contains a cytidylyl molybdenum cofactor [3]. The enzyme, which participates in the nicotine degradation pathway, has been characterized from the soil bacterium Arthrobacter nicotinovorans [1,2].
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1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + acceptor + H2O
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + reduced acceptor
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?
6-hydroxypseudooxynicotine + 2,6-dichlorophenolindophenol + H2O
6-hydroxy-3-succinoylsemialdehyde-pyridine + methylamine + reduced 2,6-dichlorophenolindophenol
6-hydroxypseudooxynicotine + 2,6-dichlorophenolindophenol + H2O
6-hydroxy-3-succinoylsemialdehyde-pyridine + methylamine + reduced 2,6-dichlorophenolindophenol
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6-hydroxypseudooxynicotine + 2,6-dichlorophenolindophenol + H2O
6-hydroxy-3-succinoylsemialdehyde-pyridine + methylamine + reduced 2,6-dichlorophenolindophenol
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FAD
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contains 1 mol FAD, 1 mol molybdenum, 4 mol iron and 2 mol labile sulfur per mol of enzyme
molybdopterin cytosine dinucleotide
cofactor is required for assembly of the heterotrimeric molybdenum enzyme
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Iron
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contains 1 mol FAD, 1 mol molybdenum, 4 mol iron and 2 mol labile sulfur per mol of enzyme
Molybdenum
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contains 1 mol FAD, 1 mol molybdenum, 4 mol iron and 2 mol labile sulfur per mol of enzyme
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brenda
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brenda
encoded on megaplasmid pAO1
UniProt
brenda
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brenda
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15000
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1 * 82000, 1 * 30000, 1 * 15000, SDS-PAGE
30000
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1 * 82000, 1 * 30000, 1 * 15000, SDS-PAGE
82000
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1 * 82000, 1 * 30000, 1 * 15000, SDS-PAGE
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heterotrimer
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1 * 82000, 1 * 30000, 1 * 15000, SDS-PAGE
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x * 73349, calculated from amino acid sequence
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x * 73349, calculated from amino acid sequence
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expressed in Escherichia coli
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Freudenberg, W.; Koenig, K.; Andreesen, J.R.
Nicotine dehydrogenase from Arthrobacter oxidans: A molybdenum-containing hydroxylase
FEMS Microbiol. Lett.
52
13-18
1988
Pseudarthrobacter oxydans
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Sachelaru, P.; Schiltz, E.; Brandsch, R.
A functional mobA gene for molybdopterin cytosine dinucleotide cofactor biosynthesis is required for activity and holoenzyme assembly of the heterotrimeric nicotine dehydrogenases of Arthrobacter nicotinovorans
Appl. Environ. Microbiol.
72
5126-5131
2006
Paenarthrobacter nicotinovorans (Q93NH4)
brenda
Li, H.; Xie, K.; Yu, W.; Hu, L.; Huang, H.; Xie, H.; Wang, S.
Nicotine dehydrogenase complexed with 6-hydroxypseudooxynicotine oxidase involved in the hybrid nicotine-degrading pathway in Agrobacterium tumefaciens S33
Appl. Environ. Microbiol.
82
1745-1755
2016
Agrobacterium tumefaciens, Agrobacterium tumefaciens S33
brenda
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1.5.99.14 6-hydroxypseudooxynicotine dehydrogenase
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