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Disease on EC 1.5.3.2 - N-methyl-L-amino-acid oxidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
RNA Demethylase FTO Mediated RNA m6A Modification Is Involved in Maintaining Maternal-Fetal Interface in Spontaneous Abortion.
Acute Kidney Injury
DNA demethylase Tet2 suppresses cisplatin-induced acute kidney injury.
Adenocarcinoma
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling.
Adenocarcinoma of Lung
ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia.
Epigenetic Role of Histone Lysine Methyltransferase and Demethylase on the Expression of Transcription Factors Associated with the Epithelial-to-Mesenchymal Transition of Lung Adenocarcinoma Metastasis to the Brain.
H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression.
Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells.
Alzheimer Disease
DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models.
Anthrax
The role of NF-kappaB and H3K27me3 demethylase, Jmjd3, on the anthrax lethal toxin tolerance of RAW 264.7 cells.
Atherosclerosis
TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H2S System.
Bone Resorption
Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation.
Brain Neoplasms
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Breast Neoplasms
ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability.
Corrigendum: The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer.
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer.
GSKJ4, an H3K27me3 demethylase inhibitor, effectively suppresses the breast cancer stem cells.
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA.
JARID1B is a luminal lineage-driving oncogene in breast cancer.
JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activity.
KDM6B Counteracts EZH2-Mediated Suppression of IGFBP5 to Confer Resistance to PI3K/AKT Inhibitor Treatment in Breast Cancer.
Lysine demethylase KDM2A inhibits TET2 to promote DNA methylation and silencing of tumor suppressor genes in breast cancer.
Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3.
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
The Role of FTO in Tumors and It's Research Progress.
Unliganded progesterone receptor-mediated targeting of an RNA-containing repressive complex silences a subset of hormone-inducible genes.
UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells.
Variable expression quantitative trait loci analysis of breast cancer risk variants.
Candidiasis
New azole derivatives showing antimicrobial effects and their mechanism of antifungal activity by molecular modeling studies.
Carcinogenesis
ALKBH1 Promotes N6-methyladenine DNA Modifications in Glioblastoma.
ALKBH5 Drives FOXM1 Expression to Promote Brain Tumor Stem Cell Growth.
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
CBP-triggered KDM2B acetylation accelerates the carcinogenesis of colon cancer.
Characterization of DNA demethylation in normal and cancerous cell lines and the regulatory role of cell cycle proteins in human DNA demethylase activity.
Circular RNA hsa_circ_0072309 promotes tumorigenesis and invasion by regulating the miR-607/FTO axis in non-small cell lung carcinoma.
Critical Enzymatic Functions of FTO in Obesity and Cancer.
Fat mass and obesity-associated protein promotes the tumorigenesis and development of liver cancer.
FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling.
Genetic alterations of 9p24 in lymphomas and their impact for cancer (immuno-)therapy.
Histone 3 lysine-27 demethylase KDM6A coordinates with KMT2B to play an oncogenic role in NSCLC by regulating H3K4me3.
Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.
Histone demethylase KDM2B upregulates histone methyltransferase EZH2 expression and contributes to the progression of ovarian cancer in vitro and in vivo.
HPV16 E6 and E7 upregulate the histone lysine demethylase KDM2B through the c-MYC/miR-146a-5p axys.
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling.
m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation.
m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling.
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
New roles of flavoproteins in molecular cell biology: histone demethylase LSD1 and chromatin.
Progressive up-regulation of genes encoding DNA methyltransferases in the colorectal adenoma-carcinoma sequence.
Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers.
Retinoblastoma-binding protein 2 (RBP2) is frequently expressed in neuroendocrine tumors and promotes the neoplastic phenotype.
RNA demethylase ALKBH5 promotes ovarian carcinogenesis in a simulated tumour microenvironment through stimulating NF-?B pathway.
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma.
Role of JMJD6 in Breast Tumourigenesis.
[Histone methylation and its relationship with cancer].
Carcinoma
DNA methylation status of hMLH1, p16(INK4a), and CDH1 is not associated with mRNA expression levels of DNA methyltransferase and DNA demethylase in gastric carcinomas.
m6 A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis.
m6A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression.
m6A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression.
N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1? signalling axis.
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma.
System Review about Function Role of ESCC Driver Gene KDM6A by Network Biology Approach.
Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress.
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Transcriptomic Profiling and H3K27me3 Distribution Reveal Both Demethylase-Dependent and Independent Regulation of Developmental Gene Transcription in Cell Differentiation.
[The induction of Guerin's carcinoma cytochrome p450 hydroxylase activity by retinoids].
Carcinoma, Ductal
Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast.
Carcinoma, Embryonal
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
Carcinoma, Hepatocellular
Characterization of microsomal methyl sterol demethylase in two Morris hepatomas.
Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats.
DNA methylation-mediated repression of miR-941 enhances lysine (K)-specific demethylase 6B expression in hepatoma cells.
Effect of strain differences and tumor presence on microsomal drug metabolism in the guinea pig: brief communication.
Functional alterations of the endoplasmic reticulum and the detoxification systems during diethyl-nitrosamine carcinogenesis in rat liver.
Functional and structural alterations of liver ergastoplasmic membranes during DL-ethionine hepatocarcinogenesis.
Investigation of the rate-determining microsomal reaction of cholesterol biosynthesis from lanosterol in Morris hepatomas and liver.
m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation.
Role of the Hypoxia-Related Gene, JMJD1A, in Hepatocellular Carcinoma: Clinical Impact on Recurrence after Hepatic Resection.
Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.
[Effect of Basil Polysaccharide on Histone H3K9me2 Methylation and Expression of G9a and JMJD1A in Hepatoma Cells Under Hypoxic Conditions].
Carcinoma, Non-Small-Cell Lung
m6A demethylase FTO induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small cell lung cancer.
N6-methyladenosine ALKBH5 promotes non-small cell lung cancer progress by regulating TIMP3 stability.
The diagnostic performance of lysine(K)-specific demethylase 6B (KDM6B) in non-small cell lung cancer.
Transcriptional Repression of Histone Deacetylase 3 by the Histone Demethylase KDM2A Is Coupled to Tumorigenicity of Lung Cancer Cells.
Carcinoma, Ovarian Epithelial
DNA demethylase expression correlates with lung resistance protein expression in common epithelial ovarian cancers.
Carcinoma, Renal Cell
N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1? signalling axis.
Carcinoma, Squamous Cell
m6A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression.
Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress.
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Cardiomegaly
Inhibition of histone demethylase JMJD1C attenuates cardiac hypertrophy and fibrosis induced by angiotensin II.
The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice.
Cardiovascular Diseases
PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding.
Chagas Disease
Ergosterol biosynthesis and drug development for Chagas disease.
Specific treatment of Chagas disease: current status and new developments.
Chemical and Drug Induced Liver Injury
[Effect of HF on the hepatic metabolism of dimethylnitrosamine in the rat]
Cholangiocarcinoma
M6A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma.
Cholestasis
Effects of liver injury and cholestasis on microsomal enzyme activities and metabolism of halothane, enflurane and methoxyflurane in vivo in rats.
Microsomal function in biliary obstructed rats: effects of S-adenosylmethionine.
Cleft Lip
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation.
Colitis
The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells.
Colonic Neoplasms
ALKBH5 Holds Prognostic Values and Inhibits the Metastasis of Colon Cancer.
Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells.
KDM5c inhibits multidrug resistance of colon cancer cell line by down-regulating ABCC1.
Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner.
LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer.
Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells.
Colorectal Neoplasms
FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis.
Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers.
The histone H3 lysine-27 demethylase UTX plays a critical role in colorectal cancer cell proliferation.
DNA Virus Infections
Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.
Endodermal Sinus Tumor
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
Endometrial Neoplasms
ALKBH5 regulates IGF1R expression to promote the Proliferation and Tumorigenicity of Endometrial Cancer.
Epstein-Barr Virus Infections
Interplay between the Epigenetic Enzyme Lysine (K)-Specific Demethylase 2B and Epstein-Barr Virus Infection.
Esophageal Squamous Cell Carcinoma
m6 A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis.
m6A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression.
RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma.
System Review about Function Role of ESCC Driver Gene KDM6A by Network Biology Approach.
Glioblastoma
3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line.
ALKBH1 Promotes N6-methyladenine DNA Modifications in Glioblastoma.
ALKBH5 Drives FOXM1 Expression to Promote Brain Tumor Stem Cell Growth.
Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization.
Increased expression of the histone H3 lysine 4 methyltransferase MLL4 and the histone H3 lysine 27 demethylase UTX prolonging the overall survival of patients with glioblastoma and a methylated MGMT promoter.
Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma.
Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis.
Methylation dependent down-regulation of G0S2 leads to suppression of invasion and improved prognosis of IDH1-mutant glioma.
Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells.
Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors.
Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B.
Glioma
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma.
The histone H3 Lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1.
Glomerulonephritis
[Role of histone demethylase KDM6B in HBx-mediated podocyte-macrophage transdifferentiation].
Hepatitis
Drug metabolism in liver disease: activity of hepatic microsomal metabolizing enzymes.
Hepatitis B
[Role of histone demethylase KDM6B in HBx-mediated podocyte-macrophage transdifferentiation].
Herpes Simplex
Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.
Herpes Zoster
Effects of age and adrenocorticotropin on microsomal enzymes in guinea pig adrenal inner and outer cortices.
Hirschsprung Disease
m6A demethylase ALKBH5 suppresses proliferation and migration of enteric neural crest cells by regulating TAGLN in Hirschsprung's disease.
Hodgkin Disease
Epigenetic Loss of m1A RNA Demethylase ALKBH3 in Hodgkin Lymphoma Targets Collagen Conferring Poor Clinical Outcome.
Strong KDM4B and KDM4D Expression Associates with Radioresistance and Aggressive Phenotype in Classical Hodgkin Lymphoma.
The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma.
Hyperglycemia
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.
Hypersensitivity
Effect of Pharmacological Inhibition of Fat-Mass and Obesity-Associated Protein on Nerve Trauma-Induced Pain Hypersensitivities.
Targeting sterol metabolism for the development of antileishmanials.
Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.
Hypertension
Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension.
DNA N6-methyladenine modification in hypertension.
Hypoprothrombinemias
Induction of hepatic enzymes by methaqualone and effect on warfarin-induced hypoprothrombinemia.
Ileus
[State of the microsomal oxidative system of the rat liver in acute intestinal obstruction]
Infections
A gene from the fungal plant pathogen Nectria haematococca that encodes the phytoalexin-detoxifying enzyme pisatin demethylase defines a new cytochrome P450 family.
Antifungals targeted to protein modification: focus on protein N-myristoyltransferase.
Antifungals targeted to sphingolipid synthesis: focus on inositol phosphorylceramide synthase.
Biochemical properties of the products of cytochrome P450 genes (PDA) encoding pisatin demethylase activity in nectria haematococca
Contributions of both ATP-binding cassette transporter and Cyp51A proteins are essential for azole resistance in Aspergillus fumigatus.
DNA Methylation Profile of ?-1,3-Glucanase and Chitinase Genes in Flax Shows Specificity Towards Fusarium Oxysporum Strains Differing in Pathogenicity.
Hepatic microsomal enzymes in S. mansoni infected mice: II. Effect of duration of infection and lindane administration on aminopyrine demethylase and aniline hydroxylase.
Influenza virus-induced alterations of cytochrome P-450 enzyme activities following exposure of mice to coal and diesel particulates.
Jumonji C domain protein JMJ705-mediated removal of histone H3 lysine 27 trimethylation is involved in defense-related gene activation in rice.
Macrophage Polarization Modulated by Porcine Circovirus Type 2 Facilitates Bacterial Coinfection.
Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals.
MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection.
NF-?B-mediated TET2-dependent TNF promoter demethylation drives Mtb-upregulation TNF expression in macrophages.
PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding.
UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability.
Infertility
Methylation dynamics in the early mammalian embryo: implications of genome reprogramming defects for development.
Insulin Resistance
N6-methyladenosine Demethylase FTO Induces the Dysfunctions of Ovarian Granulosa Cells by Upregulating Flotillin 2.
Intellectual Disability
A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation.
A novel c.2T > C mutation of the KDM5C/JARID1C gene in one large family with X-linked intellectual disability.
DNA methylation fingerprint of monozygotic twins and their singleton sibling with intellectual disability carrying a novel KDM5C mutation.
LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors.
Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity.
Overexpression of serotonin receptor 5b expression rescues neuronal and behavioral deficits in a mouse model of Kabuki syndrome.
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation.
Kidney Neoplasms
The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells.
Leishmaniasis
Targeting sterol alpha-14 demethylase of Leishmania donovani to fight against leishmaniasis.
Leukemia
A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells.
Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization.
Critical Enzymatic Functions of FTO in Obesity and Cancer.
FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling.
KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia.
Key roles of histone methyltransferase and demethylase in leukemogenesis.
Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.
Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia.
ORY-1001 Suppresses Cell Growth and Induces Apoptosis in Lung Cancer Through Triggering HK2 Mediated Warburg Effect.
Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors.
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.
The Role of FTO in Tumors and It's Research Progress.
The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells.
Upregulation of CD11b and CD86 through LSD1 inhibition promotes myeloid differentiation and suppresses cell proliferation in human monocytic leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia.
Leukemia, Myeloid
Emerging epigenetic therapeutics for myeloid leukemia: modulating demethylase activity with ascorbate.
Rubbing Out Leukemia Stem Cells by Erasing the Eraser.
Leukemia, Myeloid, Acute
Ascorbate Inhibits Proliferation and Promotes Myeloid Differentiation in TP53-Mutant Leukemia.
Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy.
FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase.
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.
It's Not What You Say But How You Say It: Targeting RNA Methylation in AML.
Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.
Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions.
LSD1 inhibitors disrupt the GFI1 transcription repressor complex.
Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation.
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.
The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells.
Liver Cirrhosis
Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis.
Liver Diseases
Drug metabolism in liver disease: activity of hepatic microsomal metabolizing enzymes.
Relationship between metabolic clearance rate of antipyrine and hepatic microsomal drug-oxidizing enzyme activities in humans without liver disease.
Liver Neoplasms
Fat mass and obesity-associated protein promotes the tumorigenesis and development of liver cancer.
HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372.
Lung Neoplasms
Epigenetic regulation of epithelial-mesenchymal transition by KDM6A histone demethylase in lung cancer cells.
Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT.
JumonjiC demethylase inhibitors show potential for targeting chemotherapy-resistant lung cancers.
Lysine?specific demethylase 2 contributes to the proliferation of small cell lung cancer by regulating the expression of TFPI?2.
m6A demethylase FTO induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small cell lung cancer.
N6-methyladenosine ALKBH5 promotes non-small cell lung cancer progress by regulating TIMP3 stability.
Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.
The diagnostic performance of lysine(K)-specific demethylase 6B (KDM6B) in non-small cell lung cancer.
The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA.
The Role of FTO in Tumors and It's Research Progress.
Transcriptional Repression of Histone Deacetylase 3 by the Histone Demethylase KDM2A Is Coupled to Tumorigenicity of Lung Cancer Cells.
Lymphocytic Choriomeningitis
UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability.
Lymphoma, B-Cell
Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs.
Lymphoma, Large B-Cell, Diffuse
Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs.
Malnutrition
Malnutrition and drugs: clinical implications.
[The liver monooxygenase system in nutritional deficiency in rats in early ontogeny]
Medulloblastoma
Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma.
Melanoma
H3K27 Demethylase JMJD3 Employs the NF-?B and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis.
Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I.
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.
Meningioma
Epigenetic Role of Histone 3 Lysine Methyltransferase and Demethylase in Regulating Apoptosis Predicting the Recurrence of Atypical Meningioma.
Metabolic Diseases
NADP modulates RNA m6A methylation and adipogenesis via enhancing FTO activity.
Mouth Neoplasms
Targeting JARID1B's demethylase activity blocks a subset of its functions in oral cancer.
Mycoses
Fungal Infection Induces Anthocyanin Biosynthesis and Changes in DNA Methylation Configuration of Blood Orange [Citrus sinensis L. (Osbeck)].
Fusarium infection alters the m6A-modified transcript landscape in the cornea.
Molecular Dynamics Investigations of Binding Mechanism for Triazoles Inhibitors to CYP51.
Myelodysplastic Syndromes
Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy.
Neoplasm Metastasis
Downregulation of miR-335 exhibited an oncogenic effect via promoting KDM3A/YAP1 networks in clear cell renal cell carcinoma.
Epigenetic Role of Histone Lysine Methyltransferase and Demethylase on the Expression of Transcription Factors Associated with the Epithelial-to-Mesenchymal Transition of Lung Adenocarcinoma Metastasis to the Brain.
Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer.
FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis.
LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer.
Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial?mesenchymal transition.
m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2-mediated YAP activity in NSCLC.
m6A demethylase FTO induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small cell lung cancer.
Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase.
N6-Methyladenosine RNA Demethylase FTO Promotes Gastric Cancer Metastasis by Down-Regulating the m6A Methylation of ITGB1.
Recent advances of m6A methylation modification in esophageal squamous cell carcinoma.
Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress.
Neoplasms
3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line.
5-Aza-2'-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene.
A fluorescent nanobiosensor for the facile analysis of m6A RNA demethylase activity.
A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition.
A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells.
ALKBH5 Holds Prognostic Values and Inhibits the Metastasis of Colon Cancer.
ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2?-Mediated Glycolysis.
ALKBH5 promotes the proliferation of renal cell carcinoma by regulating AURKB expression in an m6A-dependent manner.
ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment.
ALKBH5-mediated m6A-demethylation of USP1 regulated T-cell acute lymphoblastic leukemia cell glucocorticoid resistance by Aurora B.
An Update of Lysine Specific Demethylase 1 Inhibitor: A Patent Review (2016-2020).
Biological roles of LSD1 beyond its demethylase activity.
Breaking the LSD1/KDM1A addiction: therapeutic targeting of the epigenetic modifier in AML.
CBP-triggered KDM2B acetylation accelerates the carcinogenesis of colon cancer.
Characterization of DNA demethylation in normal and cancerous cell lines and the regulatory role of cell cycle proteins in human DNA demethylase activity.
Characterization of microsomal methyl sterol demethylase in two Morris hepatomas.
Clinical analysis of NSCLC patients reveals lack of association between EGFR mutation and TET1 downregulation.
Corrigendum: Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers.
Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression.
Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate.
Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression.
DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC.
DNA methylation and chromosome instability in breast cancer cell lines.
DNA methylation reprogramming of human cancer cells by expression of a plant 5-methylcytosine DNA glycosylase.
Effect of BIX-01294 on proliferation, apoptosis and histone methylation of acute T lymphoblastic leukemia cells.
Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast.
Endothelial progenitor cells-secreted extracellular vesicles containing microRNA-93-5p confer protection against sepsis-induced acute kidney injury via the KDM6B/H3K27me3/TNF-? axis.
EnMCB: an R/bioconductor package for predicting disease progression based on methylation correlated blocks using ensemble models.
Enzymatic activities of human lung tissue: relationship with smoking habits.
Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers.
Epigenetic regulation of epithelial-mesenchymal transition by KDM6A histone demethylase in lung cancer cells.
Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A.
FLI-06 suppresses proliferation, induces apoptosis and cell cycle arrest by targeting LSD1 and Notch pathway in esophageal squamous cell carcinoma cells.
FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis.
FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13.
FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling.
Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model.
Histone 3 lysine-27 demethylase KDM6A coordinates with KMT2B to play an oncogenic role in NSCLC by regulating H3K4me3.
Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma.
Histone demethylases in physiology and cancer: a tale of two enzymes, JMJD3 and UTX.
Histone Lysine Demethylase Inhibitors.
Histone lysine methylation and demethylation pathways in cancer.
HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372.
How does DNA methyltransferase cause oncogenic transformation?
Hypomethylation and hypoexpression of human CYP2E1 gene in lung tumors.
Identification of catechols as histone-lysine demethylase inhibitors.
Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells.
Inhibition of the histone H3K27 demethylase UTX enhances tumor cell radiosensitivity.
Interplay between the Epigenetic Enzyme Lysine (K)-Specific Demethylase 2B and Epstein-Barr Virus Infection.
It's Not What You Say But How You Say It: Targeting RNA Methylation in AML.
JARID1-targeted histone H3 demethylase inhibitors exhibit anti-proliferative activity and overcome cisplatin resistance in canine oral melanoma cell lines.
Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene.
JMJD6 promotes hepatocellular carcinoma carcinogenesis by targeting CDK4.
Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks.
Jumonji/ARID1 B (JARID1B) protein promotes breast tumor cell cycle progression through epigenetic repression of microRNA let-7e.
JumonjiC demethylase inhibitors show potential for targeting chemotherapy-resistant lung cancers.
KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease.
KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling.
KDM4B plays an important role in mitochondrial apoptosis by upregulating HAX1 expression in colorectal cancer.
KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family.
KDM5B is essential for the hyper-activation of PI3K/AKT signaling in prostate tumorigenesis.
KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia.
KDM6B is an androgen regulated gene and plays oncogenic roles by demethylating H3K27me3 at cyclin D1 promoter in prostate cancer.
KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBP? transcription.
lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans.
Long noncoding RNA GAS5-AS1 suppresses growth and metastasis of cervical cancer by increasing GAS5 stability.
Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors.
Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner.
Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.
LSD1: more than demethylation of histone lysine residues.
Lysine-specific demethylase 1 (LSD1) serves as an potential epigenetic determinant to regulate inflammatory responses in mastitis.
Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation.
Lysine-specific demethylase 2A expression is associated with cell growth and cyclin D1 expression in colorectal adenocarcinoma.
m6 A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis.
m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2-mediated YAP activity in NSCLC.
M6A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma.
m6A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression.
m6A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression.
M6A Demethylase FTO Plays a Tumor Suppressor Role in Thyroid Cancer.
m6A mRNA methylation: A pleiotropic regulator of cancer.
MassSQUIRM: An assay for quantitative measurement of lysine demethylase activity.
Mechanism of N6-methyladenosine modification and its emerging role in cancer.
Mechanistic insights into KDM4A driven genomic instability.
Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis.
Methyl-CpG-binding domain 2: a protective role in bladder carcinoma.
MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer.
Molecular dynamics simulations indicate an induced-fit mechanism for LSD1/CoREST-H3-histone molecular recognition.
NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.
Novel Small Molecule RNA m6A Demethylase AlkBH5 Inhibitors for Treating Cancer.
Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells.
Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia.
Orthogonal Demethylase-Activated Deoxyribozyme for Intracellular Imaging and Gene Regulation.
Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21.
Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinoma.
Overexpression of UTX promotes tumor progression in Oral tongue squamous cell carcinoma patients receiving surgical resection: a case control study.
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma.
Predictive Value of KDM5C Alterations for Immune Checkpoint Inhibitors Treatment Outcomes in Patients With Cancer.
Promoter methylation status of VEGF receptor genes: A possible epigenetic biomarker to anticipate the efficacy of intracellular-acting VEGF-targeted drugs in cancer cells.
Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors.
Recent advances of m6A methylation modification in esophageal squamous cell carcinoma.
Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers.
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.
RNA demethylase ALKBH5 promotes ovarian carcinogenesis in a simulated tumour microenvironment through stimulating NF-?B pathway.
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
RNA N-6-methyladenosine enzymes and resistance of cancer cells to chemotherapy and radiotherapy.
Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance.
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.
Strong KDM4B and KDM4D Expression Associates with Radioresistance and Aggressive Phenotype in Classical Hodgkin Lymphoma.
Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases.
Succinate: a new epigenetic hacker.
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
TET2 promotes anti-tumor immunity by governing G-MDSCs and CD8+ T-cell numbers.
The biological function of m6A demethylase ALKBH5 and its role in human disease.
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
The Critical Role of RNA m6A Methylation in Cancer.
The Functions of the Demethylase JMJD3 in Cancer.
The H3K27me3 demethylase dUTX is a suppressor of notch- and Rb-dependent tumors in Drosophila.
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.
The histone demethylase UTX enables RB-dependent cell fate control.
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity.
The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.
The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers.
The Prognostic Significance Of JMJD3 In Primary Sarcomatoid Carcinoma Of The Lung, A Rare Subtype Of Lung Cancer.
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.
The Role of FTO in Tumors and It's Research Progress.
The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase.
Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response.
Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs.
Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines.
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance.
Unraveling a connection between DNA demethylation repair and cancer.
Unravelling KDM4 histone demethylase inhibitors for cancer therapy.
UTX condensation underlies its tumour-suppressive activity.
UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs.
Xenobiotic metabolizing enzymes in genetically and chemically initiated mouse liver tumors.
[Mechanism of the mutagenic/carcinogenic action of cigarette smoke at the pulmonary level: enzymatic induction, activation and detoxification]
[The induction of Guerin's carcinoma cytochrome p450 hydroxylase activity by retinoids].
Nervous System Diseases
Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A.
Neuroblastoma
Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation.
Neurodegenerative Diseases
Molecular dynamics simulations indicate an induced-fit mechanism for LSD1/CoREST-H3-histone molecular recognition.
Neuroinflammatory Diseases
Jmjd3 is involved in the susceptibility to depression induced by maternal separation via enhancing the neuroinflammation in the prefrontal cortex and hippocampus of male rats.
Obesity
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.
Diazirine Photocrosslinking Recruits Activated FTO Demethylase Complexes for Specific N(6)-methyladenosine Recognition.
Effect of genetic obesity and experimental diabetes on hepatic microsomal mixed function oxidase activities.
Erasing m6A-dependent transcription signature of stress-sensitive genes triggers antidepressant actions.
Expression of miR-33 from an SREBF2 Intron Targets the FTO Gene in the Chicken.
Fasting induced cytoplasmic Fto expression in some neurons of rat hypothalamus.
FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signalling pathway.
FTO inhibits UPRmt-induced apoptosis by activating JAK2/STAT3 pathway and reducing m6A level in adipocytes.
FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription.
FTO: An Emerging Molecular Player in Neuropsychiatric Diseases.
FTO: linking m6A demethylation to adipogenesis.
HAMR: high-throughput annotation of modified ribonucleotides.
Hepatic expression of FTO and fatty acid metabolic genes changes in response to lipopolysaccharide with alterations in m(6)A modification of relevant mRNAs in the chicken.
Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo.
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
Maternal obesity aggravates the abnormality of porcine placenta by increasing N6-methyladenosine.
Meclofenamic acid represses spermatogonial proliferation through modulating m6A RNA modification.
N6-methyl-adenosine modification in messenger and long non-coding RNA.
N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1? signalling axis.
Pharmacological inhibition of FTO.
RNA Demethylase FTO Mediated RNA m6A Modification Is Involved in Maintaining Maternal-Fetal Interface in Spontaneous Abortion.
RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases.
Role of the N6-methyladenosine RNA mark in gene regulation and its implications on development and disease.
Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m6A signaling.
The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation.
The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG.
The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers.
Vitamin C Inhibits the Metabolic Changes Induced by Tet1 Insufficiency Under High Fat Diet Stress.
Opportunistic Infections
Characterization of Aspergillus fumigatus cross-resistance between clinical and DMI azole drugs.
Osteonecrosis
The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG.
Osteoporosis
KDM5A controls bone morphogenic protein 2-induced osteogenic differentiation of bone mesenchymal stem cells during osteoporosis.
The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG.
Osteosarcoma
ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma.
Epigenetic Profiling Identifies LIF as a Super-enhancer-Controlled Regulator of Stem Cell-like Properties in Osteosarcoma.
miR-140 inhibits osteosarcoma progression by impairing USP22-mediated LSD1 stabilization and promoting p21 expression.
Ovarian Neoplasms
DNA demethylase expression correlates with lung resistance protein expression in common epithelial ovarian cancers.
DNA demethylase is expressed in ovarian cancers and the expression correlates with demethylation of CpG sites in the promoter region of c-erbB-2 and survivin genes.
Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial?mesenchymal transition.
Pancreatic Neoplasms
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling.
m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling.
RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner.
Parkinson Disease
Peptidyl argininedeiminase 2 CpG island in multiple sclerosis white matter is hypomethylated.
Peripheral Nerve Injuries
N6-Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons.
Pre-Eclampsia
Compromised JMJD6 histone demethylase activity impacts on VHL gene repression in preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.
UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia.
Prostatic Neoplasms
AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase.
Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens.
DNA methyltransferase and demethylase in human prostate cancer.
JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer.
JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis.
JMJD3 is a histone H3K27 demethylase.
KDM5B is essential for the hyper-activation of PI3K/AKT signaling in prostate tumorigenesis.
LSD1 activates a lethal prostate cancer gene network independently of its demethylase function.
Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase.
Resistance to docetaxel in prostate cancer is associated with androgen receptor activation and loss of KDM5D expression.
Role of JMJD3 Demethylase and Its Inhibitor GSK-J4 in Regulation of MGMT, TRA2A, RPS6KA2, and U2AF1 Genes in Prostate Cancer Cell Lines.
The FTO m6A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m6A levels.
Protein-Energy Malnutrition
Malnutrition and drugs: clinical implications.
Renal Insufficiency, Chronic
Regulation of autophagy in leukocytes through RNA N6-adenosine methylation in chronic kidney disease patients.
Retinoblastoma
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation.
The nanoscale geometry of TiO2 nanotubes influences the osteogenic differentiation of human adipose-derived stem cells by modulating H3K4 trimethylation.
Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines.
Rhabdomyosarcoma
Role for the Histone Demethylase KDM4B in Rhabdomyosarcoma via CDK6 and CCNA2: Compensation by KDM4A and Apoptotic Response of Targeting Both KDM4B and KDM4A.
Riboflavin Deficiency
Effects of riboflavin on the dimethylnitrosamine demethylase system in the rat liver.
RNA Virus Infections
Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation.
Sarcoma
Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy.
Sarcoma, Ewing
Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy.
Ewing sarcoma resistance to SP-2509 is not mediated through KDM1A/LSD1 mutation.
Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response.
Seizures
Correspondence of increased debrisoquine 4-monooxygenase activity with seizure-susceptibility in Mongolian gerbils.
Seminoma
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
Sepsis
Influence of antibiotics and food intake on liver glutathione and cytochrome P-450 in septic rats.
Shock, Septic
Targeted Inhibition of FTO Demethylase Protects Mice Against LPS-Induced Septic Shock by Suppressing NLRP3 Inflammasome.
Small Cell Lung Carcinoma
Lysine?specific demethylase 2 contributes to the proliferation of small cell lung cancer by regulating the expression of TFPI?2.
Squamous Cell Carcinoma of Head and Neck
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
The m6A RNA Modification Quantity and mRNA Expression Level of RNA Methylation-Related Genes in Head and Neck Squamous Cell Carcinoma Cell Lines and Patients.
Starvation
A CxxC Domain That Binds to Unmethylated CpG Is Required for KDM2A to Control rDNA Transcription.
CxxC-ZF Domain Is Needed for KDM2A to Demethylate Histone in rDNA Promoter in Response to Starvation.
Demethylation of the Protein Phosphatase PP2A Promotes Demethylation of Histones to Enable Their Function as a Methyl Group Sink.
Effect of polychlorinated biphenyls (Aroclor 1254) on inducible and repressible microsomal N-demethylases in the mouse and rat.
Histone demethylase KDM3A is required for enhancer activation of hippo target genes in colorectal cancer.
JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation.
SF-KDM2A binds to ribosomal RNA gene promoter, reduces H4K20me3 level, and elevates ribosomal RNA transcription in breast cancer cells.
Stomach Neoplasms
Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer.
Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer.
Expression pattern of histone lysine-specific demethylase 6B in gastric cancer.
N6-Methyladenosine RNA Demethylase FTO Promotes Gastric Cancer Metastasis by Down-Regulating the m6A Methylation of ITGB1.
Omeprazole improves chemosensitivity of gastric cancer cells by m6A demethylase FTO-mediated activation of mTORC1 and DDIT3 up-regulation.
Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers.
Stupor
Effects of the antitumor agents from various natural sources on drug-metabolizing system, phagocytic activity and complement system in sarcoma 180-bearing mice.
Thiamine Deficiency
Effects of thiamine deficiency on hepatic cytochromes P450 and drug-metabolizing enzyme activities.
Thyroid Neoplasms
M6A Demethylase FTO Plays a Tumor Suppressor Role in Thyroid Cancer.
Triple Negative Breast Neoplasms
KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer.
Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Tuberculosis
Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.
Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.
Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors.
Modeling and interactions of Aspergillus fumigatus lanosterol 14-alpha demethylase 'A' with azole antifungals.
MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection.
Repurposing of Fluvastatin Against Candida albicans CYP450 Lanosterol 14 ?-demethylase, a Target Enzyme for Antifungal Therapy: An In silico and In vitro Study.
type ii protein arginine methyltransferase deficiency
PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD).
Uremia
Effect of uremia on rates of ethanol disappearance from the blood and on the activities of the ethanol-oxidizing enzymes.
Urinary Bladder Neoplasms
Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer.
Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression.
Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction.
Uterine Cervical Neoplasms
The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells.
Uveitis
Hypomethylation of Notch1 DNA is associated with the occurrence of uveitis.
Virus Diseases
Arabidopsis m(6)A demethylase activity modulates viral infection of a plant virus and the m(6)A abundance in its genomic RNAs.
Human and Arabidopsis alpha-ketoglutarate-dependent dioxygenase homolog proteins-New players in important regulatory processes.
Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication.
RdDM pathway components differentially modulate Tobamovirus symptom development.
T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.
TET3 Inhibits Type I IFN Production Independent of DNA Demethylation.
Vitamin E Deficiency
The dependence on vitamin E and selenium of drug demethylation in rat liver microsomal fractions.
Wilms Tumor
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.