Disease on EC 1.5.3.2 - N-methyl-L-amino-acid oxidase
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Abortion, Spontaneous
RNA Demethylase FTO Mediated RNA m6A Modification Is Involved in Maintaining Maternal-Fetal Interface in Spontaneous Abortion.
Adenocarcinoma
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling.
Adenocarcinoma of Lung
ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia.
Adenocarcinoma of Lung
Epigenetic Role of Histone Lysine Methyltransferase and Demethylase on the Expression of Transcription Factors Associated with the Epithelial-to-Mesenchymal Transition of Lung Adenocarcinoma Metastasis to the Brain.
Adenocarcinoma of Lung
H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression.
Adenocarcinoma of Lung
Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells.
Alzheimer Disease
DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models.
Anthrax
The role of NF-kappaB and H3K27me3 demethylase, Jmjd3, on the anthrax lethal toxin tolerance of RAW 264.7 cells.
Atherosclerosis
TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H2S System.
Bone Resorption
Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation.
Brain Neoplasms
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Breast Neoplasms
ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
Breast Neoplasms
Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability.
Breast Neoplasms
Corrigendum: The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
Breast Neoplasms
Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer.
Breast Neoplasms
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer.
Breast Neoplasms
GSKJ4, an H3K27me3 demethylase inhibitor, effectively suppresses the breast cancer stem cells.
Breast Neoplasms
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA.
Breast Neoplasms
JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activity.
Breast Neoplasms
KDM6B Counteracts EZH2-Mediated Suppression of IGFBP5 to Confer Resistance to PI3K/AKT Inhibitor Treatment in Breast Cancer.
Breast Neoplasms
Lysine demethylase KDM2A inhibits TET2 to promote DNA methylation and silencing of tumor suppressor genes in breast cancer.
Breast Neoplasms
Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.
Breast Neoplasms
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Breast Neoplasms
RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3.
Breast Neoplasms
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
Breast Neoplasms
Unliganded progesterone receptor-mediated targeting of an RNA-containing repressive complex silences a subset of hormone-inducible genes.
Breast Neoplasms
UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells.
Breast Neoplasms
Variable expression quantitative trait loci analysis of breast cancer risk variants.
Candidiasis
New azole derivatives showing antimicrobial effects and their mechanism of antifungal activity by molecular modeling studies.
Carcinogenesis
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Carcinogenesis
CBP-triggered KDM2B acetylation accelerates the carcinogenesis of colon cancer.
Carcinogenesis
Characterization of DNA demethylation in normal and cancerous cell lines and the regulatory role of cell cycle proteins in human DNA demethylase activity.
Carcinogenesis
Circular RNA hsa_circ_0072309 promotes tumorigenesis and invasion by regulating the miR-607/FTO axis in non-small cell lung carcinoma.
Carcinogenesis
Fat mass and obesity-associated protein promotes the tumorigenesis and development of liver cancer.
Carcinogenesis
FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling.
Carcinogenesis
Genetic alterations of 9p24 in lymphomas and their impact for cancer (immuno-)therapy.
Carcinogenesis
Histone 3 lysine-27 demethylase KDM6A coordinates with KMT2B to play an oncogenic role in NSCLC by regulating H3K4me3.
Carcinogenesis
Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.
Carcinogenesis
Histone demethylase KDM2B upregulates histone methyltransferase EZH2 expression and contributes to the progression of ovarian cancer in vitro and in vivo.
Carcinogenesis
HPV16 E6 and E7 upregulate the histone lysine demethylase KDM2B through the c-MYC/miR-146a-5p axys.
Carcinogenesis
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling.
Carcinogenesis
m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation.
Carcinogenesis
m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling.
Carcinogenesis
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Carcinogenesis
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
Carcinogenesis
New roles of flavoproteins in molecular cell biology: histone demethylase LSD1 and chromatin.
Carcinogenesis
Progressive up-regulation of genes encoding DNA methyltransferases in the colorectal adenoma-carcinoma sequence.
Carcinogenesis
Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers.
Carcinogenesis
Retinoblastoma-binding protein 2 (RBP2) is frequently expressed in neuroendocrine tumors and promotes the neoplastic phenotype.
Carcinogenesis
RNA demethylase ALKBH5 promotes ovarian carcinogenesis in a simulated tumour microenvironment through stimulating NF-?B pathway.
Carcinogenesis
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Carcinogenesis
RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma.
Carcinoma
DNA methylation status of hMLH1, p16(INK4a), and CDH1 is not associated with mRNA expression levels of DNA methyltransferase and DNA demethylase in gastric carcinomas.
Carcinoma
m6 A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis.
Carcinoma
m6A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression.
Carcinoma
m6A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression.
Carcinoma
N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1? signalling axis.
Carcinoma
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
Carcinoma
RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma.
Carcinoma
System Review about Function Role of ESCC Driver Gene KDM6A by Network Biology Approach.
Carcinoma
Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress.
Carcinoma
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Carcinoma
Transcriptomic Profiling and H3K27me3 Distribution Reveal Both Demethylase-Dependent and Independent Regulation of Developmental Gene Transcription in Cell Differentiation.
Carcinoma
[The induction of Guerin's carcinoma cytochrome p450 hydroxylase activity by retinoids].
Carcinoma, Ductal
Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast.
Carcinoma, Embryonal
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
Carcinoma, Hepatocellular
Characterization of microsomal methyl sterol demethylase in two Morris hepatomas.
Carcinoma, Hepatocellular
Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats.
Carcinoma, Hepatocellular
DNA methylation-mediated repression of miR-941 enhances lysine (K)-specific demethylase 6B expression in hepatoma cells.
Carcinoma, Hepatocellular
Effect of strain differences and tumor presence on microsomal drug metabolism in the guinea pig: brief communication.
Carcinoma, Hepatocellular
Functional alterations of the endoplasmic reticulum and the detoxification systems during diethyl-nitrosamine carcinogenesis in rat liver.
Carcinoma, Hepatocellular
Functional and structural alterations of liver ergastoplasmic membranes during DL-ethionine hepatocarcinogenesis.
Carcinoma, Hepatocellular
Investigation of the rate-determining microsomal reaction of cholesterol biosynthesis from lanosterol in Morris hepatomas and liver.
Carcinoma, Hepatocellular
m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation.
Carcinoma, Hepatocellular
Role of the Hypoxia-Related Gene, JMJD1A, in Hepatocellular Carcinoma: Clinical Impact on Recurrence after Hepatic Resection.
Carcinoma, Hepatocellular
Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.
Carcinoma, Hepatocellular
[Effect of Basil Polysaccharide on Histone H3K9me2 Methylation and Expression of G9a and JMJD1A in Hepatoma Cells Under Hypoxic Conditions].
Carcinoma, Non-Small-Cell Lung
m6A demethylase FTO induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
N6-methyladenosine ALKBH5 promotes non-small cell lung cancer progress by regulating TIMP3 stability.
Carcinoma, Non-Small-Cell Lung
The diagnostic performance of lysine(K)-specific demethylase 6B (KDM6B) in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Transcriptional Repression of Histone Deacetylase 3 by the Histone Demethylase KDM2A Is Coupled to Tumorigenicity of Lung Cancer Cells.
Carcinoma, Ovarian Epithelial
DNA demethylase expression correlates with lung resistance protein expression in common epithelial ovarian cancers.
Carcinoma, Renal Cell
N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1? signalling axis.
Carcinoma, Squamous Cell
m6A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression.
Carcinoma, Squamous Cell
Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress.
Carcinoma, Squamous Cell
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Cardiomegaly
Inhibition of histone demethylase JMJD1C attenuates cardiac hypertrophy and fibrosis induced by angiotensin II.
Cardiomegaly
The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice.
Cardiovascular Diseases
PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding.
Chemical and Drug Induced Liver Injury
[Effect of HF on the hepatic metabolism of dimethylnitrosamine in the rat]
Cholangiocarcinoma
M6A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma.
Cholestasis
Effects of liver injury and cholestasis on microsomal enzyme activities and metabolism of halothane, enflurane and methoxyflurane in vivo in rats.
Cholestasis
Microsomal function in biliary obstructed rats: effects of S-adenosylmethionine.
Cleft Lip
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation.
Colitis
The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells.
Colonic Neoplasms
ALKBH5 Holds Prognostic Values and Inhibits the Metastasis of Colon Cancer.
Colonic Neoplasms
Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells.
Colonic Neoplasms
KDM5c inhibits multidrug resistance of colon cancer cell line by down-regulating ABCC1.
Colonic Neoplasms
Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner.
Colonic Neoplasms
LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer.
Colonic Neoplasms
Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells.
Colorectal Neoplasms
FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis.
Colorectal Neoplasms
Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers.
Colorectal Neoplasms
The histone H3 lysine-27 demethylase UTX plays a critical role in colorectal cancer cell proliferation.
DNA Virus Infections
Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.
Endodermal Sinus Tumor
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
Endometrial Neoplasms
ALKBH5 regulates IGF1R expression to promote the Proliferation and Tumorigenicity of Endometrial Cancer.
Epstein-Barr Virus Infections
Interplay between the Epigenetic Enzyme Lysine (K)-Specific Demethylase 2B and Epstein-Barr Virus Infection.
Esophageal Squamous Cell Carcinoma
m6 A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis.
Esophageal Squamous Cell Carcinoma
m6A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression.
Esophageal Squamous Cell Carcinoma
RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
System Review about Function Role of ESCC Driver Gene KDM6A by Network Biology Approach.
Glioblastoma
3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line.
Glioblastoma
Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization.
Glioblastoma
Increased expression of the histone H3 lysine 4 methyltransferase MLL4 and the histone H3 lysine 27 demethylase UTX prolonging the overall survival of patients with glioblastoma and a methylated MGMT promoter.
Glioblastoma
Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma.
Glioblastoma
Methylation dependent down-regulation of G0S2 leads to suppression of invasion and improved prognosis of IDH1-mutant glioma.
Glioblastoma
Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells.
Glioblastoma
Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors.
Glioblastoma
Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B.
Glioma
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma.
Glioma
The histone H3 Lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1.
Glomerulonephritis
[Role of histone demethylase KDM6B in HBx-mediated podocyte-macrophage transdifferentiation].
Hepatitis
Drug metabolism in liver disease: activity of hepatic microsomal metabolizing enzymes.
Hepatitis B
[Role of histone demethylase KDM6B in HBx-mediated podocyte-macrophage transdifferentiation].
Herpes Simplex
Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.
Herpes Zoster
Effects of age and adrenocorticotropin on microsomal enzymes in guinea pig adrenal inner and outer cortices.
Hirschsprung Disease
m6A demethylase ALKBH5 suppresses proliferation and migration of enteric neural crest cells by regulating TAGLN in Hirschsprung's disease.
Hodgkin Disease
Epigenetic Loss of m1A RNA Demethylase ALKBH3 in Hodgkin Lymphoma Targets Collagen Conferring Poor Clinical Outcome.
Hodgkin Disease
Strong KDM4B and KDM4D Expression Associates with Radioresistance and Aggressive Phenotype in Classical Hodgkin Lymphoma.
Hodgkin Disease
The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma.
Hyperglycemia
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.
Hypersensitivity
Effect of Pharmacological Inhibition of Fat-Mass and Obesity-Associated Protein on Nerve Trauma-Induced Pain Hypersensitivities.
Hypersensitivity
Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.
Hypertension
Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension.
Hypoprothrombinemias
Induction of hepatic enzymes by methaqualone and effect on warfarin-induced hypoprothrombinemia.
Ileus
[State of the microsomal oxidative system of the rat liver in acute intestinal obstruction]
Infections
A gene from the fungal plant pathogen Nectria haematococca that encodes the phytoalexin-detoxifying enzyme pisatin demethylase defines a new cytochrome P450 family.
Infections
Antifungals targeted to protein modification: focus on protein N-myristoyltransferase.
Infections
Antifungals targeted to sphingolipid synthesis: focus on inositol phosphorylceramide synthase.
Infections
Biochemical properties of the products of cytochrome P450 genes (PDA) encoding pisatin demethylase activity in nectria haematococca
Infections
Contributions of both ATP-binding cassette transporter and Cyp51A proteins are essential for azole resistance in Aspergillus fumigatus.
Infections
DNA Methylation Profile of ?-1,3-Glucanase and Chitinase Genes in Flax Shows Specificity Towards Fusarium Oxysporum Strains Differing in Pathogenicity.
Infections
Hepatic microsomal enzymes in S. mansoni infected mice: II. Effect of duration of infection and lindane administration on aminopyrine demethylase and aniline hydroxylase.
Infections
Influenza virus-induced alterations of cytochrome P-450 enzyme activities following exposure of mice to coal and diesel particulates.
Infections
Jumonji C domain protein JMJ705-mediated removal of histone H3 lysine 27 trimethylation is involved in defense-related gene activation in rice.
Infections
Macrophage Polarization Modulated by Porcine Circovirus Type 2 Facilitates Bacterial Coinfection.
Infections
Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals.
Infections
MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection.
Infections
NF-?B-mediated TET2-dependent TNF promoter demethylation drives Mtb-upregulation TNF expression in macrophages.
Infections
PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding.
Infections
UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability.
Infertility
Methylation dynamics in the early mammalian embryo: implications of genome reprogramming defects for development.
Insulin Resistance
N6-methyladenosine Demethylase FTO Induces the Dysfunctions of Ovarian Granulosa Cells by Upregulating Flotillin 2.
Intellectual Disability
A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation.
Intellectual Disability
A novel c.2T > C mutation of the KDM5C/JARID1C gene in one large family with X-linked intellectual disability.
Intellectual Disability
DNA methylation fingerprint of monozygotic twins and their singleton sibling with intellectual disability carrying a novel KDM5C mutation.
Intellectual Disability
LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors.
Intellectual Disability
Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity.
Intellectual Disability
Overexpression of serotonin receptor 5b expression rescues neuronal and behavioral deficits in a mouse model of Kabuki syndrome.
Intellectual Disability
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation.
Kidney Neoplasms
The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells.
Leishmaniasis
Targeting sterol alpha-14 demethylase of Leishmania donovani to fight against leishmaniasis.
Leukemia
A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells.
Leukemia
Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization.
Leukemia
FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling.
Leukemia
KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia.
Leukemia
Key roles of histone methyltransferase and demethylase in leukemogenesis.
Leukemia
Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.
Leukemia
Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia.
Leukemia
ORY-1001 Suppresses Cell Growth and Induces Apoptosis in Lung Cancer Through Triggering HK2 Mediated Warburg Effect.
Leukemia
Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors.
Leukemia
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.
Leukemia
The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells.
Leukemia
Upregulation of CD11b and CD86 through LSD1 inhibition promotes myeloid differentiation and suppresses cell proliferation in human monocytic leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia.
Leukemia, Myeloid
Emerging epigenetic therapeutics for myeloid leukemia: modulating demethylase activity with ascorbate.
Leukemia, Myeloid, Acute
Ascorbate Inhibits Proliferation and Promotes Myeloid Differentiation in TP53-Mutant Leukemia.
Leukemia, Myeloid, Acute
Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy.
Leukemia, Myeloid, Acute
FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase.
Leukemia, Myeloid, Acute
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.
Leukemia, Myeloid, Acute
It's Not What You Say But How You Say It: Targeting RNA Methylation in AML.
Leukemia, Myeloid, Acute
Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.
Leukemia, Myeloid, Acute
Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions.
Leukemia, Myeloid, Acute
Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation.
Leukemia, Myeloid, Acute
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.
Leukemia, Myeloid, Acute
The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells.
Liver Cirrhosis
Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis.
Liver Diseases
Drug metabolism in liver disease: activity of hepatic microsomal metabolizing enzymes.
Liver Diseases
Relationship between metabolic clearance rate of antipyrine and hepatic microsomal drug-oxidizing enzyme activities in humans without liver disease.
Liver Neoplasms
Fat mass and obesity-associated protein promotes the tumorigenesis and development of liver cancer.
Liver Neoplasms
HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372.
Lung Neoplasms
Epigenetic regulation of epithelial-mesenchymal transition by KDM6A histone demethylase in lung cancer cells.
Lung Neoplasms
Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT.
Lung Neoplasms
JumonjiC demethylase inhibitors show potential for targeting chemotherapy-resistant lung cancers.
Lung Neoplasms
Lysine?specific demethylase 2 contributes to the proliferation of small cell lung cancer by regulating the expression of TFPI?2.
Lung Neoplasms
m6A demethylase FTO induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small cell lung cancer.
Lung Neoplasms
N6-methyladenosine ALKBH5 promotes non-small cell lung cancer progress by regulating TIMP3 stability.
Lung Neoplasms
Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.
Lung Neoplasms
The diagnostic performance of lysine(K)-specific demethylase 6B (KDM6B) in non-small cell lung cancer.
Lung Neoplasms
The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA.
Lung Neoplasms
Transcriptional Repression of Histone Deacetylase 3 by the Histone Demethylase KDM2A Is Coupled to Tumorigenicity of Lung Cancer Cells.
Lymphocytic Choriomeningitis
UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability.
Lymphoma, B-Cell
Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs.
Lymphoma, Large B-Cell, Diffuse
Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs.
Malnutrition
[The liver monooxygenase system in nutritional deficiency in rats in early ontogeny]
Medulloblastoma
Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma.
Melanoma
H3K27 Demethylase JMJD3 Employs the NF-?B and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis.
Melanoma
Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.
Melanoma
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Melanoma
N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I.
Melanoma
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.
Meningioma
Epigenetic Role of Histone 3 Lysine Methyltransferase and Demethylase in Regulating Apoptosis Predicting the Recurrence of Atypical Meningioma.
Metabolic Diseases
NADP modulates RNA m6A methylation and adipogenesis via enhancing FTO activity.
Mouth Neoplasms
Targeting JARID1B's demethylase activity blocks a subset of its functions in oral cancer.
Mycoses
Fungal Infection Induces Anthocyanin Biosynthesis and Changes in DNA Methylation Configuration of Blood Orange [Citrus sinensis L. (Osbeck)].
Mycoses
Molecular Dynamics Investigations of Binding Mechanism for Triazoles Inhibitors to CYP51.
Myelodysplastic Syndromes
Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy.
Neoplasm Metastasis
Downregulation of miR-335 exhibited an oncogenic effect via promoting KDM3A/YAP1 networks in clear cell renal cell carcinoma.
Neoplasm Metastasis
Epigenetic Role of Histone Lysine Methyltransferase and Demethylase on the Expression of Transcription Factors Associated with the Epithelial-to-Mesenchymal Transition of Lung Adenocarcinoma Metastasis to the Brain.
Neoplasm Metastasis
Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer.
Neoplasm Metastasis
FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis.
Neoplasm Metastasis
LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer.
Neoplasm Metastasis
Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial?mesenchymal transition.
Neoplasm Metastasis
m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2-mediated YAP activity in NSCLC.
Neoplasm Metastasis
m6A demethylase FTO induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small cell lung cancer.
Neoplasm Metastasis
Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase.
Neoplasm Metastasis
N6-Methyladenosine RNA Demethylase FTO Promotes Gastric Cancer Metastasis by Down-Regulating the m6A Methylation of ITGB1.
Neoplasm Metastasis
Recent advances of m6A methylation modification in esophageal squamous cell carcinoma.
Neoplasm Metastasis
Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress.
Neoplasms
3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line.
Neoplasms
5-Aza-2'-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene.
Neoplasms
A fluorescent nanobiosensor for the facile analysis of m6A RNA demethylase activity.
Neoplasms
A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition.
Neoplasms
A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells.
Neoplasms
ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2?-Mediated Glycolysis.
Neoplasms
ALKBH5 promotes the proliferation of renal cell carcinoma by regulating AURKB expression in an m6A-dependent manner.
Neoplasms
ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment.
Neoplasms
ALKBH5-mediated m6A-demethylation of USP1 regulated T-cell acute lymphoblastic leukemia cell glucocorticoid resistance by Aurora B.
Neoplasms
An Update of Lysine Specific Demethylase 1 Inhibitor: A Patent Review (2016-2020).
Neoplasms
Breaking the LSD1/KDM1A addiction: therapeutic targeting of the epigenetic modifier in AML.
Neoplasms
Characterization of DNA demethylation in normal and cancerous cell lines and the regulatory role of cell cycle proteins in human DNA demethylase activity.
Neoplasms
Clinical analysis of NSCLC patients reveals lack of association between EGFR mutation and TET1 downregulation.
Neoplasms
Corrigendum: Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers.
Neoplasms
Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression.
Neoplasms
Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate.
Neoplasms
Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression.
Neoplasms
DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC.
Neoplasms
DNA methylation reprogramming of human cancer cells by expression of a plant 5-methylcytosine DNA glycosylase.
Neoplasms
Effect of BIX-01294 on proliferation, apoptosis and histone methylation of acute T lymphoblastic leukemia cells.
Neoplasms
Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast.
Neoplasms
Endothelial progenitor cells-secreted extracellular vesicles containing microRNA-93-5p confer protection against sepsis-induced acute kidney injury via the KDM6B/H3K27me3/TNF-? axis.
Neoplasms
EnMCB: an R/bioconductor package for predicting disease progression based on methylation correlated blocks using ensemble models.
Neoplasms
Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers.
Neoplasms
Epigenetic regulation of epithelial-mesenchymal transition by KDM6A histone demethylase in lung cancer cells.
Neoplasms
Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A.
Neoplasms
FLI-06 suppresses proliferation, induces apoptosis and cell cycle arrest by targeting LSD1 and Notch pathway in esophageal squamous cell carcinoma cells.
Neoplasms
FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13.
Neoplasms
FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling.
Neoplasms
Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model.
Neoplasms
Histone 3 lysine-27 demethylase KDM6A coordinates with KMT2B to play an oncogenic role in NSCLC by regulating H3K4me3.
Neoplasms
Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma.
Neoplasms
Histone demethylases in physiology and cancer: a tale of two enzymes, JMJD3 and UTX.
Neoplasms
HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372.
Neoplasms
Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells.
Neoplasms
Inhibition of the histone H3K27 demethylase UTX enhances tumor cell radiosensitivity.
Neoplasms
Interplay between the Epigenetic Enzyme Lysine (K)-Specific Demethylase 2B and Epstein-Barr Virus Infection.
Neoplasms
JARID1-targeted histone H3 demethylase inhibitors exhibit anti-proliferative activity and overcome cisplatin resistance in canine oral melanoma cell lines.
Neoplasms
Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks.
Neoplasms
Jumonji/ARID1 B (JARID1B) protein promotes breast tumor cell cycle progression through epigenetic repression of microRNA let-7e.
Neoplasms
JumonjiC demethylase inhibitors show potential for targeting chemotherapy-resistant lung cancers.
Neoplasms
KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease.
Neoplasms
KDM4B plays an important role in mitochondrial apoptosis by upregulating HAX1 expression in colorectal cancer.
Neoplasms
KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family.
Neoplasms
KDM5B is essential for the hyper-activation of PI3K/AKT signaling in prostate tumorigenesis.
Neoplasms
KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia.
Neoplasms
KDM6B is an androgen regulated gene and plays oncogenic roles by demethylating H3K27me3 at cyclin D1 promoter in prostate cancer.
Neoplasms
KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBP? transcription.
Neoplasms
lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans.
Neoplasms
Long noncoding RNA GAS5-AS1 suppresses growth and metastasis of cervical cancer by increasing GAS5 stability.
Neoplasms
Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors.
Neoplasms
Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner.
Neoplasms
Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.
Neoplasms
Lysine-specific demethylase 1 (LSD1) serves as an potential epigenetic determinant to regulate inflammatory responses in mastitis.
Neoplasms
Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation.
Neoplasms
Lysine-specific demethylase 2A expression is associated with cell growth and cyclin D1 expression in colorectal adenocarcinoma.
Neoplasms
m6 A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis.
Neoplasms
m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2-mediated YAP activity in NSCLC.
Neoplasms
M6A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma.
Neoplasms
m6A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression.
Neoplasms
m6A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression.
Neoplasms
MassSQUIRM: An assay for quantitative measurement of lysine demethylase activity.
Neoplasms
MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer.
Neoplasms
Molecular dynamics simulations indicate an induced-fit mechanism for LSD1/CoREST-H3-histone molecular recognition.
Neoplasms
NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.
Neoplasms
Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells.
Neoplasms
Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia.
Neoplasms
Orthogonal Demethylase-Activated Deoxyribozyme for Intracellular Imaging and Gene Regulation.
Neoplasms
Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21.
Neoplasms
Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinoma.
Neoplasms
Overexpression of UTX promotes tumor progression in Oral tongue squamous cell carcinoma patients receiving surgical resection: a case control study.
Neoplasms
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
Neoplasms
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma.
Neoplasms
Predictive Value of KDM5C Alterations for Immune Checkpoint Inhibitors Treatment Outcomes in Patients With Cancer.
Neoplasms
Promoter methylation status of VEGF receptor genes: A possible epigenetic biomarker to anticipate the efficacy of intracellular-acting VEGF-targeted drugs in cancer cells.
Neoplasms
Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors.
Neoplasms
Recent advances of m6A methylation modification in esophageal squamous cell carcinoma.
Neoplasms
Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers.
Neoplasms
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.
Neoplasms
RNA demethylase ALKBH5 promotes ovarian carcinogenesis in a simulated tumour microenvironment through stimulating NF-?B pathway.
Neoplasms
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Neoplasms
RNA N-6-methyladenosine enzymes and resistance of cancer cells to chemotherapy and radiotherapy.
Neoplasms
Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance.
Neoplasms
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.
Neoplasms
Strong KDM4B and KDM4D Expression Associates with Radioresistance and Aggressive Phenotype in Classical Hodgkin Lymphoma.
Neoplasms
Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases.
Neoplasms
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Neoplasms
The H3K27me3 demethylase dUTX is a suppressor of notch- and Rb-dependent tumors in Drosophila.
Neoplasms
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.
Neoplasms
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
Neoplasms
The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity.
Neoplasms
The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.
Neoplasms
The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers.
Neoplasms
The Prognostic Significance Of JMJD3 In Primary Sarcomatoid Carcinoma Of The Lung, A Rare Subtype Of Lung Cancer.
Neoplasms
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.
Neoplasms
The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase.
Neoplasms
Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response.
Neoplasms
Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs.
Neoplasms
Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines.
Neoplasms
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance.
Neoplasms
UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs.
Neoplasms
Xenobiotic metabolizing enzymes in genetically and chemically initiated mouse liver tumors.
Neoplasms
[Mechanism of the mutagenic/carcinogenic action of cigarette smoke at the pulmonary level: enzymatic induction, activation and detoxification]
Neoplasms
[The induction of Guerin's carcinoma cytochrome p450 hydroxylase activity by retinoids].
Nervous System Diseases
Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A.
Neuroblastoma
Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation.
Neurodegenerative Diseases
Molecular dynamics simulations indicate an induced-fit mechanism for LSD1/CoREST-H3-histone molecular recognition.
Neuroinflammatory Diseases
Jmjd3 is involved in the susceptibility to depression induced by maternal separation via enhancing the neuroinflammation in the prefrontal cortex and hippocampus of male rats.
Obesity
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.
Obesity
Diazirine Photocrosslinking Recruits Activated FTO Demethylase Complexes for Specific N(6)-methyladenosine Recognition.
Obesity
Effect of genetic obesity and experimental diabetes on hepatic microsomal mixed function oxidase activities.
Obesity
Erasing m6A-dependent transcription signature of stress-sensitive genes triggers antidepressant actions.
Obesity
FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signalling pathway.
Obesity
FTO inhibits UPRmt-induced apoptosis by activating JAK2/STAT3 pathway and reducing m6A level in adipocytes.
Obesity
FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription.
Obesity
Hepatic expression of FTO and fatty acid metabolic genes changes in response to lipopolysaccharide with alterations in m(6)A modification of relevant mRNAs in the chicken.
Obesity
Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo.
Obesity
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
Obesity
Maternal obesity aggravates the abnormality of porcine placenta by increasing N6-methyladenosine.
Obesity
Meclofenamic acid represses spermatogonial proliferation through modulating m6A RNA modification.
Obesity
N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1? signalling axis.
Obesity
RNA Demethylase FTO Mediated RNA m6A Modification Is Involved in Maintaining Maternal-Fetal Interface in Spontaneous Abortion.
Obesity
Role of the N6-methyladenosine RNA mark in gene regulation and its implications on development and disease.
Obesity
The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation.
Obesity
The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG.
Obesity
The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers.
Obesity
Vitamin C Inhibits the Metabolic Changes Induced by Tet1 Insufficiency Under High Fat Diet Stress.
Opportunistic Infections
Characterization of Aspergillus fumigatus cross-resistance between clinical and DMI azole drugs.
Osteonecrosis
The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG.
Osteoporosis
KDM5A controls bone morphogenic protein 2-induced osteogenic differentiation of bone mesenchymal stem cells during osteoporosis.
Osteoporosis
The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG.
Osteosarcoma
ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma.
Osteosarcoma
Epigenetic Profiling Identifies LIF as a Super-enhancer-Controlled Regulator of Stem Cell-like Properties in Osteosarcoma.
Osteosarcoma
miR-140 inhibits osteosarcoma progression by impairing USP22-mediated LSD1 stabilization and promoting p21 expression.
Ovarian Neoplasms
DNA demethylase expression correlates with lung resistance protein expression in common epithelial ovarian cancers.
Ovarian Neoplasms
DNA demethylase is expressed in ovarian cancers and the expression correlates with demethylation of CpG sites in the promoter region of c-erbB-2 and survivin genes.
Ovarian Neoplasms
Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial?mesenchymal transition.
Pancreatic Neoplasms
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling.
Pancreatic Neoplasms
m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling.
Pancreatic Neoplasms
RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner.
Parkinson Disease
Peptidyl argininedeiminase 2 CpG island in multiple sclerosis white matter is hypomethylated.
Peripheral Nerve Injuries
N6-Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons.
Pre-Eclampsia
Compromised JMJD6 histone demethylase activity impacts on VHL gene repression in preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia.
Prostatic Neoplasms
AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase.
Prostatic Neoplasms
Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens.
Prostatic Neoplasms
JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer.
Prostatic Neoplasms
JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis.
Prostatic Neoplasms
KDM5B is essential for the hyper-activation of PI3K/AKT signaling in prostate tumorigenesis.
Prostatic Neoplasms
LSD1 activates a lethal prostate cancer gene network independently of its demethylase function.
Prostatic Neoplasms
Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase.
Prostatic Neoplasms
Resistance to docetaxel in prostate cancer is associated with androgen receptor activation and loss of KDM5D expression.
Prostatic Neoplasms
Role of JMJD3 Demethylase and Its Inhibitor GSK-J4 in Regulation of MGMT, TRA2A, RPS6KA2, and U2AF1 Genes in Prostate Cancer Cell Lines.
Prostatic Neoplasms
The FTO m6A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m6A levels.
Renal Insufficiency, Chronic
Regulation of autophagy in leukocytes through RNA N6-adenosine methylation in chronic kidney disease patients.
Retinoblastoma
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation.
Retinoblastoma
The nanoscale geometry of TiO2 nanotubes influences the osteogenic differentiation of human adipose-derived stem cells by modulating H3K4 trimethylation.
Retinoblastoma
Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines.
Rhabdomyosarcoma
Role for the Histone Demethylase KDM4B in Rhabdomyosarcoma via CDK6 and CCNA2: Compensation by KDM4A and Apoptotic Response of Targeting Both KDM4B and KDM4A.
Riboflavin Deficiency
Effects of riboflavin on the dimethylnitrosamine demethylase system in the rat liver.
RNA Virus Infections
Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation.
Sarcoma
Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy.
Sarcoma, Ewing
Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy.
Sarcoma, Ewing
Ewing sarcoma resistance to SP-2509 is not mediated through KDM1A/LSD1 mutation.
Sarcoma, Ewing
Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response.
Seizures
Correspondence of increased debrisoquine 4-monooxygenase activity with seizure-susceptibility in Mongolian gerbils.
Seminoma
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
Sepsis
Influence of antibiotics and food intake on liver glutathione and cytochrome P-450 in septic rats.
Shock, Septic
Targeted Inhibition of FTO Demethylase Protects Mice Against LPS-Induced Septic Shock by Suppressing NLRP3 Inflammasome.
Small Cell Lung Carcinoma
Lysine?specific demethylase 2 contributes to the proliferation of small cell lung cancer by regulating the expression of TFPI?2.
Squamous Cell Carcinoma of Head and Neck
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
The m6A RNA Modification Quantity and mRNA Expression Level of RNA Methylation-Related Genes in Head and Neck Squamous Cell Carcinoma Cell Lines and Patients.
Starvation
A CxxC Domain That Binds to Unmethylated CpG Is Required for KDM2A to Control rDNA Transcription.
Starvation
CxxC-ZF Domain Is Needed for KDM2A to Demethylate Histone in rDNA Promoter in Response to Starvation.
Starvation
Demethylation of the Protein Phosphatase PP2A Promotes Demethylation of Histones to Enable Their Function as a Methyl Group Sink.
Starvation
Effect of polychlorinated biphenyls (Aroclor 1254) on inducible and repressible microsomal N-demethylases in the mouse and rat.
Starvation
Histone demethylase KDM3A is required for enhancer activation of hippo target genes in colorectal cancer.
Starvation
JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation.
Starvation
SF-KDM2A binds to ribosomal RNA gene promoter, reduces H4K20me3 level, and elevates ribosomal RNA transcription in breast cancer cells.
Stomach Neoplasms
Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer.
Stomach Neoplasms
Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer.
Stomach Neoplasms
Expression pattern of histone lysine-specific demethylase 6B in gastric cancer.
Stomach Neoplasms
N6-Methyladenosine RNA Demethylase FTO Promotes Gastric Cancer Metastasis by Down-Regulating the m6A Methylation of ITGB1.
Stomach Neoplasms
Omeprazole improves chemosensitivity of gastric cancer cells by m6A demethylase FTO-mediated activation of mTORC1 and DDIT3 up-regulation.
Stomach Neoplasms
Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers.
Stupor
Effects of the antitumor agents from various natural sources on drug-metabolizing system, phagocytic activity and complement system in sarcoma 180-bearing mice.
Thiamine Deficiency
Effects of thiamine deficiency on hepatic cytochromes P450 and drug-metabolizing enzyme activities.
Triple Negative Breast Neoplasms
KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer.
Triple Negative Breast Neoplasms
Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Tuberculosis
Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.
Tuberculosis
Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.
Tuberculosis
Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors.
Tuberculosis
Modeling and interactions of Aspergillus fumigatus lanosterol 14-alpha demethylase 'A' with azole antifungals.
Tuberculosis
MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection.
Tuberculosis
Repurposing of Fluvastatin Against Candida albicans CYP450 Lanosterol 14 ?-demethylase, a Target Enzyme for Antifungal Therapy: An In silico and In vitro Study.
type ii protein arginine methyltransferase deficiency
PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD).
Uremia
Effect of uremia on rates of ethanol disappearance from the blood and on the activities of the ethanol-oxidizing enzymes.
Urinary Bladder Neoplasms
Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer.
Urinary Bladder Neoplasms
Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression.
Urinary Bladder Neoplasms
Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction.
Uterine Cervical Neoplasms
The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells.
Virus Diseases
Arabidopsis m(6)A demethylase activity modulates viral infection of a plant virus and the m(6)A abundance in its genomic RNAs.
Virus Diseases
Human and Arabidopsis alpha-ketoglutarate-dependent dioxygenase homolog proteins-New players in important regulatory processes.
Virus Diseases
Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.
Virus Diseases
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
Virus Diseases
N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication.
Virus Diseases
RdDM pathway components differentially modulate Tobamovirus symptom development.
Virus Diseases
T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.
Vitamin E Deficiency
The dependence on vitamin E and selenium of drug demethylation in rat liver microsomal fractions.
Wilms Tumor
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
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