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Information on EC - spermine oxidase

for references in articles please use BRENDA:EC1.5.3.16
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EC Tree
     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.3 With oxygen as acceptor
       spermine oxidase
IUBMB Comments
The enzyme from Arabidopsis thaliana (AtPAO1) oxidizes norspermine to norspermidine with high efficiency . The mammalian enzyme, encoded by the SMOX gene, is a cytosolic enzyme that catalyses the oxidation of spermine at the exo (three-carbon) side of the tertiary amine. No activity with spermidine. Weak activity with N1-acetylspermine. A flavoprotein (FAD). Differs in specificity from EC (N1-acetylpolyamine oxidase), EC (polyamine oxidase (propane-1,3-diamine-forming)), EC (N8-acetylspermidine oxidase (propane-1,3-diamine-forming) and EC (non-specific polyamine oxidase).
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The enzyme appears in viruses and cellular organisms
AtPAO1, AtPAO4, AtPAO5, Fms1 protein, GhPAO, hSMO, MmSMO, mSMO, mSMOalpha, mSMOmu, more
spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2
show the reaction diagram
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