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Information on EC 1.5.1.5 - methylenetetrahydrofolate dehydrogenase (NADP+) and Organism(s) Pseudomonas aeruginosa
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EC Tree 1 Oxidoreductases
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)
IUBMB Comments
In eukaryotes, occurs as a trifunctional enzyme also having methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) and formate—tetrahydrofolate ligase (EC 6.3.4.3) activity. In some prokaryotes occurs as a bifunctional enzyme also having methenyltetrahydrofolate cyclohydrolase activity (EC 3.5.4.9).
The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
- 1.5.1.5
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one-carbon
-
cyclohydrolase
- thymidylate
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trifunctional
- methenyltetrahydrofolate
- 5,10-methenyltetrahydrofolate
- 10-formyltetrahydrofolate
- mthfd1l
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folate-dependent
- formyltetrahydrofolate
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folate-mediated
-
c1-tetrahydrofolate
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3.5.4.9
-
transcobalamin
-
10-formyl-thf
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6.3.4.3
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remethylation
-
5,10-methenyl-thf
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1-carbon
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dehydrogenase-cyclohydrolase
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megaloblastic
- medicine
Reaction Schemes
showSynonyms
methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate dehydrogenase, mthfd2 protein, ch2-thf dehydrogenase, mthfd1 protein, mitochondrial methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate dehydrogenase (nadp+ dependent), n5,n10-methylenetetrahydrofolate dehydrogenase, bmmthfd, more
top
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
5,10-methylenetetrahydrofolate dehydrogenase
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-
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methylenetetrahydrofolate dehydrogenase
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-
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N5,N10-methylenetetrahydrofolate dehydrogenase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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-
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redox reaction
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-
-
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reduction
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-
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-
PATHWAY SOURCE
PATHWAYS
KEGG
MetaCyc
folate transformations I, folate transformations II (plants), folate transformations III (E. coli), formaldehyde oxidation VII (THF pathway), formate assimilation into 5,10-methylenetetrahydrofolate, purine nucleobases degradation II (anaerobic), reductive acetyl coenzyme A pathway I (homoacetogenic bacteria), reductive glycine pathway of autotrophic CO2 fixation
SYSTEMATIC NAME
IUBMB Comments
5,10-methylenetetrahydrofolate:NADP+ oxidoreductase
In eukaryotes, occurs as a trifunctional enzyme also having methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) and formate---tetrahydrofolate ligase (EC 6.3.4.3) activity. In some prokaryotes occurs as a bifunctional enzyme also having methenyltetrahydrofolate cyclohydrolase activity (EC 3.5.4.9).
CAS REGISTRY NUMBER
COMMENTARY
9029-14-5
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Highest Expressing Human Cell Lines
Cell Line LinksUNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
EXTERNAL LINKS (specific for EC-Number 1.5.1.5)
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Release 2026.1 (March 2026)
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