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Information on EC 1.5.1.31 - berberine reductase

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EC Tree
     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.31 berberine reductase
IUBMB Comments
Involved in alkaloid biosynthesis in Corydalis cava to give (R)-canadine with the opposite configuration to the precursor of berberine (see EC 1.3.3.8 tetrahydroberberine oxidase). Also acts on 7,8-dihydroberberine.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
(R)-canadine synthase, (S)-tetrahydroprotoberberine oxidase, STOX, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+
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