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Information on EC 1.5.1.3 - dihydrofolate reductase and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC1.5.1.3

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IUBMB Comments

The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate.

The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The enzyme appears in selected viruses and cellular organisms

Synonyms
dhfr, dihydrofolate reductase, thy-1, dhfr-ts, hdhfr, dihydrofolate reductase-thymidylate synthase, ecdhfr, pcdhfr, r67 dhfr, ts-dhfr, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7,8-dihydrofolate reductase
-
-
-
-
dehydrogenase, tetrahydrofolate
-
-
-
-
DHFR
-
-
-
-
DHFR type IIIC
-
-
-
-
dihydrofolate reductase-thymidylate synthase
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-
-
-
dihydrofolate reductase:thymidylate synthase
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-
-
-
dihydrofolic acid reductase
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-
-
-
dihydrofolic reductase
-
-
-
-
folic acid reductase
-
-
-
-
folic reductase
-
-
-
-
NADPH-dihydrofolate reductase
-
-
-
-
pteridine reductase:dihydrofolate reductase
-
-
-
-
reductase, dihydrofolate
-
-
-
-
tetrahydrofolate dehydrogenase
-
-
-
-
thymidylate synthetase-dihydrofolate reductase
-
-
-
-
Trimethoprim resistance protein
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
dTMP de novo biosynthesis (mitochondrial), folate transformations II (plants), folate transformations III (E. coli), tetrahydrofolate biosynthesis I
SYSTEMATIC NAME
IUBMB Comments
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate.
CAS REGISTRY NUMBER
COMMENTARY hide
9002-03-3
-
Highest Expressing Human Cell Lines
Cell Line Links Gene Links
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A072ZQB2_PSEAI
234
0
25403
TrEMBL
-
A0A081HD68_PSEAI
168
0
18203
TrEMBL
-
A0A1I9WCN5_PSEAI
165
0
17738
TrEMBL
-
A0A286LFK3_PSEAI
157
0
17503
TrEMBL
-
A0A5P9WCV3_PSEAI
186
0
20864
TrEMBL
-
A0A6A9JYH2_PSEAI
168
0
18233
TrEMBL
-
A0A6M3GZS6_PSEAI
165
0
18456
TrEMBL
Mitochondrion (Reliability: 5)
A0A7G8A9J4_PSEAI
157
0
17644
TrEMBL
-
A0A7G8AC63_PSEAI
78
0
8352
TrEMBL
-
A0A844NK26_PSEAI
234
0
25465
TrEMBL
-
A0ABD7K908_PSEAI
168
0
18333
TrEMBL
-
A0ABD7K5Q8_PSEAI
234
0
25524
TrEMBL
-
B5WYT8_PSEAI
97
0
10648
TrEMBL
Mitochondrion (Reliability: 5)
F4ZVS8_PSEAI
78
0
8483
TrEMBL
-
F4ZVS7_PSEAI
78
0
8446
TrEMBL
-
G8EFF9_PSEAI
152
0
16972
TrEMBL
other Location (Reliability: 5)
G8GBB1_PSEAI
152
0
16930
TrEMBL
-
H9TTY0_PSEAI
97
0
10666
TrEMBL
-
Q3HYB5_PSEAI
157
0
17575
TrEMBL
-
Q3ZEI9_PSEAI
157
0
17445
TrEMBL
Mitochondrion (Reliability: 1)
Q53CM2_PSEAI
78
0
8251
TrEMBL
-
Q58IZ0_PSEAI
78
0
8386
TrEMBL
-
Q5R1Q4_PSEAI
157
0
17561
TrEMBL
-
Q60FK0_PSEAI
165
0
18127
TrEMBL
-
Q689B1_PSEAI
157
0
17559
TrEMBL
-
T1WHJ1_PSEAI
165
0
17867
TrEMBL
-