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Disease on EC 1.4.3.13 - protein-lysine 6-oxidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abscess
Hypoxia-inducible factor 1-regulated lysyl oxidase is involved in Staphylococcus aureus abscess formation.
Adenocarcinoma
A Phase II Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First-Line Treatment of Pancreatic Adenocarcinoma.
LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer.
Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis.
Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution.
Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.
Specific protein 1(SP1) regulates the epithelial-mesenchymal transition via lysyl oxidase-like 2(LOXL2) in pancreatic ductal adenocarcinoma.
Adenocarcinoma of Lung
Comprehensive analysis of competitive endogenous RNA associated with immune infiltration in lung adenocarcinoma.
Down-regulation of lysyl oxidase-like 2 (LOXL2) is associated with disease progression in lung adenocarcinomas.
Increased lysyl oxidase-like 2 associates with a poor prognosis in non-small cell lung cancer.
LOXL1 Is Regulated by Integrin ?11 and Promotes Non-Small Cell Lung Cancer Tumorigenicity.
Lysyl oxidase: A lung adenocarcinoma biomarker of invasion and survival.
Lysyl oxidase: a lung adenocarcinoma biomarker of invasion and survival.
miR-210 promotes lung adenocarcinoma proliferation, migration, and invasion by targeting lysyl oxidase-like 4.
Albinism
Genetic diseases of copper metabolism.
Albuminuria
Lysyl oxidase like-2 contributes to renal fibrosis in Col4?3/Alport mice.
Lysyl oxidase-like 2 inhibition ameliorates glomerulosclerosis and albuminuria in diabetic nephropathy.
Alopecia
Progressive hair loss and myocardial degeneration in rough coat mice: reduced lysyl oxidase-like (LOXL) in the skin and heart.
Alzheimer Disease
Evidence for increased lysyl oxidase, the extracellular matrix-forming enzyme, in Alzheimer's disease brain.
Extracellular matrix modulator lysyl oxidase colocalizes with amyloid-beta pathology in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis--Dutch type.
Genetic variants in urinary bladder cancer: collective power of the "wimp SNPs"
No association of LOXL1 gene polymorphisms with Alzheimer's disease.
Amyotrophic Lateral Sclerosis
Mutations in the lysyl oxidase gene are not associated with amyotrophic lateral sclerosis.
Up-regulation and altered distribution of lysyl oxidase in the central nervous system of mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis.
Aneurysm
Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm.
Brachial artery aneurysms in Menkes disease.
Inhibition of aortic aneurysm development in blotchy mice by beta adrenergic blockade independent of altered lysyl oxidase activity.
Mutations in the lysyl oxidase gene not associated with intracranial aneurysm in central European families.
The Expression Patterns and Roles of Lysyl Oxidases in Aortic Dissection.
Aneurysm, Dissecting
LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections.
Overexpression of microRNA-30a contributes to the development of aortic dissection by targeting lysyl oxidase.
The Expression Patterns and Roles of Lysyl Oxidases in Aortic Dissection.
Anovulation
Lysyl oxidase blockade ameliorates anovulation in polycystic ovary syndrome.
Aortic Aneurysm
A novel swine model of abdominal aortic aneurysm.
Elevated expression levels of lysyl oxidases protect against aortic aneurysm progression in Marfan syndrome.
Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice.
Increased frequency of congenital heart defects in Menkes disease.
Inhibition of aortic aneurysm development in blotchy mice by beta adrenergic blockade independent of altered lysyl oxidase activity.
LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice.
Marfan syndrome and aortic aneurysm: Lysyl oxidases to the rescue?
Porcine Model of Infrarenal Abdominal Aortic Aneurysm.
Preventive Effects of Quercetin against the Onset of Atherosclerosis-Related Acute Aortic Syndromes in Mice.
Regulation of lysyl oxidase by interferon-gamma in rat aortic smooth muscle cells.
Aortic Aneurysm, Abdominal
Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase.
Inhibition of development of experimental abdominal aortic aneurysm by c-jun N-terminal protein kinase inhibitor combined with lysyl oxidase gene modified smooth muscle progenitor cells.
LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice.
Lysyl Oxidase Inhibition Ablates Sexual Dimorphism of Abdominal Aortic Aneurysm Formation in Mice.
Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm.
The Role of Lysyl Oxidase Family Members in the Stabilization of Abdominal Aortic Aneurysms.
Aortic Aneurysm, Thoracic
Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress.
Mechanical behavior and matrisome gene expression in the aneurysm-prone thoracic aorta of newborn lysyl oxidase knockout mice.
Moderate aerobic exercise prevents matrix degradation and death in a mouse model of aortic dissection and aneurysm.
Aortic Diseases
LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections.
Aortic Valve Stenosis
MicroRNA-19b is a potential biomarker of increased myocardial collagen cross-linking in patients with aortic stenosis and heart failure.
Arteriosclerosis
Changes in aortic lysyl oxidase activity in diet-induced atherosclerosis in the rabbit.
Increased lysyl oxidase activity in blood vessels of hypertensive rats and effect of beta-aminopropionitrile on arteriosclerosis.
Arteriovenous Fistula
Inhibition of Lysyl Oxidase with ?-aminopropionitrile Improves Venous Adaptation after Arteriovenous Fistula Creation.
Arthritis
Lysyl oxidase is involved in synovial hyperplasia and angiogenesis in rats with collagen?induced arthritis.
Arthritis, Rheumatoid
A novel function for lysyl oxidase in pluripotent mesenchymal cell proliferation and relevance to inflammation-associated osteopenia.
Copper response to rheumatoid arthritis.
Lysyl oxidase is involved in synovial hyperplasia and angiogenesis in rats with collagen?induced arthritis.
Astrocytoma
Active lysyl oxidase (LOX) correlates with focal adhesion kinase (FAK)/paxillin activation and migration in invasive astrocytes.
Atherosclerosis
Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening.
Changes in aortic lysyl oxidase activity in diet-induced atherosclerosis in the rabbit.
Immunohistochemical localization of lysyl oxidase in normal human skin.
The role of lysyl oxidase-like 1 and fibulin-5 in the development of atherosclerosis and pelvic organ prolapse.
Atrial Fibrillation
Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation.
Increased serum lysyl oxidase-like 2 levels correlate with the degree of left atrial fibrosis in patients with atrial fibrillation.
LOXL2 Inhibitor Attenuates Angiotensin II-Induced Atrial Fibrosis and Vulnerability to Atrial Fibrillation through Inhibition of Transforming Growth Factor Beta-1 Smad2/3 Pathway.
Autoimmune Diseases
Glycoprotein Pathways Altered in Frontotemporal Dementia With Autoimmune Disease.
Benign Paroxysmal Positional Vertigo
A novel genetic variant associated with benign paroxysmal positional vertigo within the LOXL1.
Biliary Atresia
Abundant Expression of Lysyl Oxidase-Like 2 Protein in Intra-Hepatic Bile Ducts of Infants with Biliary Atresia.
Abundant Expression of Lysyl Oxidase-like 2 Protein in Intrahepatic Bile Ducts of Infants With Biliary Atresia.
Blister
Lysyl oxidase-like 2 level and glaucoma surgical outcomes.
Bone Diseases
A novel function for lysyl oxidase in pluripotent mesenchymal cell proliferation and relevance to inflammation-associated osteopenia.
Impaired Gastric Hormone Regulation of Osteoblasts and Lysyl Oxidase Drives Bone Disease in Diabetes Mellitus.
Bone Diseases, Metabolic
A novel function for lysyl oxidase in pluripotent mesenchymal cell proliferation and relevance to inflammation-associated osteopenia.
Brain Injuries
Beta-aminopropionitrile treatment can accelerate recovery of mice after spinal cord injury.
Lysyl oxidase, the extracellular matrix-forming enzyme, in rat brain injury sites.
Brain Neoplasms
Lysyl oxidase genetic variants and the prognosis of glioma.
Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression.
Site-specific expression of amine oxidases in breast cancer metastases.
Breast Neoplasms
3D hydrogel breast cancer models for studying the effects of hypoxia on epithelial to mesenchymal transition.
A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer.
A molecular role for lysyl oxidase in breast cancer invasion.
A Polymorphism in the Lysyl Oxidase Propeptide Domain Accelerates Carcinogen-induced Cancer.
Alternatively spliced lysyl oxidase-like 4 isoforms have a pro-metastatic role in cancer.
An Impermeant Ganetespib Analog Inhibits Extracellular Hsp90-Mediated Cancer Cell Migration that Involves Lysyl Oxidase 2-like Protein.
Association between lysyl oxidase and fibrotic focus in relation with inflammation in breast cancer.
Association of the G473A polymorphism and expression of lysyl oxidase with breast cancer risk and survival in European women: a hospital-based case-control study.
Associations Between Elastography Findings and Clinicopathological Factors in Breast Cancer.
Baicalein Inhibits Epithelial to Mesenchymal Transition via Downregulation of Cyr61 and LOXL-2 in MDA-MB231 Breast Cancer Cells.
Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis.
Correction to: Forkhead Box F1 promotes breast cancer cell migration by upregulating lysyl oxidase and suppressing Smad2/3 signaling.
Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy.
Detection of Lysyl Oxidase-Like 2 (LOXL2), a Biomarker of Metastasis from Breast Cancers Using Human Blood Samples.
Dormant tumor cells expressing LOXL2 acquire a stem-like phenotype mediating their transition to proliferative growth.
Expression of the lysyl oxidase propeptide in hepatocellular carcinoma and its clinical relevance.
EZH2-mediated Epigenetic Silencing of miR-29/miR-30 targets LOXL4 and contributes to Tumorigenesis, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer.
Forkhead Box F1 promotes breast cancer cell migration by upregulating lysyl oxidase and suppressing Smad2/3 signaling.
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression.
Human breast cancer cell metastasis is attenuated by lysyl oxidase inhibitors through down-regulation of focal adhesion kinase and the paxillin-signaling pathway.
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation.
Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration.
Identification of drivers of breast cancer invasion by secretome analysis: insight into CTGF signaling.
Increased lysyl oxidase-like 2 associates with a poor prognosis in non-small cell lung cancer.
Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide.
Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis.
Involvement of miR-30b in kynurenine-mediated lysyl oxidase expression.
LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.
LOXL2 expression is associated with invasiveness and negatively influences survival in breast cancer patients.
LOXL2 in epithelial cell plasticity and tumor progression.
LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling.
LOXL2 Inhibitors and Breast Cancer Progression.
LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells.
LOXL2-mediated matrix remodeling in metastasis and mammary gland involution.
LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer.
Lysyl Oxidase 473 G>A Polymorphism and Breast Cancer Susceptibility in Chinese Han Population.
Lysyl oxidase contributes to mechanotransduction-mediated regulation of transforming growth factor-? signaling in breast cancer cells.
Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer.
Lysyl oxidase expression and inhibition in uveal melanoma.
Lysyl oxidase expression is regulated by the H3K27 demethylase Jmjd3 in tumor-associated M2-like macrophages.
Lysyl oxidase gene expression in the stromal reaction to in situ and invasive ductal breast carcinoma.
Lysyl oxidase plays a pivotal role in promoting metastasis of breast cancer cells.
Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling.
Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis.
Lysyl oxidase regulates actin filament formation through the p130(Cas)/Crk/DOCK180 signaling complex.
Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism.
Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis.
Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization.
Lysyl oxidase-like 2 (LOXL2) controls tumor-associated cell proliferation through the interaction with MARCKSL1.
Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas.
Lysyl oxidase-like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors.
Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells.
Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavities.
Lysyl Oxidase-Like Protein 2 Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer.
Lysyl oxidase-like protein localizes to sites of de novo fibrinogenesis in fibrosis and in the early stromal reaction of ductal breast carcinomas.
Lysyl oxidase-like protein LOXL2 promotes lung metastasis of breast cancer.
MCF-7 Cells Expressing Nuclear-associated Lysyl Oxidase-like 2 (LOXL2) Exhibit an Epithelial-to-Mesenchymal Transition (EMT) Phenotype and are Highly Invasive In Vitro.
Molecular mechanisms mediating metastasis of hypoxic breast cancer cells.
Novel mechanism for OSM-promoted extracellular matrix remodeling in breast cancer: LOXL2 upregulation and subsequent ECM alignment.
P2Y2R activation by nucleotides released from the highly metastatic breast cancer cell MDA-MB-231 contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment.
Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion.
Peroxiredoxin-1 Tyr194 phosphorylation regulates LOX-dependent extracellular matrix remodelling in breast cancer.
Platelets are associated with xenograft tumor growth and the clinical malignancy of ovarian cancer through an angiogenesis-dependent mechanism.
Post-translational Modifications of Recombinant Human Lysyl Oxidase-like 2 (rhLOXL2) Secreted from Drosophila S2 Cells.
Potential options for managing LOX+ ER- breast cancer patients.
Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer.
Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts.
Regulation of Breast Cancer-Induced Osteoclastogenesis by MacroH2A1.2 Involving EZH2-Mediated H3K27me3.
Retraction Note: Baicalein Inhibits Epithelial to Mesenchymal Transition via Downregulation of Cyr61 and LOXL-2 in MDA-MB231 Breast Cancer Cells.
RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2.
Role of extracellular matrix in breast cancer development: a brief update.
Silencing of lysyl oxidase gene expression by RNA interference suppresses metastasis of breast cancer.
Site-specific expression of amine oxidases in breast cancer metastases.
Stromal miR-200s contribute to breast cancer cell invasion through CAF activation and ECM remodeling.
Suppression for lung metastasis by depletion of collagen I and lysyl oxidase via losartan assisted with paclitaxel-loaded pH-sensitive liposomes in breast cancer.
Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer.
Targeting lysyl oxidase for molecular imaging in breast cancer.
The Lysyl Oxidase Inhibitor, beta-Aminopropionitrile, Diminishes the Metastatic Colonization Potential of Circulating Breast Cancer Cells.
The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells.
The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells.
The tumor cell-derived matrix of lobular breast cancer: a new vulnerability.
The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer.
UXT is a LOX-PP Interacting Protein that Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells.
[Mechanism of lysyl oxidase (LOX) in breast cancer invasion and metastasis].
Bronchiolitis Obliterans
Constrictive bronchiolitis obliterans. Characterisation of fibrogenesis and lysyl oxidase expression patterns.
Bronchopulmonary Dysplasia
Perturbations to lysyl oxidase expression broadly influence the transcriptome of lung fibroblasts.
Carcinogenesis
Association between lysyl oxidase and fibrotic focus in relation with inflammation in breast cancer.
Association of expression aberrances and genetic polymorphisms of lysyl oxidase with areca-associated oral tumorigenesis.
ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis.
Clinical Implications of Lysyl Oxidase-Like Protein 2 Expression in Pancreatic Cancer.
Correlations of lysyl oxidase with MMP2/MMP9 expression and its prognostic value in non-small cell lung cancer.
Evolving roles of lysyl oxidase family in tumorigenesis and cancer therapy.
EZH2-mediated Epigenetic Silencing of miR-29/miR-30 targets LOXL4 and contributes to Tumorigenesis, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer.
Identification of a novel lysyl oxidase-like 2 alternative splicing isoform, LOXL2 ?e13, in esophageal squamous cell carcinoma.
Identification of LOXL3-associating immune infiltration landscape and prognostic value in hepatocellular carcinoma.
Insilico study of anti-carcinogenic lysyl oxidase-like 2 inhibitors.
Is copper chelation an effective anti-angiogenic strategy for cancer treatment?
LOXL1 exerts oncogenesis and stimulates angiogenesis through the LOXL1-FBLN5/?v?3 integrin/FAK-MAPK axis in ICC.
LOXL1 Is Regulated by Integrin ?11 and Promotes Non-Small Cell Lung Cancer Tumorigenicity.
Lysyl oxidase (LOX) family members: rationale and their potential as therapeutic targets for liver fibrosis.
Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis.
Lysyl oxidase family members in urological tumorigenesis and fibrosis.
Lysyl oxidase-like 2 (LOXL2) controls tumor-associated cell proliferation through the interaction with MARCKSL1.
Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.
Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability.
Lysyl Oxidase-Like 4 Fosters an Immunosuppressive Microenvironment During Hepatocarcinogenesis.
Lysyl oxidases: from enzyme activity to extracellular matrix cross-links.
Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level.
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin.
PKC-MEK-MAPK-dependent signal transduction pathway mediates the stimulation of lysyl oxidase expression by serum and PDGF in rat aortic smooth muscle cells.
Salidroside ameliorated hypoxia-induced tumorigenesis of BxPC-3 cells via downregulating hypoxia-inducible factor (HIF)-1? and LOXL2.
The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
Transcriptional switching model for the regulation of tumorigenesis and metastasis by the ha-ras oncogene - transcriptional changes in the ha-ras tumor-suppressor gene lysyl oxidase.
Carcinoma
A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.
A novel splice variant of LOXL2 promotes progression of human papillomavirus-negative head and neck squamous cell carcinoma.
A truncated splice variant of human lysyl oxidase-like 2 promotes migration and invasion in esophageal squamous cell carcinoma.
Alternatively spliced lysyl oxidase-like 4 isoforms have a pro-metastatic role in cancer.
Characterisation of seven newly established head and neck squamous cell carcinoma cell lines.
Clinical significance of LOXL4 expression and features of LOXL4-associated protein-protein interaction network in esophageal squamous cell carcinoma.
Differential expression of LOXL4 in normal and tumour tissue samples of laryngeal squamous cell carcinoma.
Elevated exosomal lysyl oxidase like 2 is a potential biomarker for head and neck squamous cell carcinoma.
Exploration of potential roles of a new LOXL2 splicing variant using network knowledge in esophageal squamous cell carcinoma.
Expression of lysyl oxidase is correlated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.
Functional analysis of LOXL2 in pancreatic carcinoma.
Functional analysis of the 5' flanking domain of the LOXL4 gene in head and neck squamous cell carcinoma cells.
Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer.
Identification of a novel lysyl oxidase-like 2 alternative splicing isoform, LOXL2 ?e13, in esophageal squamous cell carcinoma.
Increased lysyl oxidase-like 2 associates with a poor prognosis in non-small cell lung cancer.
Insilico study of anti-carcinogenic lysyl oxidase-like 2 inhibitors.
LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.
LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype.
LOXL2 in epithelial cell plasticity and tumor progression.
LOXL2 upregulates phosphorylation of ezrin to promote cytoskeletal reorganization and tumor cell invasion.
LOXL4 as a selective molecular marker in primary and metastatic head/neck carcinoma.
LOXL4 is a selectively expressed candidate diagnostic antigen in head and neck cancer.
Lysyl oxidase and enhancement of cell proliferation and angiogenesis in oral squamous cell carcinoma.
Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC).
Lysyl oxidase family members in urological tumorigenesis and fibrosis.
Lysyl oxidase is associated with the epithelial-mesenchymal transition of gastric cancer cells in hypoxia.
Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer.
Lysyl oxidase like-4 monoclonal antibody demonstrates therapeutic effect against head and neck squamous cell carcinoma cells and xenografts.
Lysyl oxidase-like 2 (LOXL2) from stromal fibroblasts stimulates the progression of gastric cancer.
Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas.
Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.
Lysyl oxidase-like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors.
Lysyl oxidase-like 2 promotes esophageal squamous cell carcinoma cell migration independent of catalytic activity.
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.
Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavities.
Major Action of Endogenous Lysyl Oxidase in Clear Cell Renal Cell Carcinoma Progression and Collagen Stiffness Revealed by Primary Cell Cultures.
Overexpression of a novel lysyl oxidase-like gene in human head and neck squamous cell carcinomas.
PACE4 Proteolytically Processes LOXL2 with little impact on its catalytic activity.
Platelets are associated with xenograft tumor growth and the clinical malignancy of ovarian cancer through an angiogenesis-dependent mechanism.
Protein-protein Interaction Network Analyses for Elucidating the Roles of LOXL2-delta72 in Esophageal Squamous Cell Carcinoma.
Re: Tumour-Suppressive MicroRNA-29s Directly Regulate LOXL2 Expression and Inhibit Cancer Cell Migration and Invasion in Renal Cell Carcinoma.
Reactive oxygen species promote ovarian cancer progression via the HIF-1?/LOX/E-cadherin pathway.
Receptor activity modifying protein-3 mediates the protumorigenic activity of lysyl oxidase-like protein-2.
Recognition of lysyl oxidase as a potential predictive biomarker for oral squamous cell carcinoma: an immunohistochemical study.
Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase-like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.
Reduction of LOX- and LOXL2-mRNA expression in head and neck squamous cell carcinomas.
Regulation of the collagen cross-linking enzymes LOXL2 and PLOD2 by tumor-suppressive microRNA-26a/b in renal cell carcinoma.
Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway.
Selective expression of lysyl oxidase (LOX) in the stromal reactions of broncho-pulmonary carcinomas.
Selective upregulation and amplification of the lysyl oxidase like-4 (LOXL4) gene in head and neck squamous cell carcinoma.
Significance of HIF-1? Expression and LOXL-2 Localization in Progression of Oral Squamous Cell Carcinoma.
Significance of the Lysyl Oxidase Members Lysyl Oxidase Like 1, 3, and 4 in Gastric Cancer.
SMYD3 stimulates EZR and LOXL2 transcription to enhance proliferation, migration and invasion in esophageal squamous cell carcinoma.
Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor-?-Deficient Mouse Mammary Carcinomas.
Switching on-off Snail: LOXL2 versus GSK3beta.
The Lysyl Oxidase LOX Is Absent in Basal and Squamous Cell Carcinomas and Its Knockdown Induces an Invading Phenotype in a Skin Equivalent Model.
The upregulation of lysyl oxidase in oral submucous fibrosis and squamous cell carcinoma.
Tumor-suppressive microRNA-29 family inhibits cancer cell migration and invasion directly targeting LOXL2 in lung squamous cell carcinoma.
Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma.
Tumour-suppressive microRNA-29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma.
Upregulation of MIAT Regulates LOXL2 Expression by Competitively Binding MiR-29c in Clear Cell Renal Cell Carcinoma.
Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03.
[Expression of lysyl oxidase gene in upper digestive tract carcinomas and its clinical significance]
Carcinoma, Bronchogenic
Lysyl oxidase expression in bronchogenic carcinoma.
Carcinoma, Ductal
PACE4 Proteolytically Processes LOXL2 with little impact on its catalytic activity.
Carcinoma, Hepatocellular
Cancer-associated fibroblasts up-regulate CCL2, CCL26, IL6 and LOXL2 genes related to promotion of cancer progression in hepatocellular carcinoma cells.
Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis.
Expression of the lysyl oxidase propeptide in hepatocellular carcinoma and its clinical relevance.
Hepatocellular carcinoma cells cause different responses in expressions of cancer-promoting genes in different cancer-associated fibroblasts.
HIF-1? promoted vasculogenic mimicry formation in hepatocellular carcinoma through LOXL2 up-regulation in hypoxic tumor microenvironment.
Increased Expression of the Matrix-Modifying Enzyme Lysyl Oxidase-Like 2 in Aggressive Hepatocellular Carcinoma with Poor Prognosis.
Long-term ethanol exposure-induced hepatocellular carcinoma cell migration and invasion through lysyl oxidase activation are attenuated by combined treatment with pterostilbene and curcumin analogues.
LOXL2 promotes vasculogenic mimicry and tumour aggressiveness in hepatocellular carcinoma.
LOXL2 upregulates hypoxia?inducible factor?1? signaling through Snail?FBP1 axis in hepatocellular carcinoma cells.
LOXL4 is downregulated in hepatocellular carcinoma with a favorable prognosis.
Lysyl oxidase assists tumor?initiating cells to enhance angiogenesis in hepatocellular carcinoma.
Lysyl oxidase induces epithelial-mesenchymal transition and predicts intrahepatic metastasis of hepatocellular carcinoma.
Lysyl Oxidase Is Predictive of Unfavorable Outcomes and Essential for Regulation of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma.
Lysyl oxidase like 4, a novel target gene of TGF-beta1 signaling, can negatively regulate TGF-beta1-induced cell motility in PLC/PRF/5 hepatoma cells.
Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma.
Matrix stiffness-mediated effects on macrophages polarization and their LOXL2 expression.
MIR29A Impedes Metastatic Behaviors in Hepatocellular Carcinoma via Targeting LOX, LOXL2, and VEGFA.
The effect of LOXL2 in hepatocellular carcinoma.
The Long Noncoding RNA LOXL1-AS1 Promotes the Proliferation, Migration, and Invasion in Hepatocellular Carcinoma.
Carcinoma, Lobular
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1.
Carcinoma, Non-Small-Cell Lung
Correlations of lysyl oxidase with MMP2/MMP9 expression and its prognostic value in non-small cell lung cancer.
Expression and significance of hypoxia inducible factor-1? and lysyl oxidase in non-small cell lung cancer.
Forkhead box C1 promotes metastasis and invasion of non-small cell lung cancer by binding directly to the lysyl oxidase promoter.
Increased lysyl oxidase-like 2 associates with a poor prognosis in non-small cell lung cancer.
LOXL1 Is Regulated by Integrin ?11 and Promotes Non-Small Cell Lung Cancer Tumorigenicity.
Lysyl oxidase mediates hypoxia-induced radioresistance in non-small cell lung cancer A549 cells.
The effect of lysyl oxidase polymorphism on susceptibility and prognosis of nonsmall cell lung cancer.
Carcinoma, Ovarian Epithelial
The role of Lysyl oxidase in epithelial ovarian cancer.
Carcinoma, Renal Cell
Major Action of Endogenous Lysyl Oxidase in Clear Cell Renal Cell Carcinoma Progression and Collagen Stiffness Revealed by Primary Cell Cultures.
Re: Tumour-Suppressive MicroRNA-29s Directly Regulate LOXL2 Expression and Inhibit Cancer Cell Migration and Invasion in Renal Cell Carcinoma.
Regulation of the collagen cross-linking enzymes LOXL2 and PLOD2 by tumor-suppressive microRNA-26a/b in renal cell carcinoma.
Tumour-suppressive microRNA-29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma.
Upregulation of MIAT Regulates LOXL2 Expression by Competitively Binding MiR-29c in Clear Cell Renal Cell Carcinoma.
Carcinoma, Squamous Cell
A novel splice variant of LOXL2 promotes progression of human papillomavirus-negative head and neck squamous cell carcinoma.
Elevated exosomal lysyl oxidase like 2 is a potential biomarker for head and neck squamous cell carcinoma.
Functional analysis of the 5' flanking domain of the LOXL4 gene in head and neck squamous cell carcinoma cells.
Increased lysyl oxidase-like 2 associates with a poor prognosis in non-small cell lung cancer.
LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.
LOXL2 in epithelial cell plasticity and tumor progression.
LOXL4 as a selective molecular marker in primary and metastatic head/neck carcinoma.
LOXL4 is a selectively expressed candidate diagnostic antigen in head and neck cancer.
Lysyl oxidase like-4 monoclonal antibody demonstrates therapeutic effect against head and neck squamous cell carcinoma cells and xenografts.
Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.
Lysyl oxidase-like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors.
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.
Overexpression of a novel lysyl oxidase-like gene in human head and neck squamous cell carcinomas.
Reduction of LOX- and LOXL2-mRNA expression in head and neck squamous cell carcinomas.
Selective upregulation and amplification of the lysyl oxidase like-4 (LOXL4) gene in head and neck squamous cell carcinoma.
The Lysyl Oxidase LOX Is Absent in Basal and Squamous Cell Carcinomas and Its Knockdown Induces an Invading Phenotype in a Skin Equivalent Model.
The upregulation of lysyl oxidase in oral submucous fibrosis and squamous cell carcinoma.
Tumor-suppressive microRNA-29 family inhibits cancer cell migration and invasion directly targeting LOXL2 in lung squamous cell carcinoma.
Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma.
Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03.
Cardiomegaly
Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice.
Early intervention with a potent endothelin-A/endothelin-B receptor antagonist aggravates left ventricular remodeling after myocardial infarction in rats.
Newer findings on a unified perspective of copper restriction and cardiomyopathy.
TRAF3IP2 Mediates Aldosterone/Salt-Induced Cardiac Hypertrophy and Fibrosis.
Cardiomyopathies
A Global Assessment of Circulating Prolysyl Oxidase in Nonischemic Patients With Garden-variety Heart Failure With Preserved Ejection Fraction.
Newer findings on a unified perspective of copper restriction and cardiomyopathy.
Cardiomyopathy, Dilated
Secreted Phospholipase A2-IIA Modulates Transdifferentiation of Cardiac Fibroblast through EGFR Transactivation: An Inflammation-Fibrosis Link.
Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human dilated cardiomyopathy.
Cardiovascular Diseases
LOXL1 Gene Sequence Variants and Vascular Disease in Exfoliation Syndrome and Exfoliative Glaucoma.
Lysyl Oxidase G473A Polymorphism Is Associated with Increased Risk of Coronary Artery Diseases.
Lysyl oxidase overexpression accelerates cardiac remodeling and aggravates angiotensin II-induced hypertrophy.
Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases.
Carpal Tunnel Syndrome
Lysyl oxidase activity in the cells of flexor retinaculum of individuals with carpal tunnel syndrome.
Cataract
Association of LOXL1 Gene Polymorphisms with Exfoliation Glaucoma Patients.
Associations of polymorphisms in LOXL1 and copper chaperone genes with pseudoexfoliation-syndrome-related cataract in a Chinese Uygur population.
Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review.
Lack of association of LOXL1 gene variants in Japanese patients with central retinal vein occlusion without clinically detectable pseudoexfoliation material deposits.
LOXL1 expression in lens capsule tissue specimens from individuals with pseudoexfoliation syndrome and glaucoma.
LOXL1 genetic polymorphisms are associated with exfoliation glaucoma in the Japanese population.
LOXL1 Hypermethylation in Pseudoexfoliation Syndrome in the Uighur Population.
LOXL1 variants in elderly Japanese patients with exfoliation syndrome/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract.
Lysyl oxidase-like 1 polymorphisms in a southwestern Greek cataract population with pseudoexfoliation syndrome.
Cerebral Hemorrhage
Extracellular matrix modulator lysyl oxidase colocalizes with amyloid-beta pathology in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis--Dutch type.
Cerebrovascular Disorders
LOXL1 Gene Sequence Variants and Vascular Disease in Exfoliation Syndrome and Exfoliative Glaucoma.
Cholangiocarcinoma
67 laminin receptor promotes the malignant potential of tumour cells up-regulating lysyl oxidase-like 2 expression in cholangiocarcinoma.
Impact of stroma LOXL2 overexpression on the prognosis of intrahepatic cholangiocarcinoma.
LOXL1 exerts oncogenesis and stimulates angiogenesis through the LOXL1-FBLN5/?v?3 integrin/FAK-MAPK axis in ICC.
The interaction of LOXL2 with GATA6 induces VEGFA expression and angiogenesis in cholangiocarcinoma.
Cholangitis
Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis.
Cholangitis, Sclerosing
Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis.
Simtuzumab for Primary Sclerosing Cholangitis: Phase 2 Study Results With Insights on the Natural History of the Disease.
Cholestasis
Lysyl oxidase like protein-2 (LOXL-2); a novel marker for prediction of intrahepatic cholestasis of pregnancy.
Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis.
MIR29A Impedes Metastatic Behaviors in Hepatocellular Carcinoma via Targeting LOX, LOXL2, and VEGFA.
Cholestasis, Intrahepatic
Lysyl oxidase like protein-2 (LOXL-2); a novel marker for prediction of intrahepatic cholestasis of pregnancy.
Choroidal Neovascularization
Increased choroidal neovascularization following laser induction in mice lacking lysyl oxidase-like 1.
The Role of LOX and LOXL2 in the Pathogenesis of an Experimental Model of Choroidal Neovascularization.
Chronic Kidney Disease-Mineral and Bone Disorder
Advanced glycation end products suppress lysyl oxidase and induce bone collagen degradation in a rat model of renal osteodystrophy.
Cleft Palate
Association between a common missense variant in LOXL3 gene and the risk of non-syndromic cleft palate.
Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice.
Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice.
Coinfection
Simtuzumab treatment of advanced liver fibrosis in HIV and HCV-infected adults: results of a 6-month open-label safety trial.
Colonic Neoplasms
Epithelial-mesenchymal transition and metastasis of colon cancer cells induced by the FAK pathway in cancer-associated fibroblasts.
LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival.
Lysyl Oxidase Gene G473A Polymorphism and Cigarette Smoking in Association with a High Risk of Lung and Colorectal Cancers in a North Chinese Population.
Lysyl oxidase-like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors.
Colorectal Neoplasms
A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second-Line Treatment of Metastatic
Differential expression of the LOX family genes in human colorectal adenocarcinomas.
Elevated LOXL2 expression by LINC01347/miR-328-5p axis contributes to 5-FU chemotherapy resistance of colorectal cancer.
Evaluation of serum lysyl oxidase as a blood test for colorectal cancer.
Identification and characterization of the promoter of cancer-related gene LOXL2.
LOXL1 modulates the malignant progression of colorectal cancer by inhibiting the transcriptional activity of YAP.
Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK.
Lysyl Oxidase Gene G473A Polymorphism and Cigarette Smoking in Association with a High Risk of Lung and Colorectal Cancers in a North Chinese Population.
Lysyl oxidase in colorectal cancer.
Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis.
Lysyl oxidase rs1800449 polymorphism and cancer risk among Asians: evidence from a meta-analysis and a case-control study of colorectal cancer.
Lysyl oxidase-like 2 is highly expressed in colorectal cancer cells and promotes the development of colorectal cancer.
Lysyl oxidase: A colorectal cancer biomarker of lung and hepatic metastasis.
Neutrophils expressing lysyl oxidase-like 4 protein are present in colorectal cancer liver metastases resistant to anti-angiogenic therapy.
Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis.
Somatic mutations of the lysyl oxidase gene on chromosome 5q23.1 in colorectal tumors.
The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer.
TIMP-1 expression in human colorectal cancer is associated with TGF-B1, LOXL2, INHBA1, TNF-AIP6 and TIMP-2 transcript profiles.
ZEB1 promotes colorectal cancer cell invasion and disease progression by enhanced LOXL2 transcription.
[Expression of LOX in Colorectal Cancer Tissues and Its Relationship with Progress and Prognosis].
Congenital Abnormalities
Differential Molecular Expression of Extracellular Matrix and Inflammatory Genes at the Corneal Cone Apex Drives Focal Weakening in Keratoconus.
Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice.
Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice.
Lysyl oxidase-like 3b is critical for cartilage maturation during zebrafish craniofacial development.
Connective Tissue Diseases
Immunohistochemical localization of lysyl oxidase in normal human skin.
Contracture
Dupuytren's contracture: morphological and biochemical changes in palmar aponeurosis.
Non-linear optical microscopy and histological analysis of collagen, elastin and lysyl oxidase expression in breast capsular contracture.
Coronary Artery Disease
Lysyl Oxidase G473A Polymorphism Is Associated with Increased Risk of Coronary Artery Diseases.
Cryptosporidiosis
Trans-suppression of host CDH3 and LOXL4 genes during Cryptosporidium parvum infection involves nuclear delivery of parasite Cdg7_FLc_1000 RNA.
Cutis Laxa
An X-linked form of cutis laxa due to deficiency of lysyl oxidase.
Congenital cutis laxa and lysyl oxidase deficiency.
Defects in the biochemistry of collagen in diseases of connective tissue.
Defining the Clinical, Molecular and Ultrastructural Characteristics in Occipital Horn Syndrome: Two New Cases and Review of the Literature.
Elastin production and degradation in cutis laxa acquisita.
Epigenetic silencing of lysyl oxidase-like-1 through DNA hypermethylation in an autosomal recessive cutis laxa case.
Genetic diseases of copper metabolism.
Lysyl Oxidase Like 1: Biological roles and regulation.
Methylation of LOXL1 Promoter by DNMT3A in Aged Human Skin Fibroblasts.
X-linked cutis laxa: defective cross-link formation in collagen due to decreased lysyl oxidase activity.
Cystadenoma
Platelets are associated with xenograft tumor growth and the clinical malignancy of ovarian cancer through an angiogenesis-dependent mechanism.
Cystinosis
Copper deficiency in patients with cystinosis with cysteamine toxicity.
Cysts
Significance of matrix metalloproteinases in the pathophysiology of the ovary and uterus.
Diabetes Mellitus
Impaired Gastric Hormone Regulation of Osteoblasts and Lysyl Oxidase Drives Bone Disease in Diabetes Mellitus.
Increased activity of serum amine oxidases in granuloma annulare, necrobiosis lipoidica and diabetes.
Diabetes Mellitus, Type 2
Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
Diabetic Foot
Impact of lysyl oxidase (G473A) polymorphism on diabetic foot ulcers.
Diabetic Nephropathies
Lysyl oxidase-like 2 inhibition ameliorates glomerulosclerosis and albuminuria in diabetic nephropathy.
Diabetic Retinopathy
Decreased lysyl oxidase level protects against development of retinal vascular lesions in diabetic retinopathy.
Effects of High Glucose-Induced Lysyl Oxidase Propeptide on Retinal Endothelial Cell Survival: Implications for Diabetic Retinopathy.
High Glucose Increases Binding of Lysyl Oxidase to Extracellular Matrix Proteins: Implications for Diabetic Retinopathy.
Homocysteine levels in vitreous of proliferative diabetic retinopathy and rhegmatogenous retinal detachment- its modulating role on lysyl oxidase activity.
Inhibition of Diabetes-Induced Lysyl Oxidase Overexpression Prevents Retinal Vascular Lesions Associated With Diabetic Retinopathy.
Lysyl oxidase activity in the ocular tissues and the role of LOX in proliferative diabetic retinopathy and rhegmatogenous retinal detachment.
Upregulation of Lysyl Oxidase Expression in Vitreous of Diabetic Subjects: Implications for Diabetic Retinopathy.
Digestive System Neoplasms
Prognostic utility and clinical significance of lysyl oxidase-like 2 protein expression in digestive system cancers.
Diverticulum
Defining the Clinical, Molecular and Ultrastructural Characteristics in Occipital Horn Syndrome: Two New Cases and Review of the Literature.
Down Syndrome
Genetic diseases of copper metabolism.
Dupuytren Contracture
Dupuytren's contracture: morphological and biochemical changes in palmar aponeurosis.
Echinococcosis
Echinococcus multilocularis: relationship between susceptibility/resistance and liver fibrogenesis in experimental mice.
Mechanism of collagen network stabilization in human irreversible granulomatous liver fibrosis.
Ehlers-Danlos Syndrome
Defects in the biochemistry of collagen in diseases of connective tissue.
Genetic diseases of copper metabolism.
Lysyl oxidase deficiency in Ehlers-Danlos syndrome type V.
Molecular defects in the Ehlers-Danlos syndrome.
The Ehlers-Danlos syndromes.
Type IX Ehlers-Danlos syndrome and Menkes syndrome: the decrease in lysyl oxidase activity is associated with a corresponding deficiency in the enzyme protein.
Endometriosis
Deregulation of LOXL1 and HTRA1 gene expression in endometriosis.
Dysregulation of Lysyl Oxidase Expression in Lesions and Endometrium of Women With Endometriosis.
Single-nucleotide polymorphisms in the lysyl oxidase-like protein 4 and complement component 3 genes are associated with increased risk for endometriosis and endometriosis-associated infertility.
Eosinophilic Esophagitis
Fibrostenotic eosinophilic esophagitis might reflect epithelial lysyl oxidase induction by fibroblast-derived TNF-?.
Erectile Dysfunction
Amelioration of Cavernosal Fibrosis and Erectile Function by Lysyl Oxidase Inhibition in a Rat Model of Cavernous Nerve Injury.
Effect of lysyl oxidase (LOX) on corpus cavernous fibrosis caused by ischaemic priapism.
Esophageal Neoplasms
Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis.
Lysyl oxidase impacts disease outcomes and correlates with global DNA hypomethylation in esophageal cancer.
Lysyl oxidase-like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors.
Esophageal Squamous Cell Carcinoma
A truncated splice variant of human lysyl oxidase-like 2 promotes migration and invasion in esophageal squamous cell carcinoma.
Clinical significance of LOXL4 expression and features of LOXL4-associated protein-protein interaction network in esophageal squamous cell carcinoma.
Exploration of potential roles of a new LOXL2 splicing variant using network knowledge in esophageal squamous cell carcinoma.
Expression of lysyl oxidase is correlated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.
Identification of a novel lysyl oxidase-like 2 alternative splicing isoform, LOXL2 ?e13, in esophageal squamous cell carcinoma.
LOXL2 upregulates phosphorylation of ezrin to promote cytoskeletal reorganization and tumor cell invasion.
Lysyl oxidase-like 2 promotes esophageal squamous cell carcinoma cell migration independent of catalytic activity.
Protein-protein Interaction Network Analyses for Elucidating the Roles of LOXL2-delta72 in Esophageal Squamous Cell Carcinoma.
Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase-like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.
SMYD3 stimulates EZR and LOXL2 transcription to enhance proliferation, migration and invasion in esophageal squamous cell carcinoma.
Exanthema
Deregulation of LOXL1 and HTRA1 gene expression in endometriosis.
Exfoliation Syndrome
An investigation into LOXL1 variants in black South African individuals with exfoliation syndrome.
Analysis of LOXL1 single nucleotide polymorphisms in Polish population with pseudoexfoliation syndrome.
Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people.
Association between Chronic Obstructive Pulmonary Disease and Exfoliation Syndrome: The Utah Project on Exfoliation Syndrome.
Association between Obstructive Sleep Apnea and Exfoliation Syndrome: The Utah Project on Exfoliation Syndrome.
Association between Polymorphisms in Lysyl Oxidase-Like 1 and Susceptibility to Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.
Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.
Association of LOXL1 gene common sequence variants in Jordanian patients with exfoliation syndrome and exfoliative glaucoma.
Association of LOXL1 Gene Polymorphisms with Exfoliation Glaucoma Patients.
Association of LOXL1 gene polymorphisms with exfoliation syndrome/glaucoma and primary open angle glaucoma in a Turkish population.
Association of LOXL1 gene polymorphisms with pseudoexfoliation in the Japanese.
Association of LOXL1 gene with Finnish exfoliation syndrome patients.
Association of LOXL1 polymorphisms with pseudoexfoliation in the Chinese.
Association of LOXL1 polymorphisms with pseudoexfoliation, glaucoma, intraocular pressure, and systemic diseases in a Greek population. The Thessaloniki eye study.
Association of lysyl oxidase-like 1 gene common sequence variants in Greek patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.
Association of Lysyl Oxidase-Like 1 Gene Polymorphism in Turkish Patients With Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.
Association of Lysyl Oxidase-like 1 Gene Polymorphism in Turkish Patients With Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.
Association of Lysyl Oxidase-Like 1 Gene Polymorphism in Turkish Patients With Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.
Association of lysyl oxidase-like 1 gene polymorphisms in pseudoexfoliation syndrome and pseudoexfoliation glaucoma in a Spanish population.
Association of lysyl oxidase-like 1 gene polymorphisms with exfoliation syndrome in Koreans.
Association of non-synonymous single nucleotide polymorphisms in the LOXL1 gene with pseudoexfoliation syndrome in India.
Association of polymorphisms in APOE and LOXL1 with pseudoexfoliation syndrome and pseudoexfoliation glaucoma in a Turkish population.
Biological effect of LOXL1 coding variants associated with pseudoexfoliation syndrome.
Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review.
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.
Correlation of the intronic LOXL1 polymorphism rs11638944 with pseudoexfoliation syndrome and glaucoma in a Greek population.
DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity.
Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma.
Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma.
Evaluation of LOXL1 polymorphisms in exfoliation syndrome in a Chinese population.
Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population.
Evaluation of LOXL1 polymorphisms in eyes with exfoliation glaucoma in Japanese.
Evaluation of LOXL1 polymorphisms in primary open-angle glaucoma in southern and northern Chinese.
Evaluation of lysyl oxidase-like 1 gene polymorphisms in pseudoexfoliation syndrome in a Korean population.
Exfoliation syndrome and exfoliation glaucoma-associated LOXL1 variations are not involved in pigment dispersion syndrome and pigmentary glaucoma.
Exfoliation syndrome associated with LOXL1 gene polymorphisms in a Black patient from Latin America: a case report.
Exfoliation Syndrome: A Disease of Autophagy and LOXL1 Proteopathy.
Expression and regulation of LOXL1 and elastin-related genes in eyes with exfoliation syndrome.
From epidemiology to lysyl oxidase like one (LOXL1) polymorphisms discovery: phenotyping and genotyping exfoliation syndrome and exfoliation glaucoma in Iceland.
Genetic association of LOXL1 gene variants and exfoliation glaucoma in a Utah cohort.
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.
Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus.
Genetics, Diagnosis, and Monitoring of Pseudoexfoliation Glaucoma.
Integral role for lysyl oxidase-like-1 in conventional outflow tissue function and behavior.
Lack of association between lysyl oxidase-like 1 polymorphism in pseudoexfoliation syndrome and pseudoexfoliation glaucoma in North Indian population.
Lack of association of LOXL1 gene variants in Japanese patients with central retinal vein occlusion without clinically detectable pseudoexfoliation material deposits.
LOXL1 Deficiency in the Lamina Cribrosa as Candidate Susceptibility Factor for a Pseudoexfoliation-Specific Risk of Glaucoma.
LOXL1 expression in lens capsule tissue specimens from individuals with pseudoexfoliation syndrome and glaucoma.
LOXL1 folding in exfoliation glaucoma.
LOXL1 gene analysis in Turkish patients with exfoliation glaucoma.
LOXL1 gene polymorphism candidates for exfoliation glaucoma are also associated with a risk for primary open-angle glaucoma in a Caucasian population from central Russia.
LOXL1 Gene Polymorphism With Exfoliation Syndrome/Exfoliation Glaucoma: A Meta-Analysis.
LOXL1 gene polymorphisms are associated with exfoliation syndrome/exfoliation glaucoma risk: An updated meta-analysis.
LOXL1 Gene Sequence Variants and Vascular Disease in Exfoliation Syndrome and Exfoliative Glaucoma.
LOXL1 GENE VARIANTS IN ASSOCIATION WITH EXFOLIATION SYNDROME IN GEORGIAN POPULATION.
LOXL1 genetic polymorphisms are associated with exfoliation glaucoma in the Japanese population.
LOXL1 Hypermethylation in Pseudoexfoliation Syndrome in the Uighur Population.
LOXL1 mutations are associated with exfoliation syndrome in patients from the midwestern United States.
LOXL1 Polymorphisms: Genetic Biomarkers that Presage Environmental Determinants of Exfoliation Syndrome.
LOXL1 promoter haplotypes are associated with exfoliation syndrome in a US Caucasian population.
LOXL1 variants in elderly Japanese patients with exfoliation syndrome/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract.
LOXL1-associated candidate epithelial pathomechanisms in exfoliation glaucoma.
Lysyl Oxidase Like 1: Biological roles and regulation.
Lysyl oxidase-like 1 gene in the reversal of promoter risk allele in pseudoexfoliation syndrome.
Lysyl Oxidase-like 1 Gene Polymorphisms in German Patients With Normal Tension Glaucoma, Pigmentary Glaucoma and Exfoliation Glaucoma.
Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome.
Lysyl oxidase-like 1 polymorphisms and exfoliation syndrome in the Japanese population.
Lysyl oxidase-like 1 polymorphisms in a southwestern Greek cataract population with pseudoexfoliation syndrome.
Lysyl oxidase-like protein 1 (LOXL1) gene polymorphisms and exfoliation glaucoma in a Central European population.
Major LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population.
MALDI MS imaging analysis of apolipoprotein E and lysyl oxidase-like 1 in human lens capsules affected by pseudoexfoliation syndrome.
Mass cytometry and transcriptomic profiling reveal body-wide pathology induced by Loxl1 deficiency.
Molecular Genetics of Glaucoma: Subtype and Ethnicity Considerations.
Multiple Gene Polymorphisms Associated with Exfoliation Syndrome in the Uygur Population.
No association of LOXL1 gene polymorphisms with Alzheimer's disease.
Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population.
Ocular and systemic manifestations of exfoliation syndrome.
Possible Protective Effect of LOXL1 Variant in the Cohort of Chernobyl Catastrophe Clean-Up Workers.
Prevalence of high-risk alleles in the LOXL1 gene and its association with pseudoexfoliation syndrome and exfoliation glaucoma in a Latin American population.
Prevalence of Pseudoexfoliation Glaucoma Risk-associated Variants within Lysyl Oxidase-like 1 in an Irish Population.
Prospects for gene-environment interactions in exfoliation syndrome.
Recent advances in risk factors associated with ocular exfoliation syndrome.
Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome.
Review: The role of LOXL1 in exfoliation syndrome/glaucoma.
Risk for Exfoliation Syndrome in Women With Pelvic Organ Prolapse : A Utah Project on Exfoliation Syndrome (UPEXS) Study.
The association of LOXL1 polymorphisms with exfoliation syndrome/glaucoma: Meta-analysis.
The LOXL1 gene variations are not associated with primary open-angle and primary angle-closure glaucomas.
The microfibril hypothesis of glaucoma: implications for treatment of elevated intraocular pressure.
The protective variant rs7173049 at LOXL1 locus impacts on retinoic acid signaling pathway in pseudoexfoliation syndrome.
The role of lysyl oxidase-like 1 (LOXL1) in exfoliation syndrome and glaucoma.
The role of lysyl oxidase-like 1 DNA copy number variants in exfoliation glaucoma.
The T allele of lysyl oxidase-like 1 rs41435250 is a novel risk factor for pseudoexfoliation syndrome and pseudoexfoliation glaucoma independently and through intragenic epistatic interaction.
The use of microarray technology in deciphering the cause of genetic eye diseases: LOXL1 and exfoliation syndrome.
Three Single Nucleotide Polymorphisms of LOXL1' in a Turkish Population with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.
Variations in LOXL1 associated with exfoliation glaucoma do not affect amine oxidase activity.
[Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population].
Exostoses
Defining the Clinical, Molecular and Ultrastructural Characteristics in Occipital Horn Syndrome: Two New Cases and Review of the Literature.
Eye Diseases
Identification of differentially expressed genes in keratoconus epithelium analyzed on microarrays.
The use of microarray technology in deciphering the cause of genetic eye diseases: LOXL1 and exfoliation syndrome.
Fatty Liver
Hepatic stellate cells-specific LOXL1 deficiency abrogates hepatic inflammation, fibrosis, and corrects lipid metabolic abnormalities in non-obese NASH mice.
Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
Liver immune responses to inflammatory stimuli in a diet-induced obesity model of zebrafish.
Foot Ulcer
Impact of lysyl oxidase (G473A) polymorphism on diabetic foot ulcers.
Fractures, Spontaneous
Pamidronate treatment improves bone mineral density in children with Menkes disease.
Gingival Overgrowth
Cytokine regulation of gingival fibroblast lysyl oxidase, collagen, and elastin.
Multiple Functions of Lysyl Oxidase Like-2 in Oral Fibroproliferative Processes.
Glaucoma
Analysis of LOXL1 polymorphisms in a Saudi Arabian population with pseudoexfoliation glaucoma.
Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma.
Association between Polymorphisms in Lysyl Oxidase-Like 1 and Susceptibility to Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.
Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.
Association of LOXL1 gene common sequence variants in Jordanian patients with exfoliation syndrome and exfoliative glaucoma.
Association of LOXL1 Gene Polymorphisms with Exfoliation Glaucoma Patients.
Association of LOXL1 gene polymorphisms with exfoliation syndrome/glaucoma and primary open angle glaucoma in a Turkish population.
Association of LOXL1 gene polymorphisms with pseudoexfoliation in the Japanese.
Association of LOXL1 polymorphisms with pseudoexfoliation in the Chinese.
Association of LOXL1 polymorphisms with pseudoexfoliation, glaucoma, intraocular pressure, and systemic diseases in a Greek population. The Thessaloniki eye study.
Association of lysyl oxidase-like 1 gene common sequence variants in Greek patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.
Association of Lysyl Oxidase-Like 1 Gene Polymorphism in Turkish Patients With Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.
Association of Lysyl Oxidase-like 1 Gene Polymorphism in Turkish Patients With Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.
Association of Lysyl Oxidase-Like 1 Gene Polymorphism in Turkish Patients With Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.
Association of lysyl oxidase-like 1 gene polymorphisms in pseudoexfoliation syndrome and pseudoexfoliation glaucoma in a Spanish population.
Association of non-synonymous single nucleotide polymorphisms in the LOXL1 gene with pseudoexfoliation syndrome in India.
Association of polymorphisms in APOE and LOXL1 with pseudoexfoliation syndrome and pseudoexfoliation glaucoma in a Turkish population.
Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review.
Common sequence variants in the LOXL1 gene in pigment dispersion syndrome and pigmentary glaucoma.
Corneal Stiffness and Collagen Cross-Linking Proteins in Glaucoma: Potential for Novel Therapeutic Strategy.
Correlation of the intronic LOXL1 polymorphism rs11638944 with pseudoexfoliation syndrome and glaucoma in a Greek population.
Differential Lysyl oxidase like 1 expression in pseudoexfoliation glaucoma is orchestrated via DNA methylation.
DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity.
Ethnicity-Based Differences in the Association of LOXL1 Polymorphisms with Pseudoexfoliation/Pseudoexfoliative Glaucoma: A Meta-Analysis.
Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma.
Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma.
Exfoliation syndrome and exfoliation glaucoma-associated LOXL1 variations are not involved in pigment dispersion syndrome and pigmentary glaucoma.
Exfoliation syndrome in sub-Saharan Africa.
Expression and regulation of LOXL1 and elastin-related genes in eyes with exfoliation syndrome.
Genetic variants in urinary bladder cancer: collective power of the "wimp SNPs"
Genetics and genomics of pseudoexfoliation syndrome/glaucoma.
Genetics of pseudoexfoliation syndrome.
Genotype-correlated expression of lysyl oxidase-like 1 in ocular tissues of patients with pseudoexfoliation syndrome/glaucoma and normal patients.
Lack of association between LOXL1 gene polymorphisms and primary open angle glaucoma in the Saudi Arabian population.
Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations.
Lack of association between lysyl oxidase-like 1 polymorphism in pseudoexfoliation syndrome and pseudoexfoliation glaucoma in North Indian population.
Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma: a meta-analysis.
LOXL1 Deficiency in the Lamina Cribrosa as Candidate Susceptibility Factor for a Pseudoexfoliation-Specific Risk of Glaucoma.
LOXL1 expression in lens capsule tissue specimens from individuals with pseudoexfoliation syndrome and glaucoma.
LOXL1 folding in exfoliation glaucoma.
LOXL1 Gene Polymorphism With Exfoliation Syndrome/Exfoliation Glaucoma: A Meta-Analysis.
LOXL1 gene polymorphisms are associated with exfoliation syndrome/exfoliation glaucoma risk: An updated meta-analysis.
LOXL1 Gene Sequence Variants and Vascular Disease in Exfoliation Syndrome and Exfoliative Glaucoma.
LOXL1 gene variants and their association with pseudoexfoliation glaucoma (XFG) in Spanish patients.
LOXL1 variants in elderly Japanese patients with exfoliation syndrome/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract.
Lysyl Oxidase Like 1: Biological roles and regulation.
Lysyl Oxidase-like 1 Gene Polymorphisms in German Patients With Normal Tension Glaucoma, Pigmentary Glaucoma and Exfoliation Glaucoma.
Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome.
Lysyl oxidase-like 2 level and glaucoma surgical outcomes.
Mass cytometry and transcriptomic profiling reveal body-wide pathology induced by Loxl1 deficiency.
Molecular pathology of pseudoexfoliation syndrome/glaucoma - New insights from LOXL1 gene associations.
Possible Protective Effect of LOXL1 Variant in the Cohort of Chernobyl Catastrophe Clean-Up Workers.
Prevalence of Pseudoexfoliation Glaucoma Risk-associated Variants within Lysyl Oxidase-like 1 in an Irish Population.
Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1.
Review: The role of LOXL1 in exfoliation syndrome/glaucoma.
Role of Lysyl oxidase-like 1 gene polymorphisms in Pakistani patients with pseudoexfoliative glaucoma.
The association of LOXL1 polymorphisms with exfoliation syndrome/glaucoma: Meta-analysis.
The LOXL1 gene variations are not associated with primary open-angle and primary angle-closure glaucomas.
The microfibril hypothesis of glaucoma: implications for treatment of elevated intraocular pressure.
The molecular pathophysiology of pseudoexfoliation glaucoma.
The Role of LOX and LOXL2 in Scar Formation After Glaucoma Surgery.
The role of lysyl oxidase-like 1 (LOXL1) in exfoliation syndrome and glaucoma.
The T allele of lysyl oxidase-like 1 rs41435250 is a novel risk factor for pseudoexfoliation syndrome and pseudoexfoliation glaucoma independently and through intragenic epistatic interaction.
[Association between LOXL1 gene polymorphisms and primary open angle glaucoma in Sichuan population].
[New pathogenetic insights into pseudoexfoliation syndrome/glaucoma. Therapeutically relevant?].
Glaucoma, Angle-Closure
The LOXL1 gene variations are not associated with primary open-angle and primary angle-closure glaucomas.
Glaucoma, Open-Angle
Association between Obstructive Sleep Apnea and Exfoliation Syndrome: The Utah Project on Exfoliation Syndrome.
Association of LOXL1 gene polymorphisms with exfoliation syndrome/glaucoma and primary open angle glaucoma in a Turkish population.
Association of LOXL1 polymorphisms with pseudoexfoliation, glaucoma, intraocular pressure, and systemic diseases in a Greek population. The Thessaloniki eye study.
Associations of polymorphisms of LOXL1 gene with primary open-angle glaucoma: a meta-analysis based on 5,293 subjects.
Common sequence variants in the LOXL1 gene in pigment dispersion syndrome and pigmentary glaucoma.
DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity.
Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma.
Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma.
Evaluation of LOXL1 polymorphisms in primary open-angle glaucoma in southern and northern Chinese.
Exfoliation syndrome and exfoliation glaucoma-associated LOXL1 variations are not involved in pigment dispersion syndrome and pigmentary glaucoma.
Genetic polymorphism related to exfoliative glaucoma is also associated with primary open-angle glaucoma risk.
Lack of association between LOXL1 gene polymorphisms and primary open angle glaucoma in the Saudi Arabian population.
Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations.
Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma: a meta-analysis.
LOXL1 gene polymorphism candidates for exfoliation glaucoma are also associated with a risk for primary open-angle glaucoma in a Caucasian population from central Russia.
LOXL1 variants in elderly Japanese patients with exfoliation syndrome/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract.
Lysyl Oxidase-like 1 Gene Polymorphisms in German Patients With Normal Tension Glaucoma, Pigmentary Glaucoma and Exfoliation Glaucoma.
Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome.
Major LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population.
Population differences in elastin maturation in optic nerve head tissue and astrocytes.
The protective variant rs7173049 at LOXL1 locus impacts on retinoic acid signaling pathway in pseudoexfoliation syndrome.
[Association between LOXL1 gene polymorphisms and primary open angle glaucoma in Sichuan population].
Glioblastoma
LCN2-interacting proteins and their expression patterns in brain tumors.
LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma.
LOXL3 Silencing Affected Cell Adhesion and Invasion in U87MG Glioma Cells.
Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression.
Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma.
Glioma
Clinical relevance of lysyl oxidase-like 2 and functional mechanisms in glioma.
In silico identification of the prognostic biomarkers and therapeutic targets associated with cancer stem cell characteristics of glioma.
LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2.
LOXL1 regulates cell apoptosis and migration in human neuroglioma U87 and U251 cells via Wnt/?-catenin signaling.
LOXL2 Upregulation in Gliomas Drives Tumorigenicity by Activating Autophagy to Promote TMZ Resistance and Trigger EMT.
LOXL3 Silencing Affected Cell Adhesion and Invasion in U87MG Glioma Cells.
Lysyl oxidase genetic variants and the prognosis of glioma.
Over-expression of lysyl oxidase is associated with poor prognosis and response to therapy of patients with lower grade gliomas.
Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma.
Granuloma
Activity and extractability of lysyl oxidase and collagen proteins in developing granuloma tissue.
Inhibition of lysyl oxidase by isoniazid and its effect on wound healing.
Transient expression of lysyl oxidase by liver myofibroblasts in murine schistosomiasis.
Granuloma Annulare
Increased activity of serum amine oxidases in granuloma annulare, necrobiosis lipoidica and diabetes.
Head and Neck Neoplasms
LOXL4 is a selectively expressed candidate diagnostic antigen in head and neck cancer.
Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer.
Vaccination strategy to target lysyl oxidase-like 4 in dendritic cell based immunotherapy for head and neck cancer.
Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03.
Hearing Loss
Targeted Deletion of Loxl3 by Col2a1-Cre Leads to Progressive Hearing Loss.
Hearing Loss, Conductive
Targeted Deletion of Loxl3 by Col2a1-Cre Leads to Progressive Hearing Loss.
Heart Defects, Congenital
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.
Heart Diseases
Expression of matrix metalloproteinases, their inhibitors, and lysyl oxidase in myocardial samples from dogs with end-stage systemic and cardiac diseases.
Human lysyl oxidase-like 2.
Inhibitor of lysyl oxidase improves cardiac function and the collagen/MMP profile in response to volume overload.
Heart Failure
'Mysterious' moose disease in Sweden. Similarities to copper deficiency and/or molybdenosis in cattle and sheep. Biochemical background of clinical signs and organ lesions.
Collagen cross-linking but not collagen amount associates with elevated filling pressures in hypertensive patients with stage C heart failure: potential role of lysyl oxidase.
Detrimental role of lysyl oxidase in cardiac remodeling.
Featured Article: Cardioprotective effects of lysyl oxidase inhibition against volume overload-induced extracellular matrix remodeling.
Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure.
Induction of LOX by TGF-?1/Smad/AP-1 signaling aggravates rat myocardial fibrosis and heart failure.
Inhibitor of lysyl oxidase improves cardiac function and the collagen/MMP profile in response to volume overload.
Lysyl oxidase overexpression accelerates cardiac remodeling and aggravates angiotensin II-induced hypertrophy.
MicroRNA-19b is a potential biomarker of increased myocardial collagen cross-linking in patients with aortic stenosis and heart failure.
Osteopontin-mediated myocardial fibrosis in heart failure: a role for lysyl oxidase?
Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment.
Hepatitis
Serum lysyl oxidase activity in chronic liver disease in comparison with serum levels of prolyl hydroxylase and laminin.
Serum lysyl oxidase activity in patients with various liver diseases.
Hepatitis C
Simtuzumab treatment of advanced liver fibrosis in HIV and HCV-infected adults: results of a 6-month open-label safety trial.
Hepatitis, Chronic
Increased lysyl oxidase activity in culture medium of nonparenchymal cells from fibrotic livers.
Serum lysyl oxidase activity in chronic liver disease in comparison with serum levels of prolyl hydroxylase and laminin.
Serum lysyl oxidase activity in patients with various liver diseases.
Hepatoblastoma
Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2.
Hepatolenticular Degeneration
A homozygous nonsense mutation and a combination of two mutations of the Wilson disease gene in patients with different lysyl oxidase activities in cultured fibroblasts.
Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2.
Hernias, Diaphragmatic, Congenital
Lysyl oxidase expression is decreased in the developing diaphragm and lungs of nitrofen-induced congenital diaphragmatic hernia.
Perturbations to lysyl oxidase expression broadly influence the transcriptome of lung fibroblasts.
Histiocytosis, Sinus
Expressions of extracellular matrix-remodeling factors in lymph nodes from oral cancer patients.
HIV Infections
Circulating LOXL2 Levels Reflect Severity of Intestinal Fibrosis and GALT CD4(+) T Lymphocyte Depletion in Treated HIV Infection.
Homocystinuria
Increased plasma copper in patients with homocystinuria due to cystathionine beta-synthase deficiency.
Irreversible inhibition of lysyl oxidase by homocysteine thiolactone and its selenium and oxygen analogues. Implications for homocystinuria.
Hyperalgesia
Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.
Hypercholesterolemia
Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening.
Hyperhomocysteinemia
[Bone quality markers: pentosidine, homocysteine, and MTHFR polymorphism]
[Daily practice using the guidelines for prevention and treatment of osteoporosis. How do we realize the bone quality in routine practice using Japanese guideline for osteoporosis prevention and treatment?]
Hypertension
A Modification to a Murine Model for Intracranial Aneurysm Formation and Rupture.
Effect of lysyl oxidase inhibition on angiotensin II-induced arterial hypertension, remodeling, and stiffness.
Emerging Roles of Lysyl Oxidases in the Cardiovascular System: New Concepts and Therapeutic Challenges.
Increased lysyl oxidase activity in blood vessels of hypertensive rats and effect of beta-aminopropionitrile on arteriosclerosis.
Lysyl Oxidase Induces Vascular Oxidative Stress and Contributes to Arterial Stiffness and Abnormal Elastin Structure in Hypertension: Role of p38MAPK.
Lysyl oxidase-like 2 depletion is protective in age-associated vascular stiffening.
Lysyl oxidases play a causal role in vascular remodeling in clinical and experimental pulmonary arterial hypertension.
Pharmacologically induced thoracic and abdominal aortic aneurysms in mice.
Prediction of marker genes associated with hypertension by bioinformatics analyses.
Preventive Effects of Quercetin against the Onset of Atherosclerosis-Related Acute Aortic Syndromes in Mice.
The Role of Lysyl Oxidase Family Members in the Stabilization of Abdominal Aortic Aneurysms.
Vasa vasorum formation is associated with rupture of intracranial aneurysms.
Hypertension, Pulmonary
Perturbations to lysyl oxidase expression broadly influence the transcriptome of lung fibroblasts.
Suppression of Phosphatidylinositol 3-Kinase/Akt Signaling Attenuates Hypoxia-Induced Pulmonary Hypertension Through the Downregulation of Lysyl Oxidase.
Hypertension, Renovascular
Elevated ischaemia-associated lysyl oxidase activity in delayed graft failure 6-12 months after renal transplantation.
Idiopathic Pulmonary Fibrosis
A serological marker of the N-terminal neoepitope generated during LOXL2 maturation is elevated in patients with cancer or idiopathic pulmonary fibrosis.
Blocking LOXL2 and TGF?1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis.
Correction: Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis (doi: 10.1242/dmm.030114).
Efficacy of simtuzumab versus placebo in patients with idiopathic pulmonary fibrosis: a randomised, double-blind, controlled, phase 2 trial.
Examining lysyl oxidase-like modulation of collagen architecture in 3D spheroid models of idiopathic pulmonary fibrosis via second-harmonic generation microscopy.
Lysyl Oxidase Inhibition by Heparin in Idiopathic Pulmonary Fibrosis: Is There Still Hope?
Lysyl Oxidase Like 1: Biological roles and regulation.
Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation.
Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis.
Regulation of LOXL2 and SERPINH1 by antitumor microRNA-29a in lung cancer with idiopathic pulmonary fibrosis.
Serum lysyl oxidase like-2 levels and idiopathic pulmonary fibrosis disease progression.
Immunoglobulin G4-Related Disease
B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease.
Infections
Collagen metabolism in fibrotic liver. Effects of concanavalin A and aggregated myeloma immunoglobin G.
Human Influenza A virus causes myocardial and cardiac-specific conduction system infection associated with early inflammation and premature death.
Trans-suppression of host CDH3 and LOXL4 genes during Cryptosporidium parvum infection involves nuclear delivery of parasite Cdg7_FLc_1000 RNA.
Infertility
Expression of lysyl oxidase and effect of copper chloride and ammonium tetrathiomolybdate on bovine ovarian follicle granulosa cells cultured in serum-free media.
Single-nucleotide polymorphisms in the lysyl oxidase-like protein 4 and complement component 3 genes are associated with increased risk for endometriosis and endometriosis-associated infertility.
Infertility, Male
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.
Insulin Resistance
Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
Intracranial Aneurysm
A Modification to a Murine Model for Intracranial Aneurysm Formation and Rupture.
A Novel Association between Lysyl Oxidase Gene Polymorphism and Intracranial Aneurysm in Koreans.
Exome Sequencing Identifies LOXL2 Mutation as a Cause of Familial Intracranial Aneurysm.
Lack of association of Lysyl oxidase (LOX) gene polymorphisms with intracranial aneurysm in a south Indian population.
Mutations in the lysyl oxidase gene not associated with intracranial aneurysm in central European families.
Polymorphisms in Lysyl Oxidase Family Genes Are Associated With Intracranial Aneurysm Susceptibility in a Chinese Population.
Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms.
Ischemic Stroke
LOXL1 Gene Sequence Variants and Vascular Disease in Exfoliation Syndrome and Exfoliative Glaucoma.
Lysyl oxidase polymorphisms and ischemic stroke-a case control study.
Keloid
Alteration of collagen composition and cross-linking in keloid tissues.
Ameliorating Fibrotic Phenotypes of Keloid Dermal Fibroblasts through an Epidermal Growth Factor-Mediated Extracellular Matrix Remodeling.
Pathologic scar formation. Morphologic and biochemical correlates.
Keratoconus
Association of Common Variants in LOX with Keratoconus: A Meta-Analysis.
Association of Lysyl oxidase (LOX) polymorphisms with the risk of Keratoconus in an Iranian population.
Association with Corneal Remodeling Related Genes, ALDH3A1, LOX, and SPARC Genes Variations in Korean Keratoconus Patients.
Attenuation of lysyl oxidase and collagen gene expression in keratoconus patient corneal epithelium corresponds to disease severity.
Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas.
Mutational screening of VSX1, SPARC, SOD1, LOX, and TIMP3 in keratoconus.
Outcomes of Corneal Cross-Linking Correlate With Cone-Specific Lysyl Oxidase Expression in Patients With Keratoconus.
Plasma homocysteine levels in patients with keratoconus.
The impairment of lysyl oxidase in keratoconus and in keratoconus-associated disorders.
Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and case-control studies.
[Gene expression of down-regulation of lysyl oxidases family in keratoconus corneal fibroblasts induced by combination of mechanical stretching and prostaglandin E 2].
[The role of tear acidity and Cu-cofactor of lysyl oxidase activity in the pathogenesis of keratoconus].
Kidney Diseases
Lysyl oxidase like-2 contributes to renal fibrosis in Col4?3/Alport mice.
Laryngeal Neoplasms
Differential expression of LOXL4 in normal and tumour tissue samples of laryngeal squamous cell carcinoma.
Expression of Lysyl Oxidase Predictive of Distant Metastasis of Laryngeal Cancer.
Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer.
Leiomyoma
Erratum to "Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases".
Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases.
Leukemia
Tocotrienol-rich fraction from annatto ameliorates expression of lysyl oxidase in human osteoblastic MG-63 cells.
Leukemia, Myeloid, Acute
Lysyl oxidase expression is associated with inferior outcome and Extramedullary disease of acute myeloid leukemia.
Liver Cirrhosis
Carvacrol Downregulates Lysyl Oxidase Expression and Ameliorates Oxidative Stress in the Liver of Rats with Carbon Tetrachloride-Induced Liver Fibrosis.
Co-administration of resveratrol and beta-aminopropionitrile attenuates liver fibrosis development via targeting lysyl oxidase in CCl4-induced liver fibrosis in rats.
Coexpression of the lysyl oxidase-like gene (LOXL) and the gene encoding type III procollagen in induced liver fibrosis.
Differential fibrotic phenotypes of hepatic stellate cells within 3D liver organoids.
Immunohistochemical localization of lysyl oxidase in normal human skin.
Inhibition of lysyl oxidase-like 1 (LOXL1) expression arrests liver fibrosis progression in cirrhosis by reducing elastin crosslinking.
Knockdown of LOXL1 inhibits TGF-?1-induced proliferation and fibrogenesis of hepatic stellate cells by inhibition of Smad2/3 phosphorylation.
LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis.
Lysyl oxidase (LOX) family members: rationale and their potential as therapeutic targets for liver fibrosis.
Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice.
Lysyl Oxidase as a Serum Biomarker of Liver Fibrosis in Patients with Severe Obesity and Obstructive Sleep Apnea.
Lysyl oxidase: mechanism, regulation and relationship to liver fibrosis.
Mechanism of collagen network stabilization in human irreversible granulomatous liver fibrosis.
MIR29A Impedes Metastatic Behaviors in Hepatocellular Carcinoma via Targeting LOX, LOXL2, and VEGFA.
Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal.
Serum lysyl oxidase activity in chronic liver disease in comparison with serum levels of prolyl hydroxylase and laminin.
Serum lysyl oxidase activity in patients with various liver diseases.
Withaferin A reverses bile duct ligation-induced liver fibrosis by modulating extracellular matrix deposition: Role of LOXL2/Snail1, vimentin, and NF?B signaling.
Liver Cirrhosis, Biliary
Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis.
Serum lysyl oxidase activity in patients with various liver diseases.
Liver Diseases
Increased lysyl oxidase activity in culture medium of nonparenchymal cells from fibrotic livers.
Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
Serum lysyl oxidase activity in chronic liver disease in comparison with serum levels of prolyl hydroxylase and laminin.
Serum lysyl oxidase activity in patients with various liver diseases.
Simtuzumab treatment of advanced liver fibrosis in HIV and HCV-infected adults: results of a 6-month open-label safety trial.
[Plasma lysyl oxidase activity in human liver disease]
Liver Diseases, Alcoholic
Serum lysyl oxidase activity in patients with various liver diseases.
Liver Neoplasms
Derepression of LOXL4 inhibits liver cancer growth by reactivating compromised p53.
Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer.
Transcriptome analysis of PPAR? target genes reveals the involvement of lysyl oxidase in human placental cytotrophoblast invasion.
Low Tension Glaucoma
LOXL1 variants in elderly Japanese patients with exfoliation syndrome/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract.
Lysyl Oxidase-like 1 Gene Polymorphisms in German Patients With Normal Tension Glaucoma, Pigmentary Glaucoma and Exfoliation Glaucoma.
Lung Diseases
A serological marker of the N-terminal neoepitope generated during LOXL2 maturation is elevated in patients with cancer or idiopathic pulmonary fibrosis.
Perturbations to lysyl oxidase expression broadly influence the transcriptome of lung fibroblasts.
Lung Diseases, Interstitial
LOXL2, a copper-dependent monoamine oxidase, activates lung fibroblasts through the TGF-?/Smad pathway.
The serum level and significance of lysyl oxidase-like 2 in patients with rheumatoid arthritis-associated interstitial lung disease.
[Blood copper levels in a group of patients with asbestosis]
Lung Injury
Significance of nuclear LOXL2 inhibition in fibroblasts and myofibroblasts in the fibrotic process of acute respiratory distress syndrome.
Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injury.
The influence of proline analogs on bleomycin-induced lung injury in rats.
Lung Neoplasms
Blimp1 activation by AP-1 in human lung cancer cells promotes a migratory phenotype and is inhibited by the lysyl oxidase propeptide.
Correlations of lysyl oxidase with MMP2/MMP9 expression and its prognostic value in non-small cell lung cancer.
Down-regulation of lysyl oxidase-like 2 (LOXL2) is associated with disease progression in lung adenocarcinomas.
Down-regulation of MBNL1-AS1 contributes to tumorigenesis of NSCLC via sponging miR-135a-5p.
Downregulation of lysyl oxidase-like 4 LOXL4 by miR-135a-5p promotes lung cancer progression in vitro and in vivo.
Expression and significance of hypoxia inducible factor-1? and lysyl oxidase in non-small cell lung cancer.
Forkhead box C1 promotes metastasis and invasion of non-small cell lung cancer by binding directly to the lysyl oxidase promoter.
Genetic polymorphism of lysyl oxidase, glutathione S-transferase M1, glutathione-S-transferase T1, and glutathione S-transferase P1 genes as risk factors for lung cancer in Egyptian patients.
Increased lysyl oxidase-like 2 associates with a poor prognosis in non-small cell lung cancer.
LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling.
LOXL1 Is Regulated by Integrin ?11 and Promotes Non-Small Cell Lung Cancer Tumorigenicity.
Lysyl oxidase expression in bronchogenic carcinoma.
Lysyl Oxidase Gene G473A Polymorphism and Cigarette Smoking in Association with a High Risk of Lung and Colorectal Cancers in a North Chinese Population.
Lysyl oxidase mediates hypoxia-induced radioresistance in non-small cell lung cancer A549 cells.
miR-210 promotes lung adenocarcinoma proliferation, migration, and invasion by targeting lysyl oxidase-like 4.
MiR-504 inhibits cell proliferation and invasion by targeting LOXL2 in non small cell lung cancer.
Regulation of LOXL2 and SERPINH1 by antitumor microRNA-29a in lung cancer with idiopathic pulmonary fibrosis.
Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells.
Roles of Ki-67, p53, transforming growth factor-? and lysyl oxidase in the metastasis of lung cancer.
The effect of lysyl oxidase polymorphism on susceptibility and prognosis of nonsmall cell lung cancer.
The Lysyl Oxidase Propeptide Interacts with the Receptor-Type Protein Tyrosine Phosphatase Kappa and Inhibits {beta}-Catenin Transcriptional Activity in Lung Cancer Cells.
[Effects of lysyl oxidase down-regulation on invasion, migration and E-cadherin protein expression of hypoxic lung cancer cells].
Lymphatic Metastasis
Combined use of lysyl oxidase, carcino-embryonic antigen, and carbohydrate antigens improves the sensitivity of biomarkers in predicting lymph node metastasis and peritoneal metastasis in gastric cancer.
Differential expression of LOXL4 in normal and tumour tissue samples of laryngeal squamous cell carcinoma.
Elevated exosomal lysyl oxidase like 2 is a potential biomarker for head and neck squamous cell carcinoma.
Exposure to desflurane anesthesia confers colorectal cancer cells metastatic capacity through deregulation of miR-34a/LOXL3.
Expression of lysyl oxidase is correlated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.
LOXL4 is a selectively expressed candidate diagnostic antigen in head and neck cancer.
Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC).
Lysyl oxidase-like 2 (LOXL2) from stromal fibroblasts stimulates the progression of gastric cancer.
Lysyl oxidase-like 4 (LOXL4) promotes proliferation and metastasis of gastric cancer via FAK/Src pathway.
Lysyl Oxidase-Like Protein 2 Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer.
Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB.
Potential association of LOXL1 with peritoneal dissemination in gastric cancer possibly via promotion of EMT.
Prognostic utility and clinical significance of lysyl oxidase-like 2 protein expression in digestive system cancers.
Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase-like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.
Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway.
Selective upregulation and amplification of the lysyl oxidase like-4 (LOXL4) gene in head and neck squamous cell carcinoma.
Significance of the Lysyl Oxidase Members Lysyl Oxidase Like 1, 3, and 4 in Gastric Cancer.
Vaccination strategy to target lysyl oxidase-like 4 in dendritic cell based immunotherapy for head and neck cancer.
[Expression of LOX and MMP-2 in gastric cancer tissue and the effects of LOX and MMP-2 on tumor invasion and metastasis].
Macular Degeneration
Genetic variants in urinary bladder cancer: collective power of the "wimp SNPs"
Interaction of two functional genetic variants LOXL1 rs1048661 and VEGFA rs3025039 on the risk of age-related macular degeneration in Chinese women.
Polymorphisms in ARMS2 (LOC387715) and LOXL1 genes in the Japanese with age-related macular degeneration.
Polymorphisms in ARMS2 (LOC387715) and LOXL1 Genes in the Japanese With Age-Related Macular Degeneration.
Marfan Syndrome
Elevated expression levels of lysyl oxidases protect against aortic aneurysm progression in Marfan syndrome.
Lysyl oxidase activity and synthesis of desmosines in cultured human aortic cells and skin fibroblasts: comparison of cell lines from control subjects and patients with the Marfan syndrome or other annulo-aortic ectasia.
Lysyl oxidase in osteogenesis imperfecta and Marfan's syndrome.
Marfan syndrome and aortic aneurysm: Lysyl oxidases to the rescue?
[Cardiovascular pathology of Marfan syndrome]
Medulloblastoma
LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma.
Melanoma
A serological marker of the N-terminal neoepitope generated during LOXL2 maturation is elevated in patients with cancer or idiopathic pulmonary fibrosis.
Biophytum sensitivum (L.) DC inhibits tumor cell invasion and metastasis through a mechanism involving regulation of MMPs, prolyl hydroxylase, lysyl oxidase, nm23, ERK-1, ERK-2, STAT-1, and proinflammatory cytokine gene expression in metastatic lung tissue.
Divergent roles of lysyl oxidase family members in ornithine decarboxylase- and RAS-transformed mouse fibroblasts and human melanoma cells.
Evaluation of Fluorine-18-Labeled ?1(I)-N-Telopeptide Analogs as Substrate-Based Radiotracers for PET Imaging of Melanoma-Associated Lysyl Oxidase.
Immunohistochemistry analysis reveals lysyl oxidase-like 3 as a novel prognostic marker for primary melanoma.
LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer.
Lysyl oxidase expression and inhibition in uveal melanoma.
Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability.
Vernonia cinerea Less. Inhibits Tumor Cell Invasion and Pulmonary Metastasis in C57BL/6 Mice.
Menkes Kinky Hair Syndrome
A homozygous nonsense mutation and a combination of two mutations of the Wilson disease gene in patients with different lysyl oxidase activities in cultured fibroblasts.
Biochemical indicator for evaluation of connective tissue abnormalities in Menkes' disease.
Brachial artery aneurysms in Menkes disease.
Expression and accumulation of lysyl oxidase, elastin, and type I procollagen in human Menkes and mottled mouse fibroblasts.
Expression of mRNAs for lysyl oxidase and type III procollagen in cultured fibroblasts from patients with the Menkes and occipital horn syndromes as determined by quantitative polymerase chain reaction.
Increased frequency of congenital heart defects in Menkes disease.
Markedly reduced activity of lysyl oxidase in skin and aorta from a patient with Menkes' disease showing unusually severe connective tissue manifestations.
Severe bilateral panlobular emphysema and pulmonary arterial hypoplasia: unusual manifestations of Menkes disease.
Type IX Ehlers-Danlos syndrome and Menkes syndrome: the decrease in lysyl oxidase activity is associated with a corresponding deficiency in the enzyme protein.
Mesothelioma, Malignant
Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavities.
Metabolic Syndrome
Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?
Myocardial lysyl oxidase regulation of cardiac remodeling in a murine model of diet-induced metabolic syndrome.
Microaneurysm
Blood Vessel Basement Membrane Alterations in Human Retinal Microaneurysms During Aging.
Mitochondrial Myopathies
Genetic diseases of copper metabolism.
Mouth Neoplasms
Lysyl oxidase in oral cancer: Friend or foe?
Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB.
Myocardial Infarction
Immunohistochemical detection of differentially localized up-regulation of lysyl oxidase and down-regulation of matrix metalloproteinase-1 in rhesus monkey model of chronic myocardial infarction.
Lysyl oxidase expression in cardiac fibroblasts is regulated by ?2?1 integrin interactions with the cellular microenvironment.
Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction.
Myocardial Ischemia
Decreased copper concentrations but increased lysyl oxidase activity in ischemic hearts of rhesus monkeys.
Myocarditis
Secreted Phospholipase A2-IIA Modulates Transdifferentiation of Cardiac Fibroblast through EGFR Transactivation: An Inflammation-Fibrosis Link.
Myoma
The hypoxic tumor microenvironment regulates invasion of aggressive oral carcinoma cells.
Myopia
Crosslinking Enzyme Lysyl Oxidase Modulates Scleral Remodeling in Form-Deprivation Myopia.
Exome sequencing identified null mutations in LOXL3 associated with early-onset high myopia.
Nasopharyngeal Carcinoma
Silencing of hypoxia-inducible tumor suppressor lysyl oxidase gene by promoter methylation activates carbonic anhydrase IX in nasopharyngeal carcinoma.
Necrobiosis Lipoidica
Increased activity of serum amine oxidases in granuloma annulare, necrobiosis lipoidica and diabetes.
Neoplasm Metastasis
Amentoflavone Inhibits Experimental Tumor Metastasis Through a Regulatory Mechanism Involving MMP-2, MMP-9, Prolyl Hydroxylase, Lysyl Oxidase, VEGF, ERK-1, ERK-2, STAT-1, nm23 and Cytokines in Lung Tissues of C57BL/6 Mice.
ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis.
Biophytum sensitivum (L.) DC inhibits tumor cell invasion and metastasis through a mechanism involving regulation of MMPs, prolyl hydroxylase, lysyl oxidase, nm23, ERK-1, ERK-2, STAT-1, and proinflammatory cytokine gene expression in metastatic lung tissue.
Blocking drug-induced autophagy with chloroquine in HCT-116 colon cancer cells enhances DC maturation and T cell responses induced by tumor cell lysate.
Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases.
Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: The role of hypoxia inducible factor 1 pathway.
Caffeine suppresses metastasis in a transgenic mouse model: a prototype molecule for prophylaxis of metastasis.
Clinical Implications of Lysyl Oxidase-Like Protein 2 Expression in Pancreatic Cancer.
Combined use of lysyl oxidase, carcino-embryonic antigen, and carbohydrate antigens improves the sensitivity of biomarkers in predicting lymph node metastasis and peritoneal metastasis in gastric cancer.
Comparing hydrazine-derived reactive groups as inhibitors of quinone-dependent amine oxidases.
Comprehensive analysis on the expression levels and prognostic values of LOX family genes in kidney renal clear cell carcinoma.
Correlations of lysyl oxidase with MMP2/MMP9 expression and its prognostic value in non-small cell lung cancer.
Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy.
Deregulation of FoxM1b leads to tumour metastasis.
Detection of Lysyl Oxidase-Like 2 (LOXL2), a Biomarker of Metastasis from Breast Cancers Using Human Blood Samples.
Differential expression of LOXL4 in normal and tumour tissue samples of laryngeal squamous cell carcinoma.
Divergent roles of lysyl oxidase family members in ornithine decarboxylase- and RAS-transformed mouse fibroblasts and human melanoma cells.
Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways.
Elevated exosomal lysyl oxidase like 2 is a potential biomarker for head and neck squamous cell carcinoma.
Emerging role of LOXL2 in the promotion of pancreas cancer metastasis.
Epithelial-mesenchymal transition and metastasis of colon cancer cells induced by the FAK pathway in cancer-associated fibroblasts.
Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression.
Evaluation of Fluorine-18-Labeled ?1(I)-N-Telopeptide Analogs as Substrate-Based Radiotracers for PET Imaging of Melanoma-Associated Lysyl Oxidase.
Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis.
Exposure to desflurane anesthesia confers colorectal cancer cells metastatic capacity through deregulation of miR-34a/LOXL3.
Expression of lysyl oxidase is correlated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.
Expression of Lysyl Oxidase Predictive of Distant Metastasis of Laryngeal Cancer.
EZH2-mediated Epigenetic Silencing of miR-29/miR-30 targets LOXL4 and contributes to Tumorigenesis, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer.
Forkhead box C1 promotes metastasis and invasion of non-small cell lung cancer by binding directly to the lysyl oxidase promoter.
Functional analysis of LOXL2 in pancreatic carcinoma.
HIF-1? promoted vasculogenic mimicry formation in hepatocellular carcinoma through LOXL2 up-regulation in hypoxic tumor microenvironment.
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression.
Human breast cancer cell metastasis is attenuated by lysyl oxidase inhibitors through down-regulation of focal adhesion kinase and the paxillin-signaling pathway.
Hypoxia-derived exosomes induce putative altered pathways in biosynthesis and ion regulatory channels in glioblastoma cells.
Hypoxia-mediated metastasis.
Identification of a novel lysyl oxidase-like 2 alternative splicing isoform, LOXL2 ?e13, in esophageal squamous cell carcinoma.
Identification of functional hypoxia inducible factor response elements in the human lysyl oxidase gene promoter.
Impact of lysyl oxidase (G473A) polymorphism on diabetic foot ulcers.
Increased expression of hypoxia-inducible factor-1 alpha and its impact on transcriptional changes and prognosis in malignant tumours of the ocular adnexa.
Increased Expression of the Matrix-Modifying Enzyme Lysyl Oxidase-Like 2 in Aggressive Hepatocellular Carcinoma with Poor Prognosis.
Increased lysyl oxidase-like 2 associates with a poor prognosis in non-small cell lung cancer.
Inhibition of Metastasis of B16F-10 Melanoma Cells in C57BL/6 Mice by an Extract of Calendula Officinalis L Flowers.
Inhibition of the LOX enzyme family members with old and new ligands. Selectivity analysis revisited.
Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis.
Insilico study of anti-carcinogenic lysyl oxidase-like 2 inhibitors.
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1.
Involvement of miR-30b in kynurenine-mediated lysyl oxidase expression.
Ionizing radiation induces tumor cell lysyl oxidase secretion.
LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.
LOXL 2 Promotes The Epithelial-Mesenchymal Transition And Malignant Progression Of Cervical Cancer.
LOXL1 exerts oncogenesis and stimulates angiogenesis through the LOXL1-FBLN5/?v?3 integrin/FAK-MAPK axis in ICC.
LOXL1 modulates the malignant progression of colorectal cancer by inhibiting the transcriptional activity of YAP.
LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.
LOXL2 expression is associated with invasiveness and negatively influences survival in breast cancer patients.
LOXL2 in cancer: Regulation, downstream effectors and novel roles.
LOXL2 in epithelial cell plasticity and tumor progression.
LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling.
LOXL2 Inhibitors and Breast Cancer Progression.
LOXL2 promotes oncogenic progression in alveolar rhabdomyosarcoma independently of its catalytic activity.
LOXL2 promotes vasculogenic mimicry and tumour aggressiveness in hepatocellular carcinoma.
LOXL2 upregulates hypoxia?inducible factor?1? signaling through Snail?FBP1 axis in hepatocellular carcinoma cells.
LOXL2 upregulates phosphorylation of ezrin to promote cytoskeletal reorganization and tumor cell invasion.
LOXL2-mediated matrix remodeling in metastasis and mammary gland involution.
LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer.
LOXL3 Silencing Affected Cell Adhesion and Invasion in U87MG Glioma Cells.
LOXL4 is a selectively expressed candidate diagnostic antigen in head and neck cancer.
LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer.
Lysyl Oxidase (LOX) and Hypoxia-Induced Metastases.
Lysyl oxidase contributes to mechanotransduction-mediated regulation of transforming growth factor-? signaling in breast cancer cells.
Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK.
Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC).
Lysyl oxidase expression is regulated by the H3K27 demethylase Jmjd3 in tumor-associated M2-like macrophages.
Lysyl oxidase in cancer inhibition and metastasis.
Lysyl oxidase in cancer research.
Lysyl oxidase in colorectal cancer.
Lysyl oxidase induces epithelial-mesenchymal transition and predicts intrahepatic metastasis of hepatocellular carcinoma.
Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness.
Lysyl oxidase is essential for hypoxia-induced metastasis.
Lysyl oxidase is induced by cell density-mediated cell cycle suppression via RB-E2F1-HIF-1? axis.
Lysyl Oxidase Is Predictive of Unfavorable Outcomes and Essential for Regulation of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma.
Lysyl oxidase may play a critical role in hypoxia-induced NSCLC cells invasion and migration.
Lysyl oxidase mediates hypoxia-induced radioresistance in non-small cell lung cancer A549 cells.
Lysyl oxidase mediates hypoxic control of metastasis.
Lysyl oxidase plays a pivotal role in promoting metastasis of breast cancer cells.
Lysyl oxidase promotes liver metastasis of gastric cancer via facilitating the reciprocal interactions between tumor cells and cancer associated fibroblasts.
Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis.
Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis.
Lysyl Oxidase, Extracellular Matrix Remodeling and Cancer Metastasis.
Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization.
Lysyl oxidase-like 2 (LOXL2) controls tumor-associated cell proliferation through the interaction with MARCKSL1.
Lysyl oxidase-like 2 (LOXL2) from stromal fibroblasts stimulates the progression of gastric cancer.
Lysyl oxidase-like 2 is a regulator of angiogenesis through modulation of endothelial-to-mesenchymal transition.
Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma.
Lysyl oxidase-like 2 is highly expressed in colorectal cancer cells and promotes the development of colorectal cancer.
Lysyl oxidase-like 2 promotes esophageal squamous cell carcinoma cell migration independent of catalytic activity.
Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability.
Lysyl oxidase-like 4 (LOXL4) promotes proliferation and metastasis of gastric cancer via FAK/Src pathway.
Lysyl Oxidase-Like Protein 2 Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer.
Lysyl oxidase-like protein LOXL2 promotes lung metastasis of breast cancer.
Lysyl oxidase: A colorectal cancer biomarker of lung and hepatic metastasis.
Lysyl oxidase: a potential target for cancer therapy.
Lysyl oxidases: from enzyme activity to extracellular matrix cross-links.
Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB.
Model Combining Tumor Molecular and Clinicopathologic Risk Factors Predicts Sentinel Lymph Node Metastasis in Primary Cutaneous Melanoma.
Molecular mechanisms mediating metastasis of hypoxic breast cancer cells.
Neutrophils expressing lysyl oxidase-like 4 protein are present in colorectal cancer liver metastases resistant to anti-angiogenic therapy.
Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.
Opening the LOX to bone metastasis: The role of secreted lysyl oxidase in skeletal recurrence of breast cancers.
Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis.
Potential association of LOXL1 with peritoneal dissemination in gastric cancer possibly via promotion of EMT.
Potential options for managing LOX+ ER- breast cancer patients.
Prognostic utility and clinical significance of lysyl oxidase-like 2 protein expression in digestive system cancers.
Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase-like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.
Regulation of lysyl oxidase expression in THP-1 cell-derived M2-like macrophages.
Regulation of the collagen cross-linking enzymes LOXL2 and PLOD2 by tumor-suppressive microRNA-26a/b in renal cell carcinoma.
Retraction Note: Lysyl oxidase is essential for hypoxia-induced metastasis.
RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2.
Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis.
Roles of Ki-67, p53, transforming growth factor-? and lysyl oxidase in the metastasis of lung cancer.
Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway.
Selective upregulation and amplification of the lysyl oxidase like-4 (LOXL4) gene in head and neck squamous cell carcinoma.
Significance of the Lysyl Oxidase Members Lysyl Oxidase Like 1, 3, and 4 in Gastric Cancer.
Silencing of lysyl oxidase gene expression by RNA interference suppresses metastasis of breast cancer.
Silibinin Inhibits NSCLC Metastasis by Targeting the EGFR/LOX Pathway.
Simultaneously targeting cancer-associated fibroblasts and angiogenic vessel as a treatment for TNBC.
Site-specific expression of amine oxidases in breast cancer metastases.
Stromal miR-200s contribute to breast cancer cell invasion through CAF activation and ECM remodeling.
Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor-?-Deficient Mouse Mammary Carcinomas.
Suppression for lung metastasis by depletion of collagen I and lysyl oxidase via losartan assisted with paclitaxel-loaded pH-sensitive liposomes in breast cancer.
The function and mechanisms of action of LOXL2 in cancer (Review).
The hypoxic tumor microenvironment regulates invasion of aggressive oral carcinoma cells.
The pathological significance of LOXL2 in pre-metastatic niche formation of HCC and its related molecular mechanism.
The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer.
The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis.
Transcriptional switching model for the regulation of tumorigenesis and metastasis by the ha-ras oncogene - transcriptional changes in the ha-ras tumor-suppressor gene lysyl oxidase.
Tumor-secreted LOXL2 Activates Fibroblasts Through FAK Signaling.
Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma.
Vaccination strategy to target lysyl oxidase-like 4 in dendritic cell based immunotherapy for head and neck cancer.
Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03.
ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis.
[Expression of LOX and MMP-2 in gastric cancer tissue and the effects of LOX and MMP-2 on tumor invasion and metastasis].
[Mechanism of lysyl oxidase (LOX) in breast cancer invasion and metastasis].
Neoplasms
2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.
67 laminin receptor promotes the malignant potential of tumour cells up-regulating lysyl oxidase-like 2 expression in cholangiocarcinoma.
A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples.
A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer.
A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.
A novel asymmetric 3D in-vitro assay for the study of tumor cell invasion.
A novel splice variant of LOXL2 promotes progression of human papillomavirus-negative head and neck squamous cell carcinoma.
A Phase II Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First-Line Treatment of Pancreatic Adenocarcinoma.
A Polymorphism in the Lysyl Oxidase Propeptide Domain Accelerates Carcinogen-induced Cancer.
A serological marker of the N-terminal neoepitope generated during LOXL2 maturation is elevated in patients with cancer or idiopathic pulmonary fibrosis.
A Theoretical Approach to Coupling the Epithelial-Mesenchymal Transition (EMT) to Extracellular Matrix (ECM) Stiffness via LOXL2.
A truncated splice variant of human lysyl oxidase-like 2 promotes migration and invasion in esophageal squamous cell carcinoma.
Aberrant Collagen Cross-linking in Human Oral Squamous Cell Carcinoma.
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment.
Alternatively spliced lysyl oxidase-like 4 isoforms have a pro-metastatic role in cancer.
Amentoflavone Inhibits Experimental Tumor Metastasis Through a Regulatory Mechanism Involving MMP-2, MMP-9, Prolyl Hydroxylase, Lysyl Oxidase, VEGF, ERK-1, ERK-2, STAT-1, nm23 and Cytokines in Lung Tissues of C57BL/6 Mice.
An Impermeant Ganetespib Analog Inhibits Extracellular Hsp90-Mediated Cancer Cell Migration that Involves Lysyl Oxidase 2-like Protein.
Analysis of lysyl oxidase as a marker for diagnosis of canine mammary tumors.
Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships.
Associations Between Elastography Findings and Clinicopathological Factors in Breast Cancer.
ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis.
Author Correction: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.
Autocrine growth factor regulation of lysyl oxidase expression in transformed fibroblasts.
beta-catenin signaling and regulation of cyclin D1 promoter in NRK-49F cells transformed by down-regulation of the tumor suppressor lysyl oxidase.
Biophytum sensitivum (L.) DC inhibits tumor cell invasion and metastasis through a mechanism involving regulation of MMPs, prolyl hydroxylase, lysyl oxidase, nm23, ERK-1, ERK-2, STAT-1, and proinflammatory cytokine gene expression in metastatic lung tissue.
Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours.
Blimp1 activation by AP-1 in human lung cancer cells promotes a migratory phenotype and is inhibited by the lysyl oxidase propeptide.
Blocking drug-induced autophagy with chloroquine in HCT-116 colon cancer cells enhances DC maturation and T cell responses induced by tumor cell lysate.
Cancer Associated Fibroblasts and Senescent Thyroid Cells in the Invasive Front of Thyroid Carcinoma.
Cancer-associated fibroblasts up-regulate CCL2, CCL26, IL6 and LOXL2 genes related to promotion of cancer progression in hepatocellular carcinoma cells.
Characterization of gene expression induced by RET with MEN2A or MEN2B mutation.
Characterization of recombinant lysyl oxidase propeptide.
Circular RNA circ_0000228 promotes the malignancy of cervical cancer via microRNA-195-5p/ lysyl oxidase-like protein 2 axis.
Clinical Implications of Lysyl Oxidase-Like Protein 2 Expression in Pancreatic Cancer.
Clinical relevance of lysyl oxidase-like 2 and functional mechanisms in glioma.
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion.
Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis.
Combined effects of tumor necrosis factor-? and interleukin-1? on lysyl oxidase and matrix metalloproteinase expression in human knee synovial fibroblasts
Combined use of lysyl oxidase, carcino-embryonic antigen, and carbohydrate antigens improves the sensitivity of biomarkers in predicting lymph node metastasis and peritoneal metastasis in gastric cancer.
Comparative functional study of the lysyl oxidase promoter in fibroblasts, Ras-transformed fibroblasts, myofibroblasts and smooth muscle cells.
Comparing hydrazine-derived reactive groups as inhibitors of quinone-dependent amine oxidases.
Comprehensive analysis on the expression levels and prognostic values of LOX family genes in kidney renal clear cell carcinoma.
Control of lysyl oxidase activity through site-specific deuteration of lysine.
Correlations of lysyl oxidase with MMP2/MMP9 expression and its prognostic value in non-small cell lung cancer.
Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy.
Deficient production of lysyl oxidase in cultures of malignantly transformed human cells.
Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2: definition of the regions involved.
Derepression of LOXL4 inhibits liver cancer growth by reactivating compromised p53.
Desmoplasia in pancreatic cancer. Can we fight it?
Detection of Lysyl Oxidase-Like 2 (LOXL2), a Biomarker of Metastasis from Breast Cancers Using Human Blood Samples.
Determination of cell uptake pathways for tumor inhibitor lysyl oxidase propeptide.
Differential expression of LOXL4 in normal and tumour tissue samples of laryngeal squamous cell carcinoma.
Differential expression of the LOX family genes in human colorectal adenocarcinomas.
Divergent roles of lysyl oxidase family members in ornithine decarboxylase- and RAS-transformed mouse fibroblasts and human melanoma cells.
Dormant tumor cells expressing LOXL2 acquire a stem-like phenotype mediating their transition to proliferative growth.
Down-regulation of lysyl oxidase-induced tumorigenic transformation in NRK-49F cells characterized by constitutive activation of ras proto-oncogene.
Down-regulation of lysyl oxidase-like 2 (LOXL2) is associated with disease progression in lung adenocarcinomas.
Drosophila lysyl oxidases Dmloxl-1 and Dmloxl-2 are differentially expressed and the active DmLOXL-1 influences gene expression and development.
Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways.
Elevated exosomal lysyl oxidase like 2 is a potential biomarker for head and neck squamous cell carcinoma.
Emerging role of LOXL2 in the promotion of pancreas cancer metastasis.
Enzymatic and non-enzymatic functions of the lysyl oxidase family in bone.
Enzyme-Initiated Assembly of an Extracellular-Like Two-Dimensional Nanonetwork as a Method to Detect Procancerous Activity.
Epithelial-mesenchymal transition and metastasis of colon cancer cells induced by the FAK pathway in cancer-associated fibroblasts.
Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease.
Evaluation of Fluorine-18-Labeled ?1(I)-N-Telopeptide Analogs as Substrate-Based Radiotracers for PET Imaging of Melanoma-Associated Lysyl Oxidase.
Evidence, Mechanism, and Clinical Relevance of the Transdifferentiation from Lung Adenocarcinoma to Squamous Cell Carcinoma.
Evolving roles of lysyl oxidase family in tumorigenesis and cancer therapy.
Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis.
Expression of LOXs and MMP-1, 2, 3 by ACL Fibroblasts and Synoviocytes Impact of Coculture and TNF-?.
Expression of lysyl oxidase in human osteosarcoma and its clinical significance: A tumor suppressive role of LOX in human osteosarcoma cells.
Expression of lysyl oxidase is correlated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.
Expression of the lysyl oxidase propeptide in hepatocellular carcinoma and its clinical relevance.
Expressions of extracellular matrix-remodeling factors in lymph nodes from oral cancer patients.
Extracellular processing of lysyl oxidase-like 2 and its effect on amine oxidase activity.
EZH2-mediated Epigenetic Silencing of miR-29/miR-30 targets LOXL4 and contributes to Tumorigenesis, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer.
Fibroblast-specific inhibition of TGF-?1 signaling attenuates lung and tumor fibrosis.
Functional analysis of the 5' flanking domain of the LOXL4 gene in head and neck squamous cell carcinoma cells.
Heparanase 2 attenuates head and neck tumor vascularity and growth.
Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage.
Hepatocellular carcinoma cells cause different responses in expressions of cancer-promoting genes in different cancer-associated fibroblasts.
HIF-1? promoted vasculogenic mimicry formation in hepatocellular carcinoma through LOXL2 up-regulation in hypoxic tumor microenvironment.
High Lysyl Oxidase (LOX) in the Non-Malignant Prostate Epithelium Predicts a Poor Outcome in Prostate Cancer Patient Managed by Watchful Waiting.
Human breast cancer cell metastasis is attenuated by lysyl oxidase inhibitors through down-regulation of focal adhesion kinase and the paxillin-signaling pathway.
Human lysyl oxidase-like 2.
Hypermethylated SFRP1, but none of other nine genes "informative" for western countries, is valuable for bladder cancer detection in Mainland China.
Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts.
Hypoxia-derived exosomes induce putative altered pathways in biosynthesis and ion regulatory channels in glioblastoma cells.
Hypoxia-mediated metastasis.
Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration.
Hypoxic tumor microenvironments reduce collagen I fiber density.
Identification and characterization of the promoter of cancer-related gene LOXL2.
Identification of a novel lysyl oxidase-like 2 alternative splicing isoform, LOXL2 ?e13, in esophageal squamous cell carcinoma.
Identification of functional hypoxia inducible factor response elements in the human lysyl oxidase gene promoter.
Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization.
Identification of LOXL3-associating immune infiltration landscape and prognostic value in hepatocellular carcinoma.
Identification of the lysyl oxidase gene as target of the antioncogenic transcription factor, IRF-1, and its possible role in tumor suppression.
Immunohistochemical localization of lysyl oxidase in normal human skin.
Immunohistochemistry analysis reveals lysyl oxidase-like 3 as a novel prognostic marker for primary melanoma.
Increased expression of hypoxia-inducible factor-1 alpha and its impact on transcriptional changes and prognosis in malignant tumours of the ocular adnexa.
Increased Expression of the Matrix-Modifying Enzyme Lysyl Oxidase-Like 2 in Aggressive Hepatocellular Carcinoma with Poor Prognosis.
Increasing matrix stiffness upregulates vascular endothelial growth factor expression in hepatocellular carcinoma cells mediated by integrin ?1.
Influence of Lysyl oxidase Polymorphisms in Cancer Risk: An Updated Meta-analysis.
Influences of Tumor Necrosis Factor-? on Lysyl Oxidases and Matrix Metalloproteinases of Injured Anterior Cruciate Ligament and Medial Collateral Ligament Fibroblasts.
Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases.
Inhibition of LOXL2 Enhances the Radiosensitivity of Castration-Resistant Prostate Cancer Cells Associated with the Reversal of the EMT Process.
Inhibition of Lysyl Oxidases Improves Drug Diffusion and Increases Efficacy of Cytotoxic Treatment in 3D Tumor Models.
Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix.
Inhibition of the LOX enzyme family members with old and new ligands. Selectivity analysis revisited.
Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression.
Insights from the in silico structural, functional and phylogenetic characterization of canine lysyl oxidase protein.
Insilico study of anti-carcinogenic lysyl oxidase-like 2 inhibitors.
Interactive effect of bisphenol A (BPA) exposure with -22G/C polymorphism in LOX gene on the risk of osteosarcoma.
Intracellular lysyl oxidase: effect of a specific inhibitor on nuclear mass in proliferating cells.
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1.
Involvement of cytoskeleton-associated proteins in the commitment of C3H10T1/2 pluripotent stem cells to adipocyte lineage induced by BMP2/4.
In Vivo Expansion of Cancer Stemness Affords Novel Cancer Stem Cell Targets: Malignant Rhabdoid Tumor as an Example.
Ionizing radiation attracts tumor targeting and apoptosis by radiotropic lysyl oxidase traceable nanoparticles.
Ionizing radiation induces tumor cell lysyl oxidase secretion.
LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.
LncRNA LOXL1-AS1 regulates the tumorigenesis and development of lung adenocarcinoma through sponging miR-423-5p and targeting MYBL2.
Long non-conding RNA LOXL1-AS1 sponges miR-589-5p to up-regulate CBX5 expression in renal cell carcinoma.
Low extracellular lysyl oxidase expression is associated with poor prognosis in patients with prostate cancer.
Low Numbers of Vascular Vessels Correlate to Progression in Hormone-Naïve Prostate Carcinomas Undergoing Radical Prostatectomy.
LOX expression in primary nasopharyngeal carcinoma: correlation with prognostic parameters and outcome.
LOX-catalyzed collagen stabilization is a proximal cause for intrinsic resistance to chemotherapy.
LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis.
LOXL 2 Promotes The Epithelial-Mesenchymal Transition And Malignant Progression Of Cervical Cancer.
LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer.
LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2.
LOXL1 Is Regulated by Integrin ?11 and Promotes Non-Small Cell Lung Cancer Tumorigenicity.
LOXL1 modulates the malignant progression of colorectal cancer by inhibiting the transcriptional activity of YAP.
LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition.
LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype.
LOXL2 in cancer: Regulation, downstream effectors and novel roles.
LOXL2 in epithelial cell plasticity and tumor progression.
LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling.
LOXL2 Inhibitors and Breast Cancer Progression.
Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation.
LOXL2 promotes oncogenic progression in alveolar rhabdomyosarcoma independently of its catalytic activity.
LOXL2 promotes vasculogenic mimicry and tumour aggressiveness in hepatocellular carcinoma.
LOXL2 status correlates with tumor stage and regulates integrin levels to promote tumor progression in ccRCC.
LOXL2 upregulates hypoxia?inducible factor?1? signaling through Snail?FBP1 axis in hepatocellular carcinoma cells.
LOXL2 upregulates phosphorylation of ezrin to promote cytoskeletal reorganization and tumor cell invasion.
LOXL2 Upregulation in Gliomas Drives Tumorigenicity by Activating Autophagy to Promote TMZ Resistance and Trigger EMT.
LOXL2-mediated matrix remodeling in metastasis and mammary gland involution.
LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer.
LOXL3 Silencing Affected Cell Adhesion and Invasion in U87MG Glioma Cells.
LOXL4 as a selective molecular marker in primary and metastatic head/neck carcinoma.
LOXL4 is a selectively expressed candidate diagnostic antigen in head and neck cancer.
LOXL4 is downregulated in hepatocellular carcinoma with a favorable prognosis.
LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer.
Lysyl Oxidase (LOX) transcriptionally regulates SNAI2 expression and TIMP4 secretion in human cancers.
Lysyl oxidase activates cancer stromal cells and promotes gastric cancer progression: quantum dot-based identification of biomarkers in cancer stromal cells.
Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis.
Lysyl Oxidase and the Tumor Microenvironment.
Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.
Lysyl oxidase expression and inhibition in uveal melanoma.
Lysyl oxidase expression in bronchogenic carcinoma.
Lysyl oxidase expression is associated with inferior outcome and Extramedullary disease of acute myeloid leukemia.
Lysyl oxidase expression is regulated by the H3K27 demethylase Jmjd3 in tumor-associated M2-like macrophages.
Lysyl oxidase gene expression in the stromal reaction to in situ and invasive ductal breast carcinoma.
Lysyl Oxidase Genetic Variants Affect Gene Expression in Cervical Cancer.
Lysyl oxidase impacts disease outcomes and correlates with global DNA hypomethylation in esophageal cancer.
Lysyl oxidase in cancer inhibition and metastasis.
Lysyl oxidase in cancer research.
Lysyl oxidase in colorectal cancer.
Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness.
Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone.
Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.
Lysyl oxidase is associated with increased thrombosis and platelet reactivity.
Lysyl oxidase is downregulated by the EWS/FLI1 oncoprotein and its propeptide domain displays tumor supressor activities in ewing sarcoma cells.
Lysyl oxidase is essential for hypoxia-induced metastasis.
Lysyl oxidase is induced by cell density-mediated cell cycle suppression via RB-E2F1-HIF-1? axis.
Lysyl oxidase is involved in synovial hyperplasia and angiogenesis in rats with collagen?induced arthritis.
Lysyl Oxidase Is Predictive of Unfavorable Outcomes and Essential for Regulation of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma.
Lysyl Oxidase Isoforms and Potential Therapeutic Opportunities for Fibrosis and Cancer.
Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer.
Lysyl oxidase like-4 monoclonal antibody demonstrates therapeutic effect against head and neck squamous cell carcinoma cells and xenografts.
Lysyl oxidase may play a critical role in hypoxia-induced NSCLC cells invasion and migration.
Lysyl oxidase mediates hypoxia-induced radioresistance in non-small cell lung cancer A549 cells.
Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis.
Lysyl oxidase promotes liver metastasis of gastric cancer via facilitating the reciprocal interactions between tumor cells and cancer associated fibroblasts.
Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling.
Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation.
Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis.
Lysyl oxidase propeptide stimulates osteoblast and osteoclast differentiation and enhances PC3 and DU145 prostate cancer cell effects on bone in vivo.
Lysyl oxidase rs1800449 polymorphism and cancer risk among Asians: evidence from a meta-analysis and a case-control study of colorectal cancer.
Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis.
Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis.
Lysyl oxidase, cellular senescence and tumor suppression.
Lysyl Oxidase, Extracellular Matrix Remodeling and Cancer Metastasis.
Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization.
Lysyl oxidase-like 2 (LOXL2) controls tumor-associated cell proliferation through the interaction with MARCKSL1.
Lysyl oxidase-like 2 (LOXL2) from stromal fibroblasts stimulates the progression of gastric cancer.
Lysyl oxidase-like 2 (LOXL2)-mediated cross-linking of tropoelastin.
Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.
Lysyl oxidase-like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors.
Lysyl oxidase-like 2 is a regulator of angiogenesis through modulation of endothelial-to-mesenchymal transition.
Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma.
Lysyl oxidase-like 2 is highly expressed in colorectal cancer cells and promotes the development of colorectal cancer.
Lysyl oxidase-like 2 promotes esophageal squamous cell carcinoma cell migration independent of catalytic activity.
Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells.
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.
Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability.
Lysyl oxidase-like 4 (LOXL4) promotes proliferation and metastasis of gastric cancer via FAK/Src pathway.
Lysyl Oxidase-Like 4 Fosters an Immunosuppressive Microenvironment During Hepatocarcinogenesis.
Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavities.
Lysyl Oxidase-Like Protein 2 Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer.
Lysyl oxidase-like protein localizes to sites of de novo fibrinogenesis in fibrosis and in the early stromal reaction of ductal breast carcinomas.
Lysyl oxidase-like protein LOXL2 promotes lung metastasis of breast cancer.
Lysyl oxidase-like-2 promotes tumour angiogenesis and is a potential therapeutic target in angiogenic tumours.
Lysyl oxidase: a potential target for cancer therapy.
Lysyl oxidase: from basic science to future cancer treatment.
Lysyl Oxidase: Its Diversity in Health and Diseases.
Lysyl oxidases: a novel multifunctional amine oxidase family.
Lysyl oxidases: linking structures and immunity in the tumor microenvironment.
Major Action of Endogenous Lysyl Oxidase in Clear Cell Renal Cell Carcinoma Progression and Collagen Stiffness Revealed by Primary Cell Cultures.
Mass cytometry and transcriptomic profiling reveal body-wide pathology induced by Loxl1 deficiency.
Matrix stiffness-mediated effects on macrophages polarization and their LOXL2 expression.
Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB.
Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling.
Methylation of LOXL1 Promoter by DNMT3A in Aged Human Skin Fibroblasts.
MicroRNAs and the hallmarks of cancer.
miR-210 promotes lung adenocarcinoma proliferation, migration, and invasion by targeting lysyl oxidase-like 4.
Molecular Mechanisms and Potential Therapeutic Targets in Incisional Hernia.
Molecular mechanisms mediating metastasis of hypoxic breast cancer cells.
Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia.
Mutual Expression of ALDH1A1, LOX, and Collagens in Ovarian Cancer Cell Lines as Combined CSCs- and ECM-Related Models of Drug Resistance Development.
Neutrophils expressing lysyl oxidase-like 4 protein are present in colorectal cancer liver metastases resistant to anti-angiogenic therapy.
NNK, a tobacco-specific carcinogen, inhibits the expression of lysyl oxidase, a tumor suppressor.
Non-coding RNA LOXL1-AS1 exhibits oncogenic activity in ovarian cancer via regulation of miR-18b-5p/VMA21 axis.
Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.
Opening the LOX to bone metastasis: The role of secreted lysyl oxidase in skeletal recurrence of breast cancers.
Optical molecular imaging of lysyl oxidase activity - detection of active fibrogenesis in human lung tissue.
Orthotopic non-metastatic and metastatic oral cancer mouse models.
Over-expression of lysyl oxidase is associated with poor prognosis and response to therapy of patients with lower grade gliomas.
P2Y2R activation by nucleotides released from the highly metastatic breast cancer cell MDA-MB-231 contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment.
PACE4 Proteolytically Processes LOXL2 with little impact on its catalytic activity.
Peptides derived from the copper-binding region of lysyl oxidase exhibit antiangiogeneic properties by inhibiting enzyme activity: an in vitro study.
Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis.
Perturbations to lysyl oxidase expression broadly influence the transcriptome of lung fibroblasts.
Potential association of LOXL1 with peritoneal dissemination in gastric cancer possibly via promotion of EMT.
Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer.
Predicting Outcome and Therapy Response in mCRC Patients Using an Indirect Method for CTCs Detection by a Multigene Expression Panel: A Multicentric Prospective Validation Study.
Prognostic and clinicopathological significance of LOXL2 in cancers: A systematic review and meta-analysis.
Prognostic and therapeutic implications of extracellular matrix associated gene signature in renal clear cell carcinoma.
Prognostic utility and clinical significance of lysyl oxidase-like 2 protein expression in digestive system cancers.
Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment.
Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase.
Quantification of ?-aminopropionitrile, an inhibitor of lysyl oxidase activity, in plasma and tumor of mice by liquid chromatography tandem mass spectrometry.
Quantitative assessment of gene methylation in neoplastic and non-neoplastic gastric epithelia using methylation-specific DNA microarray.
Radiotherapy-Resistant Breast Cancer Cells Enhance Tumor Progression by Enhancing Premetastatic Niche Formation through the HIF-1?-LOX Axis.
Re: Tumour-Suppressive MicroRNA-29s Directly Regulate LOXL2 Expression and Inhibit Cancer Cell Migration and Invasion in Renal Cell Carcinoma.
Receptor activity modifying protein-3 mediates the protumorigenic activity of lysyl oxidase-like protein-2.
Recognition of lysyl oxidase as a potential predictive biomarker for oral squamous cell carcinoma: an immunohistochemical study.
Recombinant Human Lysyl Oxidase-like 2 Secreted from Human Embryonic Kidney Cells Displays Complex and Acidic Glycans at All Three N-Linked Glycosylation Sites.
Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts.
Reduced lysyl oxidase messenger RNA levels in experimental and human prostate cancer.
Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase-like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.
Reduction of LOX- and LOXL2-mRNA expression in head and neck squamous cell carcinomas.
Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence.
Regulation of collagen deposition and lysyl oxidase by tumor necrosis factor-alpha in osteoblasts.
Regulation of Extracellular Matrix Remodeling Proteins by Osteoblasts in Titanium Nanoparticle-Induced Aseptic Loosening Model.
Regulation of lysyl oxidase expression in THP-1 cell-derived M2-like macrophages.
Reorganized Collagen in the Tumor Microenvironment of Gastric Cancer and Its Association with Prognosis.
Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells.
Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression.
Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis.
Roles of Copper-Binding Proteins in Breast Cancer.
Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer.
Salidroside ameliorated hypoxia-induced tumorigenesis of BxPC-3 cells via downregulating hypoxia-inducible factor (HIF)-1? and LOXL2.
SCUBE3 regulation of early lung cancer angiogenesis and metastatic progression.
Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway.
Secretory leukocyte protease inhibitor mediates proliferation of human endometrial epithelial cells by positive and negative regulation of growth-associated genes.
Selective upregulation and amplification of the lysyl oxidase like-4 (LOXL4) gene in head and neck squamous cell carcinoma.
Significance of HIF-1? Expression and LOXL-2 Localization in Progression of Oral Squamous Cell Carcinoma.
Significance of Intratumoral Fibrosis in Clear Cell Renal Cell Carcinoma.
Significance of Lysyl oxidase?like 2 gene expression on the epithelial?mesenchymal status of hepatocellular carcinoma.
Significance of the Lysyl Oxidase Members Lysyl Oxidase Like 1, 3, and 4 in Gastric Cancer.
Silencing of hypoxia-inducible tumor suppressor lysyl oxidase gene by promoter methylation activates carbonic anhydrase IX in nasopharyngeal carcinoma.
Silibinin Inhibits NSCLC Metastasis by Targeting the EGFR/LOX Pathway.
Somatic mutations of the lysyl oxidase gene on chromosome 5q23.1 in colorectal tumors.
Specific protein 1(SP1) regulates the epithelial-mesenchymal transition via lysyl oxidase-like 2(LOXL2) in pancreatic ductal adenocarcinoma.
Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor-?-Deficient Mouse Mammary Carcinomas.
Suppression for lung metastasis by depletion of collagen I and lysyl oxidase via losartan assisted with paclitaxel-loaded pH-sensitive liposomes in breast cancer.
Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer.
Targeting Lysyl Oxidase Family Meditated Matrix Cross-Linking as an Anti-Stromal Therapy in Solid Tumours.
Targeting the lysyl oxidases in tumour desmoplasia.
Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis.
TGF-?1 promotes linear invadosome formation in hepatocellular carcinoma cells, through DDR1 up-regulation and collagen I cross-linking.
The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene).
The Core Promoter and Redox-sensitive Cis-elements as Key Targets for Inactivation of the Lysyl Oxidase Gene by Cadmium.
The effect of LOXL2 in hepatocellular carcinoma.
The function and mechanisms of action of LOXL2 in cancer (Review).
The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth.
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.
The Interactome of Cancer-Related Lysyl Oxidase and Lysyl Oxidase-Like Proteins.
The lysyl oxidase like 2/3 enzymatic inhibitor, PXS-5153A, reduces crosslinks and ameliorates fibrosis.
The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells.
The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1.
The pathological significance of LOXL2 in pre-metastatic niche formation of HCC and its related molecular mechanism.
The potential for LOXL2 as a target for future cancer treatment.
The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells.
The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells.
The rationale for targeting the LOX family in cancer.
The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer.
The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer.
Three-dimensional decellularized tumor extracellular matrices with different stiffness as bioengineered tumor scaffolds.
Tumor potential in rat wounds after short- and long-term administration of platelet-rich plasma.
Tumor suppressive effect of lysyl oxidase proenzyme.
Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces.
Tumor-secreted LOXL2 Activates Fibroblasts Through FAK Signaling.
Tumor-suppressive microRNA-29 family inhibits cancer cell migration and invasion directly targeting LOXL2 in lung squamous cell carcinoma.
Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma.
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.
Tumour-suppressive microRNA-29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma.
Understanding the molecular mechanism associated with reversal of oral submucous fibrosis targeting hydroxylysine aldehyde-derived collagen cross-links.
Upregulated LOX and increased collagen content associated with aggressive clinicopathological features and unfavorable outcome in oral squamous cell carcinoma.
UXT is a LOX-PP Interacting Protein that Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells.
Vaccination strategy to target lysyl oxidase-like 4 in dendritic cell based immunotherapy for head and neck cancer.
VEGF-ablation therapy reduces drug delivery and therapeutic response in ECM-dense tumors.
Vitamin D controls resistance artery function through regulation of perivascular adipose tissue hypoxia and inflammation.
Wnt signaling and Loxl2 promote aggressive osteosarcoma.
ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis.
[Expression of LOX and MMP-2 in gastric cancer tissue and the effects of LOX and MMP-2 on tumor invasion and metastasis].
[Mapping of a deletion interval on 8p21-22 in prostate cancer by gene dosage PCR]
Neoplasms, Glandular and Epithelial
Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells.
Neoplasms, Squamous Cell
Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB.
Neoplastic Cells, Circulating
Predicting Outcome and Therapy Response in mCRC Patients Using an Indirect Method for CTCs Detection by a Multigene Expression Panel: A Multicentric Prospective Validation Study.
Nephritis, Hereditary
Lysyl oxidase like-2 contributes to renal fibrosis in Col4?3/Alport mice.
Neuroblastoma
LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.
Molecular and physiological characterization of RV remodeling in a murine model of pulmonary stenosis.
Neurodegenerative Diseases
No association of LOXL1 gene polymorphisms with Alzheimer's disease.
Nevus
Divergent roles of lysyl oxidase family members in ornithine decarboxylase- and RAS-transformed mouse fibroblasts and human melanoma cells.
Non-alcoholic Fatty Liver Disease
Hepatic stellate cells-specific LOXL1 deficiency abrogates hepatic inflammation, fibrosis, and corrects lipid metabolic abnormalities in non-obese NASH mice.
Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
Simtuzumab Is Ineffective for Patients With Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis.
Obesity
3D Bioprinting of Breast Cancer Models for Drug Resistance Study.
Increased aortic stiffness and attenuated lysyl oxidase activity in obesity.
Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
The lysyl oxidase inhibitor (?-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats.
The lysyl oxidase inhibitor ?-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats.
Obesity, Morbid
Lysyl Oxidase as a Serum Biomarker of Liver Fibrosis in Patients with Severe Obesity and Obstructive Sleep Apnea.
Ocular Hypertension
Integral role for lysyl oxidase-like-1 in conventional outflow tissue function and behavior.
Odontogenic Tumors
Identification of the involvement of LOXL4 in generation of keratocystic odontogenic tumors by RNA-Seq analysis.
Optic Nerve Glioma
Increased Tissue Stiffness in Tumors from Mice with Neurofibromatosis-1 Optic Glioma.
Oral Submucous Fibrosis
Association between lysyl oxidase polymorphisms and oral submucous fibrosis in older male areca chewers.
Comparative Evaluation of role of Lysyl oxidase gene (LOXG473A) expression in pathogenesis and malignant transformation of Oral Submucous Fibrosis.
Effect of Lysyl Oxidase G473 A Polymorphism on Lysyl Oxidase and Total Soluble Collagen Expression in Oral Submucous Fibrosis.
Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan.
Molecular screening of lysyl oxidase G473A polymorphism in oral submucous fibrosis.
The upregulation of lysyl oxidase in oral submucous fibrosis and squamous cell carcinoma.
Osteoarthritis
Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis.
Identification of functional hypoxia inducible factor response elements in the human lysyl oxidase gene promoter.
Leptin promotes apoptosis and inhibits autophagy of chondrocytes through upregulating lysyl oxidase-like 3 during osteoarthritis pathogenesis.
LncRNA LOXL1-AS1 is transcriptionally activated by JUND and contributes to osteoarthritis progression via targeting the miR-423-5p/KDM5C axis.
LOXL2 as a protective in osteoarthritis cartilage.
LOXL2 attenuates osteoarthritis through inactivating Integrin/FAK signaling.
Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.
Osteoarthritis, Knee
Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.
Osteogenesis Imperfecta
An unusual pattern of peptide-bound lysine metabolism in collagen from an infant with lethal perinatal osteogenesis imperfecta.
Defects in the biochemistry of collagen in diseases of connective tissue.
Lysyl oxidase in osteogenesis imperfecta and Marfan's syndrome.
Osteoporosis
'Mysterious' moose disease in Sweden. Similarities to copper deficiency and/or molybdenosis in cattle and sheep. Biochemical background of clinical signs and organ lesions.
A novel function for lysyl oxidase in pluripotent mesenchymal cell proliferation and relevance to inflammation-associated osteopenia.
Pamidronate treatment improves bone mineral density in children with Menkes disease.
Osteosarcoma
A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain.
Expression of lysyl oxidase in human osteosarcoma and its clinical significance: A tumor suppressive role of LOX in human osteosarcoma cells.
Functional analysis of the promoter and first intron of the human lysyl oxidase gene.
Interactive effect of bisphenol A (BPA) exposure with -22G/C polymorphism in LOX gene on the risk of osteosarcoma.
Lysyl oxidase (LOX) mRNA expression and genes of the differentiated osteoblastic phenotype are upregulated in human osteosarcoma cells by suramin.
Lysyl oxidase polymorphisms and susceptibility to osteosarcoma.
Molecular events that contribute to lysyl oxidase enzyme activity and insoluble collagen accumulation in osteosarcoma cell clones.
Wnt signaling and Loxl2 promote aggressive osteosarcoma.
Ovarian Neoplasms
Association between Lysyl Oxidase G473A Polymorphism and Ovarian Cancer in the Han Chinese Population.
Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis.
Lysyl Oxidase G473A Polymorphism Is Associated with Increased Risk of Ovarian Cancer.
The plasma peptides of ovarian cancer.
The prognostic value of the lysyl oxidase family in ovarian cancer.
Uncovering the role of nuclear Lysyl oxidase (LOX) in advanced high grade serous ovarian cancer.
Pancreatic Neoplasms
A serological marker of the N-terminal neoepitope generated during LOXL2 maturation is elevated in patients with cancer or idiopathic pulmonary fibrosis.
Clinical Implications of Lysyl Oxidase-Like Protein 2 Expression in Pancreatic Cancer.
Emerging role of LOXL2 in the promotion of pancreas cancer metastasis.
Functional analysis of LOXL2 in pancreatic carcinoma.
Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis.
miR-29a Is Repressed by MYC in Pancreatic Cancer and Its Restoration Drives Tumor-Suppressive Effects via Downregulation of LOXL2.
Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells.
Salidroside ameliorated hypoxia-induced tumorigenesis of BxPC-3 cells via downregulating hypoxia-inducible factor (HIF)-1? and LOXL2.
Paralysis
Embryo movements regulate tendon mechanical property development.
Pelvic Floor Disorders
Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice.
Perinatal Death
Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice.
Peritoneal Fibrosis
Targeting lysyl oxidase reduces peritoneal fibrosis.
Polycystic Ovary Syndrome
Lysyl oxidase blockade ameliorates anovulation in polycystic ovary syndrome.
Significance of matrix metalloproteinases in the pathophysiology of the ovary and uterus.
Potassium Deficiency
Copper response to rheumatoid arthritis.
Pre-Eclampsia
Downregulation of lysyl oxidase and lysyl oxidase-like protein 2 suppressed the migration and invasion of trophoblasts by activating the TGF-?/collagen pathway in preeclampsia.
Upregulation of miR-29a suppressed the migration and invasion of trophoblasts by directly targeting LOXL2 in preeclampsia.
Priapism
Effect of lysyl oxidase (LOX) on corpus cavernous fibrosis caused by ischaemic priapism.
Primary Myelofibrosis
Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies.
Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase.
Lysyl oxidase inhibition in primary myelofibrosis: A renewed strategy.
Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connection.
Novel lysyl oxidase inhibitors attenuate hallmarks of primary myelofibrosis in mice.
Upregulation of lysyl oxidase and adhesion to collagen of human megakaryocytes and platelets in primary myelofibrosis.
procollagen-lysine 5-dioxygenase deficiency
Defects in the biochemistry of collagen in diseases of connective tissue.
Progeria
Arterial stiffness and cardiac dysfunction in Hutchinson-Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase.
Prostatic Neoplasms
A serological marker of the N-terminal neoepitope generated during LOXL2 maturation is elevated in patients with cancer or idiopathic pulmonary fibrosis.
Analysis of hypoxia-associated gene expression in prostate cancer: lysyl oxidase and glucose transporter-1 expression correlate with Gleason score.
Determination of cell uptake pathways for tumor inhibitor lysyl oxidase propeptide.
Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways.
High Lysyl Oxidase (LOX) in the Non-Malignant Prostate Epithelium Predicts a Poor Outcome in Prostate Cancer Patient Managed by Watchful Waiting.
Hypoxia and Prostate Cancer Aggressiveness: A Tale With Many Endings.
Inhibition of LOXL2 Enhances the Radiosensitivity of Castration-Resistant Prostate Cancer Cells Associated with the Reversal of the EMT Process.
Inhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has Tumour-Promoting and Tumour-Suppressing Roles in Experimental Prostate Cancer.
Low extracellular lysyl oxidase expression is associated with poor prognosis in patients with prostate cancer.
LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma.
Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling.
Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis.
Lysyl oxidase propeptide stimulates osteoblast and osteoclast differentiation and enhances PC3 and DU145 prostate cancer cell effects on bone in vivo.
Reduced lysyl oxidase messenger RNA levels in experimental and human prostate cancer.
Regulation of metastasis-promoting LOXL2 gene expression by antitumor microRNAs in prostate cancer.
[Mapping of a deletion interval on 8p21-22 in prostate cancer by gene dosage PCR]
Protein Deficiency
Hepatic collagen content and lysyl oxidase activity in rats fed a low protein-ethanol diet.
Lysyl Oxidase-Like 1 Protein Deficiency Protects Mice from Adenoviral Transforming Growth Factor-?1-induced Pulmonary Fibrosis.
protein-lysine 6-oxidase deficiency
A skeletal and connective tissue disorder associated with lysyl oxidase deficiency and abnormal copper metabolism.
Aortic elastin abnormalities in osteogenesis imperfecta type II.
Congenital cutis laxa and lysyl oxidase deficiency.
Downregulation of lysyl oxidase in cadmium-resistant fibroblasts.
Ehlers-Danlos type V (X-linked form): a lysyl oxidase deficiency.
Failure of elastic fiber homeostasis leads to pelvic floor disorders.
Hepatic stellate cells-specific LOXL1 deficiency abrogates hepatic inflammation, fibrosis, and corrects lipid metabolic abnormalities in non-obese NASH mice.
Increased frequency of congenital heart defects in Menkes disease.
LOXL1 Deficiency in the Lamina Cribrosa as Candidate Susceptibility Factor for a Pseudoexfoliation-Specific Risk of Glaucoma.
LOXL1 deficiency negatively impacts the biomechanical properties of the mouse vagina and supportive tissues.
LOXL3 novel mutation causing a rare form of autosomal recessive Stickler syndrome.
Lysyl oxidase deficiency in Ehlers-Danlos syndrome type V.
Lysyl oxidase deficiency in lung and fibroblasts from mice with hereditary emphysema.
Lysyl oxidase deficiency: a new cause of human arterial dissection.
Mass cytometry and transcriptomic profiling reveal body-wide pathology induced by Loxl1 deficiency.
Role of lysyl oxidase like 1 in regulation of postpartum connective tissue metabolism in the mouse vagina.
Targeted Deletion of Loxl3 by Col2a1-Cre Leads to Progressive Hearing Loss.
X-linked cutis laxa: defective cross-link formation in collagen due to decreased lysyl oxidase activity.
Pterygium
Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review.
Pulmonary Arterial Hypertension
Lysyl oxidases play a causal role in vascular remodeling in clinical and experimental pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
[Bone quality in COPD.]
Pulmonary Fibrosis
Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis.
Hypoxia-inducible factor-1? regulates epithelial-to-mesenchymal transition in paraquat-induced pulmonary fibrosis by activating lysyl oxidase.
LOX/LOXL in pulmonary fibrosis: potential therapeutic targets.
LOXL2, a copper-dependent monoamine oxidase, activates lung fibroblasts through the TGF-?/Smad pathway.
Lysyl oxidase promotes epithelial-to-mesenchymal transition during paraquat-induced pulmonary fibrosis.
Lysyl Oxidase-Like 1 Protein Deficiency Protects Mice from Adenoviral Transforming Growth Factor-?1-induced Pulmonary Fibrosis.
N-acetylcysteine downregulation of lysyl oxidase activity alleviating bleomycin-induced pulmonary fibrosis in rats.
The copper chelator tetrathiomolybdate regressed bleomycin-induced pulmonary fibrosis in mice, by reducing lysyl oxidase expressions.
The serum level and significance of lysyl oxidase-like 2 in patients with rheumatoid arthritis-associated interstitial lung disease.
Rectal Neoplasms
Lysyl Oxidase Gene G473A Polymorphism and Cigarette Smoking in Association with a High Risk of Lung and Colorectal Cancers in a North Chinese Population.
Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.
Renal Insufficiency, Chronic
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition.
[Bone quality].
Respiratory Distress Syndrome
Significance of nuclear LOXL2 inhibition in fibroblasts and myofibroblasts in the fibrotic process of acute respiratory distress syndrome.
Retinal Detachment
Effects of Lysyl Oxidase Genetic Variants on the Susceptibility to Rhegmatogenous Retinal Detachment and Proliferative Vitreoretinopathy.
Lysyl oxidase activity in the ocular tissues and the role of LOX in proliferative diabetic retinopathy and rhegmatogenous retinal detachment.
Retinal Vein Occlusion
Analysis of LOXL1 gene variants in Japanese patients with branch retinal vein occlusion.
Lack of association of LOXL1 gene variants in Japanese patients with central retinal vein occlusion without clinically detectable pseudoexfoliation material deposits.
Retinoblastoma
Hypoxia inhibits growth, proliferation, and increases response to chemotherapy in retinoblastoma cells.
Rhabdomyosarcoma, Alveolar
LOXL2 promotes oncogenic progression in alveolar rhabdomyosarcoma independently of its catalytic activity.
Sarcoma
Deficient production of lysyl oxidase in cultures of malignantly transformed human cells.
Sarcoma, Ewing
Lysyl oxidase is downregulated by the EWS/FLI1 oncoprotein and its propeptide domain displays tumor supressor activities in ewing sarcoma cells.
Schistosomiasis
Transient expression of lysyl oxidase by liver myofibroblasts in murine schistosomiasis.
Scleroderma, Localized
Increased expression of lysyl oxidase in skin with scleroderma.
[The diagnostic importance of research on the lysyl oxidase activity in children with circumscribed scleroderma]
Scleroderma, Systemic
Brief report: lysyl oxidase is a potential biomarker of fibrosis in systemic sclerosis.
Increased expression of lysyl oxidase in skin with scleroderma.
Lysyl oxidase directly contributes to extracellular matrix production and fibrosis in systemic sclerosis.
Lysyl Oxidase in Systemic Sclerosis: Getting Under the Skin.
Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through LOXL4: New Evidence from 3D Skin-like Tissues.
Scoliosis
Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype.
Elevated hair copper level in idiopathic scoliosis: preliminary observations.
Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations.
Skin Diseases
[The diagnostic importance of research on the lysyl oxidase activity in children with circumscribed scleroderma]
Sleep Apnea, Obstructive
Lysyl Oxidase as a Serum Biomarker of Liver Fibrosis in Patients with Severe Obesity and Obstructive Sleep Apnea.
Small Cell Lung Carcinoma
MiR-504 inhibits cell proliferation and invasion by targeting LOXL2 in non small cell lung cancer.
Spasm
Copper metabolism in mottled mouse mutants: copper therapy of brindled (Mobr) mice.
Spinal Cord Injuries
Beta-aminopropionitrile treatment can accelerate recovery of mice after spinal cord injury.
Squamous Cell Carcinoma of Head and Neck
A novel splice variant of LOXL2 promotes progression of human papillomavirus-negative head and neck squamous cell carcinoma.
Differential expression of LOXL4 in normal and tumour tissue samples of laryngeal squamous cell carcinoma.
Elevated exosomal lysyl oxidase like 2 is a potential biomarker for head and neck squamous cell carcinoma.
Functional analysis of the 5' flanking domain of the LOXL4 gene in head and neck squamous cell carcinoma cells.
LOXL4 as a selective molecular marker in primary and metastatic head/neck carcinoma.
LOXL4 is a selectively expressed candidate diagnostic antigen in head and neck cancer.
Lysyl oxidase and enhancement of cell proliferation and angiogenesis in oral squamous cell carcinoma.
Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC).
Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer.
Lysyl oxidase like-4 monoclonal antibody demonstrates therapeutic effect against head and neck squamous cell carcinoma cells and xenografts.
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.
Overexpression of a novel lysyl oxidase-like gene in human head and neck squamous cell carcinomas.
Recognition of lysyl oxidase as a potential predictive biomarker for oral squamous cell carcinoma: an immunohistochemical study.
Reduction of LOX- and LOXL2-mRNA expression in head and neck squamous cell carcinomas.
Selective upregulation and amplification of the lysyl oxidase like-4 (LOXL4) gene in head and neck squamous cell carcinoma.
Significance of HIF-1? Expression and LOXL-2 Localization in Progression of Oral Squamous Cell Carcinoma.
Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma.
Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03.
Starvation
Changes in lung lysyl oxidase activity in streptozotocin-diabetes and in starvation.
Verteporfin as a Medical Treatment in Peyronie's Disease.
Stomach Neoplasms
A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer.
Combined use of lysyl oxidase, carcino-embryonic antigen, and carbohydrate antigens improves the sensitivity of biomarkers in predicting lymph node metastasis and peritoneal metastasis in gastric cancer.
Inhibition of lysyl oxidase expression by dextran sulfate affects invasion and migration of gastric cancer cells.
LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer.
Lysyl oxidase activates cancer stromal cells and promotes gastric cancer progression: quantum dot-based identification of biomarkers in cancer stromal cells.
Lysyl oxidase and hypoxia-inducible factor 1?: biomarkers of gastric cancer.
Lysyl oxidase G473A polymorphism is closely associated with susceptibility to gastric cancer in a South Korean population.
Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.
Lysyl oxidase is associated with the epithelial-mesenchymal transition of gastric cancer cells in hypoxia.
Lysyl oxidase isoforms in gastric cancer.
Lysyl oxidase promotes liver metastasis of gastric cancer via facilitating the reciprocal interactions between tumor cells and cancer associated fibroblasts.
Lysyl oxidase-like 2 (LOXL2) from stromal fibroblasts stimulates the progression of gastric cancer.
Lysyl oxidase-like 4 (LOXL4) promotes proliferation and metastasis of gastric cancer via FAK/Src pathway.
Potential association of LOXL1 with peritoneal dissemination in gastric cancer possibly via promotion of EMT.
Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway.
Significance of the Lysyl Oxidase Members Lysyl Oxidase Like 1, 3, and 4 in Gastric Cancer.
Silencing of hypoxia-inducible tumor suppressor lysyl oxidase gene by promoter methylation activates carbonic anhydrase IX in nasopharyngeal carcinoma.
[Effect of lysyl oxidase on migration and adhesion of human gastric cancer HGC-27 cells in vitro].
[Expression of LOX and MMP-2 in gastric cancer tissue and the effects of LOX and MMP-2 on tumor invasion and metastasis].
Thrombosis
Biomechanical consequences of compromised elastic fiber integrity and matrix cross-linking on abdominal aortic aneurysmal enlargement.
Emerging Factors Implicated in Fibrotic Organ-Associated Thrombosis: The Case of Two Organs.
Lysyl oxidase is associated with increased thrombosis and platelet reactivity.
Thyroid Neoplasms
GINS2 promotes cell proliferation and inhibits cell apoptosis in thyroid cancer by regulating CITED2 and LOXL2.
Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness.
Tracheobronchomegaly
Neonatal deaths and pulmonary dysplasia due to D-penicillamine in the rat.
Tremor
Copper metabolism in mottled mouse mutants: copper therapy of brindled (Mobr) mice.
Triple Negative Breast Neoplasms
Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression.
LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells.
LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer.
Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer.
Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer.
Urinary Bladder Neoplasms
Hypermethylated SFRP1, but none of other nine genes "informative" for western countries, is valuable for bladder cancer detection in Mainland China.
LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer.
Lysyl oxidase family members in urological tumorigenesis and fibrosis.
miR-193a-3p regulates the multi-drug resistance of bladder cancer by targeting the LOXL4 gene and the Oxidative Stress pathway.
Urinary Incontinence
Expression and significance of lysyl oxidase-like 1 and fibulin-5 in the cardinal ligament tissue of patients with pelvic floor dysfunction.
TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like-1 gene may have a role in stress urinary incontinence physiopathology.
Uterine Cervical Neoplasms
Circular RNA circ_0000228 promotes the malignancy of cervical cancer via microRNA-195-5p/ lysyl oxidase-like protein 2 axis.
Inactivation of lysyl oxidase by ?-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells.
LOXL 2 Promotes The Epithelial-Mesenchymal Transition And Malignant Progression Of Cervical Cancer.
Lysyl Oxidase Genetic Variants Affect Gene Expression in Cervical Cancer.
Vascular Diseases
LOXL1 Gene Sequence Variants and Vascular Disease in Exfoliation Syndrome and Exfoliative Glaucoma.
PACE4 Proteolytically Processes LOXL2 with little impact on its catalytic activity.
Vascular System Injuries
Elastic tissue disruption is a major pathogenic factor to human vascular disease.
Lysyl oxidase expression in a rat model of arterial balloon injury.
Transforming growth factor-beta 1 increases lysyl oxidase enzyme activity and mRNA in rat aortic smooth muscle cells.
Venous Insufficiency
Down-regulation of lysyl oxydase-like in aging and venous insufficiency.
Vertigo
A novel genetic variant associated with benign paroxysmal positional vertigo within the LOXL1.
Vitamin B 6 Deficiency
The effect of pyridoxine deficiency on lysyl oxidase activity in the chick.
Vitamin D Deficiency
Vitamin D controls resistance artery function through regulation of perivascular adipose tissue hypoxia and inflammation.
Vitreoretinopathy, Proliferative
Effects of Lysyl Oxidase Genetic Variants on the Susceptibility to Rhegmatogenous Retinal Detachment and Proliferative Vitreoretinopathy.