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Information on EC 1.4.1.4 - glutamate dehydrogenase (NADP+)
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EC Tree
1.4.1.4 glutamate dehydrogenase (NADP+)Specify your search results
Word Map
- 1.4.1.4
- ammonia
- 2-oxoglutarate
- neurospora
- crassa
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6.3.1.2
- gogat
- nad-gdhs
- sorokiniana
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ammonium-inducible
- ectomycorrhizal
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phosphate-specific
- molecular biology
- analysis
- biotechnology
- synthesis
- agriculture
- medicine
- food industry
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
nadp-gdh, nadp-dependent glutamate dehydrogenase, nadp-glutamate dehydrogenase, nadp-specific glutamate dehydrogenase, nadp-linked glutamate dehydrogenase, nadph-dependent glutamate dehydrogenase, nadp+-dependent glutamate dehydrogenase, glutamate dehydrogenase (nadp+), nadp+-dependent gdh, nadp-dependent gdh, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
APE1386
BpNADPGDH I
BpNADPGDH II
dehydrogenase, glutamate (nicotinamide adenine dinucleotide phosphate)
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-
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GDH
GDH1
Gdh1p
GDH3
Gdh3p
GdhA
GDHB
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activity staining, inhibition and thermal stability studies indicate the carbon source-dependent presence of three (GDHA, GDHB and GDHC) forms of NADP-GDH in Pseudomonas aeruginosa strain PPD
GDHC
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activity staining, inhibition and thermal stability studies indicate the carbon source-dependent presence of three (GDHA, GDHB and GDHC) forms of NADP-GDH in Pseudomonas aeruginosa strain PPD
GDHI
GDHI'
GDHII
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activity staining, inhibition and thermal stability studies indicate the carbon source-dependent presence of two (GDHI and GDHII) forms of NADP-GDH in Pseudomonas aeruginosa strain PP4
GDHP
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activity staining, inhibition and thermal stability studies indicate the carbon source-dependent presence of one GDHP form of NADP-GDH in Acinetobacter lwoffii strain ISP4
GluDH
glutamate dehydrogenase
glutamate dehydrogenase 1
glutamate dehydrogenase 3
glutamic acid dehydrogenase
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glutamic dehydrogenase
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hyphal-form specific BpNADPGDH II
L-glutamate dehydrogenase
NAD(P)H-dependent glutamate dehydrogenase
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NADP(+)-dependent glutamate dehydrogenase
NADP(H)-dependent glutamate dehydrogenase
NADP(H)-GDH
NADP(H)-specific glutamate dehydrogenase
NADP+-dependent GDH
NADP+-dependent glutamate dehydrogenase
NADP+-Gdh
NADP-dependent GDH
NADP-dependent GluDH
NADP-dependent glutamate dehydrogenase
NADP-dependent glutamate dehydrogenase 1
NADP-dependent glutamate dehydrogenase 2
NADP-GDH
NADP-GDH 1
NADP-GDH 2
NADP-glutamate dehydrogenase
NADP-linked glutamate dehydrogenase
NADP-ylGdh1p
NADPH-dependent GDH
NADPH-dependent glutamate dehydrogenase
Pcal_1606
RocG
YALI0F17820g
yeast-form specific BpNADPGDH I
ylGDH1
GdhA
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activity staining, inhibition and thermal stability studies indicate the carbon source-dependent presence of three (GDHA, GDHB and GDHC) forms of NADP-GDH in Pseudomonas aeruginosa strain PPD
GDHI
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activity staining, inhibition and thermal stability studies indicate the carbon source-dependent presence of two (GDHI and GDHII) forms of NADP-GDH in Pseudomonas aeruginosa strain PP4
L-glutamate dehydrogenase
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NADP-dependent glutamate dehydrogenase
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2 isoenzymes: a yeast-form isoenzyme and a mycelium-form isoenzyme
NADP-GDH
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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oxidative deamination
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redox reaction
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reduction
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reductive amination
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
L-glutamate:NADP+ oxidoreductase (deaminating)
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CAS REGISTRY NUMBER
COMMENTARY
9029-11-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-aminopentanoate + H2O + NADP+
2-oxopentanoate + NH3 + NADPH + H+
-
activity with 2-oxovalerate amd 2-aminopentanoate is 25% and 17% compared to the activity with 2-oxoglutarate and L-glutamate
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r
2-oxovalerate + NADPH + NH3
L-2-aminovalerate + NADP+ + H2O
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15% of the activity with 2-oxoglutarate
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-
?
L-homoserine + H2O + NAD+
4-hydroxy-2-oxobutanoate + NH3 + NADH
-
-
-
?
2-oxoadipate + NADPH + NH3
L-2-aminoadipate + NADP+ + H2O
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6.3% of the activity with 2-oxoglutarate
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?
2-oxoadipate + NADPH + NH3
L-2-aminoadipate + NADP+ + H2O
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6.3% of the activity with 2-oxoglutarate
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?
2-oxobutanoate + NH3 + NADPH + H+
L-2-aminobutanoate + H2O + NADP+
2.6% of the activity with 2-oxoglutarate
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r
2-oxobutanoate + NH3 + NADPH + H+
L-2-aminobutanoate + H2O + NADP+
2.6% of the activity with 2-oxoglutarate
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r
2-oxobutyrate + NADPH + NH3
L-2-aminobutyrate + NADP+ + H2O
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12% of the activity with 2-oxoglutarate
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?
2-oxobutyrate + NADPH + NH3
L-2-aminobutyrate + NADP+ + H2O
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12% of the activity with 2-oxoglutarate
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?
2-oxoglutarate + NAD(P)H + NH3
L-glutamate + NAD(P)+ + H2O
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-
-
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?
2-oxoglutarate + NAD(P)H + NH3
L-glutamate + NAD(P)+ + H2O
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-
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?
2-oxoglutarate + NAD(P)H + NH3
L-glutamate + NAD(P)+ + H2O
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-
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?
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
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-
-
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r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
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-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
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-
-
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r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
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-
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?
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
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ammonia-assimilating enzyme
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r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
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ammonia-assimilating enzyme
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r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
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the enzyme primary functions to assimilate ammonium when its extracellular concentration is in a narrow range. The enzyme may not be the main enzyme for ammonia assimilation in Kluyveromyces marxianus
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?
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
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the enzyme primary functions to assimilate ammonium when its extracellular concentration is in a narrow range. The enzyme may not be the main enzyme for ammonia assimilation in Kluyveromyces marxianus
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?
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
Aeropyrum pernix K1 JCM 9820
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
Bacillus sp. (in: Bacteria) KSM-635
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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weak activity
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?
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
AKQ74236
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?
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
AKQ74236
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?
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
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r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
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r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
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136% of the activtiy with L-glutamate
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r