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2-aminopentanoate + H2O + NADP+
2-oxopentanoate + NH3 + NADPH + H+
-
activity with 2-oxovalerate amd 2-aminopentanoate is 25% and 17% compared to the activity with 2-oxoglutarate and L-glutamate
-
-
r
2-oxoadipate + NADPH + NH3
L-2-aminoadipate + NADP+ + H2O
2-oxobutanoate + NH3 + NADPH + H+
L-2-aminobutanoate + H2O + NADP+
2-oxobutyrate + NADPH + NH3
L-2-aminobutyrate + NADP+ + H2O
2-oxoglutarate + NAD(P)H + NH3
L-glutamate + NAD(P)+ + H2O
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
2-oxoglutarate + NH3 + NADH
L-glutamate + H2O + NAD+
-
-
-
-
r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADPH
L-glutamate + H2O + NADP+
-
-
-
-
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
2-oxovalerate + NADPH + NH3
L-2-aminovalerate + NADP+ + H2O
-
15% of the activity with 2-oxoglutarate
-
-
?
2-oxovalerate + NH3 + NADPH + H+
L-valine + H2O + NADP+
L-2-oxoglutarate + NADPH + NH3
glutamate + NADP+ + H2O
-
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + NAD(P)+ + H2O
2-oxoglutarate + NAD(P)H + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
L-homoserine + H2O + NAD+
4-hydroxy-2-oxobutanoate + NH3 + NADH
-
-
-
?
L-norvaline + H2O + NADP+
2-oxopentanoate + NH3 + NADPH + H+
additional information
?
-
2-oxoadipate + NADPH + NH3

L-2-aminoadipate + NADP+ + H2O
-
6.3% of the activity with 2-oxoglutarate
-
-
?
2-oxoadipate + NADPH + NH3
L-2-aminoadipate + NADP+ + H2O
-
6.3% of the activity with 2-oxoglutarate
-
-
?
2-oxobutanoate + NH3 + NADPH + H+

L-2-aminobutanoate + H2O + NADP+
2.6% of the activity with 2-oxoglutarate
-
-
r
2-oxobutanoate + NH3 + NADPH + H+
L-2-aminobutanoate + H2O + NADP+
2.6% of the activity with 2-oxoglutarate
-
-
r
2-oxobutyrate + NADPH + NH3

L-2-aminobutyrate + NADP+ + H2O
-
12% of the activity with 2-oxoglutarate
-
-
?
2-oxobutyrate + NADPH + NH3
L-2-aminobutyrate + NADP+ + H2O
-
12% of the activity with 2-oxoglutarate
-
-
?
2-oxoglutarate + NAD(P)H + NH3

L-glutamate + NAD(P)+ + H2O
-
-
-
-
?
2-oxoglutarate + NAD(P)H + NH3
L-glutamate + NAD(P)+ + H2O
-
-
-
-
?
2-oxoglutarate + NAD(P)H + NH3
L-glutamate + NAD(P)+ + H2O
-
-
-
-
?
2-oxoglutarate + NAD(P)H + NH3
L-glutamate + NAD(P)+ + H2O
-
-
-
?
2-oxoglutarate + NAD(P)H + NH3
L-glutamate + NAD(P)+ + H2O
-
-
-
-
?
2-oxoglutarate + NAD(P)H + NH3
L-glutamate + NAD(P)+ + H2O
-
-
-
?
2-oxoglutarate + NAD(P)H + NH3
L-glutamate + NAD(P)+ + H2O
-
-
-
?
2-oxoglutarate + NAD(P)H + NH3
L-glutamate + NAD(P)+ + H2O
-
-
-
?
2-oxoglutarate + NADPH + NH3

L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
?
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
?
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
?
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
?
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
ammonia-assimilating enzyme
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
ammonia-assimilating enzyme
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
the enzyme primary functions to assimilate ammonium when its extracellular concentration is in a narrow range. The enzyme may not be the main enzyme for ammonia assimilation in Kluyveromyces marxianus
-
-
?
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
the enzyme primary functions to assimilate ammonium when its extracellular concentration is in a narrow range. The enzyme may not be the main enzyme for ammonia assimilation in Kluyveromyces marxianus
-
-
?
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
?
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
?
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
-
-
-
r
2-oxoglutarate + NH3 + NADH + H+

L-glutamate + H2O + NAD+
-
NH4Cl used in enzyme assay
-
-
r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
NH4Cl used in enzyme assay
-
-
r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
NH4Cl used in enzyme assay
-
-
r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
NH4Cl used in enzyme assay
-
-
r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
NH4Cl used in enzyme assay
-
-
r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
NH4Cl used in enzyme assay
-
-
r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
-
-
r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
-
-
r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
NH4Cl used in enzyme assay
-
-
r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
NH4Cl used in enzyme assay
-
-
r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
NH4Cl used in enzyme assay
-
-
r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
NH4Cl used in enzyme assay
-
-
r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
weak activity
-
-
?
2-oxoglutarate + NH3 + NADPH + H+

L-glutamate + H2O + NADP+
AKQ74236
-
-
-
?
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
AKQ74236
-
-
-
?
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
-
-
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
-
-
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
136% of the activtiy with L-glutamate
-
-
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
136% of the activtiy with L-glutamate
-
-
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
-
-
-
?
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
-
-
-
?
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
-
-
-
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
-
-
-
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
-
-
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
referred reaction
-
-
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
-
-
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
-
-
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
-
-
-
ir
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
-
-
-
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
-
-
-
r
2-oxoglutarate + NH4+ + NADPH

L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
Thermophilic bacillus
-
-
-
-
?
2-oxoglutarate + NH4+ + NADPH
L-glutamate + NADP+
-
-
-
-
?
2-oxovalerate + NH3 + NADPH + H+

L-valine + H2O + NADP+
4.2% of the activity with 2-oxoglutarate
-
-
r
2-oxovalerate + NH3 + NADPH + H+
L-valine + H2O + NADP+
4.2% of the activity with 2-oxoglutarate
-
-
r
L-glutamate + H2O + NADP+

2-oxoglutarate + NH3 + NADPH
-
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH
-
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH
-
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH
-
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH
-
-
-
-
?
L-glutamate + H2O + NADP+

2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
usage of NH4Cl as substrate for the reverse reaction
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
usage of NH4Cl as substrate for the reverse reaction
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
the enzyme shows a strict specificity for L-glutamate and NADP+ on oxidative deamination and for 2-oxoglutarate and NADPH on reductive amination. No activity with the following amino acids in oxidative deamination: D-glutamate, L-norvaline, L-2-aminobutyrate, L-valine, L-alanine, L-aspartate, L-serine, L-cysteine, L-lysine, or L-phenylalanin. No activity with the following amino acids in reductive amination: pyruvate, 2-oxovalerate, 2-oxoisocaproate, 2-oxobutyrate, or 2-oxoisovalerate
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
the enzyme shows a strict specificity for L-glutamate and NADP+ on oxidative deamination and for 2-oxoglutarate and NADPH on reductive amination
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
the enzyme shows a strict specificity for L-glutamate and NADP+ on oxidative deamination and for 2-oxoglutarate and NADPH on reductive amination
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
AKQ74236
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
AKQ74236
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
reaction cycle, specificities of forward and reverse reactions, overview
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
reaction cycle, overview
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
usage of NH4Cl as substrate for the reverse reaction
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
usage of NH4Cl as substrate for the reverse reaction
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + NADP+ + H2O

2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
biphasic kinetic behavior for ammonia, biphasic kinetic behavior for L-glutamate
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
biphasic kinetic behavior for ammonia
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
biphasic kinetic behavior for ammonia
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
biphasic kinetic behavior for ammonia
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
biphasic kinetic behavior for ammonia
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
biphasic kinetic behavior for ammonia
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
Thermophilic bacillus
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
biphasic kinetic behavior for ammonia
r
L-norvaline + H2O + NADP+

2-oxopentanoate + NH3 + NADPH + H+
3% of the activity with L-glutamate
-
-
r
L-norvaline + H2O + NADP+
2-oxopentanoate + NH3 + NADPH + H+
3% of the activity with L-glutamate
-
-
r
additional information

?
-
-
glutamate dehydrogenase functions physiologically for the synthesis of L-glutamate from 2-oxoglutarate and ammonia
-
-
?
additional information
?
-
-
no reaction with D-glutamate, L-glutamine or DL-2-hydroxyglutarate as possible substrates in place of L-glutamate, methylamine is unable to replace ammonium in the biosynthetic reaction
-
-
?
additional information
?
-
-
no reaction with D-glutamate, L-glutamine or DL-2-hydroxyglutarate as possible substrates in place of L-glutamate, methylamine is unable to replace ammonium in the biosynthetic reaction
-
-
?
additional information
?
-
-
the yeast form specific isoenzyme is induced in presence of glucose, the mycelium-form is not induced. Possible involvement of the enzyme in yeast-mycelium transition
-
-
?
additional information
?
-
-
enzyme synthesis is increased under hyperosmotic conditions in the halotolerant yeast
-
-
?
additional information
?
-
-
enzyme synthesis is increased under hyperosmotic conditions in the halotolerant yeast
-
-
?
additional information
?
-
-
enzyme additionally shows activity towards hexanol and isoamyl alcohol
-
-
?
additional information
?
-
-
enzyme additionally shows activity towards hexanol and isoamyl alcohol
-
-
?
additional information
?
-
-
no activity with 2-oxoisovalerate and pyruvate
-
-
?
additional information
?
-
-
no activity with 2-oxoisovalerate and pyruvate
-
-
?
additional information
?
-
-
the enzyme is encoded by gdhA. In strains expressing high levels of gdhA mRNA, two promoters, gdhA P1 and gdhA P2, initiate transcription of gdhA. In strains expressing low mRNA levels, gdhA P2 is not active because of weak expression of GdhR, an associated regulatory gene. 2-Oxoglutarate inhibits binding of GdhR to gdhA P2
-
-
?
additional information
?
-
Like PfGDH1, PfGDH2 is an NADP(H)-dependent enzyme with a specific activity comparable to PfGDH1 but with slightly higher Km values for its substrates
-
-
?
additional information
?
-
Like PfGDH1, PfGDH2 is an NADP(H)-dependent enzyme with a specific activity comparable to PfGDH1 but with slightly higher Km values for its substrates
-
-
?
additional information
?
-
PfGDH1, like PfGDH2, is an NADP(H)-dependent enzyme with a specific activity comparable to PfGDH2 but with slightly lower Km values for its substrates
-
-
?
additional information
?
-
PfGDH1, like PfGDH2, is an NADP(H)-dependent enzyme with a specific activity comparable to PfGDH2 but with slightly lower Km values for its substrates
-
-
?
additional information
?
-
the enzyme also shows low activity with NAD+/NADH, 17% and 7% of the activity with NADP+ and NADPH, respectively. The enzyme also shows low activity with L-norvaline as substrates for oxidative deamination, and with 2-oxovalerate and 2-oxobutyrate for reducive amination, substrate specificity, overview. No activity with L-glutamine, L-alanine, L-aspartate, L-cysteine, L-serine, L-lysine, L-phenylalanine, and L-tryptophan, or with 2-oxoisocaproate, 2-oxocaproate, and pyruvate
-
-
?
additional information
?
-
the enzyme also shows low activity with NAD+/NADH, 17% and 7% of the activity with NADP+ and NADPH, respectively. The enzyme also shows low activity with L-norvaline as substrates for oxidative deamination, and with 2-oxovalerate and 2-oxobutyrate for reducive amination, substrate specificity, overview. No activity with L-glutamine, L-alanine, L-aspartate, L-cysteine, L-serine, L-lysine, L-phenylalanine, and L-tryptophan, or with 2-oxoisocaproate, 2-oxocaproate, and pyruvate
-
-
?
additional information
?
-
-
in yeast, NADP+-dependent enzymes, EC 1.4.1.4, encoded by GDH1 and GDH3, are reported to synthesize glutamate from 2-oxtoglutarate, while an NAD+-dependent enzyme, EC 1.4.1.2, encoded by GDH2, catalyzes the reverse reaction. Gdh1p is the primary GDH enzyme and Gdh2p and Gdh3p play evident roles during aerobic glutamate metabolism
-
-
?
additional information
?
-
-
glutamate dehydrogenase represents an enzymatic link between major catabolic and biosynthetic pathways via the tricarboxylic acid cycle intermediate 2-oxoglutarate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
additional information
?
-
2-oxoglutarate + NADPH + NH3

L-glutamate + NADP+ + H2O
-
ammonia-assimilating enzyme
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
ammonia-assimilating enzyme
-
-
r
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
the enzyme primary functions to assimilate ammonium when its extracellular concentration is in a narrow range. The enzyme may not be the main enzyme for ammonia assimilation in Kluyveromyces marxianus
-
-
?
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
the enzyme primary functions to assimilate ammonium when its extracellular concentration is in a narrow range. The enzyme may not be the main enzyme for ammonia assimilation in Kluyveromyces marxianus
-
-
?
2-oxoglutarate + NH3 + NADPH + H+

L-glutamate + H2O + NADP+
-
-
-
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
-
-
-
ir
L-glutamate + H2O + NADP+

2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
reaction cycle, specificities of forward and reverse reactions, overview
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
-
-
-
r
L-glutamate + NADP+ + H2O

2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
Thermophilic bacillus
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
-
-
-
r
additional information

?
-
-
glutamate dehydrogenase functions physiologically for the synthesis of L-glutamate from 2-oxoglutarate and ammonia
-
-
?
additional information
?
-
-
the yeast form specific isoenzyme is induced in presence of glucose, the mycelium-form is not induced. Possible involvement of the enzyme in yeast-mycelium transition
-
-
?
additional information
?
-
-
enzyme synthesis is increased under hyperosmotic conditions in the halotolerant yeast
-
-
?
additional information
?
-
-
enzyme synthesis is increased under hyperosmotic conditions in the halotolerant yeast
-
-
?
additional information
?
-
-
the enzyme is encoded by gdhA. In strains expressing high levels of gdhA mRNA, two promoters, gdhA P1 and gdhA P2, initiate transcription of gdhA. In strains expressing low mRNA levels, gdhA P2 is not active because of weak expression of GdhR, an associated regulatory gene. 2-Oxoglutarate inhibits binding of GdhR to gdhA P2
-
-
?
additional information
?
-
Like PfGDH1, PfGDH2 is an NADP(H)-dependent enzyme with a specific activity comparable to PfGDH1 but with slightly higher Km values for its substrates
-
-
?
additional information
?
-
Like PfGDH1, PfGDH2 is an NADP(H)-dependent enzyme with a specific activity comparable to PfGDH1 but with slightly higher Km values for its substrates
-
-
?
additional information
?
-
PfGDH1, like PfGDH2, is an NADP(H)-dependent enzyme with a specific activity comparable to PfGDH2 but with slightly lower Km values for its substrates
-
-
?
additional information
?
-
PfGDH1, like PfGDH2, is an NADP(H)-dependent enzyme with a specific activity comparable to PfGDH2 but with slightly lower Km values for its substrates
-
-
?
additional information
?
-
-
in yeast, NADP+-dependent enzymes, EC 1.4.1.4, encoded by GDH1 and GDH3, are reported to synthesize glutamate from 2-oxtoglutarate, while an NAD+-dependent enzyme, EC 1.4.1.2, encoded by GDH2, catalyzes the reverse reaction. Gdh1p is the primary GDH enzyme and Gdh2p and Gdh3p play evident roles during aerobic glutamate metabolism
-
-
?
additional information
?
-
-
glutamate dehydrogenase represents an enzymatic link between major catabolic and biosynthetic pathways via the tricarboxylic acid cycle intermediate 2-oxoglutarate
-
-
?
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2,4-pyridinedicarboxylate
2-hydroxyethyl disulfide
attenuation of reductive amination (forward) activity but a negligible effect on oxidative deamination (reverse) activity
Ag2+
-
at 1 mM, 60% inhibition
AgNO3
-
1 mM, 30°C, complete loss of aminating activity
BaCl2
-
1 mM, 30°C, 15% loss of aminating activity
CaCl2
-
1 mM, 30°C, 11% loss of aminating activity
CH2ICOOH
-
1 mM, 30°C, 15% loss of aminating activity
cystine
strongly and selectively inhibits the reductive amination reaction
dimethyl ester of isophthalic acid
-
dimethyl ester of isophthalate (DMIP), but not isophthalate, inhibits Aspergillus niger growth on agar as well as in liquid culture. This is ascribed to the inability of isophthalate to enter fungal mycelia. Dimethyl ester of isophthalic acid is hydrolysed intracellularly to isophthalate. Subsequent to DMIP addition, intracellular isophthalate can be demonstrated. Addition of NH4+ to DMIP-treated Aspergillus niger mycelia results in intensive vacuolation, retraction of cytoplasm and autolysis
dithiothreitol
-
1 mM, 30.7% residual activity
EDTA
-
1 mM, 5.3% residual activity
FeSO3(NH4)2SO4
-
1 mM, 30°C, 14% loss of aminating activity
glutamate
-
competitive inhibitor of the amination reaction
Glutaric acid
-
at 20 mM, 25% inhibition
glyoxylate
-
at 20 mM, 30% inhibition
Hexachlorophene
15% inhibition at 0.016 mM; 80% inhibition at 0.016 mM
hydroxylamine
-
competitive inhibitor with ammonia and uncompetitive inhibitor with both 2-oxoglutarate and NADPH
iodoacetamide
-
at 4 mM, complete inactivation
isocitrate
10 M, 64% of initial activity
L-glutamate
-
substrate inhibition above 15 mM
L-Glutamic acid
-
at 20 mM 25% inhibition
L-homoserine
-
competitive inhibitor with respect to both ammonia and glutamine
L-tryptophan
-
at 20 mM, 15% inhibition
N-ethylmaleimide
-
at 0.8 mM, 44% inhibition
NAD+
-
0.3 mM, 50.5% residual activity
NADH
-
0.3 mM, 5.3% residual activity
NADP+
-
inhibits at higher 2-oxoglutarate levels
NADPH
-
0.3 mM, 3.8% residual activity
nitrogen assimilation control protein
-
represses the transcription of the gene gdhA
-
p-chloromercuriphenyl sulfonate
-
inactivetes, can be reversed by addition of cysteine
p-hydroxymercuribenzoic acid
Pb2+
-
5 mM, 19.8% residual activity
potassium phosphate
-
over 0.1 M at oxidative deamination
pyruvate
-
at 10 mM slight inhibitory
sodium dodecylsulfate
-
at 0.7% w/v after 1 h 5% activity
succinate
-
competitive inhibitor with 2 oxoglutarate, uncompetitive with NADPH and non-competitive with ammonia
2,4-pyridinedicarboxylate

-
-
2,4-pyridinedicarboxylate
-
inhibits less efficiently
2,4-pyridinedicarboxylate
-
weak inhibitor
2-Methyleneglutarate

-
-
2-Methyleneglutarate
-
weak inhibitor
2-oxoglutarate

-
shows allosteric properties and a sigmoid response (nH=2.5) towards 2-oxoglutarate saturation
2-oxoglutarate
-
substrate inhibition above 2.0 mM
2-oxoglutarate
-
competitive inhibitor of the deamination
4-chloromercuribenzoate

-
at 1 mM, 86% inhibition
4-chloromercuribenzoate
-
at 1 mM and 10 mM, 30% inhibition and 100% inhibition
4-chloromercuribenzoate
-
at 0.01 mM, 35% inhibition
ADP

-
at 4 mM slight inhibitory
ADP
-
at 0.3 mM, 22% inhibition of oxidative deamination
ADP
-
at 1 mM, 57% inhibition for oxidative deamination and 23% inhibition for reductive amination respectively
AlCl3

-
1 mM, 30°C, 23% loss of aminating activity
AlCl3
-
at 1 mM, 30% inhibition
AlCl3
-
at 1 mM, 21% inhibition
AMP

-
slight inhibitory
AMP
-
inhibitory at higher concentrations than 1 mM
AMP
-
at 0.3 mM 33% inhibition of oxidative deamination
ATP

-
at 4 mM slight inhibitory
ATP
-
1 mM, 14.4% residual activity
Ca2+

-
at 1 mM 27% inhibition
Ca2+
-
5 mM, 93.5% residual activity
fumarate

-
at 5 mM 20% inhibition
fumarate
-
at 20 mM 30% inhibition
guanidine hydrochloride

-
complete loss of activity
guanidine hydrochloride
-
complete loss of activity
Hg2+

-
at 1 mM, 70% inhibition
Hg2+
-
at 1 mM, 100% activity loss
Hg2+
-
at 1 mM, 10% inhibition
Hg2+
-
at 1 mM, 100% activity loss
Hg2+
1 mM, 76% residual activity
Hg2+
-
at 0.1 mM, complete activity loss
HgCl2

-
1 mM, 30°C, 48% loss of aminating activity
HgCl2
-
at 1 mM, 64% inhibition
HgCl2
-
at 1 mM, 45% inhibition
HgCl2
-
at 0.01 mM, 27% inhibition
HgCl2
-
at 1 mM, no activity, oxidative deamination
isophthalate

-
-
isophthalate
-
a competitive inhibitor of glutamate dehydrogenase, is involved in C and N metabolism
isophthalate
-
potent in vitro inhibitor
isophthalate
-
weak inhibitor
isophthalate
-
a competitive inhibitor of glutamate dehydrogenase, is involved in C and N metabolism
KCl

-
500 mM, 80-90% inhibition, by high ionic strength
KCl
100 mM, 45% residual activity
KCl
1 M, 30% loss of activity
malate

-
at 5 mM, 20% inhibition
malate
-
at 20 mM, 30% inhibition
Mg2+

-
at 1 mM, 16% activity loss
Mg2+
-
5 mM, 68% residual activity
Mn2+

-
at 1 mM, 19% activity loss
Mn2+
-
5 mM, 51.8% residual activity
MnCl2

-
at 1 mM, 63% inhibition
MnCl2
-
at 1 mM, 20% inhibition
NaCl

-
50 mM, 50% inhibition. 100 mM, about 60% inhibition. 500 mM, about 90% inhibition by high ionic strength
NaCl
100 mM, 59% residual activity
NH4+

-
-
NH4+
-
inhibits the oxidative deamination activity as a product, inhibition is non-competitive with respect to L-glutamate
oxaloacetate

-
at 20 mM slight inhibitory
oxaloacetate
-
at 20 mM, 60% inhibition
oxaloacetate
10 mM, 63% residual activity
p-hydroxymercuribenzoic acid

-
at 0.08 mM, 50% inhibition
p-hydroxymercuribenzoic acid
-
at 10 mM, 90% inhibition after 40 min
Pb(CH3COO)2

-
at 1 mM, 59% inhibition
Pb(CH3COO)2
-
at 1 mM, 64% inhibition
pyridoxal 5'-phosphate

-
at 10 mM, 90% inhibition, complete protection when 16.8 mM 2-oxoglutarate and 1.68 mM NADP+ are added
pyridoxal 5'-phosphate
-
at 1 mM, 35% inhibition
pyridoxal 5'-phosphate
-
at 1 mM, 45% inhibition
Urea

-
at 0°C 1 h at 2 M 65% inhibition
Urea
-
at 8 M stable for 10 min
Urea
-
no activity at 6 mM
Urea
-
inactivation with 2 mM urea
Urea
-
fully active at 20°C in 8 mM urea
Zn2+

-
at 1 mM, 64% activity loss
Zn2+
-
at 1 mM, 40% inhibition
additional information

-
not inhibited by D-glutamate, L-glutamine or DL-2-hydroxyglutarate
-
additional information
not inhibitory/activating: oxidized glutathione
-
additional information
-
not inhibitory/activating: oxidized glutathione
-
additional information
-
2-oxoglutarate and NH3 show substrate inhibition
-
additional information
inhibitors hexachlorophene, GW5074, and bithionol are more effective on PfGDH2 than on PfGDH1; inhibitors hexachlorophene, GW5074, and bithionol are more effective on PfGDH2 than on PfGDH1
-
additional information
inhibitors hexachlorophene, GW5074, and bithionol are more effective on PfGDH2 than on PfGDH1; inhibitors hexachlorophene, GW5074, and bithionol are more effective on PfGDH2 than on PfGDH1
-
additional information
-
no effect: EDTA, o-phenanthroline, sodium azide, 8-hydroxyquinoline in the concentration raneg of 1-10 mM
-
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0.004 - 606
2-oxoglutarate
0.0417 - 1349
L-glutamate
3.629
NAD+
-
pH 9.0, 50°C
additional information
additional information
-
0.004
2-oxoglutarate

-
pH not specified in the publication, 30°C
0.018
2-oxoglutarate
-
pH 8.5, 40°C
0.16
2-oxoglutarate
-
reductive amination at 80°C
0.2
2-oxoglutarate
-
reductive amination
0.2
2-oxoglutarate
pH 7.0, 25°C, recombinant enzyme
0.27
2-oxoglutarate
pH 8.0, 80°C
0.28
2-oxoglutarate
-
reductive amination
0.31
2-oxoglutarate
-
isoform Gdh1, pH 5.8, 30°C
0.32
2-oxoglutarate
-
reductive amination
0.34
2-oxoglutarate
-
reductive amination at 25°C
0.34
2-oxoglutarate
-
pH 5.8, 30°C
0.36
2-oxoglutarate
-
reductive amination
0.365
2-oxoglutarate
pH 7.0, 25°C, recombinant enzyme
0.37
2-oxoglutarate
-
isoform Gdh1, pH 7.5, 30°C
0.4
2-oxoglutarate
-
reductive amination
0.4
2-oxoglutarate
-
isoform Gdh3, pH 7.5, 30°C
0.46
2-oxoglutarate
-
pH 7.5, 30°C
0.5
2-oxoglutarate
-
reductive amination
0.5
2-oxoglutarate
-
reductive amination at 60°C
0.64
2-oxoglutarate
-
reductive amination
0.64
2-oxoglutarate
-
reductive amination
0.68
2-oxoglutarate
-
in the presence of 100 mM NH4Cl, at 25°C and pH 8
0.68
2-oxoglutarate
-
wild-type EcGDH, Vmax: 464 micromol/min/mg, pH 8.0, 25°C
0.77
2-oxoglutarate
-
reductive amination
0.89
2-oxoglutarate
wild-type, pH 7.0,30°C
0.93
2-oxoglutarate
-
reductive amination
1
2-oxoglutarate
-
reductive amination
1.1
2-oxoglutarate
-
in the presence of 200 mM NH4Cl, at 25°C and pH 8
1.2
2-oxoglutarate
-
reductive amination
1.25
2-oxoglutarate
-
reductive amination
1.3
2-oxoglutarate
Thermophilic bacillus
-
reductive amination
1.48
2-oxoglutarate
-
isoform Gdh3, S0.5 value, Hill coefficient 2.4, pH 5.8, 30°C
1.5
2-oxoglutarate
-
reductive amiantion
1.54
2-oxoglutarate
-
reductive amination
1.7
2-oxoglutarate
-
reductive amination at 50°C
1.7
2-oxoglutarate
-
reductive amination at 80°C
1.7
2-oxoglutarate
pH 9.0, 50°C
1.7
2-oxoglutarate
pH 8.3, 50°C
1.7
2-oxoglutarate
pH 9.5, 50°C, recombinant enzyme
1.95
2-oxoglutarate
-
S0.5 value, Hill coefficient 4, pH 5.8, 30°C
2
2-oxoglutarate
-
reductive amination at 0.6 M NH4Cl
2
2-oxoglutarate
-
reductive amination at 56°C
2.2
2-oxoglutarate
-
pH 8.0, 25°C
2.41
2-oxoglutarate
-
reductive amination
2.5 - 3
2-oxoglutarate
-
in the presence of 400 mM NH4Cl, at 25°C and pH 8
3
2-oxoglutarate
-
reductive amination at 25°C
3
2-oxoglutarate
-
reductive amination at 25°C
3.13
2-oxoglutarate
-
reductive amination at 30°C
3.2
2-oxoglutarate
-
reductive amination at 33°C
3.2
2-oxoglutarate
-
pH 7.0, 38.5°C, DELTA40N-homohexamer
3.25
2-oxoglutarate
-
reductive amination
3.61
2-oxoglutarate
-
S0.5 value, Hill coefficient 4.4, pH 7.5, 30°C
3.97
2-oxoglutarate
-
pH 8.0, 30°C, recombinant enzyme
4
2-oxoglutarate
-
reductive amination
4
2-oxoglutarate
mutant C141S, S0.5 value, Hill coefficient 2.3, pH 8.0, temperature not specified in the publication
4.73
2-oxoglutarate
AKQ74236
25°C, pH 7.5
4.78
2-oxoglutarate
-
28°C
4.78
2-oxoglutarate
wild-type, S0.5 value, Hill coefficient 3.2, pH 8.0, temperature not specified in the publication
5
2-oxoglutarate
-
reductive amination
5
2-oxoglutarate
-
pH 7.0, 38.5°C, alpha-homohexamer
5.6
2-oxoglutarate
-
reductive amination
5.7
2-oxoglutarate
recombinant wild-type, S0.5 value, Hill coefficient 3.5, pH 8.0, temperature not specified in the publication
6
2-oxoglutarate
-
pH 7.6, 60°C
6.8
2-oxoglutarate
-
pH 7.0, 38.5°C, beta-homohexamer
9
2-oxoglutarate
-
reductive amination at 1 M NH4Cl
15.5
2-oxoglutarate
mutant C415S, S0.5 value, Hill coefficient 4.9, pH 8.0, temperature not specified in the publication
25.1
2-oxoglutarate
wild-type inactivated by 2-hydroxyethyl disulfide, S0.5 value, Hill coefficient 2.4, pH 8.0, temperature not specified in the publication
285
2-oxoglutarate
-
chimeric protein CEC consisting of the substrate-binding domain of CsGDH and the coenzyme-binding domain of Escherichia coli GDH, 781 mM NH4Cl, Vmax: 2260 micromol/min/mg, pH 8.0, 25°C
606
2-oxoglutarate
-
chimeric protein CEC consisting of the substrate-binding domain of CsGDH and the coenzyme-binding domain of Escherichia coli GDH, 1800 mM NH4Cl, Vmax: 200 micromol/min/mg, pH 8.0, 25°C
0.0417
L-glutamate

-
pH not specified in the publication, 30°C
0.22
L-glutamate
-
oxidative deamination at 80°C
0.6
L-glutamate
-
pH 7.6, 60°C
0.61
L-glutamate
pH 8.0, 25°C, recombinant enzyme
1.05
L-glutamate
pH 8.0, 25°C, recombinant enzyme
1.1
L-glutamate
Thermophilic bacillus
-
oxidative deamination
1.3
L-glutamate
-
oxidative deamination
1.3
L-glutamate
pH 8.0, 80°C
2
L-glutamate
-
reductive amination
2.2
L-glutamate
-
oxidative deamination
2.3
L-glutamate
-
oxidative deamination
2.3
L-glutamate
-
oxidative deamination
2.3
L-glutamate
-
at 25°C and pH 8
2.3
L-glutamate
-
wild-type EcGDH, Vmax: 37.9 micromol/min/mg, pH 8.0, 25°C
3.2
L-glutamate
-
oxidative deamination at 25°C
3.3
L-glutamate
-
oxidative deamination at 50°C
3.3
L-glutamate
pH 8.3, 50°C
3.4
L-glutamate
pH 10.5, 50°C, recombinant enzyme
3.4
L-glutamate
pH 9.5, 50°C
3.7
L-glutamate
-
reductive amination
3.9
L-glutamate
-
oxidative deamination at 60°C
5.18
L-glutamate
-
oxidative deamination
5.5
L-glutamate
-
oxidative deamination
6.06
L-glutamate
-
oxidative deamination at 30°C
6.36
L-glutamate
-
oxidative deamination, Gdh3p gene
9.12
L-glutamate
-
oxidative deamination at 80°C
9.79
L-glutamate
-
oxidative deamination, Gdh1p gene
10
L-glutamate
-
oxidative deamination
14.2
L-glutamate
-
oxidative deamination
15.15
L-glutamate
-
pH 8.0, 30°C, recombinant enzyme
18
L-glutamate
-
oxidative deamination, biphasic kinetics
21
L-glutamate
-
pH 7.0, 38.5°C, beta-homohexamer
23.29
L-glutamate
AKQ74236
25°C, pH 7.5
25
L-glutamate
-
pH 7.0, 38.5°C, DELTA40N-homohexamer
27
L-glutamate
-
oxidative deamination at 33°C
28.6
L-glutamate
-
oxidative deamination
28.6
L-glutamate
mutant C141S, pH 9.3, temperature not specified in the publication
29
L-glutamate
-
oxidative deamination
30.9
L-glutamate
recombinant wild-type, pH 9.3, temperature not specified in the publication
32.3
L-glutamate
-
oxidative deamination
34
L-glutamate
-
pH 7.0, 38.5°C, alpha-homohexamer
34.6
L-glutamate
wild-type, pH 9.3, temperature not specified in the publication
36.8
L-glutamate
mutant C415S, pH 9.3, temperature not specified in the publication
38.2
L-glutamate
-
oxidative deamination
44
L-glutamate
-
oxidative deamination
49.8
L-glutamate
wild-type inactivated by 2-hydroxyethyl disulfide, S0.5 value, Hill coefficient 1.9, pH 9.3, temperature not specified in the publication
50
L-glutamate
wild-type, pH 7.0,30°C
67.4
L-glutamate
-
oxidative deamination
79
L-glutamate
-
oxidative deamination
81
L-glutamate
-
oxidative deamination, biphasic kinetics
225
L-glutamate
-
oxidative deamination
1349
L-glutamate
-
chimeric protein CEC consisting of the substrate-binding domain of CsGDH and the coenzyme-binding domain of Escherichia coli GDH, Vmax: 121.9 micromol/min/mg, pH 8.0, 25°C
0.16
NADH

wild-type, pH 7.0,30°C
0.36
NADH
-
pH 7.6, 50°C
0.368
NADH
-
pH 9.0, 50°C
0.69
NADH
mutant K136A, pH 7.0,30°C
0.00007
NADP+

-
pH not specified in the publication, 30°C
0.0064
NADP+
-
oxidative deamination
0.0098
NADP+
-
recombinant enzyme, oxidative deamination
0.01
NADP+
-
oxidative deamination at 25°C
0.0102
NADP+
-
wild-type enzyme, oxidative deamination
0.0105
NADP+
-
oxidative deamination, Gdh3p gene
0.013
NADP+
-
oxidative deamination
0.013
NADP+
-
oxidative deamination
0.0141
NADP+
-
oxidative deamination, Gdh1p gene
0.015
NADP+
-
pH 7.0, 38.5°C, DELTA40N-homohexamer
0.017
NADP+
wild-type, pH 9.3, temperature not specified in the publication
0.018
NADP+
-
wild-type EcGDH, Vmax: 45.6 micromol/min/mg, pH 8.0, 25°C
0.0184
NADP+
wild-type enzyme, pH 8.0, temperature not specified in the publication
0.019
NADP+
pH 8.0, 25°C, recombinant enzyme
0.02
NADP+
-
pH 7.6, 60°C
0.02
NADP+
pH 8.0, 25°C, recombinant enzyme
0.022
NADP+
wild-type inactivated by 2-hydroxyethyl disulfide, pH 9.3, temperature not specified in the publication
0.023
NADP+
-
oxidative deamination
0.027
NADP+
-
pH 7.0, 38.5°C, alpha-homohexamer
0.028
NADP+
-
pH 7.0, 38.5°C, beta-homohexamer
0.028
NADP+
recombinant wild-type, pH 9.3, temperature not specified in the publication
0.029
NADP+
-
oxidative deamination at 80°C
0.029
NADP+
-
oxidative deamination at 30°C
0.03
NADP+
-
oxidative deamination
0.031
NADP+
-
oxidative deamination
0.0328
NADP+
mutant K289Q, pH 8.0, temperature not specified in the publication
0.035
NADP+
pH 10.5, 50°C, recombinant enzyme
0.035
NADP+
pH 9.5, 50°C
0.038
NADP+
-
oxidative deamination at 80°C
0.039
NADP+
-
oxidative deamination
0.039
NADP+
-
oxidative deamination at 50°C
0.039
NADP+
pH 8.3, 50°C
0.04
NADP+
-
oxidative deamination
0.04
NADP+
-
oxidative deamination
0.041
NADP+
-
pH 8.0, 30°C, recombinant enzyme
0.042
NADP+
-
oxidative deamination
0.043
NADP+
-
oxidative deamination
0.043
NADP+
-
oxidative deamination
0.044
NADP+
-
oxidative deamination
0.045
NADP+
-
oxidative deamination
0.05
NADP+
-
oxidative deamination
0.053
NADP+
-
oxidative deam