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Information on EC 1.3.8.3 - (R)-benzylsuccinyl-CoA dehydrogenase

for references in articles please use BRENDA:EC1.3.8.3

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IUBMB Comments

Requires FAD as prosthetic group. Unlike other acyl-CoA dehydrogenases, this enzyme exhibits high substrate- and enantiomer specificity; it is highly specific for (R)-benzylsuccinyl-CoA and is inhibited by (S)-benzylsuccinyl-CoA. Forms the third step in the anaerobic toluene metabolic pathway in Thauera aromatica. Ferricenium ion is an effective artificial electron acceptor.

The expected taxonomic range for this enzyme is: Bacteria, Archaea

Synonyms
(r)-benzylsuccinyl-coa dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-2-benzylsuccinyl-CoA + electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + reduced electron-transferring flavoprotein
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
toluene degradation to benzoyl-CoA (anaerobic)
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