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Information on EC 1.3.8.10 - cyclohex-1-ene-1-carbonyl-CoA dehydrogenase
for references in articles please use BRENDA:EC1.3.8.10
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EC Tree 1 Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.8 With a flavin as acceptor
1.3.8.10 cyclohex-1-ene-1-carbonyl-CoA dehydrogenase
IUBMB Comments
Contains FAD. The enzyme, characterized from the strict anaerobic bacterium Syntrophus aciditrophicus, is involved in production of cyclohexane-1-carboxylate, a byproduct produced by that organism during fermentation of benzoate and crotonate to acetate.
The enzyme appears in viruses and cellular organisms
Reaction Schemes
showSynonyms
ch1coa dehydrogenase, cyclohexanecarboxyl-coa dehydrogenase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Ch1CoA dehydrogenase
cyclohex-1-ene-1-carboxyl-CoA dehydrogenase
cyclohexanecarboxyl-CoA dehydrogenase
Gmet_3306
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
cyclohex-1-ene-1-carbonyl-CoA + electron-transfer flavoprotein = cyclohex-1,5-diene-1-carbonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
benzoate fermentation (to acetate and cyclohexane carboxylate), benzoyl-CoA degradation III (anaerobic), crotonate fermentation (to acetate and cyclohexane carboxylate)
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SYSTEMATIC NAME
IUBMB Comments
cyclohex-1-ene-1-carbonyl-CoA:electron transfer flavoprotein oxidoreductase
Contains FAD. The enzyme, characterized from the strict anaerobic bacterium Syntrophus aciditrophicus, is involved in production of cyclohexane-1-carboxylate, a byproduct produced by that organism during fermentation of benzoate and crotonate to acetate.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
cyclohex-1,5-diene-1-carbonyl-CoA + ferricenium hexafluorophosphate
benzoyl-CoA + ferrocenium hexafluorophosphate
cyclohex-1,5-diene-1-carbonyl-CoA + Ti(III) citrate
cyclohex-1-ene-1-carbonyl-CoA + oxidized Ti(III) citrate
cyclohex-1-ene-1-carbonyl-CoA + ferricenium hexafluorophosphate
cyclohex-1,5-diene-1-carbonyl-CoA + ferrocenium hexafluorophosphate
cyclohexa-1,5-diene-1-carbonyl-CoA + ferricenium hexafluorophosphate
benzoyl-CoA + ferrocenium hexafluorophosphate
cyclohex-1,5-diene-1-carbonyl-CoA + ferricenium hexafluorophosphate
benzoyl-CoA + ferrocenium hexafluorophosphate
Substrates: -
Products: -
Products: -
?
cyclohex-1,5-diene-1-carbonyl-CoA + ferricenium hexafluorophosphate
benzoyl-CoA + ferrocenium hexafluorophosphate
Substrates: -
Products: -
Products: -
?
cyclohex-1,5-diene-1-carbonyl-CoA + Ti(III) citrate
cyclohex-1-ene-1-carbonyl-CoA + oxidized Ti(III) citrate
-
Substrates: Ti(III) citrate (5mM) in the presence of methyl viologen (1 mM) serves as the electron donor
Products: -
Products: -
r
cyclohex-1,5-diene-1-carbonyl-CoA + Ti(III) citrate
cyclohex-1-ene-1-carbonyl-CoA + oxidized Ti(III) citrate
-
Substrates: Ti(III) citrate (5mM) in the presence of methyl viologen (1 mM) serves as the electron donor
Products: -
Products: -
r
cyclohex-1-ene-1-carbonyl-CoA + ferricenium hexafluorophosphate
cyclohex-1,5-diene-1-carbonyl-CoA + ferrocenium hexafluorophosphate
Substrates: -
Products: -
Products: -
?
cyclohex-1-ene-1-carbonyl-CoA + ferricenium hexafluorophosphate
cyclohex-1,5-diene-1-carbonyl-CoA + ferrocenium hexafluorophosphate
Substrates: -
Products: -
Products: -
?
cyclohex-1-ene-1-carbonyl-CoA + ferricenium hexafluorophosphate
cyclohex-1,5-diene-1-carbonyl-CoA + ferrocenium hexafluorophosphate
-
Substrates: -
Products: -
Products: -
r
cyclohex-1-ene-1-carbonyl-CoA + ferricenium hexafluorophosphate
cyclohex-1,5-diene-1-carbonyl-CoA + ferrocenium hexafluorophosphate
-
Substrates: -
Products: -
Products: -
r
cyclohexa-1,5-diene-1-carbonyl-CoA + ferricenium hexafluorophosphate
benzoyl-CoA + ferrocenium hexafluorophosphate
-
Substrates: -
Products: -
Products: -
ir
cyclohexa-1,5-diene-1-carbonyl-CoA + ferricenium hexafluorophosphate
benzoyl-CoA + ferrocenium hexafluorophosphate
-
Substrates: -
Products: -
Products: -
ir
additional information
?
-
Substrates: no substrates: cyclohexanoyl-CoA, cyclohex-2-ene-1-carboxyl-CoA, cyclohex-3-ene-1-carboxyl-CoA, butanoyl-CoA, nor crotonyl-CoA
Products: -
Products: -
?
additional information
?
-
Substrates: no substrates: cyclohexanoyl-CoA, cyclohex-2-ene-1-carboxyl-CoA, cyclohex-3-ene-1-carboxyl-CoA, butanoyl-CoA, nor crotonyl-CoA
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity with ChCoA, 6-hydroxycyclohex-1-en-1-carboxyl-CoA, butyryl-CoA, glutaryl-CoA, succinyl-CoA, or cyclohexane carboxylate
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity with ChCoA, 6-hydroxycyclohex-1-en-1-carboxyl-CoA, butyryl-CoA, glutaryl-CoA, succinyl-CoA, or cyclohexane carboxylate
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.005
cyclohex-1-ene-1-carbonyl-CoA
-
Km less than 0.005 mM, at pH 7.0 and 30Ā°C
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
1
substrate cyclohex-1,5-diene-1-carbonyl-CoA, pH 6.8, 30Ā°C
2.1
-
using (E)-2-cyclohex-1,5-diene-1-carbonyl-CoA as substrate, at pH 7.0 and 30Ā°C
9.5
-
using cyclohex-1-ene-1-carbonyl-CoA as substrate, at pH 7.0 and 30Ā°C
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
Geobacter metallireducens grows exponentially with cyclohexane carboxylic acid as the sole carbon source and nitrate as a terminal electron acceptor. Cyclohexane carboxylic acid degradation involves its activation by a succinyl-CoA-dependent CoA transferase followed by the oxidation to cyclohexadienoyl-CoA by cyclohexanoyl-CoA- and cyclohex-1-ene-1-carboxyl-CoA dehydrogenase activities
physiological function
-
Geobacter metallireducens grows exponentially with cyclohexane carboxylic acid as the sole carbon source and nitrate as a terminal electron acceptor. Cyclohexane carboxylic acid degradation involves its activation by a succinyl-CoA-dependent CoA transferase followed by the oxidation to cyclohexadienoyl-CoA by cyclohexanoyl-CoA- and cyclohex-1-ene-1-carboxyl-CoA dehydrogenase activities
-
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). CH1CO_SYNAS
Syntrophus aciditrophicus (strain SB)
414
0
45178
Swiss-Prot
-
A0A6L5C3G6_9PSED
387
0
42746
TrEMBL
-
A0A2S6QHV8_9PROT
393
0
43661
TrEMBL
-
A0A6J5GMS1_9BURK
386
0
42978
TrEMBL
-
A0A2S6REE8_9PROT
385
0
43358
TrEMBL
-
A0A2S6UMF9_9PROT
393
0
43643
TrEMBL
-
Q39QF5_GEOMG
Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)
380
0
40990
TrEMBL
-
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
homotetramer
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kung, J.; Seifert, J.; von Bergen, M.; Bolla, M.
Cyclohexanecarboxyl-coenzyme a (CoA) and cyclohex-1-ene-1-carboxyl-CoA dehydrogenases, two enzymes involved in the fermentation of benzoate and crotonate in Syntrophus aciditrophicus
J. Bacteriol.
195
3193-3200
2013
Syntrophus aciditrophicus, Syntrophus aciditrophicus SB
brenda
Kung, J.W.; Meier, A.K.; Mergelsberg, M.; Boll, M.
Enzymes involved in a novel anaerobic cyclohexane carboxylic acid degradation pathway
J. Bacteriol.
196
3667-3674
2014
Geobacter metallireducens (Q39QF5), Geobacter metallireducens DSM 7210 (Q39QF5)
brenda
EXTERNAL LINKS (specific for EC-Number 1.3.8.10)
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Release 2023.1 (January 2023)
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