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Information on EC 1.3.1.82 - (-)-isopiperitenone reductase

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IUBMB Comments
The reaction occurs in the opposite direction to that shown above. The enzyme participates in the menthol-biosynthesis pathway of Mentha plants. (+)-Pulegone, (+)-cis-isopulegone and (-)-menthone are not substrates. The enzyme has a preference for NADPH as the reductant, with NADH being a poor substitute . The enzyme is highly regioselective for the reduction of the endocyclic 1,2-double bond, and is stereoselective, producing only the 1R-configured product. It is a member of the short-chain dehydrogenase/reductase superfamily.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
IPR, isopiperitenone reductase, More, NADPH-dependent isopiperitenone reductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(+)-cis-isopulegone + NADP+ = (-)-isopiperitenone + NADPH + H+
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