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EC Tree
IUBMB Comments Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). Enzymes that can utilize both cofactors have been reported from some Proteobacteria, including Burkholderia caryophylli, Burkholderia cepacia, Pseudomonas marginata and Delftia acidovorans.
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
arogenate dehydrogenase, arogenate dehydrogenase isoform 2, cyclohexadienyl dehydrogenase, tyrA, TyrAc, TyrC,
ZmTyrA ,
more
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arogenate dehydrogenase
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arogenate dehydrogenase isoform 2
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cyclohexadienyl dehydrogenase
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L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2
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L-arogenate:NAD(P)+ oxidoreductase (decarboxylating)
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). Enzymes that can utilize both cofactors have been reported from some Proteobacteria, including Burkholderia caryophylli, Burkholderia cepacia, Pseudomonas marginata and Delftia acidovorans.
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L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
L-arogenate + NAD+
L-tyrosine + NADH + CO2
prephenate + NAD(P)+
p-hydroxyphenylpyruvate + NAD(P)H + CO2
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-
-
-
?
L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
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-
-
?
L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
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-
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?
L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
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-
-
?
L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
Flavobacterium paucimobilis
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-
?
L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
Flavobacterium suaveolens
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-
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?
L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
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-
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?
L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
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-
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?
L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
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-
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?
L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
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-
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?
L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
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-
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?
L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
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-
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?
L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
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-
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
Flavobacterium paucimobilis
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
Flavobacterium suaveolens
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
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L-arogenate + NAD(P)+
L-tyrosine + NAD(P)H + CO2
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-
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
Flavobacterium paucimobilis
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
Flavobacterium suaveolens
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
L-arogenate + NAD+
L-tyrosine + NADH + CO2
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i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine
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?
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NAD(P)+
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NAD+
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NAD+
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NADP+ is a better electron acceptor than NAD+
NAD+
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NADP+ is a better electron acceptor than NAD+
NAD+
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NADP+ is a better electron acceptor than NAD+
NAD+
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NADP+ is a better electron acceptor than NAD+
NAD+
Flavobacterium suaveolens
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NADP+ is a better electron acceptor than NAD+
NAD+
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NADP+ is a better electron acceptor than NAD+
NAD+
Flavobacterium paucimobilis
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NADP+ is a better electron acceptor than NAD+
NAD+
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NADP+ is a better electron acceptor than NAD+
NAD+
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NAD+ and NADP+ equally effective
NAD+
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slight preference for NAD+ over NADP+
NADP+
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NADP+
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NADP+ is a better electron acceptor than NAD+
NADP+
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NADP+ is a better electron acceptor than NAD+
NADP+
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NADP+ is a better electron acceptor than NAD+
NADP+
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NADP+ is a better electron acceptor than NAD+
NADP+
Flavobacterium suaveolens
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NADP+ is a better electron acceptor than NAD+
NADP+
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NADP+ is a better electron acceptor than NAD+
NADP+
Flavobacterium paucimobilis
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NADP+ is a better electron acceptor than NAD+
NADP+
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NADP+ is a better electron acceptor than NAD+
NADP+
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NAD+ and NADP+ equally effective
NADP+
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slight preference for NAD+ over NADP+
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additional information
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TyrC is not sensitive to L-Tyr inhibition
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L-phenylalanine
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L-phenylalanine
Flavobacterium paucimobilis
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L-tyrosine
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L-tyrosine
Flavobacterium paucimobilis
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L-tyrosine
Flavobacterium suaveolens
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slightly enhanced activity
L-tyrosine
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slightly enhanced activity
phenylalanine
Flavobacterium suaveolens
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slightly enhanced activity
phenylalanine
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slightly enhanced activity
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1.74
L-prephenate
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mutant D208N, pH 7.6, temperature not specified in the publication
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0.9
L-arogenate
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wild-type, pH 7.6, temperature not specified in the publication
0.85
L-arogenate
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mutant D208N, pH 7.6, temperature not specified in the publication
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0.59
L-prephenate
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mutant D208N, pH 7.6, temperature not specified in the publication
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4
L-arogenate
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wild-type, pH 7.6, temperature not specified in the publication
0.57
L-arogenate
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mutant D208N, pH 7.6, temperature not specified in the publication
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additional information
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additional information
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additional information
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additional information
Flavobacterium paucimobilis
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additional information
Flavobacterium suaveolens
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additional information
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additional information
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additional information
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additional information
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TyrC has a specific activity of 1.54 IU/mg protein, while in the presence of 0.6 mM L-Tyr the specific activity was 1.34 IU/mg protein
additional information
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brenda
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brenda
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brenda
Flavobacterium paucimobilis
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brenda
Flavobacterium suaveolens
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brenda
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brenda
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brenda
ATCC 15926
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brenda
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brenda
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UniProt
brenda
strain ATCC 31821
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brenda
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brenda
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metabolism
the enzyme catalyzes a step in the tyrosine biosynthesis. The presence of urea in conjunction with nitrate induced the upregulation of genes coding for shikimate kinase, TyrA and a putative serine carboxypeptidase
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B6SS03_MAIZE
349
0
38562
TrEMBL
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D208N
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mutation introduces prephenate dehydrogenase activity
D208N
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mutation introduces prephenate dehydrogenase activity
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expression in Escherichia coli
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the enzyme is transcriptionally upregulated by urea and nitrate
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Waldner-Sander, S.; Keller, B.; Keller, E.; Lingens, F.
Zur Biosynthese von Phenylalanin und Tyrosin bei Flavobakterien
Hoppe-Seyler's Z. Physiol. Chem.
364
1467-1473
1983
Flavobacterium aquatile, Empedobacter brevis, Novosphingobium capsulatum, Agromyces mediolanus, Sphingomonas paucimobilis, [Flavobacterium] lutescens, Myroides odoratus, Flavobacterium paucimobilis, Flavobacterium suaveolens
brenda
Keller, B.; Keller, E.; Salcher, O.; Lingens, F.
Arogenate (pretyrosine) pathway of tyrosine and phenylalanine biosynthesis in Pseudomonas aureofaciens ATCC 15926
J. Gen. Microbiol.
128
1199-1202
1982
Pseudomonas chlororaphis subsp. aureofaciens
brenda
Chavez-Bejar, M.I.; Lara, A.R.; Lopez, H.; Hernandez-Chavez, G.; Martinez, A.; Ramirez, O.T.; Bolivar, F.; Gosset, G.
Metabolic engineering of Escherichia coli for L-tyrosine production by expression of genes coding for the chorismate mutase domain of the native chorismate mutase-prephenate dehydratase and a cyclohexadienyl dehydrogenase from Zymomonas mobilis
Appl. Environ. Microbiol.
74
3284-3290
2008
Zymomonas mobilis
brenda
Zanin, L.; Zamboni, A.; Monte, R.; Tomasi, N.; Varanini, Z.; Cesco, S.; Pinton, R.
Transcriptomic analysis highlights reciprocal interactions of urea and nitrate for nitrogen acquisition by maize roots
Plant Cell Physiol.
56
532-548
2015
Zea mays (B6SS03)
brenda
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