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Information on EC 1.3.1.78 - arogenate dehydrogenase (NADP+)

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IUBMB Comments
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NADP+-dependent enzymes usually predominate in higher plants.The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly [2,3].
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Word Map
  • 1.3.1.78
  • kinase-inactive
  • prephenate
  • gadd45
  • malformation
  • annexin
  • ifngamma
  • neurulation
  • perinuclear
  • calcium-dependent
  • mekks
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
Synonyms
ADH1, ADH2, arogenate dehydrogenase, arogenate dehydrogenase isoform 1, arogenate dehydrogenase isoform 2, cyclohexadienyl dehydrogenase, TyrAa, TyrAAT, TyrAAT1, TyrAsy, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-arogenate + NADP+ = L-tyrosine + NADPH + CO2
show the reaction diagram
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