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Disease on EC 1.3.1.72 - DELTA24-sterol reductase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenoma
Expression of the antiapoptotic gene seladin-1 and octreotide-induced apoptosis in growth hormone-secreting and nonfunctioning pituitary adenomas.
Adrenal Gland Neoplasms
Seladin-1 expression is regulated by promoter methylation in adrenal cancer.
Adrenocortical Adenoma
Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours.
The human homolog of Diminuto/Dwarf1 gene (hDiminuto): a novel ACTH-responsive gene overexpressed in benign cortisol-producing adrenocortical adenomas.
Alzheimer Disease
Alzheimer's disease: brain desmosterol levels.
Androgen receptor regulation of the seladin-1/DHCR24 gene: altered expression in prostate cancer.
Aromatase/Seladin-1 Interactions in Human Neuronal Cell Culture, the Hippocampus of Healthy Rats and Transgenic Alzheimer's Disease Mice.
DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.
DHCR24 overexpression modulates microglia polarization and inflammatory response via Akt/GSK3? signaling in A?25-35 treated BV-2 cells.
Down-regulation of seladin-1 increases bace1 levels and activity through enhanced GGA3 depletion during apoptosis.
Effect of hesperetin against oxidative stress via ER- and TrkA-mediated actions in PC12 cells.
Estrogen receptor-mediated neuroprotection: The role of the Alzheimer's disease-related gene seladin-1.
Expression of the antiapoptotic gene seladin-1 and octreotide-induced apoptosis in growth hormone-secreting and nonfunctioning pituitary adenomas.
Gender dependent effect of DHCR24 polymorphism on the risk for Alzheimer's disease.
Genetic regulatory subnetworks and key regulating genes in rat hippocampus perturbed by prenatal malnutrition: implications for major brain disorders.
Heme oxygenase effect on mesenchymal stem cells action on experimental Alzheimer's disease.
Hippocampal DHCR24 down regulation in a rat model of streptozotocin-induced cognitive decline.
Identification and analysis of the promoter region of the human DHCR24 gene: involvement of DNA methylation and histone acetylation.
Interactions of Aromatase and Seladin-1: A Neurosteroidogenic and Gender Perspective.
Intermittent high glucose concentrations reduce neuronal precursor survival by altering the IGF system: the involvement of the neuroprotective factor DHCR24 (Seladin-1).
Is Seladin-1 Really a Selective Alzheimer's Disease Indicator?
Membrane cholesterol as a mediator of the neuroprotective effects of estrogens.
Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1.
Neuronal differentiation of rat hair follicle stem cells: the involvement of the neuroprotective factor Seladin-1 (DHCR24).
Neuroprotective effects of estrogens: the role of cholesterol.
New insights on the neuroprotective role of sterols and sex steroids: The seladin-1/DHCR24 paradigm.
Prescription of lipophilic statins to Alzheimer's disease patients: some controversies to consider.
Recombinant adenovirus-mediated overexpression of 3?-hydroxysteroid-?24 reductase.
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1.
Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease.
Serum seladin-1 levels in diabetes mellitus and Alzheimer's disease patients.
Simvastatin modulates the Alzheimer's disease-related gene seladin-1.
Statin-like drugs for the treatment of brain cholesterol loss in Alzheimer's disease.
The association study between DHCR24 polymorphisms and Alzheimer's disease.
The selective Alzheimer's disease indicator-1 gene (Seladin-1/DHCR24) is a liver X receptor target gene.
Upregulation of seladin-1 and nestin expression in bone marrow mesenchymal stem cell transplantation via the ERK1/2 and PI3K/Akt signaling pathways in an Alzheimer's disease model.
[Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis]
Breast Neoplasms
24-Dehydrocholesterol reductase promotes the growth of breast cancer stem-like cells through the Hedgehog pathway.
Carcinogenesis
Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers.
Carcinoma
DHCR24 is an Independent Predictor of Progression in Patients with Non-Muscle-Invasive Urothelial Carcinoma, and Its Functional Role is Involved in the Aggressive Properties of Urothelial Carcinoma Cells.
Seladin-1 expression is regulated by promoter methylation in adrenal cancer.
Carcinoma, Hepatocellular
Development of Serum DHCR24 Antibody as a Marker for Hepatocellular Carcinoma: The End of the Beginning.
Genomic polymorphisms in 3?-hydroxysterol ?24-reductase promoter sequences.
Cardiomyopathy, Dilated
Dhcr24 activates the PI3K/Akt/HKII pathway and protects against dilated cardiomyopathy in mice.
Cataract
Cholesterol synthesis in the vertebrate retina: effects of U18666A on rat retinal structure, photoreceptor membrane assembly, and sterol metabolism and composition.
E2012-induced cataract and its predictive biomarkers.
Chondrodysplasia Punctata
Genetic disorders of cholesterol biosynthesis in mice and humans.
Confusion
The Twisted Dwarf's ABC: How Immunophilins Regulate Auxin Transport.
Cystadenocarcinoma, Mucinous
Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours.
Cystadenocarcinoma, Serous
Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours.
delta24-sterol reductase deficiency
Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay.
DHCR24 Knock-Down Induced Tau Hyperphosphorylation at Thr181, Ser199, Thr231, Ser262, Ser396 Epitopes and Inhibition of Autophagy by Overactivation of GSK3?/mTOR Signaling.
Phenotypic spectrum of fetal Smith-Lemli-Opitz syndrome.
Diabetes Mellitus
Serum seladin-1 levels in diabetes mellitus and Alzheimer's disease patients.
Diabetes Mellitus, Type 2
3?-Hydroxysteroid-?24 Reductase (DHCR24) Protects Pancreatic ? Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Scavenging Excessive Intracellular Reactive Oxygen Species.
Diabetic Neuropathies
Intermittent high glucose concentrations reduce neuronal precursor survival by altering the IGF system: the involvement of the neuroprotective factor DHCR24 (Seladin-1).
Dwarfism
Dominant and pleiotropic effects of a GAI gene in wheat results from a lack of interaction between DELLA and GID1.
Molecular characterization of Rht-1 dwarfing genes in hexaploid wheat.
The maize DWARF1 encodes a gibberellin 3-oxidase and is dual localized to the nucleus and cytosol.
Endometrial Neoplasms
Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma.
Epilepsy
Interactions of Aromatase and Seladin-1: A Neurosteroidogenic and Gender Perspective.
Hepatitis B
Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C.
Hepatitis C
Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes.
Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase.
Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C.
Hepatitis, Chronic
Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C.
Herpes Zoster
24-dehydrocholesterol reductase/seladin-1: a key protein differentially involved in adrenocorticotropin effects observed in human and rat adrenal cortex.
Seladin-1 expression in rat adrenal gland: effect of adrenocorticotropic hormone treatment.
Hypercholesterolemia
Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed.
Hypothyroidism
Crosstalk between thyroid hormone receptor and liver X receptor in the regulation of selective Alzheimer's disease indicator-1 gene expression.
Infections
3?-Hydroxysteroid-?24 Reductase (DHCR24) Protects Pancreatic ? Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Scavenging Excessive Intracellular Reactive Oxygen Species.
Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes.
Blood-based gene expression profile of oxidative stress and antioxidant genes for identifying surrogate markers of liver tissue injury in chronic hepatitis C patients.
Genomic polymorphisms in 3?-hydroxysterol ?24-reductase promoter sequences.
Hepatitis C virus impairs P53 via persistent over-expression of 3{beta}-hydroxysterol {delta}24-reductase.
Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri.
Role of oxidative stress in hepatocarcinogenesis induced by hepatitis C virus.
The heterotrimeric G protein alpha subunit acts upstream of the small GTPase Rac in disease resistance of rice.
Leishmaniasis
Hesperidin Targets Leishmania donovani Sterol C-24 Reductase to Fight against Leishmaniasis.
Liver Cirrhosis
Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C.
Liver Diseases
Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C.
Lymphatic Metastasis
Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma.
Malnutrition
Genetic regulatory subnetworks and key regulating genes in rat hippocampus perturbed by prenatal malnutrition: implications for major brain disorders.
Melanoma
DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis.
Metabolism, Inborn Errors
Genetic disorders of cholesterol biosynthesis in mice and humans.
Mevalonate Kinase Deficiency
Genetic disorders of cholesterol biosynthesis in mice and humans.
Myocardial Infarction
MicroRNA-124 regulates cardiomyocyte apoptosis and myocardial infarction through targeting Dhcr24.
Neoplasm Metastasis
DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis.
Evolution of the androgen receptor pathway during progression of prostate cancer.
MicroRNA Profiling and Target Genes Related to Metastasis of Salivary Adenoid Cystic Carcinoma.
Neoplasms
24-Dehydrocholesterol reductase promotes the growth of breast cancer stem-like cells through the Hedgehog pathway.
An Integrative In Silico Mathematical Modelling Study of The Anti-Cancer Effect of Clove Extract ( Syzygium aromaticum ) Combined with In Vitro Metabolomics Study Using 1HNMR Spectroscopy.
Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma.
DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis.
DHCR24 predicts poor clinicopathological features of patients with bladder cancer: A STROBE-compliant study.
Editorial: Is the diminuto/dwarf1 gene involved in physiologic adrenocortical size regulation and tumor formation?
Evolution of the androgen receptor pathway during progression of prostate cancer.
Gene expression in normal urothelium depends on location within the bladder: a possible link to bladder carcinogenesis.
Polybrominated diphenyl ethers cause oxidative stress in human umbilical vein endothelial cells.
Seladin-1 and testicular germ cell tumours: new insights into cisplatin responsiveness.
Seladin-1 is a novel lipopolysaccharide (LPS)-responsive gene and inhibits the tumour necrosis factor-alpha production and osteoclast formation in response to LPS.
Neoplasms, Germ Cell and Embryonal
Seladin-1 and testicular germ cell tumours: new insights into cisplatin responsiveness.
Neuroblastoma
3 ?-hydroxysteroid-? 24 reductase (DHCR24) protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum (ER) stress.
Aromatase/Seladin-1 Interactions in Human Neuronal Cell Culture, the Hippocampus of Healthy Rats and Transgenic Alzheimer's Disease Mice.
Down-regulation of seladin-1 increases bace1 levels and activity through enhanced GGA3 depletion during apoptosis.
Membrane cholesterol as a mediator of the neuroprotective effects of estrogens.
Prevention of prion propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice.
Seladin-1/DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content.
The membrane topological analysis of 3?-hydroxysteroid-Delta24 reductase (DHCR24) on endoplasmic reticulum.
Neurodegenerative Diseases
Estrogen and selective estrogen receptor modulators exert neuroprotective effects and stimulate the expression of selective Alzheimer's disease indicator-1, a recently discovered antiapoptotic gene, in human neuroblast long-term cell cultures.
Identification and analysis of the promoter region of the human DHCR24 gene: involvement of DNA methylation and histone acetylation.
Neuroinflammatory Diseases
DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.
Ototoxicity
Inhibition of DHCR24 increases the cisplatin-induced damage to cochlear hair cells in vitro.
Ovarian Neoplasms
The plasma peptides of ovarian cancer.
Peritonitis
Inhibition of ?24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution.
Pheochromocytoma
3beta-Hydroxysteroid-delta24 reductase is a hydrogen peroxide scavenger, protecting cells from oxidative stress-induced apoptosis.
Pituitary Neoplasms
Expression of the antiapoptotic gene seladin-1 and octreotide-induced apoptosis in growth hormone-secreting and nonfunctioning pituitary adenomas.
Prostatic Neoplasms
Inhibition of DHCR24/Seladin-1 impairs cellular homeostasis in prostate cancer.
Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer.
Novel biomarkers for prostate cancer including noncoding transcripts.
Smith-Lemli-Opitz Syndrome
Defects in cholesterol synthesis genes in mouse and in humans: lessons for drug development and safer treatments.
Phenotypic spectrum of fetal Smith-Lemli-Opitz syndrome.
Subcellular localization of sterol biosynthesis enzymes.
Tauopathies
DHCR24 Knock-Down Induced Tau Hyperphosphorylation at Thr181, Ser199, Thr231, Ser262, Ser396 Epitopes and Inhibition of Autophagy by Overactivation of GSK3?/mTOR Signaling.
DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells.
Urinary Bladder Neoplasms
DHCR24 predicts poor clinicopathological features of patients with bladder cancer: A STROBE-compliant study.
Involvement of Seladin-1 in goniothalamin-induced apoptosis in urinary bladder cancer cells.
Virus Diseases
Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes.
Wilms Tumor
Gene expression during ovarian differentiation in parasitic and non-parasitic lampreys: implications for fecundity and life history types.