Reference on EC 1.21.99.4 - thyroxine 5'-deiodinase and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yu, J.; Koenig, R.J.
Regulation of hepatocyte thyroxine 5'-deiodinase by T3 and nuclear receptor coactivators as a model of the sick euthyroid syndrome
J. Biol. Chem.
275
38296-38301
2000
Homo sapiens, Mus musculus, Rattus sp.
Garcia-Macias, J.F.; Molinero, P.; Guerrero, J.M.; Osuna, C.
Expression of type II thyroxine 5'-deiodinase from rat harderian gland in Xenopus laevis oocytes
FEBS Lett.
354
110-112
1994
Homo sapiens, Rattus sp.
Santini, F.; Chopra, I.J.; Hurd, R.E.; Chua Teco, G.N.
A study of the characteristics of hepatic iodothyronine 5'-monodeiodinase in various vertebrate species
Endocrinology
131
830-834
1992
Bos taurus, Cavia porcellus, Gallus gallus, Ovis aries, Homo sapiens, Mus musculus, Rattus sp., Sus scrofa
Koehrle, J.
Iodothyronine deiodinases
Methods Enzymol.
347
125-167
2002
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus, vertebrata
Steinsapir, J.; Bianco, A.C.; Buettner, C.; Harney, J.; Larsen, P.R.
Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center
Endocrinology
141
1127-1135
2000
Homo sapiens (Q92813), Homo sapiens
Buettner, C.; Harney, J.W.; Larsen, P.R.
The role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase
Endocrinology
141
4606-4612
2000
Homo sapiens (Q92813), Homo sapiens
Kuiper, G.G.; Klootwijk, W.; Visser, T.J.
Substitution of cysteine for a conserved alanine residue in the catalytic center of type II iodothyronine deiodinase alters interaction with reducing cofactor
Endocrinology
143
1190-1198
2002
Homo sapiens (Q92813), Homo sapiens
Curcio-Morelli, C.; Gereben, B.; Zavacki, A.M.; Kim, B.W.; Huang, S.; Harney, J.W.; Larsen, P.R.; Bianco, A.C.
In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases
Endocrinology
144
937-946
2003
Homo sapiens (P49895), Homo sapiens (Q92813), Homo sapiens
Curcio, C.; Baqui, M.M.; Salvatore, D.; Rihn, B.H.; Mohr, S.; Harney, J.W.; Larsen, P.R.; Bianco, A.C.
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line
J. Biol. Chem.
276
30183-30187
2001
Homo sapiens (Q92813), Homo sapiens
Kanou, Y.; Hishinuma, A.; Tsunekawa, K.; Seki, K.; Mizuno, Y.; Fujisawa, H.; Imai, T.; Miura, Y.; Nagasaka, T.; Yamada, C.; Ieiri, T.; Murakami, M.; Murata, Y.
Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity
J. Clin. Endocrinol. Metab.
92
1451-1457
2007
Homo sapiens
Aerts, G.; Arrojo E Drigo, R.; Van Herck, S.L.; Sammels, E.; Mirebeau-Prunier, D.; Gereben, B.; Zeoeld, A.; Harney, J.W.; Huang, S.A.; Mulcahey, M.A.; Van der Geyten, S.; Van den Bergh, G.; Arckens, L.; Darras, V.M.; Zavacki, A.M.
Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells
Endocrinology
150
5171-5180
2009
Homo sapiens (P49895), Homo sapiens (Q92813)
Celi, F.S.; Coppotelli, G.; Chidakel, A.; Kelly, M.; Brillante, B.A.; Shawker, T.; Cherman, N.; Feuillan, P.P.; Collins, M.T.
The role of type 1 and type 2 5-deiodinase in the pathophysiology of the 3,5,3-triiodothyronine toxicosis of McCune-Albright syndrome
J. Clin. Endocrinol. Metab.
93
2383-2389
2008
Homo sapiens
Zavacki, A.M.; Arrojo E Drigo, R.; Freitas, B.C.; Chung, M.; Harney, J.W.; Egri, P.; Wittmann, G.; Fekete, C.; Gereben, B.; Bianco, A.C.
The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase
Mol. Cell. Biol.
29
5339-5347
2009
Homo sapiens
Meyer, E.L.; Goemann, I.M.; Dora, J.M.; Wagner, M.S.; Maia, A.L.
Type 2 iodothyronine deiodinase is highly expressed in medullary thyroid carcinoma
Mol. Cell. Endocrinol.
289
16-22
2008
Homo sapiens
Piekielko-Witkowska, A.; Master, A.; Wojcicka, A.; Boguslawska, J.; Brozda, I.; Tanski, Z.; Nauman, A.
Disturbed expression of type 1 iodothyronine deiodinase splice variants in human renal cancer
Thyroid
19
1105-1113
2009
Homo sapiens (P49895), Homo sapiens
Goto, K.; Sonoda, D.; Shimada, K.; Sase, S.; Kawashima, T.
Modeling of the 5'-deiodination of thyroxine by iodothyronine deiodinase: Chemical corroboration of a selenenyl iodide intermediate
Angew. Chem.
49
545-547
2010
Homo sapiens
Manna, D.; Mugesh, G.
A chemical model for the inner-ring deiodination of thyroxine by iodothyronine deiodinase
Angew. Chem.
49
9246-9249
2010
Homo sapiens
-
Kornasiewicz, O.; Debski, M.; Stepnowska, M.; Sza?as, A.; Bar-Andziak, E.; Krawczyk, M.
The enzymatic activity of type 1 iodothyronine deiodinase (D1) is low in liver hemangioma: a preliminary study
Arch. Immunol. Ther. Exp.
58
77-80
2010
Homo sapiens
Goemann, I.; Gereben, B.; Harney, J.; Zhu, B.; Maia, A.; Larsen, P.
Substitution of serine for proline in the active center of type 2 iodothyronine deiodinase substantially alters its in vitro biochemical properties with dithiothreitol but not its function in intact cells
Endocrinology
151
821-829
2010
Homo sapiens
Ito, M.; Toyoda, N.; Nomura, E.; Takamura, Y.; Amino, N.; Iwasaka, T.; Takamatsu, J.; Miyauchi, A.; Nishikawa, M.
Type 1 and type 2 iodothyronine deiodinases in the thyroid gland of patients with 3,5,3'-triiodothyronine-predominant Graves' disease
Eur. J. Endocrinol.
164
95-100
2011
Homo sapiens
Piehl, S.; Heberer, T.; Balizs, G.; Scanlan, T.S.; Kohrle, J.
Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates
Rapid Commun. Mass Spectrom.
22
3286-3296
2008
Homo sapiens, Mus musculus
Kornasiewicz, O.; Debski, M.; Grat, M.; Lenartowicz, B.; Stepnowska, M.; Szalas, A.; Bar-Andziak, E.; Krawczyk, M.
Enzymatic activity of type 1 iodothyronine deiodinase in selected liver tumors
Arch. Med. Sci.
10
801-805
2014
Homo sapiens (P49895), Homo sapiens
Aoki, T.; Tsunekawa, K.; Araki, O.; Ogiwara, T.; Nara, M.; Sumino, H.; Kimura, T.; Murakami, M.
Type 2 iodothyronine deiodinase activity is required for rapid stimulation of PI3K by thyroxine in human umbilical vein endothelial cells
Endocrinology
156
4312-4324
2015
Homo sapiens (Q9C0K2), Homo sapiens
Yamauchi, I.; Sakane, Y.; Yamashita, T.; Hirota, K.; Ueda, Y.; Kanai, Y.; Yamashita, Y.; Kondo, E.; Fujii, T.; Taura, D.; Sone, M.; Yasoda, A.; Inagaki, N.
Effects of growth hormone on thyroid function are mediated by type 2 iodothyronine deiodinase in humans
Endocrine
59
353-363
2018
Homo sapiens
Poplawski, P.; Rybicka, B.; Boguslawska, J.; Rodzik, K.; Visser, T.J.; Nauman, A.; Piekielko-Witkowska, A.
Induction of type 1 iodothyronine deiodinase expression inhibits proliferation and migration of renal cancer cells
Mol. Cell. Endocrinol.
442
58-67
2017
Homo sapiens
Sakane, Y.; Kanamoto, N.; Yamauchi, I.; Tagami, T.; Morita, Y.; Miura, M.; Sone, M.; Yasoda, A.; Kimura, T.; Nakao, K.; Inagaki, N.
Regulation of type 1 iodothyronine deiodinase by LXRalpha
PLoS ONE
12
e0179213
2017
Homo sapiens
Poplawski, P.; Wisniewski, J.; Rijntjes, E.; Richards, K.; Rybicka, B.; Kohrle, J.; Piekielko-Witkowska, A.
Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system
PLoS ONE
12
e0190179
2017
Homo sapiens
