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Disease on EC 1.21.99.4 - thyroxine 5'-deiodinase and Organism(s) Homo sapiens

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abnormalities, Multiple
Modeling the nonthyroidal illness syndrome.
Abortion, Habitual
Iodothyronine deiodinase 2 (DiO2) regulates trophoblast cell line cycle, invasion and apoptosis; and its downregulation is associated with early recurrent miscarriage.
Abscess
Type 3 deiodinase is highly expressed in infiltrating neutrophilic granulocytes in response to acute bacterial infection.
Acute Lung Injury
Erratum: Type 2 Deiodinase and Host Responses of Sepsis and Acute Lung Injury.
Role of type 2 deiodinase in response to acute lung injury (ALI) in mice.
Type 2 Deiodinase and Host Responses of Sepsis and Acute Lung Injury.
Adenocarcinoma, Follicular
Retinoids stimulate type I iodothyronine 5'-deiodinase activity in human follicular thyroid carcinoma cell lines.
Adenoma
Positive correlation between type 1 and 2 iodothyronine deiodinases activities in human goiters.
Thyroid hormone receptors and type I iodothyronine 5'-deiodinase activity of human thyroid toxic adenomas and benign cold nodules.
Atherosclerosis
Decreased deiodinase activity after glucose load could lead to atherosclerosis in euthyroid women with polycystic ovary syndrome.
Bacterial Infections
Type 3 deiodinase is highly expressed in infiltrating neutrophilic granulocytes in response to acute bacterial infection.
Blindness
Deficiency of type 2 iodothyronine deiodinase reduces necroptosis activity and oxidative stress responses in retinas of Leber congenital amaurosis model mice.
Bone Resorption
[Osteoporosis treatment in patients with hyperthyroidism]
Brain Injuries, Traumatic
Up-regulation of type 2 iodothyronine deiodinase mRNA in reactive astrocytes following traumatic brain injury in the rat.
Brain Ischemia
Induction of type 2 iodothyronine deiodinase in astrocytes after transient focal cerebral ischemia in the rat.
Reverse triiodothyronine (rT3) attenuates ischemia-reperfusion injury.
Brain Neoplasms
Common genetic variations of deiodinase genes and prognosis of brain tumor patients.
Expression of type II iodothyronine deiodinase in brain tumors.
Breast Neoplasms
Decreased expression of the thyroid hormone-inactivating enzyme type 3 deiodinase is associated with lower survival rates in breast cancer.
Human breast cancer tissue expresses high level of type 1 5'-deiodinase.
Thyroid hormones and selenium status in breast cancer.
Carcinogenesis
Activated Thyroid Hormone Promotes Differentiation and Chemotherapeutic Sensitization of Colorectal Cancer Stem Cells by Regulating Wnt and BMP4 Signaling.
The NANOG Transcription Factor Induces Type 2 Deiodinase Expression and Regulates the Intracellular Activation of Thyroid Hormone in Keratinocyte Carcinomas.
The Sonic Hedgehog-induced Type 3 Deiodinase Facilitates Tumorigenesis of Basal Cell Carcinoma by Reducing Gli2-inactivation.
Carcinoma
Human breast cancer tissue expresses high level of type 1 5'-deiodinase.
LRRC19-A Bridge between Selenium Adjuvant Therapy and Renal Clear Cell Carcinoma: A Study Based on Datamining.
Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels.
The deiodination of thyroxine to triiodothyronine in the testes of patients with prostate cancer.
The NANOG Transcription Factor Induces Type 2 Deiodinase Expression and Regulates the Intracellular Activation of Thyroid Hormone in Keratinocyte Carcinomas.
The Sonic Hedgehog-induced Type 3 Deiodinase Facilitates Tumorigenesis of Basal Cell Carcinoma by Reducing Gli2-inactivation.
Type I 5'-iodothyronine deiodinase activity and mRNA are remarkably reduced in renal clear cell carcinoma.
Carcinoma, Basal Cell
The Sonic Hedgehog-induced Type 3 Deiodinase Facilitates Tumorigenesis of Basal Cell Carcinoma by Reducing Gli2-inactivation.
Carcinoma, Hepatocellular
Increases in phenolic and nonphenolic ring deiodinase activity due to serum in monolayer liver cell cultures.
The relationship between deiodinase activity and inflammatory responses under the stimulation of uremic toxins.
Carcinoma, Papillary
Decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentation towards papillary carcinoma.
Carcinoma, Renal Cell
LRRC19-A Bridge between Selenium Adjuvant Therapy and Renal Clear Cell Carcinoma: A Study Based on Datamining.
Carcinoma, Squamous Cell
The NANOG Transcription Factor Induces Type 2 Deiodinase Expression and Regulates the Intracellular Activation of Thyroid Hormone in Keratinocyte Carcinomas.
Cardiomegaly
Induction of thyroid hormone-degrading deiodinase in cardiac hypertrophy and failure.
Cardiomyopathies
Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy.
Cardiomyopathy, Dilated
Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy.
Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy.
Cardiomyopathy, Restrictive
Absence of Myocardial Thyroid Hormone Inactivating Deiodinase Results in Restrictive Cardiomyopathy in Mice.
Choriocarcinoma
Functional characterisation of the CRE/TATA box unit of type 2 deiodinase gene promoter in a human choriocarcinoma cell line.
Colonic Neoplasms
?-Catenin Regulates Deiodinase Levels and Thyroid Hormone Signaling in Colon Cancer Cells.
Coronary Occlusion
Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats.
Cystic Fibrosis
Hepatic iodothyronine deiodinase type 1 activity is decreased in two DeltaF508 cystic fibrosis mouse models.
Deafness
Deletion of the thyroid hormone-activating type 2 deiodinase rescues cone photoreceptor degeneration but not deafness in mice lacking type 3 deiodinase.
Diabetes Mellitus
Age-dependent changes in glucose homeostasis in male deiodinase type 2 knockout zebrafish.
Association of Type II 5' Monodeiodinase Thr92Ala Single Nucleotide Gene Polymorphism and Circulating Thyroid Hormones Among Type 2 Diabetes Mellitus Patients.
Effect of streptozotocin-induced diabetes mellitus on type 1 deiodinase (D1) in inherited D1-deficient mice.
Effect of triiodothyronine administration on reduced expression of type 1 iodothyronine deiodinase messenger ribonucleic acid in streptozotocin-induced diabetic rats.
Free triiodothyronine /free thyroxine ratio as an index of deiodinase type 1 and 2 activities negatively correlates with casual serum insulin levels in patients with type 2 diabetes mellitus.
Response to Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated With Arterial Hypertension in Type 2 Diabetes Mellitus Patients.
The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.
Type 2 deiodinase Thr92Ala polymorphism is not associated with arterial hypertension in type 2 diabetes mellitus patients.
Type II deiodinase polymorphism: A potential risk factor of type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Age-dependent changes in glucose homeostasis in male deiodinase type 2 knockout zebrafish.
Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis.
Association of Type II 5' Monodeiodinase Thr92Ala Single Nucleotide Gene Polymorphism and Circulating Thyroid Hormones Among Type 2 Diabetes Mellitus Patients.
Free triiodothyronine /free thyroxine ratio as an index of deiodinase type 1 and 2 activities negatively correlates with casual serum insulin levels in patients with type 2 diabetes mellitus.
Response to Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated With Arterial Hypertension in Type 2 Diabetes Mellitus Patients.
The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1? signalling pathway.
The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish.
The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.
Type 2 deiodinase Thr92Ala polymorphism is not associated with arterial hypertension in type 2 diabetes mellitus patients.
Type II deiodinase polymorphism: A potential risk factor of type 2 diabetes mellitus.
Diabetes, Gestational
High levels of maternal total tri-iodothyronine, and low levels of fetal free L-thyroxine and total tri-iodothyronine, are associated with altered deiodinase expression and activity in placenta with gestational diabetes mellitus.
Peripheral deiodinase activity: A potential explanation for the association between maternal weight and gestational hyperglycemia.
Encephalomyelitis
Type 3 deiodinase expression in inflammatory spinal cord lesions in rat experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Inflammation severely alters thyroid hormone signaling in the central nervous system during experimental allergic encephalomyelitis in rat: Direct impact on OPCs differentiation failure.
Type 3 deiodinase expression in inflammatory spinal cord lesions in rat experimental autoimmune encephalomyelitis.
Endometriosis
Identification of genes with differential regulation in primate endometrium during the proliferative and secretory phases of the cycle.
Euthyroid Sick Syndromes
Differential involvement of nuclear factor-{kappa}B and activator protein-1 pathways in the interleukin-1{beta}-mediated decrease of deiodinase type 1 and thyroid hormone receptor {beta}1 mRNA.
Early changes in thyroid hormone metabolism in the heart, liver, and brown adipose tissue during the induction of low T3 syndrome in streptozotocin-diabetic rats.
Inflammatory cytokines and type I 5'-deiodinase expression in phi1 rat liver cells.
Regulation of hepatocyte thyroxine 5'-deiodinase by T3 and nuclear receptor coactivators as a model of the sick euthyroid syndrome.
The relationship between inflammatory factors, oxidative stress and DIO-1 concentration in patients with chronic renal failure accompanied with or without euthyroid sick syndrome.
[Examination of thyroxine conversion to triiodothyronine in the lungs (preliminary report)]
Fatty Liver
Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality.
Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis.
Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rat.
The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia.
Fetal Death
Effect of methyl iodide on deiodinase activity.
Fetal Growth Retardation
Placental iodothyronine deiodinase expression in normal and growth-restricted human pregnancies.
Fetal Resorption
Effect of methyl iodide on deiodinase activity.
Fibrous Dysplasia, Polyostotic
The role of type 1 and type 2 5'-deiodinase in the pathophysiology of the 3,5,3'-triiodothyronine toxicosis of McCune-Albright syndrome.
Gastritis
MANAGEMENT OF ENDOCRINE DISEASE: Pitfalls on the replacement therapy for primary and central hypothyroidism in adults.
Glucose Intolerance
Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality.
Goiter
Comparative studies of diiodotyrosine deiodinase activities in endemic goiter and congenital goiter.
Effects of Dietary Soy Intake on Maternal Thyroid Functions and Serum Anti-Thyroperoxidase Antibody Level During Early Pregnancy.
Pendred syndrome in two Galician families: insights into clinical phenotypes through cellular, genetic, and molecular studies.
Positive correlation between type 1 and 2 iodothyronine deiodinases activities in human goiters.
Goiter, Endemic
Comparative studies of diiodotyrosine deiodinase activities in endemic goiter and congenital goiter.
[Liver deiodinase activity in rats after high and low fat iodine deficient diets]
Graves Disease
Effect of antithyroid drugs on the occurrence of antibodies against type 2 deiodinase (DIO2), which are involved in hyperthyroid Graves' disease influencing the therapeutic efficacy.
Heterogenous biochemical expression of hormone activity in subclinical/overt hyperthyroidism and exogenous thyrotoxicosis.
Immunohistochemical studies using immunized Guinea pig sera with features of anti-human thyroid, eye and skeletal antibody and Graves' sera.
Mechanisms governing the relative proportions of thyroxine and 3,5,3'-triiodothyronine in thyroid secretion.
Pax-8 expression correlates with type II 5' deiodinase expression in thyroids from patients with Graves' disease.
Quantitative measurements for type 1 deiodinase messenger ribonucleic acid in human peripheral blood mononuclear cells: mechanism of the preferential increase of T3 in hyperthyroid Graves' disease.
Spin echo nuclear magnetic resonance studies on intact erythrocytes: changes in cellular metabolism as a consequence of carbimazole therapy.
Study of Deiodinase Type 2 Polymorphisms in Graves' Disease and Ophthalmopathy in a Swedish Population.
The selenium analog of 6-propylthiouracil. Measurement of its inhibitory effect on type I iodothyronine deiodinase and of its antithyroid activity.
Thr92Ala polymorphism of human type 2 deiodinase gene (hD2) affects the development of Graves' disease, treatment efficiency, and rate of remission.
Thyroid over-expression of type 1 and type 2 deiodinase may account for the syndrome of low thyroxine and increasing triiodothyronine during propylthiouracil treatment.
Type 2 deiodinase Thr92Ala polymorphism impact on clinical course and myocardial remodeling in patients with Graves' disease.
Graves Ophthalmopathy
Immunohistochemical studies using immunized Guinea pig sera with features of anti-human thyroid, eye and skeletal antibody and Graves' sera.
Hashimoto Disease
The Thr92Ala polymorphism in the type 2 deiodinase is not associated with thyroxine dose in athyroid patients or patients with Hashimoto thyroiditis.
Hearing Loss
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase.
Heart Diseases
Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction.
Heart Failure
Long-term L-Triiodothyronine (T3) treatment in stable systolic heart failure patients: a randomised, double-blind, cross-over, placebo-controlled intervention study.
Tissue thyroid hormones and thyronamines.
Hemangioendothelioma
Rapid resolution of consumptive hypothyroidism in a child with hepatic hemangioendothelioma following liver transplantation.
Hemangioma
Consumptive Hypothyroidism Due to Diffuse Hepatic Hemangiomas Treated With Propranolol Therapy.
Efficacy of Propranolol Treatment in Thyroid Dysfunction Associated with Severe Infantile Hepatic Hemangioma.
Multiple infantile hepatic hemangiomas leading to consumptive hypothyroidism successfully treated with propranolol: A case report.
The enzymatic activity of type 1 iodothyronine deiodinase (D1) is low in liver hemangioma: a preliminary study.
Hypercholesterolemia
Hypercholesterolemia and tissue-specific differential mRNA expression of type-1 5'-iodothyronine deiodinase under different selenium status in rats.
Hyperglycemia
Peripheral deiodinase activity: A potential explanation for the association between maternal weight and gestational hyperglycemia.
Hypertension
Ala92 type 2 deiodinase allele increases risk for the development of hypertension.
Impact of thyroid function and polymorphisms in the type 2 deiodinase on blood pressure: the Rotterdam Study and the Rotterdam Scan Study.
Response to Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated With Arterial Hypertension in Type 2 Diabetes Mellitus Patients.
Type 2 deiodinase Thr92Ala polymorphism is not associated with arterial hypertension in type 2 diabetes mellitus patients.
Hyperthyroidism
3,5-Diiodothyronine in vivo maintains euthyroidal expression of type 2 iodothyronine deiodinase, growth hormone, and thyroid hormone receptor beta1 in the killifish.
Activities of UDP-glucuronyltransferase, beta-glucuronidase and deiodinase types I and II in hyper- and hypothyroid rats.
Adrenergic activation of triiodothyronine production in brown adipose tissue.
Adult Mice Lacking Mct8 and Dio2 Proteins Present Alterations in Peripheral Thyroid Hormone Levels and Severe Brain and Motor Skill Impairments.
Beneficial role of ascorbic and folic acids antioxidants against thyroxin-induced testicular dysfunction in hyperthyroid rats.
Cecal microbial transplantation attenuates hyperthyroid-induced thermogenesis in Mongolian gerbils.
Consequences of monocarboxylate transporter 8 deficiency for renal transport and metabolism of thyroid hormones in mice.
Critical role of types 2 and 3 deiodinases in the negative regulation of gene expression by T?in the mouse cerebral cortex.
Disruption of the pituitary circadian clock induced by hypothyroidism and hyperthyroidism: consequences on daily pituitary hormone expression profiles.
Dual mechanisms of regulation of type I iodothyronine 5'-deiodinase in the rat kidney, liver, and thyroid gland. Implications for the treatment of hyperthyroidism with radiographic contrast agents.
Effect of antithyroid drugs on the occurrence of antibodies against type 2 deiodinase (DIO2), which are involved in hyperthyroid Graves' disease influencing the therapeutic efficacy.
Fasting-induced increase in type II iodothyronine deiodinase activity and messenger ribonucleic acid levels is not reversed by thyroxine in the rat hypothalamus.
Further characterization of thyroid hormone response elements in the human type 1 iodothyronine deiodinase gene.
Hyperthyroidism in Patients with Graves' Ophthalmopathy, and Thyroidal, Skeletal and Eye Muscle Specific Type 2 Deiodinase Enzyme Activities.
Iodothyronine deiodination in rats with severe non-thyroidal illness.
Parent-of-origin allelic contributions to deiodinase-3 expression elicit localized hyperthyroid milieu in the hippocampus.
Pituitary-thyroid interaction: effects of thyroid hormone, non thyroidal illness and various agents on TSH secretion.
Quantitative measurements for type 1 deiodinase messenger ribonucleic acid in human peripheral blood mononuclear cells: mechanism of the preferential increase of T3 in hyperthyroid Graves' disease.
Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone.
Relative developmental toxicities of pentachloroanisole and pentachlorophenol in a zebrafish model (Danio rerio).
Sources of circulating 3,5,3'-triiodothyronine in hyperthyroidism estimated after blocking of type 1 and type 2 iodothyronine deiodinases.
Thyroid disruption in walleye (Sander vitreus) exposed to environmental contaminants: cloning and use of iodothyronine deiodinases as molecular biomarkers.
Thyroid function and body weight programming by neonatal hyperthyroidism in rats - the role of leptin and deiodinase activities.
Thyroid over-expression of type 1 and type 2 deiodinase may account for the syndrome of low thyroxine and increasing triiodothyronine during propylthiouracil treatment.
Type 1 iodothyronine deiodinase is the major source of circulating T3 in hyperthyroidism: implications for therapy.
Volume 250, Number 3 (1998), in Article No. RC989358, "Quantitative Measurements for Type 1 Deiodinase Messenger Ribonucleic Acid in Human Peripheral Blood Mononuclear Cells: Mechanism of the Preferential Increase of T3 in Hyperthyroid Graves' Disease," by Mitsushige Nishikawa, Nagaoki Toyoda, Toshinaga Yonemoto, Yoshifumi Ogawa, Sakuyoshi Tabata, Noriko Sakaguchi, Toshiko Tokoro, Atsushi Gondou, Masayoshi Yoshimura, Norio Yoshikawa, and Mitsuo Inada, pages 642-646.
Hypertriglyceridemia
Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis.
Hypertrophy, Right Ventricular
MYOCARDIAL INACTIVATION OF THYROID HORMONES IN PATIENTS WITH AORTIC STENOSIS.
Hypothyroidism
5' Deiodinase activity in brain regions of adult rats: modifications in different situations of experimental hypothyroidism.
Adrenergic activation of triiodothyronine production in brown adipose tissue.
Brain gene expression in systemic hypothyroidism and mouse models of MCT8 deficiency: The Mct8-Oatp1c1-Dio2 triad.
Cognitive function in hypothyroidism: what is that deiodinase again?
Comparison of iodothyronine 5'-deiodinase and other thyroid-hormone-dependent enzyme activities in the cerebral cortex of hypothyroid neonatal rat. Evidence for adaptation to hypothyroidism.
Consumptive Hypothyroidism Due to Diffuse Hepatic Hemangiomas Treated With Propranolol Therapy.
Consumptive Hypothyroidism: Case Report of Hepatic Hemangioendotheliomas Successfully Treated with Vincristine and Systematic Review of the Syndrome.
Critical role of types 2 and 3 deiodinases in the negative regulation of gene expression by T?in the mouse cerebral cortex.
D2-Thr92Ala, thyroid hormone levels and biochemical hypothyroidism in preeclampsia.
Disruption of the pituitary circadian clock induced by hypothyroidism and hyperthyroidism: consequences on daily pituitary hormone expression profiles.
Effects of hyper- and hypothyroidism on thyroid hormone concentrations in regions of the rat brain.
Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) on sex-dependent alterations of thyroid hormones in adult zebrafish.
Efficacy of Propranolol Treatment in Thyroid Dysfunction Associated with Severe Infantile Hepatic Hemangioma.
Establishment of an Effective Radioiodide Thyroid Ablation Protocol in Mice.
Evolution of hypothyroidism in familial goitre due to deiodinase deficiency: report of a family and review of the literature.
Feedback regulation of thyrotropin-releasing hormone (TRH): mechanisms for the non-thyroidal illness syndrome.
Feedback regulation of thyrotropin-releasing hormone gene expression by thyroid hormone in the hypothalamic paraventricular nucleus.
Hypothyroidism induces type 2 iodothyronine deiodinase expression in mouse heart and testis.
Hypothyroidism induces type I iodothyronine deiodinase expression in tilapia liver.
Inhibition of pituitary type 2 deiodinase by reverse triiodothyronine does not alter thyroxine-induced inhibition of thyrotropin secretion in hypothyroid rats.
Low-dose t3 replacement restores depressed cardiac t3 levels, preserves coronary microvasculature and attenuates cardiac dysfunction in experimental diabetes mellitus.
Managing symptoms in hypothyroid patients on adequate levothyroxine: a narrative review.
Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis.
Minireview: the neural regulation of the hypothalamic-pituitary-thyroid axis.
MiR-224 targets the 3'UTR of type 1 5'-iodothyronine deiodinase possibly contributing to tissue hypothyroidism in renal cancer.
Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy.
Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.
Pathophysiological relevance of deiodinase polymorphism.
Pendred syndrome in two Galician families: insights into clinical phenotypes through cellular, genetic, and molecular studies.
Perchlorate Exposure Induces Hypothyroidism and Affects Thyroid-Responsive Genes in Liver But Not Brain of Quail Chicks.
Pituitary-thyroid interaction: effects of thyroid hormone, non thyroidal illness and various agents on TSH secretion.
Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes.
Reduction in NPY-positive neurons and dysregulation of excitability in young senescence-accelerated mouse prone 8 (SAMP8) hippocampus precede the onset of cognitive impairment.
Regulation of thyroxine 5'-deiodinase activity by 3,5,3'-triiodothyronine in cultured rat anterior pituitary cells.
Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism.
Selenium deficiency mitigates hypothyroxinemia in iodine-deficient subjects.
Severe consumptive hypothyroidism caused by multiple infantile hepatic haemangiomas.
Sunitinib-Induced Hypothyroidism Is due to Induction of Type 3 Deiodinase Activity and Thyroidal Capillary Regression.
The impact of thyroid hormone dysfunction on ischemic heart disease.
The roles of the iodothyronine deiodinases in mammalian development.
The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism.
Thyroid disease and mental disorders: cause and effect or only comorbidity?
Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study.
Thyroid hormone deiodination in the brain of young chickens acutely adapts to changes in thyroid status.
Thyroid hormones and modulation of diastolic function: a promising target for heart failure with preserved ejection fraction.
Thyroxine replacement modifies changes in deiodinase and thyroid hormone transporter expression induced by subclinical hypothyroidism in rats.
Tissue thyroid hormones and thyronamines.
Transient hypothyroxinemia in juvenile glycoprotein hormone subunit B5 knock-out mice.
Triiodothyronine administration ameliorates the demyelination/remyelination ratio in a non-human primate model of multiple sclerosis by correcting tissue hypothyroidism.
Triiodothyronine causes rapid reversal of alpha 1/cyclic adenosine monophosphate synergism on brown adipocyte respiration and type II deiodinase activity.
Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain.
Type 2 Iodothyronine Deiodinase in Skeletal Muscle: Effects of Hypothyroidism and Fasting.
Type 2 iodothyronine deiodinase is highly expressed in germ cells of adult rat testis.
Type 2 Iodothyronine Deiodinase Levels Are Higher in Slow-Twitch than Fast-Twitch Mouse Skeletal Muscle and Are Increased in Hypothyroidism.
Type 3 Deiodinase and Consumptive Hypothyroidism: A Common Mechanism for a Rare Disease.
[Hormonal and metabolic studies in a case of athyreotic hypothyroidism with secondary hypoactivity of deiodinase]
[Hypothalamic-pituitary-thyroid axis in depression]
Idiopathic Pulmonary Fibrosis
Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.
Infections
Effects of Perinatal Lipopolysaccharide (LPS) Exposure on the Developing Rat Brain; Modeling the Effect of Maternal Infection on the Developing Human CNS.
Feedback regulation of thyrotropin-releasing hormone (TRH): mechanisms for the non-thyroidal illness syndrome.
Hepatitis C Virus Infection of Human Thyrocytes: Metabolic, Hormonal, and Immunological Implications.
The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils.
Insulin Resistance
Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor.
Diet-induced insulin resistance is associated with decreased activity of type I iodothyronine 5'-deiodinase in rat liver.
Free triiodothyronine /free thyroxine ratio as an index of deiodinase type 1 and 2 activities negatively correlates with casual serum insulin levels in patients with type 2 diabetes mellitus.
Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome.
The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice.
The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men.
The rs225017 polymorphism in the 3'UTR of the human DIO2 gene is associated with increased insulin resistance.
The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish.
The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.
Type 2 deiodinase Thr92Ala polymorphism is associated with disrupted placental activity but not with dysglycemia or adverse gestational outcomes: a genetic association study.
Weight Loss Through Gastric Banding: Effects on TSH and Thyroid Hormones in Obese Subjects With Normal Thyroid Function.
Intellectual Disability
A family-based association study of DIO2 and children mental retardation in the Qinba region of China.
Iron Deficiencies
Plasma thyroid hormone kinetics are altered in iron-deficient rats.
Ischemic Stroke
Deiodinases, organic anion transporter polypeptide polymorphisms and ischemic stroke outcomes.
Kidney Failure, Chronic
The relationship between inflammatory factors, oxidative stress and DIO-1 concentration in patients with chronic renal failure accompanied with or without euthyroid sick syndrome.
Kidney Neoplasms
Determining the enzymatic activities of iodothyronine 5'-deiodinases in renal medulla and cortex.
Disturbed expression of type 1 iodothyronine deiodinase splice variants in human renal cancer.
Induction of type 1 iodothyronine deiodinase expression inhibits proliferation and migration of renal cancer cells.
MiR-224 targets the 3'UTR of type 1 5'-iodothyronine deiodinase possibly contributing to tissue hypothyroidism in renal cancer.
Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system.
Leber Congenital Amaurosis
Deficiency of type 2 iodothyronine deiodinase reduces necroptosis activity and oxidative stress responses in retinas of Leber congenital amaurosis model mice.
Liver Diseases
Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rat.
Lung Diseases
[Examination of thyroxine conversion to triiodothyronine in the lungs (preliminary report)]
Lung Diseases, Obstructive
The conversion of thyroxine to triiodothyronine in the lung: comparison of activity of type I iodothyronine 5' deiodinase in lung cancer with peripheral lung tissues.
Lung Neoplasms
Human breast cancer tissue expresses high level of type 1 5'-deiodinase.
The conversion of thyroxine to triiodothyronine in the lung: comparison of activity of type I iodothyronine 5' deiodinase in lung cancer with peripheral lung tissues.
[Examination of thyroxine conversion to triiodothyronine in the lungs (preliminary report)]
Malabsorption Syndromes
MANAGEMENT OF ENDOCRINE DISEASE: Pitfalls on the replacement therapy for primary and central hypothyroidism in adults.
Malnutrition
Liver deiodinase activity is increased in adult rats whose mothers were submitted to malnutrition during lactation.
Neonatal low-protein diet changes deiodinase activities and pituitary TSH response to TRH in adult rats.
Mesothelioma
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line.
Metabolic Syndrome
Subcutaneous Adipose Tissue Type II Deiodinase Gene Expression Reduced in Obese Individuals with Metabolic Syndrome.
Muscular Atrophy
Thyroid hormones and skeletal muscle-new insights and potential implications.
Muscular Diseases
Thyroid hormones and skeletal muscle-new insights and potential implications.
[Osteoarthropathies and Myopathies associated with Disorders of the Thyroid Endocrine System].
Myocardial Infarction
Cardiac expression of deiodinase type 3 (Dio3) following myocardial infarction is associated with the induction of a pluripotency microRNA signature from the Dlk1-Dio3 genomic region.
MicroRNA 214 Is a Potential Regulator of Thyroid Hormone Levels in the Mouse Heart Following Myocardial Infarction, by Targeting the Thyroid-Hormone-Inactivating Enzyme Deiodinase Type III.
Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats.
Remarkable effect of chalcogen substitution on an enzyme mimetic for deiodination of thyroid hormones.
Neoplasm Metastasis
The conversion of thyroxine to triiodothyronine in the lung: comparison of activity of type I iodothyronine 5' deiodinase in lung cancer with peripheral lung tissues.
Thyroxine to triiodothyronine hyperconversion thyrotoxicosis in patients with large metastases of follicular thyroid carcinoma.
Neoplasms
3,5,3'-Triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) synthesis in rats hosting the R3230AC mammary tumour.
3,5,3'-Triiodothyronine thyrotoxicosis due to increased conversion of administered levothyroxine in patients with massive metastatic follicular thyroid carcinoma.
?-Catenin Regulates Deiodinase Levels and Thyroid Hormone Signaling in Colon Cancer Cells.
A novel mechanism for the inhibition of type 2 iodothyronine deiodinase by tumor necrosis factor ?: involvement of proteasomal degradation.
Colorectal cancer causes alteration of thyroid hormone profile in newly diagnosed patients.
Consumptive Hypothyroidism: Case Report of Hepatic Hemangioendotheliomas Successfully Treated with Vincristine and Systematic Review of the Syndrome.
Decreased expression of the thyroid hormone-inactivating enzyme type 3 deiodinase is associated with lower survival rates in breast cancer.
Deiodinases and Cancer.
Deiodination in cancer growth: the role of type III deiodinase.
DIO3, the thyroid hormone inactivating enzyme, promotes tumorigenesis and metabolic reprogramming in high grade serous ovarian cancer.
Dysregulation of iodothyronine deiodinase enzyme expression and function in human pituitary tumours.
Effect of somatotropin on thyroid hormones and cytokines in lactating dairy cows during ad libitum and restricted feed intake.
Efficacy of Propranolol Treatment in Thyroid Dysfunction Associated with Severe Infantile Hepatic Hemangioma.
Enzymatic activity of type 1 iodothyronine deiodinase in selected liver tumors.
Expression and regulation of type II iodothyronine deiodinase in human thyroid gland.
INCREASED TYPE 3 DEIODINASE EXPRESSION IN PAPILLARY THYROID CARCINOMA.
Increased type 3 deiodinase expression in papillary thyroid carcinoma.
LRRC19-A Bridge between Selenium Adjuvant Therapy and Renal Clear Cell Carcinoma: A Study Based on Datamining.
MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma.
Metastatic Follicular Thyroid Carcinoma as a Cause of Low Serum Thyroxine with a Normal Thyroid Stimulating Hormone Level.
mRNA expression pattern of retinoic acid and retinoid X nuclear receptor subtypes in human thyroid papillary carcinoma.
Proinflammatory cytokines inhibit the expression and function of human type I 5'-deiodinase in HepG2 hepatocarcinoma cells.
Remarkable effect of chalcogen substitution on an enzyme mimetic for deiodination of thyroid hormones.
Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system.
Role of type 3 deiodinase in cancer.
Selenium and the control of thyroid hormone metabolism.
Sphingomyelinase and phospholipase A2 regulate type I deiodinase expression in FRTL-5 cells.
Stromal iodothyronine deiodinase 2 (DIO2) promotes the growth of intestinal tumors in Apc?716 mutant mice.
The conversion of thyroxine to triiodothyronine in the lung: comparison of activity of type I iodothyronine 5' deiodinase in lung cancer with peripheral lung tissues.
Thyroid hormone deiodinases and cancer.
Thyroid hormone receptors and type I iodothyronine 5'-deiodinase activity of human thyroid toxic adenomas and benign cold nodules.
Thyroxine to triiodothyronine hyperconversion thyrotoxicosis in patients with large metastases of follicular thyroid carcinoma.
Type 3 deiodinase and solid tumors: an intriguing pair.
Type 3 deiodinase: role in cancer growth, stemness, and metabolism.
[Iodothyronine deiodinases expression in thyroid neoplasias]
Neuroblastoma
Carbohydrate reactivation of thyroxine 5'-deiodinase (type II) in cultured mouse neuroblastoma cells is dependent upon new protein synthesis.
Cyclic adenosine 3',5'-monophosphate and glucose stimulate thyroxine 5'-deiodinase type II in cultured mouse neuroblastoma cells.
Hormonal control of a low Km (type II) iodothyronine 5'-deiodinase in cultured NB41A3 mouse neuroblastoma cells.
Methylmercury inhibition of type II 5'-deiodinase activity resulting in a decrease in growth hormone production in GH3 cells.
Methylmercury inhibits type II 5'-deiodinase activity in NB41A3 neuroblastoma cells.
Neurologic Manifestations
A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport.
Nevus, Pigmented
Germ Line Mutations in the Thyroid Hormone Receptor Alpha Gene Predispose to Cutaneous Tags and Melanocytic Nevi.
Non-alcoholic Fatty Liver Disease
Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression.
Obesity
Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor.
Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice.
Dietary soy protein induces hepatic lipogenic enzyme gene expression while suppressing hepatosteatosis in obese female Zucker rats bearing DMBA-initiated mammary tumors.
Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality.
Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis.
Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity.
Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway.
Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rat.
The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia.
Osteoarthritis
Deiodinase 2 upregulation demonstrated in osteoarthritis patients cartilage causes cartilage destruction in tissue-specific transgenic rats.
Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues.
Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility.
Novel insights into thyroid hormones from the study of common genetic variation.
Osteoarthritis susceptibility genes influence the association between hip morphology and osteoarthritis.
The effect of forced exercise on knee joints in Dio2-/- mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress.
[Osteoarthropathies and Myopathies associated with Disorders of the Thyroid Endocrine System].
Osteochondrodysplasias
Differential expression of iodothyronine deiodinase type 2 in growth plates of chickens divergently selected for incidence of tibial dyschondroplasia.
Osteosarcoma
Expression of type 2 iodothyronine deiodinase in human osteoblast is stimulated by thyrotropin.
Overweight
Maternal adiposity, smoking, and thyroid function in early pregnancy.
Pituitary Neoplasms
Dysregulation of iodothyronine deiodinase enzyme expression and function in human pituitary tumours.
Expression of type 2 iodothyronine deiodinase in corticotropin-secreting mouse pituitary tumor cells is stimulated by glucocorticoid and corticotropin-releasing hormone.
Metabolic effect of 3,3',5'-triiodothyronine in cultured growth hormone-producing rat pituitary tumor cells. Evidence for a unique mechanism of thyroid hormone action.
Nuclear all-trans retinoic acid receptors: in vitro effects of selenium.
Studies of the hormonal regulation of type 2 5'-iodothyronine deiodinase messenger ribonucleic acid in pituitary tumor cells using semiquantitative reverse transcription-polymerase chain reaction.
The effects and interactions of substrates, inhibitors, and the cellular thiol-disulfide balance on the regulation of type II iodothyronine 5'-deiodinase.
Thyroxine 5'-deiodinase in human anterior pituitary tumors.
Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes.
Polycystic Ovary Syndrome
Decreased deiodinase activity after glucose load could lead to atherosclerosis in euthyroid women with polycystic ovary syndrome.
Free triiodothyronine /free thyroxine ratio as an index of deiodinase type 1 and 2 activities negatively correlates with casual serum insulin levels in patients with type 2 diabetes mellitus.
Pre-Eclampsia
D2-Thr92Ala, thyroid hormone levels and biochemical hypothyroidism in preeclampsia.
Effect of Preeclampsia on Ultrastructure of Thyroid Gland, Hepatic Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels in Rats.
The effect of the D1-C785T polymorphism in the type 1 iodothyronine deiodinase gene on the circulating thyroid hormone levels in Romanian women with preeclampsia. Association with the degree of severity and pregnancy outcome of preeclampsia.
Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy.
Pulmonary Disease, Chronic Obstructive
Assessment of serum levels of DIO1 and DIO3 in patients diagnosed with COPD.
Association of serum deiodinase type 2 level with chronic obstructive pulmonary disease in the Polish population.
Retinopathy of Prematurity
Thyroid Activating Enzyme, Deiodinase II Is Required for Photoreceptor Function in the Mouse Model of Retinopathy of Prematurity.
Sepsis
Erratum: Type 2 Deiodinase and Host Responses of Sepsis and Acute Lung Injury.
Type 2 Deiodinase and Host Responses of Sepsis and Acute Lung Injury.
Shock, Septic
Identification of molecular mechanisms related to nonthyroidal illness syndrome in skeletal muscle and adipose tissue from patients with septic shock.
Starvation
Exercise in a pill: feasibility of energy expenditure targets.
Status Epilepticus
Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice.
Stomach Neoplasms
Prognostic Significance of Sodium Iodide Symporter and Deiodinase Enzymes mRNA Expression in Gastric Cancer.
Thyroid Cancer, Papillary
Disturbed expression of type 1 and type 2 iodothyronine deiodinase as well as titf1/nkx2-1 and pax-8 transcription factor genes in papillary thyroid cancer.
INCREASED TYPE 3 DEIODINASE EXPRESSION IN PAPILLARY THYROID CARCINOMA.
Increased type 3 deiodinase expression in papillary thyroid carcinoma.
MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma.
Positive correlation between type 1 and 2 iodothyronine deiodinases activities in human goiters.
Thyroid Diseases
Association of antipituitary antibody and type 2 iodothyronine deiodinase antibody in patients with autoimmune thyroid disease.
Functional Polymorphisms of the Type 1 and Type 2 Iodothyronine Deiodinase Genes in Autoimmune Thyroid Diseases.
Thyroid Dysgenesis
The role of serum thyroglobulin concentration and thyroid ultrasound imaging in the detection of iodide transport defects in infants.
Thyroid Neoplasms
A study of the role of DIO1 and DIO2 polymorphism in thyroid cancer and drug response to therapy in the Saudi population.
Human breast cancer tissue expresses high level of type 1 5'-deiodinase.
The Type 2 Deiodinase ORFa-Gly3Asp Polymorphism (rs12885300) Influences the Set Point of the Hypothalamus-Pituitary-Thyroid Axis in Patients Treated for Differentiated Thyroid Carcinoma.
Tumour re-differentiation effect of retinoic acid: a novel therapeutic approach for advanced thyroid cancer.
Type 2 iodothyronine deiodinase is highly expressed in medullary thyroid carcinoma.
Thyroiditis
The spectrum of thyroid function tests during hospitalization for SARS COV-2 infection.
[Endocrine complications of modern cancer therapy].
Thyrotoxicosis
Thyrotropin (TSH) action on thyroid hormone deiodination and secretion: one aspect of thyrotropin regulation of thyroid cell biology.
Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis.
thyroxine 5'-deiodinase deficiency
Abnormal Thyroid Hormone Status Differentially Affects Bone Mass Accrual and Bone Strength in C3H/HeJ Mice: A Mouse Model of Type I Deiodinase Deficiency.
Adult onset of type 3 deiodinase deficiency in mice alters brain gene expression and increases locomotor activity.
Diagnostic confusion attributable to spurious elevation of both total thyroid hormone and thyroid hormone uptake measurements in the setting of autoantibodies: case report and review of related literature.
Evolution of hypothyroidism in familial goitre due to deiodinase deficiency: report of a family and review of the literature.
Insights into the role of deiodinases from studies of genetically modified animals.
Iodothyronine-5'-deiodinase activity in progenies of hypothyroid rats.
Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells.
Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency.
Physiological role and regulation of iodothyronine deiodinases: a 2011 update.
Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency.
Type 3 deiodinase deficiency causes spatial and temporal alterations in brain T3 signaling that are dissociated from serum thyroid hormone levels.
Type 3 deiodinase deficiency results in functional abnormalities at multiple levels of the thyroid axis.