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Information on EC 1.2.4.2 - oxoglutarate dehydrogenase (succinyl-transferring) and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC1.2.4.2

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IUBMB Comments

Contains thiamine diphosphate. It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex, EC 1.2.1.105, in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, dihydrolipoyllysine-residue succinyltransferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61.

The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
alpha-ketoglutarate dehydrogenase, 2-oxoglutarate dehydrogenase, kgdhc, alpha-ketoglutarate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex, oxoglutarate dehydrogenase, kgdh, dhtkd1, ogdhl, ogdhc, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-ketoglutarate dehydrogenase
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2-OGDH
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2-oxoglutarate dehydrogenase
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2-oxoglutarate:lipoate oxidoreductase
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AKGDH
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alpha-ketoglutarate dehydrogenase
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alpha-ketoglutaric acid dehydrogenase
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alpha-ketoglutaric dehydrogenase
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alpha-KGD
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alpha-oxoglutarate dehydrogenase
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dehydrogenase, oxoglutarate
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ketoglutaric dehydrogenase
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OGDC
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oxoglutarate decarboxylase
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oxoglutarate dehydrogenase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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oxidative decarboxylation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)
Contains thiamine diphosphate. It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex, EC 1.2.1.105, in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, dihydrolipoyllysine-residue succinyltransferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61.
CAS REGISTRY NUMBER
COMMENTARY hide
9031-02-1
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Highest Expressing Human Cell Lines
Cell Line Links Gene Links
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A0C7CYR7_PSEAI
943
0
105878
TrEMBL
-
A0A367M145_PSEAI
355
0
40132
TrEMBL
-
A0A367LUU6_PSEAI
103
0
11856
TrEMBL
-
A0A367MC49_PSEAI
391
0
43253
TrEMBL
Secretory Pathway (Reliability: 4)
A0A5E5QWF9_PSEAI
943
0
105896
TrEMBL
other Location (Reliability: 2)
A0A6A9JNE2_PSEAI
943
0
105851
TrEMBL
-
A0ABD7K826_PSEAI
943
0
105878
TrEMBL
-