show all | hide all No of entries

Information on EC 1.2.3.3 - pyruvate oxidase

for references in articles please use BRENDA:EC1.2.3.3
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.3 With oxygen as acceptor
                1.2.3.3 pyruvate oxidase
IUBMB Comments
A flavoprotein (FAD) requiring thiamine diphosphate. Two reducing equivalents are transferred from the resonant carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate (AcThDP) and reduced flavin. FADH2 is reoxidized by O2 to yield H2O2 and FAD and AcThDP is cleaved phosphorolytically to acetyl phosphate and thiamine diphosphate .
Specify your search results
Select one or more organisms in this record:
Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
acetyl phosphate-producing pyruvate oxidase, phosphate-dependent pyruvate oxidase, POX, POX-2, poxB, PoxF, PyOD, PyrOx, pyruvate oxidase, pyruvate:oxygen-2-oxidoreductase (phosphorylating), more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
pyruvate + phosphate + O2 = acetyl phosphate + CO2 + H2O2
show the reaction diagram
a flavoprotein, FAD; A flavoprotein, FAD, requiring thiamine diphosphate
-
-
-
PATHWAY SOURCE
PATHWAYS
Select items on the left to see more content.