Information on EC 1.2.1.8 - betaine-aldehyde dehydrogenase and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC1.2.1.8
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This record set is specific for:
Homo sapiens


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria


The taxonomic range for the selected organisms is: Homo sapiens

EC NUMBER
COMMENTARY hide
1.2.1.8
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RECOMMENDED NAME
GeneOntology No.
betaine-aldehyde dehydrogenase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
choline degradation I
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choline degradation IV
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glycine betaine biosynthesis I (Gram-negative bacteria)
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glycine betaine biosynthesis II (Gram-positive bacteria)
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glycine betaine biosynthesis III (plants)
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glycine betaine biosynthesis
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Glycine, serine and threonine metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
betaine-aldehyde:NAD+ oxidoreductase
In many bacteria, plants and animals, the osmoprotectant betaine is synthesized in two steps: (1) choline to betaine aldehyde and (2) betaine aldehyde to betaine. This enzyme is involved in the second step and appears to be the same in plants, animals and bacteria. In contrast, different enzymes are involved in the first reaction. In plants, this reaction is catalysed by EC 1.14.15.7 (choline monooxygenase), whereas in animals and many bacteria it is catalysed by either membrane-bound EC 1.1.99.1 (choline dehydrogenase) or soluble EC 1.1.3.17 (choline oxidase) [5]. In some bacteria, betaine is synthesized from glycine through the actions of EC 2.1.1.156 (glycine/sarcosine N-methyltransferase) and EC 2.1.1.157 (sarcosine/dimethylglycine N-methyltransferase).
CAS REGISTRY NUMBER
COMMENTARY hide
9028-90-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-aminobutyraldehyde + NAD+ + H2O
4-aminobutyrate + NADH
show the reaction diagram
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?
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
show the reaction diagram
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?
betaine aldehyde + NAD+ + H2O
betaine + NADH
show the reaction diagram
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?
glycolaldehyde + NAD+ + H2O
glycolate + NADH
show the reaction diagram
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?
propionaldehyde + NAD+ + H2O
propionate + NADH
show the reaction diagram
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?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cimetidine
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.005
4-Aminobutyraldehyde
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0.05
acetaldehyde
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0.24
glycolaldehyde
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0.035
NAD+
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.001
cimetidine
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8
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reaction with 4-aminobutyraldehyde
9.5
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reaction with betaine aldehyde and propionaldehyde
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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NAD+-linked aldehyde dehydrogenase E3 isoenzyme
Manually annotated by BRENDA team
PDB
SCOP
CATH
UNIPROT
ORGANISM
P68431
Homo sapiens;
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
54000
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x * 54000, SDS-PAGE
230000
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 54000, SDS-PAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
aldehyde dehydrogenase E3 isozyme is a betaine aldehyde dehydrogenase
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