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IUBMB CommentsThe Euglena enzyme can also use NAD+ as acceptor, but more slowly.
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
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2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH + H+
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2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)
The Euglena enzyme can also use NAD+ as acceptor, but more slowly.
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2-oxoglutarate + CoA + NADP+
succinyl-CoA + CO2 + NADPH
2-oxoglutarate + CoA + NADP+
succinyl-CoA + CO2 + NADPH
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Substrates: NAD+ has 20% activity of NADP+
Products: -
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2-oxoglutarate + CoA + NADP+
succinyl-CoA + CO2 + NADPH
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Substrates: -
Products: -
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2-oxoglutarate + CoA + NADP+
succinyl-CoA + CO2 + NADPH
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Substrates: NAD+ has 4% reactivity of NADP+
Products: -
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2-oxoglutarate + CoA + NADP+
succinyl-CoA + CO2 + NADPH
2-oxoglutarate + CoA + NADP+
succinyl-CoA + CO2 + NADPH
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Substrates: NAD+ has 20% activity of NADP+
Products: -
?
2-oxoglutarate + CoA + NADP+
succinyl-CoA + CO2 + NADPH
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Substrates: -
Products: -
?
2-oxoglutarate + CoA + NADP+
succinyl-CoA + CO2 + NADPH
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Substrates: NAD+ has 4% reactivity of NADP+
Products: -
?
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CoA
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NAD+
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20% activity of NADP+
NAD+
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4% reactivity of NADP+
NADP+
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brenda
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brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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A0A656Z8U3_9PROT
595
0
65639
TrEMBL
-
Q5NWN2_AROAE
Aromatoleum aromaticum (strain EbN1)
595
0
64969
TrEMBL
-
B8KVJ9_9GAMM
626
1
69226
TrEMBL
-
Q5P1U2_AROAE
Aromatoleum aromaticum (strain EbN1)
615
0
67423
TrEMBL
-
A0A656Z9C3_9PROT
619
0
68448
TrEMBL
-
Q5P1U3_AROAE
Aromatoleum aromaticum (strain EbN1)
595
0
65482
TrEMBL
-
A0A656Z8V2_9PROT
351
0
37848
TrEMBL
-
Q5NWN0_AROAE
Aromatoleum aromaticum (strain EbN1)
351
0
37535
TrEMBL
-
Q5P1U1_AROAE
Aromatoleum aromaticum (strain EbN1)
351
0
37655
TrEMBL
-
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Inui, H.; Miyatake, K.; Nakano, Y.; Kitaoka, S.
Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis
J. Biochem.
96
931-934
1984
Euglena gracilis
brenda
Lochmeyer, C.; Fuchs, G.
NADP+-specific 2-oxoglutarate dehydrogenase in denitrifying Pseudomonas species
Arch. Microbiol.
153
226-229
1990
Pseudomonas sp.
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brenda
Ziegler, K.; Braun, K.; Bckler, A.; Fuchs, G.
Studies on the anaerobic degradation of benzoic acid and 2-aminobenzoic acid by a denitrifying Pseudomonas strain
Arch. Microbiol.
149
62-69
1987
Pseudomonas sp.
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brenda
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