Information on EC 1.2.1.41 - glutamate-5-semialdehyde dehydrogenase and Organism(s) Pseudomonas aeruginosa

Reaction Schemes

hideshow

L-glutamyl 5-phosphate

+

NADPH

+

H+

=

L-glutamate 5-semialdehyde

+

phosphate

+

NADP+

+

+

=

+

+

Synonyms
aldh18a1, pyrroline-5-carboxylate synthase, pyrroline-5-carboxylate synthetase, gamma-glutamyl phosphate reductase, aldh4, glutamic-gamma-semialdehyde dehydrogenase, glutamate semialdehyde dehydrogenase, glutamic gamma-semialdehyde dehydrogenase, pyrroline 5-carboxylate dehydrogenase, glutamate-gamma-semialdehyde dehydrogenase, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

beta-glutamylphosphate reductase

-

-

-

-

dehydrogenase, glutamate semialdehyde

-

-

-

-

gamma-glutamyl phosphate reductase

-

-

-

-

glutamate semialdehyde dehydrogenase

-

-

-

-

Glutamate-5-semialdehyde dehydrogenase

-

-

-

-

glutamate-gamma-semialdehyde dehydrogenase

-

-

-

-

glutamic gamma-semialdehyde dehydrogenase

-

-

-

-

Glutamyl-gamma-semialdehyde dehydrogenase

-

-

-

-

GPR

-

-

-

-

GSA dehydrogenase

-

-

-

-

reductase, gamma-glutamyl phosphate

-

-

-

-

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

oxidation

-

-

-

-

redox reaction

-

-

-

-

reduction

-

-

-

-

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PATHWAY SOURCE

PATHWAYS

BRENDA

arginine metabolism, proline metabolism

KEGG

Arginine and proline metabolism, Biosynthesis of secondary metabolites, Carbapenem biosynthesis

MetaCyc

L-citrulline biosynthesis, L-Ndelta-acetylornithine biosynthesis, L-ornithine biosynthesis II, L-proline biosynthesis I (from L-glutamate)

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SYSTEMATIC NAME

IUBMB Comments

L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)

-

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CAS REGISTRY NUMBER

COMMENTARY

54596-29-1

-

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

L-glutamate 5-semialdehyde + phosphate + NADP+

L-5-glutamyl phosphate + NADPH

Pseudomonas aeruginosa

-

390308

Substrates: -
Products: -

?

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COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

NADPH

Pseudomonas aeruginosa

-

-

390308

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

L-proline

Pseudomonas aeruginosa

-

25% inhibition at 50 mM

390308

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only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks include all textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks + FRENDAco-occurrence of enzyme names and organism names (less precise)

ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Pseudomonas aeruginosa

-

390308

-

-

brenda

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTIONThe reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

A0A0C6EB78 pBLAST

A0A0C6EB78_PSEAI

Pseudomonas aeruginosa

421

0

45044

TrEMBL

Show Sequence

Mitochondrion (Reliability: 1)

A0A0Q3UKG4 pBLAST

A0A0Q3UKG4_PSEAI

Pseudomonas aeruginosa

421

0

45016

TrEMBL

Show Sequence

Secretory Pathway (Reliability: 1)

A0A2R4KPH5 pBLAST

A0A2R4KPH5_PSEAI

Pseudomonas aeruginosa

421

0

45030

TrEMBL

Show Sequence

-

A0A643IW99 pBLAST

A0A643IW99_PSEAI

Pseudomonas aeruginosa

421

0

45002

TrEMBL

Show Sequence

other Location (Reliability: 3)

A0A6A9JYL0 pBLAST

A0A6A9JYL0_PSEAI

Pseudomonas aeruginosa

421

0

45121

TrEMBL

Show Sequence

Secretory Pathway (Reliability: 2)

A0A6B1Y0U7 pBLAST

A0A6B1Y0U7_PSEAI

Pseudomonas aeruginosa

421

0

45058

TrEMBL

Show Sequence

other Location (Reliability: 2)

A0A9P1RAN7 pBLAST

A0A9P1RAN7_PSEAI

Pseudomonas aeruginosa

421

0

45028

TrEMBL

Show Sequence

Secretory Pathway (Reliability: 3)

A0ABD7K5T8 pBLAST

A0ABD7K5T8_PSEAI

Pseudomonas aeruginosa

421

0

45014

TrEMBL

Show Sequence

-

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

390308

Hayzer, D.J.; Leisinger, T.

Proline biosynthesis in Escherichia coli. Purification and characterisation of glutamate-semialdehyde dehydrogenase

Eur. J. Biochem.

121

561-565

1982

Escherichia coli, Pseudomonas aeruginosa

7035170

brenda

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