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Information on EC 1.2.1.30 - carboxylate reductase (NADP+)

for references in articles please use BRENDA:EC1.2.1.30

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IUBMB Comments

The enzyme contains an adenylation domain, a phosphopantetheinyl binding domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group. The enzyme activates its substrate to an adenylate form, followed by a transfer to the phosphopantetheinyl binding domain. The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to an aldehyde and released.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
carboxylate reductases, nicar, macar, nocar, nccar, mmcar, aryl-aldehyde oxidoreductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an aromatic aldehyde + NADP+ + AMP + diphosphate = an aromatic acid + NADPH + H+ + ATP
show the reaction diagram
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