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Information on EC 1.2.1.27 - methylmalonate-semialdehyde dehydrogenase (CoA-acylating)

for references in articles please use BRENDA:EC1.2.1.27
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IUBMB Comments
Also converts 3-oxopropanoate into acetyl-CoA . The reaction occurs in two steps with the decarboxylation process preceding CoA-binding . Bicarbonate rather than CO2 is released as a final product .
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
mmsdh, msdh, methylmalonate semialdehyde dehydrogenase, odommsdh, methylmalonic acid semialdehyde dehydrogenase, mmsadh, sso1218, methylmalonate semialdehyde dehydrogenase protein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH
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