Information on EC 1.2.1.12 - glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC1.2.1.12

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EC Tree 1 Oxidoreductases 1.2 Acting on the aldehyde or oxo group of donors 1.2.1 With NAD⁺ or NADP⁺ as acceptor 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)

Also acts very slowly on D-glyceraldehyde and some other aldehydes; thiols can replace phosphate.

The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Reaction Schemes

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D-glyceraldehyde 3-phosphate

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3-phospho-D-glyceroyl phosphate

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Synonyms
gapdhs, d-glyceraldehyde-3-phosphate dehydrogenase, gapds, gadph, glyceraldehyde-3-phosphate dehydrogenases, plasmin receptor, gapc1, plasminogen-binding protein, gapcp, glyceraldehyde-3 phosphate dehydrogenase, more

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Go to Synonym Search

3-phosphoglyceraldehyde dehydrogenase

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BARS-38

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CP 17/CP 18

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dehydrogenase, glyceraldehyde phosphate

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dihydrogenase, glyceraldehyde phosphate

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G3PD

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GAPDH

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GAPDH1

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GAPDH2

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glyceraldehyde phosphate dehydrogenase (NAD)

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glyceraldehyde-3-P-dehydrogenase

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glyceraldehyde-3-phosphate dehydrogenase (NAD)

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GPD

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Gra3PDH

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GraP-DH

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Larval antigen OVB95

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Major larval surface antigen

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NAD+-G-3-P dehydrogenase

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NAD-dependent glyceraldehyde phosphate dehydrogenase

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NAD-dependent glyceraldehyde-3-phosphate dehydrogenase

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NAD-G3PDH

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NADH-glyceraldehyde phosphate dehydrogenase

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P-37

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phosphoglyceraldehyde dehydrogenase

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Plasmin receptor

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Plasminogen-binding protein

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TLAb

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triose phosphate dehydrogenase

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Go to Reaction Type Search

oxidation

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redox reaction

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reduction

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Go to Pathway Search

BRENDA

KEGG

Biosynthesis of secondary metabolites, Carbon fixation in photosynthetic organisms, Glycolysis / Gluconeogenesis, Microbial metabolism in diverse environments

MetaCyc

Bifidobacterium shunt, Entner-Doudoroff pathway I, formaldehyde assimilation III (dihydroxyacetone cycle), gluconeogenesis I, gluconeogenesis III, glycerol degradation to butanol, glycolysis I (from glucose 6-phosphate), glycolysis II (from fructose 6-phosphate), glycolysis III (from glucose), glycolysis IV, heterolactic fermentation, sucrose biosynthesis I (from photosynthesis), superpathway of glucose and xylose degradation

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Go to Systematic Name Search

D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)

Also acts very slowly on D-glyceraldehyde and some other aldehydes; thiols can replace phosphate.

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Go to CAS Registry Number Search

9001-50-7

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Go to Substrate/Product Search

D-glyceraldehyde 3-phosphate + phosphate + NAD+

3-phospho-D-glyceroyl phosphate + NADH

show the reaction diagram

Pseudomonas aeruginosa

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Substrates: -
Products: -

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additional information

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Pseudomonas aeruginosa

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Substrates: importance of the enzyme in glucose catabolism. Activity is reduced severalfold after growth on gluconeogenic substrates such as citrate compared to growth on glucose
Products: -

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Go to Natural Substrate Search

additional information

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Pseudomonas aeruginosa

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Substrates: importance of the enzyme in glucose catabolism. Activity is reduced severalfold after growth on gluconeogenic substrates such as citrate compared to growth on glucose
Products: -

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Go to Cofactor Search

NAD+

Pseudomonas aeruginosa

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Go to Inhibitor Search

6-phosphogluconate

Pseudomonas aeruginosa

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AMP

Pseudomonas aeruginosa

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ATP

Pseudomonas aeruginosa

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NADH

Pseudomonas aeruginosa

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Go to Activating Compound Search

NADPH

Pseudomonas aeruginosa

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slight activation

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Go to pH Optimum Search

9.3

Pseudomonas aeruginosa

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Go to Organism Search

Pseudomonas aeruginosa

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Manually annotated by BRENDA team

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Highest Expressing Human Cell Lines

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Cell Line Links

Gene Links

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Go to Molecular Weight Search

315000

Pseudomonas aeruginosa

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non-denaturing PAGE

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Go to Temperature Stability Search

15

Pseudomonas aeruginosa

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5 min, stable

55

Pseudomonas aeruginosa

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5 min, complete loss of activity

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Go to Storage Stability Search

4°C, 1 mM EDTA, 75% glycerol, stable

Pseudomonas aeruginosa

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top print hide References Search

Rivers, D.B.; Blevins, W.T.

Multiple enzyme forms of glyceraldehyde-3-phosphate dehydrogenase in Pseudomonas aeruginosa PAO

J. Gen. Microbiol.

133

3159-3164

1987

Pseudomonas aeruginosa

Manually annotated by BRENDA team

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Release 2026.1 (March 2026)