Information on EC 1.2.1.11 - aspartate-semialdehyde dehydrogenase and Organism(s) Pseudomonas aeruginosa

Reaction Schemes

hideshow

L-aspartate 4-semialdehyde

+

phosphate

+

NADP+

=

L-4-aspartyl phosphate

+

NADPH

+

H+

+

+

=

+

+

Synonyms
asadh, aspartate semialdehyde dehydrogenase, aspartate-beta-semialdehyde dehydrogenase, aspartate-semialdehyde dehydrogenase, aspartate beta-semialdehyde dehydrogenase, asa dh, aspartic semialdehyde dehydrogenase, l-aspartate-beta-semialdehyde dehydrogenase, asd enzyme, ecasadh, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

ASA dehydrogenase

-

-

-

-

ASA DH

-

-

-

-

ASADH

-

-

-

-

aspartate semialdehyde dehydrogenase

-

-

-

-

aspartic beta-semialdehyde dehydrogenase

-

-

-

-

aspartic semialdehyde dehydrogenase

-

-

-

-

dehydrogenase, aspartate semialdehyde

-

-

-

-

L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosphorylating)

-

-

-

-

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

oxidation

-

-

-

-

Phosphorylation

-

-

-

-

redox reaction

-

-

-

-

reduction

-

-

-

-

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PATHWAY SOURCE

PATHWAYS

BRENDA

threonine metabolism

KEGG

Biosynthesis of secondary metabolites, Cysteine and methionine metabolism, Glycine, serine and threonine metabolism, Lysine biosynthesis, Microbial metabolism in diverse environments, Monobactam biosynthesis

MetaCyc

3-dehydroquinate biosynthesis II (archaea), cremeomycin biosynthesis, dipicolinate biosynthesis, ectoine biosynthesis, grixazone biosynthesis, L-homoserine biosynthesis, L-lysine biosynthesis I, L-lysine biosynthesis II, L-lysine biosynthesis III, L-lysine biosynthesis VI, L-methionine biosynthesis IV, norspermidine biosynthesis, platensimycin biosynthesis, spermidine biosynthesis II

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SYSTEMATIC NAME

IUBMB Comments

L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)

-

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CAS REGISTRY NUMBER

COMMENTARY

9000-98-0

-

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

L-4-aspartyl phosphate + NADPH

L-aspartate 4-semialdehyde + phosphate + NADP+

Pseudomonas aeruginosa

Q51344

390202

Substrates: -
Products: -

?

L-aspartate 4-semialdehyde + phosphate + NADP+

L-4-aspartyl phosphate + NADPH

Pseudomonas aeruginosa

Q51344

390202

Substrates: -
Products: -

r

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

L-4-aspartyl phosphate + NADPH

L-aspartate 4-semialdehyde + phosphate + NADP+

Pseudomonas aeruginosa

Q51344

390202

Substrates: -
Products: -

?

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COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

NADP+

Pseudomonas aeruginosa

Q51344

-

390202

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.12

L-aspartate 4-semialdehyde

Pseudomonas aeruginosa

Q51344

-

390202

0.13

NADP+

Pseudomonas aeruginosa

Q51344

-

390202

1.5

phosphate

Pseudomonas aeruginosa

Q51344

-

390202

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

160

L-aspartate 4-semialdehyde

Pseudomonas aeruginosa

Q51344

-

390202

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SPECIFIC ACTIVITY [µmol/min/mg]

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

2 entries

additional information

Pseudomonas aeruginosa

Q51344

-

390202

additional information

Pseudomonas aeruginosa

-

-

390202

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only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks include all textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks + FRENDAco-occurrence of enzyme names and organism names (less precise)

ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Pseudomonas aeruginosa

-

390202

Q51344

Uniprot

brenda

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTIONThe reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

A0A0C6EQW5 pBLAST

A0A0C6EQW5_PSEAI

Pseudomonas aeruginosa

370

0

40495

TrEMBL

Show Sequence

-

A0A367MB72 pBLAST

A0A367MB72_PSEAI

Pseudomonas aeruginosa

370

0

40409

TrEMBL

Show Sequence

other Location (Reliability: 2)

A0A643J0M9 pBLAST

A0A643J0M9_PSEAI

Pseudomonas aeruginosa

370

0

40523

TrEMBL

Show Sequence

other Location (Reliability: 2)

A0ABD7K3Y0 pBLAST

A0ABD7K3Y0_PSEAI

Pseudomonas aeruginosa

370

0

40553

TrEMBL

Show Sequence

-

O87013 pBLAST

O87013_PSEAI

Pseudomonas aeruginosa

391

0

42089

TrEMBL

Show Sequence

-

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PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

using column chromatography on Q Sepharose XL and phenyl-Sepharose

Pseudomonas aeruginosa

Q51344

390202

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

expressed in Escherichia coli

Pseudomonas aeruginosa

Q51344

390202

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

390202

Moore, R.A.; Bocik, W.E.; Viola, R.E.

Expression and purification of aspartate beta-semialdehyde dehydrogenase from infectious microorganisms

Protein Expr. Purif.

25

189-194

2002

Haemophilus influenzae, Helicobacter pylori (O25801), Helicobacter pylori, Pseudomonas aeruginosa (Q51344), Pseudomonas aeruginosa, Vibrio cholerae (P23247), Vibrio cholerae

12071715

brenda

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