Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
beta-3-methylaspartyl phosphate + NADPH
beta-3-methylaspartate 4-semialdehyde + phosphate + NADP+
-
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
L-aspartate 4-semialdehyde + arsenate + NADP+
?
-
-
-
r
L-aspartate 4-semialdehyde + HasO42- + NADP+
?
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NAD+
L-4-aspartyl phosphate + NADH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + vanadate + NADP+
?
-
-
-
r
L-aspartate-4-semialdehyde + cacodylate + NADP+
L-4-aspartyl cacodylate + NADPH
10% of the activity with phosphate
-
r
L-aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
additional information
?
-
aspartate-4-semialdehyde + phosphate + NADP+

L-4-aspartyl phosphate + NADPH + H+
second enzyme in the lysine/homoserine biosynthetic pathways
-
r
aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
second enzyme in the lysine/homoserine biosynthetic pathways
-
r
L-4-aspartyl phosphate + NADPH

L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
synthesis of threonine
-
r
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
enzyme in pathway from L-aspartic acid to L-lysine, L-methionine, L-threonine and L-isoleucine
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
synthesis of threonine
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
synthesis of threonine
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
synthesis of threonine
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
synthesis of methionine
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
synthesis of methionine
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
?
L-4-aspartyl phosphate + NADPH

L-aspartate-4-semialdehyde + phosphate + NADP+
part of the biosynthetic aspartate pathway
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
reductive dephosphorylation
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
physiological forward reaction, reductive dephosphorylation in the aspartate biosynthetic pathway
-
r
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
physiological forward reaction direction, key enzyme in diaminopimelic acid biosynthetic pathway
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
physiological forward reaction direction, key enzyme in diaminopimelic acid biosynthetic pathway
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
2nd step in the biosynthetic aspartate pathway, also required for biosynthesis of the beta-lactam caphamycin, overview
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
2nd step in the biosynthetic aspartate pathway, also required for biosynthesis of the beta-lactam caphamycin, overview
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
reductive dephosphorylation in the aspartate biosynthetic pathway of plants and microorganisms
-
r
L-4-aspartyl phosphate + NADPH + H+

L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
r
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
r
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
r
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
r
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
r
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
?
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
?
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
r
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
r
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
r
L-aspartate 4-semialdehyde + phosphate + NAD+

L-4-aspartyl phosphate + NADH + H+
-
-
r
L-aspartate 4-semialdehyde + phosphate + NAD+
L-4-aspartyl phosphate + NADH + H+
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+

L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+

L-4-aspartyl phosphate + NADPH + H+
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
ASADH is an important enzyme, occupying the first branch position of the biosynthetic pathway of the aspartate family of amino acids, i.e. lysine, methionine, isoleucine and threonine, L-aspartate-beta-semialdehyde is a key intermediate in the biosynthesis of diaminopimelic acid
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
the enzyme takes part in the lysine/homoserine-biosynthetic pathway
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
active site structure, overview
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
ASADH is an important enzyme, occupying the first branch position of the biosynthetic pathway of the aspartate family of amino acids, i.e. lysine, methionine, isoleucine and threonine, L-aspartate-beta-semialdehyde is a key intermediate in the biosynthesis of diaminopimelic acid
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
active site structure, overview
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
the essential ASADH produces the first branch-point metabolite in the biosynthetic pathways that lead to the production of lysine, threonine, methionine and isoleucine as well as the cell-wall precursor diaminopimelate
-
?
L-aspartate-4-semialdehyde + phosphate + NADP+

L-4-aspartyl phosphate + NADPH
-
-
reverse reaction: reductive dephosphorylation
r
L-aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
?
L-aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
reductive dephosphorylation in the aspartate biosynthetic pathway
-
r
L-aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
reductive dephosphorylation in the aspartate biosynthetic pathway, aspartate-beta-semialdehydr is the key intermediate in biosynthesis of diaminopimelic acid
-
r
L-aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
formation of an acyl-enzyme intermediate
-
r
L-aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
formation of an acyl-enzyme intermediate
-
r
L-aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
r
L-aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
-
r
L-aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
reverse reaction: reductive dephosphorylation
r
additional information

?
-
-
the putative phosphate side contains arginine and a lysine that can provide electrostratic attraction to bind an oxyanion
-
?
additional information
?
-
-
maximum velocity with HAsO42- is 0.4 times that with HPO42-
-
?
additional information
?
-
-
the kinetic parameters with arsenate are comparable to those of phosphate, vanadate is an excellent substrate for the enzyme
-
?
additional information
?
-
oxyanion binding sites and structures with arsenate and periodate
-
?
additional information
?
-
-
when arsenate is substituted for phosphate the rates are about one-half those with corresponding phosphate concentrations
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
L-aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
aspartate-4-semialdehyde + phosphate + NADP+

L-4-aspartyl phosphate + NADPH + H+
second enzyme in the lysine/homoserine biosynthetic pathways
-
-
r
aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
second enzyme in the lysine/homoserine biosynthetic pathways
-
-
r
L-4-aspartyl phosphate + NADPH

L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
synthesis of threonine
-
r
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
enzyme in pathway from L-aspartic acid to L-lysine, L-methionine, L-threonine and L-isoleucine
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
synthesis of threonine
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
synthesis of threonine
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
synthesis of threonine
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
synthesis of methionine
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
synthesis of methionine
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
?
L-4-aspartyl phosphate + NADPH

L-aspartate-4-semialdehyde + phosphate + NADP+
part of the biosynthetic aspartate pathway
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
physiological forward reaction, reductive dephosphorylation in the aspartate biosynthetic pathway
-
-
r
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
physiological forward reaction direction, key enzyme in diaminopimelic acid biosynthetic pathway
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
physiological forward reaction direction, key enzyme in diaminopimelic acid biosynthetic pathway
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
2nd step in the biosynthetic aspartate pathway, also required for biosynthesis of the beta-lactam caphamycin, overview
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
2nd step in the biosynthetic aspartate pathway, also required for biosynthesis of the beta-lactam caphamycin, overview
-
-
?
L-4-aspartyl phosphate + NADPH
L-aspartate-4-semialdehyde + phosphate + NADP+
reductive dephosphorylation in the aspartate biosynthetic pathway of plants and microorganisms
-
-
r
L-4-aspartyl phosphate + NADPH + H+

L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
-
r
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
-
r
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
r
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
-
r
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
?
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
?
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
-
r
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
-
r
L-4-aspartyl phosphate + NADPH + H+
L-aspartate 4-semialdehyde + phosphate + NADP+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+

L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
ASADH is an important enzyme, occupying the first branch position of the biosynthetic pathway of the aspartate family of amino acids, i.e. lysine, methionine, isoleucine and threonine, L-aspartate-beta-semialdehyde is a key intermediate in the biosynthesis of diaminopimelic acid
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
the enzyme takes part in the lysine/homoserine-biosynthetic pathway
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
ASADH is an important enzyme, occupying the first branch position of the biosynthetic pathway of the aspartate family of amino acids, i.e. lysine, methionine, isoleucine and threonine, L-aspartate-beta-semialdehyde is a key intermediate in the biosynthesis of diaminopimelic acid
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
-
?
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
-
-
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
-
the essential ASADH produces the first branch-point metabolite in the biosynthetic pathways that lead to the production of lysine, threonine, methionine and isoleucine as well as the cell-wall precursor diaminopimelate
-
-
?
L-aspartate-4-semialdehyde + phosphate + NADP+

L-4-aspartyl phosphate + NADPH
reductive dephosphorylation in the aspartate biosynthetic pathway
-
-
r
L-aspartate-4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
-
reductive dephosphorylation in the aspartate biosynthetic pathway, aspartate-beta-semialdehydr is the key intermediate in biosynthesis of diaminopimelic acid
-
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(1R)-5-[(2-carboxyphenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
(1R)-5-[(3-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
(1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
(2R,3aR)-5-[(methylsulfonyl)methyl]-2,3,3a,4-tetrahydro-1H-indole-2-carboxylate
(2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate
(2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate
(2R,7aR)-2,3,7,7a-tetrahydro-1H-indole-2,6-dicarboxylate
(2R,7aR)-6-hydroxy-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate
(2R,7aR)-6-nitro-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate
(2R,8aR)-2,7-dinitro-1,2,8,8a-tetrahydronaphthalene
(3aR)-2-oxo-2,3,3a,4-tetrahydro-1H-benzimidazole-5-carboxylic acid
(3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one
(3aR)-5-nitro-3a,4-dihydro-1H-indene-1,3(2H)-dione
(3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
(3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
(7aR)-2-oxo-2,3,7,7a-tetrahydro-1H-indole-6-carboxylate
(7aR)-3-(carboxylatomethyl)-6-nitro-7,7a-dihydro-1H-indole-2-carboxylate
(S)-2-amino-5-fluoro-4-oxo-5-phosphono-pentanoic acid
irreversible inhibition
(S)-2-amino-5-phosphono-pent-4-ynoic acid
-
3-Chloroacetylpyridine-adenine dinucleotide phosphate
-
NADP+ and NADPH protect
3-hydroxyaspartic acid
-
-
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
4-nitro-N,N-diethylbenzimidazolinone
4-nitro-N,N-dimethylbenzimidazolinone
4-nitro-N-ethylphthalimide
4-nitro-N-methylphthalimide
5-(carboxylatocarbonyl)-1H-pyrrole-2-carboxylate
5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate
acetylenic and z-olefinic analogues
-
competitive inhibition
-
Adenosine 5'-triphosphate
-
causes a time-dependent inactivation at a concentration of 3.5 mM, 0°C, pH 6.5 and 2 mM dithiothreitol, inactivation can be completely reversed by warming the reaction mixture to 25°C, 50% inactivation occurs at a concentration of 2.5 mM, NADH protects
aromatic aldehydes
-
e.g.: benzaldehyde, weak
caulerpin
-
molecular docking and dynamics simulation of Vibrio anguillarum aspartate semialdehyde dehydrogenase with natural product caulerpin, which binds with high energy. Caulerpin can be used as antibiotic against Vibrio anguillarum in fish aquaculture industry
-
cis-5-phosphonic acid pipecolic acid
-
-
cysteine
-
in the reverse reaction
D-Cystine
-
70% inhibition at 0.01 mM, binds via the cysteine moiety covalently to the catalytic Cys135 of the enzyme, pH-dependent proces, optimal at pH 7.0-7.5, inhibition is reversible by DTT, dithioerythritol, 2-mercaptoethanol, dimercaptopropanol, and reduced glutathione, no protection by aspartate-beta-semialdehyde, NADP+ or NADPH, inhibition mechanism and kinetics
dimethyl pyridine-2,5-dicarboxylate
DTNB
-
reversible by DTT, dithioerythritol, 2-mercaptoethanol, dimercaptopropanol, and reduced glutathione
GSSG
-
oxidized glutathione
homocysteine
-
in the reverse reaction
iodoacetamide
-
at 0.1 mM: 45.4% inactivation in the absence of NADP+, 22% inactivation in the presence of 1 mM NADP+
L-2-Amino-4-oxo-5-chloropentanoic acid
L-cystine diethyl ester
-
68% inhibition at 0.01 mM, reversible by DTT, dithioerythritol, 2-mercaptoethanol, dimercaptopropanol, and reduced glutathione
L-cystine dimethyl ester
-
67% inhibition at 0.01 mM, reversible by DTT, dithioerythritol, 2-mercaptoethanol, dimercaptopropanol, and reduced glutathione
L-cystine hydroxamate
-
20% inhibition at 0.01 mM, reversible by DTT, dithioerythritol, 2-mercaptoethanol, dimercaptopropanol, and reduced glutathione
L-leucine
-
inhibits, when added to a final concentration of 10 mM in the assay system produces a decrease of 0.004 units in specific activity
methyl 5-nitropyridine-2-carboxylate
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(4-bromobenzyl)-N-(2-carboxy)ethyl-3,4-dicarboxybenzylamine
-
-
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine
N-carboxyethyl-3,4-dicarboxybenzylamine
N-carboxymethyl-3,4-dicarboxybenzylamine
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine
NADPH-Tris-chloride buffer
-
promotes a weak inactivation at 0°C, NADH protects
p-hydroxymercuribenzoate
-
-
perrhenate
-
very weak inhibitor
phosphonate
-
weak inhibitor
pipecolic acid-5-(R)-phosphate hydrochloric acid
-
-
pipecolic acid-5-(S)-phosphate hydrochloric acid
-
-
potassium phosphate
-
at a concentration of 10 mM promotes 60% inactivation at 0°C in the presence of 10 mM ATP, at a concentration of 100 mM promotes 61% inactivation in the presence of 10 mM ATP and 32% inactivation in the absence of ATP, NADH protects
S-methyl cysteine sulfoxide
inhibitor binding structure deduced from crystal structure
S-methyl-L-cysteine sulfoxide
covalently binding inhibitor via Cys134 at the active site, inactivation, inhibition and binding mechanism, reversible by addition of DTT or 2-mercaptoethanol
thieno[2,3-b]thiophene-2,5-dicarboxylate
trans-5-phosphonic acid pipecolic acid
-
-
(1R)-5-[(2-carboxyphenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate

-
-
(1R)-5-[(2-carboxyphenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
(1R)-5-[(3-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate

-
-
(1R)-5-[(3-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
(1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate

-
-
(1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
-
(2R,3aR)-5-[(methylsulfonyl)methyl]-2,3,3a,4-tetrahydro-1H-indole-2-carboxylate

-
-
(2R,3aR)-5-[(methylsulfonyl)methyl]-2,3,3a,4-tetrahydro-1H-indole-2-carboxylate
-
(2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate

-
-
(2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate
-
(2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate

-
-
(2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate
-
(2R,7aR)-2,3,7,7a-tetrahydro-1H-indole-2,6-dicarboxylate

-
-
(2R,7aR)-2,3,7,7a-tetrahydro-1H-indole-2,6-dicarboxylate
-
(2R,7aR)-6-hydroxy-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate

-
-
(2R,7aR)-6-hydroxy-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate
-
(2R,7aR)-6-nitro-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate

-
-
(2R,7aR)-6-nitro-2,3,7,7a-tetrahydro-1H-indole-2-carboxylate
-
(2R,8aR)-2,7-dinitro-1,2,8,8a-tetrahydronaphthalene

-
-
(2R,8aR)-2,7-dinitro-1,2,8,8a-tetrahydronaphthalene
-
(3aR)-2-oxo-2,3,3a,4-tetrahydro-1H-benzimidazole-5-carboxylic acid

-
-
(3aR)-2-oxo-2,3,3a,4-tetrahydro-1H-benzimidazole-5-carboxylic acid
-
(3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one

-
-
(3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one
-
(3aR)-5-nitro-3a,4-dihydro-1H-indene-1,3(2H)-dione

-
-
(3aR)-5-nitro-3a,4-dihydro-1H-indene-1,3(2H)-dione
-
(3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione

-
-
(3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
-
(3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione

-
-
(3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
-
(7aR)-2-oxo-2,3,7,7a-tetrahydro-1H-indole-6-carboxylate

-
-
(7aR)-2-oxo-2,3,7,7a-tetrahydro-1H-indole-6-carboxylate
-
(7aR)-3-(carboxylatomethyl)-6-nitro-7,7a-dihydro-1H-indole-2-carboxylate

-
-
(7aR)-3-(carboxylatomethyl)-6-nitro-7,7a-dihydro-1H-indole-2-carboxylate
-
2-Aminoadipate

-
-
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid

-
-
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
-
-
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid

-
-
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
-
-
4-nitro-N,N-diethylbenzimidazolinone

-
-
4-nitro-N,N-diethylbenzimidazolinone
-
4-nitro-N,N-dimethylbenzimidazolinone

-
-
4-nitro-N,N-dimethylbenzimidazolinone
-
4-nitro-N-ethylphthalimide

-
-
4-nitro-N-ethylphthalimide
-
4-nitro-N-methylphthalimide

-
-
4-nitro-N-methylphthalimide
-
5-(carboxylatocarbonyl)-1H-pyrrole-2-carboxylate

-
-
5-(carboxylatocarbonyl)-1H-pyrrole-2-carboxylate
-
5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate

-
-
5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate
-
dimethyl pyridine-2,5-dicarboxylate

-
-
dimethyl pyridine-2,5-dicarboxylate
-
iodoacetate

-
-
iodoacetate
-
inhibition of arsenolysis, inhibition of the reduction of beta-aspartyl phosphate
iodoacetate
-
at 1 mM: completely inhibits in the absence or presence of NADP+, at 0.1 mM: 3% inactivation in the absence of NADP+, 50% inactivation in the presence of 1 mM NADP+
L-2-Amino-4-oxo-5-chloropentanoic acid

-
L-aspartate 4-semialdehyde protects the enzyme against inactivation, both NADP+ and NADPH decrease the rate of inactivation
L-2-Amino-4-oxo-5-chloropentanoic acid
-
substrate analogue, irreversible inactivation, pseudo-first-order kinetics
L-cystine

-
complete inhibition at 0.01 mM, binds via the cysteine moiety covalently to the catalytic Cys135 of the enzyme, pH-dependent process, optimal at pH 7.0-7.5, inhibition is reversible by DTT, dithioerythritol, 2-mercaptoethanol, dimercaptopropanol, and reduced glutathione, no protection by aspartate-beta-semialdehyde, NADP+ or NADPH, inhibition mechanism and kinetics
L-cystine
inactivation, reversible by addition of DTT or 2-mercaptoethanol
L-isoleucine

-
at 1 mM: 18% repression of enzyme synthesis, at 5 mM: 62% repression of enzyme synthesis
L-isoleucine
-
inhibits, when added to a final concentration of 10 mM in the assay system produces a decrease of 0.003 units in specific activity
L-lysine

-
at 1 mM: 22% repression of the enzyme synthesis, at 5 mM: 44% repression of the enzyme synthesis, at 10 mM: 28% inhibition of the enzyme activity assayed in the reverse reaction
L-lysine
-
enzyme assayed in the reverse reaction at pH 10
L-lysine
-
slightly represses the enzyme
L-methionine

-
at 1 mM: 40% repression of the enzyme synthesis, at 5 mM: 62% repression of the enzyme synthesis
L-methionine
-
inhibits, when added to a final concentration of 10 mM in the assay system produces a decrease of 0.004 units in specific activity
L-threonine

-
at 1 mM: 25% repression of the enzyme synthesis, at 5 mM: 43% repression of the enzyme synthesis, at 10 mM: 37% inhibition of the enzyme activity assayed in the reverse reaction
L-threonine
-
enzyme assayed in the reverse reaction at pH 10
L-threonine
-
represses the enzyme considerably
methyl 5-nitropyridine-2-carboxylate

-
-
methyl 5-nitropyridine-2-carboxylate
-
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-carboxyethyl-3,4-dicarboxybenzylamine

-
-
N-carboxyethyl-3,4-dicarboxybenzylamine
-
-
N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
N-ethylmaleimide

-
-
N-ethylmaleimide
-
only 1 mol per subunit causes complete inactivation, at 0.1 mM: 91% inactivation in the absence of NADP+, 12% inactivation in the presence of 1 mM NADP+
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine

-
-
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
-
petrosamine B

-
50% inhibition at 0.306 mM. Petrosamine B is a pyridoacridine alkaloid isolated from the sponge Oceanapia sp.; isolated from the methanol extract of the saustralian sponge Oceanapia sp.
petrosamine B
-
50% inhibition at 0.306 mM. Petrosamine B is a pyridoacridine alkaloid isolated from the sponge Oceanapia sp.
thieno[2,3-b]thiophene-2,5-dicarboxylate

-
-
thieno[2,3-b]thiophene-2,5-dicarboxylate
-
Tris salts

-
-
Tris salts
-
100 mM promotes 60.5% inactivation in the presence of 10 mM ATP and 17% inactivation in the absence of ATP
additional information

-
-
-
additional information
-
not: chelating agents
-
additional information
-
no inhibition by N,N'-diacetyl-L-cystine, L-cystine di-beta-naphthylamide, disulfiram, N-acetyl-L-cystine, 2,2-dithiodipyridine, 4,4-dithiodipyridine, L- and D-cysteine, and oxidized and reduced coenzyme A
-
additional information
inhibitor binding structure and mechanism
-
additional information
-
no feed-back inhibition by threonine or methionine
-
additional information
-
-
-
additional information
-
the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening. ASADH inhibitor development, overview
-
additional information
no inhibition by pathway endproducts amino acids threonine, methionine, lysine, and isoleucine
-
additional information
-
no inhibition by pathway endproducts amino acids threonine, methionine, lysine, and isoleucine
-
additional information
-
the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening. ASADH inhibitor development, overview. No inhibition by 4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid, N-(4-bromobenzyl)-N-carboxyethyl-3,4-dicarboxybenzylamine , and N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.11 - 0.18
(1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
0.69 - 1.2
(2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate
1.2 - 2.1
(2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate
0.4 - 1.1
(3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one
2.6 - 3.3
(3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
0.15 - 0.18
(3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
1.2
(S)-2-amino-5-fluoro-4-oxo-5-phosphono-pentanoic acid
0.2 M Tris, 1 mM EDTA, pH 8.6, 15 mM phosphate, 0.15 mM NADP+, 37°C
3.9
(S)-2-amino-5-phosphono-pent-4-ynoic acid
0.2 M Tris, 1 mM EDTA, pH 8.6, 15 mM phosphate, 0.15 mM NADP+, 37°C
0.05
2'-phosphoribose AMP
-
-
0.04
3-Chloroacetylpyridine-adenine dinucleotide phosphate
-
competitive inhibitor with respect to NADP+
0.324 - 0.654
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
0.296 - 0.609
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
4
4-nitro-N,N-diethylbenzimidazolinone
0.086
4-nitro-N,N-dimethylbenzimidazolinone
4
4-nitro-N-ethylphthalimide
0.89 - 1.1
4-nitro-N-methylphthalimide
20
5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate
20
dimethyl pyridine-2,5-dicarboxylate
20
methyl 5-nitropyridine-2-carboxylate
0.476 - 1.1
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.396 - 0.749
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.529 - 0.737
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.524 - 0.721
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.329 - 0.724
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.54 - 0.708
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.509 - 0.727
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.442 - 0.665
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.43 - 0.69
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.427 - 0.684
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.441 - 0.678
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.009 - 0.639
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine
0.012 - 0.634
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
3.6
N-(4-bromobenzyl)-N-(2-carboxy)ethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.057 - 0.629
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.229 - 0.649
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.072 - 0.635
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.054 - 0.698
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.063 - 0.608
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.016 - 0.648
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.036 - 0.663
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.024 - 3.8
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.176 - 0.692
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine
0.276 - 0.655
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine
0.22 - 0.498
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine
0.303 - 0.663
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine
0.297 - 0.696
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine
2.4
N-carboxyethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.246 - 0.528
N-carboxymethyl-3,4-dicarboxybenzylamine
0.296 - 0.675
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine
additional information
additional information
-
inhibition kinetics at 21°C and pH 7.5
-
0.11
(1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate

-
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
0.18
(1R)-5-[(4-nitrophenyl)carbamoyl]cyclohexa-3,5-diene-1,3-dicarboxylate
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
0.69
(2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate

-
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
1.2
(2R,5R)-2,3,4,5-tetrahydropyridine-2,5-dicarboxylate
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
1.2
(2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate

-
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
2.1
(2R,5R)-5-nitro-2,3,4,5-tetrahydropyridine-2-carboxylate
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
0.4
(3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one

-
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
1.1
(3aR)-5-nitro-1,3,3a,4-tetrahydro-2H-benzimidazol-2-one
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
2.6
(3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione

in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
3.3
(3aR)-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
-
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
0.15
(3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione

-
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
0.18
(3aR)-6-chloro-5-nitro-3a,4-dihydro-1H-isoindole-1,3(2H)-dione
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
0.324
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid

-
pH 8.6, 22°C
0.654
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
-
pH 8.6, 22°C
0.296
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid

-
pH 8.6, 22°C
0.609
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
-
pH 8.6, 22°C
4
4-nitro-N,N-diethylbenzimidazolinone

-
Ki above 4 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
4
4-nitro-N,N-diethylbenzimidazolinone
Ki above 4 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
0.086
4-nitro-N,N-dimethylbenzimidazolinone

-
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
0.086
4-nitro-N,N-dimethylbenzimidazolinone
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
4
4-nitro-N-ethylphthalimide

-
Ki above 4 mM in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
4
4-nitro-N-ethylphthalimide
Ki above 4 mM in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
0.89
4-nitro-N-methylphthalimide

-
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
1.1
4-nitro-N-methylphthalimide
in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
20
5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate

-
Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
20
5-[[(4-nitrophenyl)amino]carbonyl]-1,3-benzenedimethylcarboxylate
Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
20
dimethyl pyridine-2,5-dicarboxylate

-
Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
20
dimethyl pyridine-2,5-dicarboxylate
Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
20
methyl 5-nitropyridine-2-carboxylate

-
Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
20
methyl 5-nitropyridine-2-carboxylate
Ki above 20 mM, in 120 mM CHES (pH 8.6) buffer and 200 mM KCl, at 22°C
0.476
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
1.1
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.396
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.749
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.529
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.737
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.524
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.721
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.329
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.724
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.54
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.708
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.509
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.727
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.442
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.665
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.43
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.69
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.427
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.684
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.441
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.678
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.009
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.639
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.012
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.634
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.057
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.629
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.229
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.649
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.072
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.635
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.054
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.698
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.063
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.608
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.016
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.648
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.036
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.663
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.024
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.628
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
3.8
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.176
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.692
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.276
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.655
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.22
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.498
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.303
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.663
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.297
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.696
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.246
N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.528
N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
0.296
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine

-
pH 8.6, 22°C
0.675
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
pH 8.6, 22°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
evolution

-
the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening
evolution
-
the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening
malfunction

deletion of the asdA gene precluded the growth of Edwardsiella ictaluri in absence of diaminopimelic acid
malfunction
-
enzyme deficiency or inhibition of enzyme activity leads to 80% reduced cell wall materials compared to the wild-type, in addition to obvious morphological differences, phenotype, overview
malfunction
-
the aspartate semialdehyde dehydrogenase (asd)-inactivated mutant exhibits significantly reduced growth in calf serum compared with the wild-type. The mutant also exhibits significantly reduced growth in medium, mimicking the concentrations of amino acids and glucose in calf serum, but can be recovered by addition of lysine and threonine
malfunction
-
enzyme deficiency or inhibition of enzyme activity leads to 80% reduced cell wall materials compared to the wild-type, in addition to obvious morphological differences, phenotype, overview
malfunction
-
the aspartate semialdehyde dehydrogenase (asd)-inactivated mutant exhibits significantly reduced growth in calf serum compared with the wild-type. The mutant also exhibits significantly reduced growth in medium, mimicking the concentrations of amino acids and glucose in calf serum, but can be recovered by addition of lysine and threonine
malfunction
-
deletion of the asdA gene precluded the growth of Edwardsiella ictaluri in absence of diaminopimelic acid
metabolism

-
aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway
metabolism
-
aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway
metabolism
-
aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway
metabolism
-
aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway
metabolism
aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway
metabolism
aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway
metabolism
the enzyme lies at the first branch point in the biosynthetic pathway of important amino acids including lysine and methionine and the cell-wall component diaminopimelate
metabolism
-
Asd is an essential enzyme for the biosynthesis of lysine, methionine, and threonine from aspartate
metabolism
-
aspartate-beta-semialdehyde dehydrogenase lies at the first branch point in the aspartate metabolic pathway which leads to the biosynthesis of several essential amino acids and some important metabolites. This pathway is crucial for many metabolic processes in plants and microbes like bacteria and fungi, but is absent in mammals
metabolism
-
aspartate-beta-semialdehyde dehydrogenase lies at the first branch point in the aspartate metabolic pathway which leads to the biosynthesis of several essential amino acids and some important metabolites. This pathway is crucial for many metabolic processes in plants and microbes like bacteria and fungi, but is absent in mammals
metabolism
aspartate-semialdehyde dehydrogenase catalyzes the reductive dephosphorylation of the substrate beta-aspartyl phosphate into aspartate semialdehyde, a key intermediate in the aspartate biosynthetic pathway and functions at a critical junction in the aspartate biosynthetic pathway
metabolism
aspartate-semialdehyde dehydrogenase catalyzes the reductive dephosphorylation of the substrate beta-aspartyl phosphate into aspartate semialdehyde, a key intermediate in the aspartate biosynthetic pathway and functions at a critical junction in the aspartate biosynthetic pathway
metabolism
the enzyme has a rate-limiting key function in the biosynthesis of amino acids L-threonine, L-lysine, and L-isoleucine from L-aspartate via L-homoserine
metabolism
-
aspartate-semialdehyde dehydrogenase catalyzes the reductive dephosphorylation of the substrate beta-aspartyl phosphate into aspartate semialdehyde, a key intermediate in the aspartate biosynthetic pathway and functions at a critical junction in the aspartate biosynthetic pathway
metabolism
-
the enzyme lies at the first branch point in the biosynthetic pathway of important amino acids including lysine and methionine and the cell-wall component diaminopimelate
metabolism
-
aspartate-semialdehyde dehydrogenase catalyzes the reductive dephosphorylation of the substrate beta-aspartyl phosphate into aspartate semialdehyde, a key intermediate in the aspartate biosynthetic pathway and functions at a critical junction in the aspartate biosynthetic pathway
metabolism
-
Asd is an essential enzyme for the biosynthesis of lysine, methionine, and threonine from aspartate
physiological function

the enzyme catalyzes the NADPH-dependent reductive dephosphorylation of 4-aspartyl phosphate to produce the key intermediate aspartate semialdehyde
physiological function
the enzyme catalyzes the NADPH-dependent reductive dephosphorylation of 4-aspartyl phosphate to produce the key intermediate aspartate semialdehyde
physiological function
-
the enzyme catalyzes the NADPH-dependent reductive dephosphorylation of 4-aspartyl phosphate to produce the key intermediate aspartate semialdehyde
physiological function
-
the enzyme catalyzes the NADPH-dependent reductive dephosphorylation of 4-aspartyl phosphate to produce the key intermediate aspartate semialdehyde
additional information

active site structure analysis and comparison, detailed overview
additional information
-
active site structure analysis and comparison, detailed overview
additional information
The structure of CnASADH belongs to the Rossmann-fold superfamily of pyridine-linked dehydrogenases and shares the same overall monomeric structural features as the other ASADHs for which structures are determined
additional information
-
The structure of CnASADH belongs to the Rossmann-fold superfamily of pyridine-linked dehydrogenases and shares the same overall monomeric structural features as the other ASADHs for which structures are determined
additional information
-
active site structure analysis and comparison, detailed overview
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.