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Information on EC 1.18.6.1 - nitrogenase

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EC Tree
     1 Oxidoreductases
         1.18 Acting on iron-sulfur proteins as donors
             1.18.6 With dinitrogen as acceptor
                1.18.6.1 nitrogenase
IUBMB Comments
Requires Mg2+. The enzyme is a complex of two components (namely dinitrogen reductase and dinitrogenase). Dinitrogen reductase is a [4Fe-4S] protein, which, in the presence of two molecules of ATP, transfers an electron from ferredoxin to the dinitrogenase component. Dinitrogenase is a molybdenum-iron protein that reduces dinitrogen to two molecules of ammonia in three successive two-electron reductions via diazene and hydrazine. The reduction is initiated by formation of hydrogen in stoichiometric amounts . Acetylene is reduced to ethylene (but only very slowly to ethane), azide to nitrogen and ammonia, and cyanide to methane and ammonia. In the absence of a suitable substrate, hydrogen is slowly formed. Ferredoxin may be replaced by flavodoxin [see EC 1.19.6.1 nitrogenase (flavodoxin)]. The enzyme does not reduce CO (cf. EC 1.18.6.2, vanadium-dependent nitrogenase).
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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4
reduced ferredoxin
+
8
H+
+
N2
+
16
ATP
+
16
H2O
=
4
oxidized ferredoxin
+
H2
+
2
NH3
+
16
ADP
+
16
phosphate
4
+
8
+
+
16
+
16
=
4
+
+
2
+
16
+
16
Synonyms
nitrogenase, mofe protein, dinitrogenase, nifhdk, nifdk, mo-nitrogenase, mofe-protein, v-nitrogenase, nitrogenase mofe protein, n2ase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 8 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate
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