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Information on EC 1.16.1.9 - ferric-chelate reductase (NADPH)

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EC Tree
     1 Oxidoreductases
         1.16 Oxidizing metal ions
             1.16.1 With NAD+ or NADP+ as acceptor
                1.16.1.9 ferric-chelate reductase (NADPH)
IUBMB Comments
Contains FAD. The enzyme, which is widespread among bacteria, catalyses the reduction of ferric iron bound to a variety of iron chelators (siderophores), including ferric triscatecholates and ferric dicitrate, resulting in the release of ferrous iron. The enzyme from the bacterium Escherichia coli has the highest efficiency with the hydrolysed ferric enterobactin complex ferric N-(2,3-dihydroxybenzoyl)-L-serine . cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.10, ferric-chelate reductase [NAD(P)H].
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
2
Fe(II)-siderophore
+
+
=
2
Fe(III)-siderophore
+
Synonyms
FCR, FCR-LM, FCR-Os, Fe(III)-chelate reductase, ferredoxin-NADP(+) oxidoreductase, ferredoxin-NADP+ oxidoreductase, ferri-siderophore reductase, ferric chelate reductase, ferric reductase, ferric siderophore reductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH
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