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Information on EC 1.14.99.37 - taxadiene 5alpha-hydroxylase

for references in articles please use BRENDA:EC1.14.99.37

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Old data from external sources may still be available.
Please check here for current data: EC 1.14.14.176
deleted, now EC 1.14.14.176
IUBMB Comments

This microsomal cytochrome-P-450-dependent enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel). The reaction includes rearrangement of the 4(5)-double bond to a 4(20)-double bond, possibly through allylic oxidation.

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