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Reference on EC 1.14.19.70 - mycocyclosin synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Duffell, K.M.; Hudson, S.A.; McLean, K.J.; Munro, A.W.; Abell, C.; Matak-Vinkovic, D.
Nanoelectrospray ionization mass spectrometric study of Mycobacterium tuberculosis CYP121-ligand interactions
Anal. Chem.
85
5707-5714
2013
Mycobacterium tuberculosis (P9WPP7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPP7)
Manually annotated by BRENDA team
Hudson, S.; McLean, K.; Surade, S.; Yang, Y.; Leys, D.; Ciulli, A.; Munro, A.; Abell, C.
Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121
Angew. Chem. Int. Ed. Engl.
51
9311-9316
2012
Mycobacterium tuberculosis (P9WPP7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPP7)
Manually annotated by BRENDA team
McLean, K.J.; Dunford, A.J.; Sabri, M.; Neeli, R.; Girvan, H.M.; Balding, P.R.; Leys, D.; Seward, H.E.; Marshall, K.R.; Munro, A.W.
CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen
Biochem. Soc. Trans.
34
1178-1182
2006
Mycobacterium tuberculosis (P9WPP7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPP7)
Manually annotated by BRENDA team
Sundaramurthi, J.C.; Kumar, S.; Silambuchelvi, K.; Hanna, L.E.
Molecular docking of azole drugs and their analogs on CYP121 of Mycobacterium tuberculosis
Bioinformation
7
130-133
2011
Mycobacterium tuberculosis (P9WPP7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPP7)
Manually annotated by BRENDA team
Leys, D.; Mowat, C.G.; McLean, K.J.; Richmond, A.; Chapman, S.K.; Walkinshaw, M.D.; Munro, A.W.
Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450
J. Biol. Chem.
278
5141-5147
2003
Mycobacterium tuberculosis (P9WPP7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPP7)
Manually annotated by BRENDA team
Seward, H.E.; Roujeinikova, A.; McLean, K.J.; Munro, A.W.; Leys, D.
Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode
J. Biol. Chem.
281
39437-39443
2006
Mycobacterium tuberculosis (P9WPP7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPP7)
Manually annotated by BRENDA team
Fonvielle, M.; Le Du, M.H.; Lequin, O.; Lecoq, A.; Jacquet, M.; Thai, R.; Dubois, S.; Grach, G.; Gondry, M.; Belin, P.
Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121: insights from biochemical studies and crystal structures
J. Biol. Chem.
288
17347-17359
2013
Mycobacterium tuberculosis (P9WPP7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPP7)
Manually annotated by BRENDA team
McLean, K.J.; Cheesman, M.R.; Rivers, S.L.; Richmond, A.; Leys, D.; Chapman, S.K.; Reid, G.A.; Price, N.C.; Kelly, S.M.; Clarkson, J.; Smith, W.E.; Munro, A.W.
Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis
J. Inorg. Biochem.
91
527-541
2002
Mycobacterium tuberculosis (P9WPP7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPP7)
Manually annotated by BRENDA team
Belin, P.; Le Du, M.H.; Fielding, A.; Lequin, O.; Jacquet, M.; Charbonnier, J.B.; Lecoq, A.; Thai, R.; Courcon, M.; Masson, C.; Dugave, C.; Genet, R.; Pernodet, J.L.; Gondry, M.
Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis
Proc. Natl. Acad. Sci. USA
106
7426-7431
2009
Mycobacterium tuberculosis (P9WPP7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPP7)
Manually annotated by BRENDA team
Kavanagh, M.E.; Gray, J.L.; Gilbert, S.H.; Coyne, A.G.; McLean, K.J.; Davis, H.J.; Munro, A.W.; Abell, C.
Substrate fragmentation for the design of M. tuberculosis CYP121 inhibitors
ChemMedChem
11
1924-1935
2016
Mycobacterium tuberculosis (P9WPP7)
Manually annotated by BRENDA team
Brengel, C.; Thomann, A.; Schifrin, A.; Allegretta, G.; Kamal, A.A.M.; Haupenthal, J.; Schnorr, I.; Cho, S.H.; Franzblau, S.G.; Empting, M.; Eberhard, J.; Hartmann, R.W.
Biophysical screening of a focused library for the discovery of CYP121 inhibitors as novel antimycobacterials
ChemMedChem
12
1616-1626
2017
Mycobacterium tuberculosis (P9WPP7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPP7)
Manually annotated by BRENDA team
Fielding, A.J.; Dornevil, K.; Ma, L.; Davis, I.; Liu, A.
Probing ligand exchange in the P450 enzyme CYP121 from Mycobacterium tuberculosis Dynamic equilibrium of the distal heme ligand as a function of pH and temperature
J. Am. Chem. Soc.
139
17484-17499
2017
Mycobacterium tuberculosis (P9WPP7), Mycobacterium tuberculosis
Manually annotated by BRENDA team
Dornevil, K.; Davis, I.; Fielding, A.J.; Terrell, J.R.; Ma, L.; Liu, A.
Cross-linking of dicyclotyrosine by the cytochrome P450 enzyme CYP121 from Mycobacterium tuberculosis proceeds through a catalytic shunt pathway
J. Biol. Chem.
292
13645-13657
2017
Mycobacterium tuberculosis (P9WPP7), Mycobacterium tuberculosis
Manually annotated by BRENDA team
Dumas, V.; Defelipe, L.; Petruk, A.; Turjanski, A.; Marti, M.
QM/MM study of the C-C coupling reaction mechanism of CYP121, an essential cytochrome p450 of Mycobacterium tuberculosis
Proteins
82
1004-1021
2014
Mycobacterium tuberculosis (P9WPP7), Mycobacterium tuberculosis
Manually annotated by BRENDA team