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Information on EC - camalexin synthase

for references in articles please use BRENDA:EC1.14.19.52
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IUBMB Comments
This cytochrome P-450 (heme thiolate) enzyme, which has been characterized from the plant Arabidopsis thaliana, catalyses the last two steps in the biosynthesis of camalexin, the main phytoalexin in that plant. The enzyme catalyses two successive oxidation events. During the first oxidation the enzyme introduces a C-N double bond, liberating hydrogen cyanide, and during the second oxidation it catalyses a decarboxylation.
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The expected taxonomic range for this enzyme is: Arabidopsis thaliana
cyp71b15, cyp71b15/pad3, more
(R)-dihydrocamalexate + [reduced NADPH-hemoprotein reductase] + O2 = camalexin + CO2 + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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2-(L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 = camalexin + hydrogen cyanide + CO2 + 2 [oxidized NADPH-hemoprotein reductase] + 4 H2O
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overall reaction
2-(L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + [reduced NADPH-hemoprotein reductase] + O2 = (R)-dihydrocamalexate + hydrogen cyanide + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
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