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Disease on EC 1.14.19.3 - acyl-CoA 6-desaturase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Coronary Syndrome
A case-control study between gene polymorphisms of polyunsaturated fatty acid metabolic rate-limiting enzymes and acute coronary syndrome in Chinese Han population.
acyl-coa 6-desaturase deficiency
A nucleotide insertion in the transcriptional regulatory region of FADS2 gives rise to human fatty acid delta-6-desaturase deficiency.
Dietary EPA and DHA prevent changes in white adipose tissue omega-3 PUFA and oxylipin content associated with a Fads2 deficiency.
Gamma-linolenic acid and tocopherol contents in the seed oil of 47 accessions from several Ribes species.
Identification of a fatty acid delta6-desaturase deficiency in human skin fibroblasts.
Utilization of arachidonic and linoleic acids by cultured human endothelial cells.
[A chance for the prevention of atopic diseases]
Alzheimer Disease
Membrane fatty acid composition shows delta-6-desaturase abnormalities in Alzheimer's disease.
Arthritis, Psoriatic
Genomic dissection of population substructure of Han Chinese and its implication in association studies.
Arthritis, Rheumatoid
Fatty acid desaturase 2 promoter mutation is not responsible for ?6-desaturase deficiency.
Asthma
FADS gene cluster modulates the effect of breastfeeding on asthma. Results from the GINIplus and LISAplus studies.
Atherosclerosis
Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver.
Delta-6-desaturase enzyme co-factors and atherosclerosis.
Delta6-Desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids.
Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids.
Fatty acids, triglycerides and syndromes of insulin resistance.
Breast Neoplasms
Cancer: a simple metabolic disease?
Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
Delta-6-desaturase activity and arachidonic acid synthesis are increased in human breast cancer tissue.
Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer.
Radiotherapy improves serum fatty acids and lipid profile in breast cancer.
The aromatase inhibitor letrozole restores FADS2 function in ER+ MCF7 human breast cancer cells.
Carcinogenesis
Risk SNP-mediated enhancer-promoter interaction drives colorectal cancer through both FADS2 and AP002754.2.
Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis.
Carcinoma, Hepatocellular
mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.
Some effects of linoleic acid and gamma-linolenic acid on the proliferation of human hepatoma cells in culture.
Cardiovascular Diseases
One-Carbon Metabolism and Lipid Metabolism in DOHaD.
Colonic Neoplasms
In vitro activity of the fatty acyl desaturases of human cancerous and noncancerous tissues.
Colorectal Neoplasms
Risk SNP-mediated enhancer-promoter interaction drives colorectal cancer through both FADS2 and AP002754.2.
Coronary Artery Disease
A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population.
Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population.
Comparison of dietary casein and soybean protein effects on plasma lipid and gastrin levels, hepatic delta 6-desaturase activity and coronary arteriosclerosis in male Sprague-Dawley rats. A 9-month study.
Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease.
Coronary Disease
Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk.
Crohn Disease
Disturbance of Fatty Acid Desaturation Mediated by FADS2 in Mesenteric Adipocytes Contributes to Chronic Inflammation of Crohn's Disease.
FADS2 and ELOVL6 mutation frequencies in Japanese Crohn's disease patients.
Cystic Fibrosis
Reduced levels of prostaglandin precursors in the blood of atopic patients: defective delta-6-desaturase function as a biochemical basis for atopy.
Darier Disease
Abnormal essential fatty acid metabolism in Darier's disease.
Death, Sudden, Cardiac
Fatty acid composition in total phospholipids of human coronary arteries in sudden cardiac death.
Dermatitis, Atopic
Atopic dermatitis and essential fatty acids: a biochemical basis for atopy?
Borage oil in the treatment of atopic dermatitis.
Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema.
Effect of Evening Primrose Oil on Korean Patients With Mild Atopic Dermatitis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Study.
Erythrocyte and plasma fatty acid patterns in dogs with atopic dermatitis and healthy dogs in the same household.
Essential fatty acids in the plasma phospholipids of patients with atopic eczema.
Evening primrose oil (Efamol) in the treatment of children with atopic eczema.
Gamma-linolenic acid levels correlate with clinical efficacy of evening primrose oil in patients with atopic dermatitis.
Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis.
Treatment of atopic eczema with evening primrose oil: rationale and clinical results.
[A chance for the prevention of atopic diseases]
Diabetes Mellitus
Association of Delta-6-Desaturase Expression with Aggressiveness of Cancer, Diabetes Mellitus, and Multiple Sclerosis: A Narrative Review
Association of FADS2 rs174575 gene polymorphism and insulin resistance in type 2 diabetes mellitus.
Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus.
Fatty acid desaturase 2 (FADS 2) rs174575 (C/G) polymorphism, circulating lipid levels and susceptibility to type-2 diabetes mellitus.
How do polyunsaturated fatty acids lower plasma cholesterol levels?
Diabetes Mellitus, Experimental
Hormonal modulation of delta6 and delta5 desaturases: case of diabetes.
Diabetes Mellitus, Type 1
Desaturase activities in rat model of insulin resistance induced by a sucrose-rich diet.
Diabetes Mellitus, Type 2
Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.
Association of FADS2 rs174575 gene polymorphism and insulin resistance in type 2 diabetes mellitus.
Association of Polymorphism in Fatty Acid Desaturase Gene with the Risk of Type 2 Diabetes in Iranian Population.
Desaturation function does not decline after menopause in human females.
Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus.
FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes.
Integrated transcriptome and phosphoproteome analyses reveal that fads2 is critical for maintaining body LC-PUFA homeostasis.
The effect of FADS2 gene rs174583 polymorphism on desaturase activities, fatty acid profile, insulin resistance, biochemical indices, and incidence of type 2 diabetes.
Transcriptomic analysis of Momordica charantia polysaccharide on streptozotocin-induced diabetic rats.
Diabetes, Gestational
Longitudinal circulating concentrations of long-chain polyunsaturated fatty acids in the third trimester of pregnancy in gestational diabetes.
Dyslipidemias
Genetic Contribution of Variants near SORT1 and APOE on LDL Cholesterol Independent of Obesity in Children.
One-Carbon Metabolism and Lipid Metabolism in DOHaD.
Eczema
Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life.
[Expression of delta6-fatty acid desaturase gene from Mortierella alpina in Pichia pastoris]
Essential Hypertension
Effects of essential fatty acids on mild to moderate essential hypertension.
Fatty Liver
Alteration of Hepatic Gene Expression along with the Inherited Phenotype of Acquired Fatty Liver in Chicken.
Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver.
Liver DNA methylation of FADS2 associates with FADS2 genotypex.
Glioblastoma
Delta-6-desaturase inhibitor enhances radiation therapy in glioblastoma in vitro and in vivo.
Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme.
mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.
Heart Failure
Delta-6-desaturase links polyunsaturated fatty acid metabolism with phospholipid remodeling and disease progression in heart failure.
Hemochromatosis
Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation?
Hepatitis
Hepatic delta 9 and delta 6 desaturase activities during the recovery period following carbon tetrachloride poisoning.
HIV Infections
Genomic dissection of population substructure of Han Chinese and its implication in association studies.
Hyperhomocysteinemia
Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia.
Hyperinsulinism
Delta-6 desaturase activity and gene expression, tissue fatty acid profile and glucose turnover rate in hereditary hypertriglyceridemic rats.
Hypertension
Influence of spontaneous hypertension on n-3 delta-6-desaturase activity and fatty acid composition of rat hepatocytes.
Liver microsomal membrane fluidity and microsomal desaturase activities in adult spontaneously hypertensive rats.
The Interaction Between Fatty Acid Desaturase-2 (FADS2) rs174583 Genetic Variant and Dietary Quality Indices (DASH and MDS) Constructs Different Metabolic Phenotypes Among Obese Individuals.
Hypertriglyceridemia
A common variant in ARHGEF10 alters delta-6 desaturase activity and influence susceptibility to hypertriglyceridemia.
Palmitoleic and Dihomo-?-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children.
Hypothyroidism
Changes in fatty acid profiles of plasma, erythrocytes and polymorphonuclear leukocytes in induced hypothyroidism in man: indirect evidence for altered delta 6 desaturase activity.
Hepatic delta 6-desaturase activity in lean and genetically obese ob/ob mice.
Infections
Dual expression of transgenic delta-5 and delta-6 desaturase in tilapia alters gut microbiota and enhances resistance to Vibrio vulnificus infection.
Transgenic expression of omega-3 PUFA synthesis genes improves zebrafish survival during Vibrio vulnificus infection.
[Expression of delta6-fatty acid desaturase gene from Mortierella alpina in Pichia pastoris]
Infertility
Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids.
Insulin Resistance
Association of Changes in Body Fatness and Fatty Acid Composition of Plasma Phospholipids During Early Puberty in Japanese Children.
Association of FADS2 rs174575 gene polymorphism and insulin resistance in type 2 diabetes mellitus.
Chronic Olanzapine Treatment Induces Disorders of Plasma Fatty Acid Profile in Balb/c Mice: A Potential Mechanism for Olanzapine-Induced Insulin Resistance.
Dietary fat, fatty acid composition in plasma and the metabolic syndrome.
Fatty Acid desaturase gene polymorphisms and metabolic measures in schizophrenia and bipolar patients taking antipsychotics.
Fatty acids, triglycerides and syndromes of insulin resistance.
Gene Expression Signature in Adipose Tissue of Acromegaly Patients.
Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study.
Insulin resistance in the hereditary hypertriglyceridemic rat is associated with an impairment of delta-6 desaturase expression in liver.
Lower estimates of delta-5 desaturase and elongase activity are related to adverse profiles for several metabolic risk factors in young Japanese women.
Palmitoleic and Dihomo-?-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children.
The effect of FADS2 gene rs174583 polymorphism on desaturase activities, fatty acid profile, insulin resistance, biochemical indices, and incidence of type 2 diabetes.
Intestinal Neoplasms
Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis.
Leukemia
Multifaceted regulation and functions of fatty acid desaturase 2 in human cancers.
Leukemia, Myeloid, Acute
Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia.
Liver Diseases
Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population.
Liver DNA methylation of FADS2 associates with FADS2 genotypex.
Magnesium Deficiency
Effect of magnesium deficiency on delta 6 desaturase activity and fatty acid composition of rat liver microsomes.
Malnutrition
Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme.
Fatty acid composition of plasma lipids in Nigerian children with protein-energy malnutrition.
One-Carbon Metabolism and Lipid Metabolism in DOHaD.
Prenatal protein depletion and delta 9, delta 6 and delta 5 desaturases in the rat.
Mastitis
Polymorphisms in Fatty Acid Desaturase 2 Gene are Associated with Milk Production Traits in Chinese Holstein Cows.
Melanoma
Multifaceted regulation and functions of fatty acid desaturase 2 in human cancers.
Possible involvement of delta-6-desaturase in control of melanoma growth by gamma-linolenic acid.
Metabolic Diseases
Integrated transcriptome and phosphoproteome analyses reveal that fads2 is critical for maintaining body LC-PUFA homeostasis.
Metabolic Syndrome
Association Between Genetic Variants in FADS1-FADS2 and ELOVL2 and Obesity, Lipid Traits, and Fatty Acids in Tunisian Population.
Carrying minor allele of FADS1 and haplotype of FADS1 and FADS2 increased the risk of metabolic syndrome and moderate but not low fat diets lowered the risk in two Korean cohorts.
Docosahexaenoic Acid Content in Plasma Phospholipids and Desaturase Indices in Obese Children.
Does genetic variation in the Delta6-desaturase promoter modify the association between alpha-linolenic acid and the prevalence of metabolic syndrome?
FADS1 modulates metabolic syndrome in schizophrenia patients receiving olanzapine monotherapy.
Omega-6 polyunsaturated fatty acids, serum zinc, delta-5- and delta-6-desaturase activities and incident metabolic syndrome.
Serum fatty acids in postinfarction middle-aged men.
Multiple Sclerosis
Alteration of delta-6-desaturase (FADS2), secretory phospholipase-A2 (sPLA2) enzymes by Hot-nature diet with co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients.
Multiple Sclerosis, Relapsing-Remitting
Alteration of delta-6-desaturase (FADS2), secretory phospholipase-A2 (sPLA2) enzymes by Hot-nature diet with co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients.
Myocardial Infarction
alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction.
Neoplasms
A rare eicosanoid precursor analogue, sciadonic acid (5Z,11Z,14Z-20:3), detected in vivo in hormone positive breast cancer tissue.
Apocryphal FADS2 activity promotes fatty acid diversification in cancer.
Association of Delta-6-Desaturase Expression with Aggressiveness of Cancer, Diabetes Mellitus, and Multiple Sclerosis: A Narrative Review
Cancer: a simple metabolic disease?
Delta-6-desaturase inhibitor enhances radiation therapy in glioblastoma in vitro and in vivo.
Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer.
Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme.
FADS2 function loss at the cancer hotspot 11q13 locus diverts lipid signaling precursor synthesis to unusual eicosanoid fatty acids.
Fatty acid desaturase 2 (FADS2) but not FADS1 desaturates branched chain and odd chain saturated fatty acids.
Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.
In silico pathway analysis and tissue specific cis-eQTL for colorectal cancer GWAS risk variants.
Inhibiting delta-6 desaturase activity suppresses tumor growth in mice.
Mammary tumor lipids and plasma lipoproteins in DMBA-intubated rats fed olive or safflower oils.
Metabolome of Mammary Tumors Differs from Normal Mammary Glands But Is Not Altered by Time-restricted Feeding Under Obesogenic Conditions.
mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.
Multifaceted regulation and functions of fatty acid desaturase 2 in human cancers.
Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 ?-linolenic acids for FADS2 mediated ?6-desaturation.
Possible involvement of delta-6-desaturase in control of melanoma growth by gamma-linolenic acid.
Prostate tumor growth can be modulated by dietarily targeting the 15-lipoxygenase-1 and cyclooxygenase-2 enzymes.
Proteomic and lipidomic signatures of lipid metabolism in NASH-associated hepatocellular carcinoma.
Risk SNP-mediated enhancer-promoter interaction drives colorectal cancer through both FADS2 and AP002754.2.
The role of delta-6- and delta-9-desaturase in the fatty acid metabolism of hepatomas with different growth rate.
[Effects of conjugated linoleic acid on the expression of critical enzymes of linoleic acid metabolism in tumor cell]
Nephrolithiasis
Pathogenesis of idiopathic calcium nephrolithiasis: update 1997.
Neuroblastoma
Alternative splicing generates a novel FADS2 alternative transcript in baboons.
Non-alcoholic Fatty Liver Disease
Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population.
Contribution of a genetic risk score to clinical prediction of hepatic steatosis in obese children and adolescents.
Liver DNA methylation of FADS2 associates with FADS2 genotypex.
Obesity
Dietary fats, membrane phospholipids and obesity.
FADS2 polymorphisms are associated with plasma arachidonic acid and estimated desaturase-5 activity in a cross-sectional study.
Genetic Contribution of Variants near SORT1 and APOE on LDL Cholesterol Independent of Obesity in Children.
Influence of genetic variants in FADS2 and ELOVL2 genes on BMI and PUFAs homeostasis in children and adolescents with obesity.
Integrated transcriptome and phosphoproteome analyses reveal that fads2 is critical for maintaining body LC-PUFA homeostasis.
Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity.
Is There a FADS2-Modulated Link between Long-Chain Polyunsaturated Fatty Acids in Plasma Phospholipids and Polyphenol Intake in Adult Subjects Who Are Overweight?
Liver DNA methylation of FADS2 associates with FADS2 genotypex.
No relations between breast cancer risk and fatty acids of erythrocyte membranes in postmenopausal women of the Malmö Diet Cancer cohort (Sweden).
Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation : longitudinal analyses in middle-aged men.
Transcriptional regulation of ?6-desaturase by peroxisome proliferative-activated receptor ? agonist in human pancreatic cancer cells: role of MEK/ERK1/2 pathway.
Obesity, Abdominal
Abdominal adiposity is associated with fatty acid desaturase activity in boys: Implications for C-reactive protein and insulin resistance.
Osteoporosis
A trans-ethnic two-stage polygenetic scoring analysis detects genetic correlation between osteoporosis and schizophrenia.
Overweight
Is There a FADS2-Modulated Link between Long-Chain Polyunsaturated Fatty Acids in Plasma Phospholipids and Polyphenol Intake in Adult Subjects Who Are Overweight?
Palmitoleic and Dihomo-?-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children.
Protein Deficiency
Effect of cross-fostering rats at birth on the normal supply of essential fatty acids during protein deficiency.
Protein-Energy Malnutrition
Fatty acid composition of plasma lipids in Nigerian children with protein-energy malnutrition.
Plasma fatty acid status in Moroccan children: increased lipid peroxidation and impaired polyunsaturated fatty acid metabolism in protein-calorie malnutrition.
Relationship between dietary oil during gestation and lactation and biosynthesis of polyunsaturated fatty acids in control and in malnourished dam and pup rats.
Psoriasis
Genomic dissection of population substructure of Han Chinese and its implication in association studies.
High-throughput transcriptome and pathogenesis analysis of clinical psoriasis.
Retinoblastoma
Loss of delta6-desaturase activity leads to impaired docosahexaenoic acid synthesis in Y-79 retinoblastoma cells.
Skin Abnormalities
Fatty acid desaturase 2 (FADS2) but not FADS1 desaturates branched chain and odd chain saturated fatty acids.
Stomach Neoplasms
Dietary n-3 and n-6 polyunsaturated fatty acids, the FADS gene, and the risk of gastric cancer in a Korean population.
Tuberous Sclerosis
mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.
Vitamin A Deficiency
Microsomal fatty acid desaturase activities in vitamin A-deficient rat liver.
Vitamin B 6 Deficiency
Interaction between vitamin B6 deficiency and low EFA dietary intake on kidney phospholipids and PGE2 in the rat.
Polyunsaturated Fatty Acid Plasma Content in Groups of General Population with lowvitamin B6 or low iron serum levels.