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Information on EC 1.14.18.8 - 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase

for references in articles please use BRENDA:EC1.14.18.8
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IUBMB Comments
A P-450 heme-thiolate protein. Requires EC 1.6.2.4, NADPH---hemoprotein reductase and cytochrome b5 for maximal activity. This enzyme is important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid .
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Word Map
  • 1.14.18.8
  • bile
  • cyp7a1
  • cholic
  • farnesoid
  • 7alpha-hydroxylase
  • chenodeoxycholic
  • cholestasis
  • enterohepatic
  • sult2a1
  • fxr-mediated
  • 27-hydroxylase
  • fxr-target
  • 4alpha
  • muricholic
  • hnf4alpha
  • obeticholic
  • guggulsterone
The enzyme appears in viruses and cellular organisms
Synonyms
cyp8b1, sterol 12alpha-hydroxylase, cyp12, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
7alpha-hydroxycholest-4-en-3-one + 2 ferrocytochrome b5 + 2 H+ + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + 2 ferricytochrome b5 + + H2O
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