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(+)-catechin + 1/2 O2
?
-
-
-
?
(+)-catechin + O2
? + 2 H2O
high activity
-
-
?
(+)-catechin hydrate + 1/2 O2
?
(+)-catechin hydrate + O2
? + 2 H2O
-
-
-
?
(+/-)-catechin + O2
?
-
58.7% activity compared to L-DOPA
-
-
?
(-)-epicatechin + 1/2 O2
?
(1R,3R,4S,5R)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid + O2
(1R,3R,4S,5R)-3-[[(2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid + H2O
-
-
-
-
?
(1S,3R,4S,5R)-4-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1,3,5-trihydroxycyclohexanecarboxylic acid + O2
(1S,3R,4S,5R)-4-[[(2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)prop-2-enoyl]oxy]-1,3,5-trihydroxycyclohexanecarboxylic acid + H2O
-
-
-
-
?
(R)-dopaxanthin + dehydroascorbic acid + O2
(R)-dopaxanthin quinone + L-ascorbic acid + H2O
(R)-tyrosine-betaxanthin + L-DOPA + O2
(R)-dopaxanthin + dopaquinone + H2O
-
i.e. (R)-portulacaxanthin II, the activity of the enzyme is not restricted to betaxanthins derived from (S)-amino acids
(R)-dopaxanthin is a pigment, quantitative product analysis
-
?
1,5-bis(4-hydroxyphenyl)-1,4-pentadiene-3-one + O2
?
-
-
-
-
?
2 2',3,4,4',6'-pentahydroxychalcone + O2
bracteatin + 2 H2O
-
-
-
?
2 2-methyl-L-dopa + O2
2 2-methyldopaquinone + 2 H2O
-
-
-
-
?
2 4-methylcatechol + O2
2 4-methyl-1,2-benzoquinone + 2 H2O
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
2 hydroquinone + O2
2 quinone + 2 H2O
2 L-dopa + O2
2 dopaquinone + 2 H2O
2 L-tyrosine + O2
2 L-dopa
2 phenol + O2
2 1,2-benzoquinone + 2 H2O
-
-
-
-
?
2 pyrocatechol + O2
?
-
-
-
-
?
2',4',6',4-tetrahydroxychalcone + O2
aureusidin + H2O
-
-
-
?
2,3-dimethylphenol + O2
?
-
11% relative activity compared to L-DOPA
-
-
?
2,4,5-trihydroxyphenethylamine + O2
?
-
-
-
-
?
2-caffeoylisocitric acid + O2
?
-
i.e., E-3-carboxy-2-(3-(3,4-dihydroxyphenyl)prop-2-enoyloxy)pentanedioic acid
-
-
?
2-caffeoylisocitric acid 6-methyl ester + O2
?
-
i.e, E-2-(3-(3,4-dihydroxyphenyl)prop-2-enoyloxy)-3-(methoxycarbonyl)pentanedioic acid
-
-
?
2-hydroxy-1-[[(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy]propane-1,2,3-tricarboxylic acid + O2
3-C-carboxy-2-deoxy-4-O-[(2E)-3-(3-methoxy-4-oxocyclohexa-1,5-dien-1-yl)prop-2-enoyl]pentaric acid + H2O
-
-
-
-
?
2-methyl-L-tyrosine + O2
2-methyldopaquinone + H2O
-
-
-
-
?
2-methylresorcinol + O2
?
-
acts as enzyme substrate and inhibitor, low activity
-
-
?
2-O-caffeoylhydroxycitric acid + O2
?
2-O-caffeoylisocitric acid + O2
?
2-O-caffeoylisocitric acid 6-methyl ester + O2
?
2-O-caffeoylthreonic acid + O2
?
-
i.e., E-2-(3-(3,4-dihydroxyphenyl)prop-2-enoyloxy)-3,4-dihydroxybutanoic acid
-
-
?
2-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-3,4-dihydroxybutanoic acid + O2
2-[[(2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)prop-2-enoyl]oxy]-3,4-dihydroxybutanoic acid + H2O
-
-
-
-
?
3'-hydroxy-larreatricin + O2
3,3'-dihydroxylarreatricin
3-hydroxylation
-
-
?
3,3',4',5,7-pentahydroxyflavone + 1/2 O2
?
-
quercetin
-
-
?
3,4,5-trihydroxy-L-phenylalanine + O2
?
3,4,5-trihydroxybenzoic acid + O2
?
3,4,5-trihydroxyphenethylamine + O2
?
-
-
-
-
r
3,4,6-trihydroxyphenylalanine + O2
?
-
-
-
-
?
3,4-dihydroxyanisol + 1/2 O2
anisol o-quinone + H2O
-
-
-
?
3,4-dihydroxybenzoic acid + 1/2 O2
(3,4-dioxocyclohexa-1,5-dien-1-yl)acetic acid + H2O
-
isoenzymes 1-3, 22%, 13%, and 13% of L-dopa activity respectively
-
?
3,4-dihydroxyhydrocinnamic acid + O2
?
-
100% activity
-
-
?
3,4-dihydroxymandelic acid + O2
?
-
9% of the activity with L-dopa
-
-
?
3,4-dihydroxyphenethylamine + O2
?
-
-
-
-
?
3,4-dihydroxyphenyl propionic acid + O2
2-(3,4-dioxocyclohexa-1,5-dien-1-yl)propionic acid + H2O
Mushroom
-
-
-
-
r
3,4-dihydroxyphenylacetic acid + 1/2 O2
(3,4-dioxocyclohexa-1,5-dien-1-yl)acetic acid + H2O
-
DHPAA
-
-
?
3,4-dihydroxyphenylacetic acid + O2
?
3,4-dihydroxyphenylalanine + 1/2 O2
dopaquinone + H2O
-
-
-
-
?
3,4-dihydroxyphenylalanine + O2
?
-
-
-
-
?
3,4-dihydroxyphenylalanine methyl ester + O2
?
-
-
-
-
?
3,4-dihydroxyphenylethanol + O2
2-(3,4-dioxocyclohexa-1,5-dien-1-yl)ethanol + H2O
-
-
-
-
r
3,4-dihydroxyphenylglycol + O2
2-(3,4-dioxocyclohexa-1,5-dien-1-yl)glycol + H2O
-
-
-
-
r
3,4-dihydroxyphenylpropionic acid + 1/2 O2
3-(3,4-dioxocyclohexa-1,5-dien-1-yl)propanoic acid + H2O
-
DHPPA
-
-
?
3,4-dihydroxyphenylpropionic acid + O2
3-(3,4-dioxocyclohexa-1,5-dien-1-yl)propionic acid
-
-
-
?
3,4-dihydroxyphenylserine + O2
?
-
-
-
-
?
3-(3,4-dihydroxyphenyl) propionic acid + 1/2 O2
3-(3,4-dihydroxyphenyl)propionic acid + H2O
-
-
-
?
3-(3,4-dihydroxyphenyl)-2-methylalanine + O2
?
-
-
-
-
?
3-(3,5-dihydroxyphenyl)-1-propanoic acid + O2
?
low activity
-
-
?
3-(4-hydroxyphenyl)propionic acid + 1/2 O2
3-(3,4-dihydroxyphenyl)propionic acid + H2O
-
-
-
?
3-aminophenol + O2
?
-
3.9% activity compared to L-DOPA
-
-
?
3-chlorophenol + O2
4-chloro-1,2-quinone + H2O
-
20% of 3-chlorophenol is oxidized after 2 h by tyrosinase
4-chloro-1,2-quinone subsequently undergoes a nucleophilic substitution reaction at the chlorine atom by excess phenol to give the corresponding phenol-quinone adduct 4-(3-chlorophenoxy)cyclohexa-3,5-diene-1,2-dione
-
?
3-fluorophenol + O2
?
-
-
-
-
?
3-hydroxy-larreatricin + O2
3,3'-dihydroxylarreatricin
3'-hydroxylation
-
-
?
3-hydroxyanthranilic acid + O2
cinnabarinic acid + H2O
-
-
-
?
3-hydroxybenzyl alcohol + O2
?
-
-
-
-
?
3-hydroxyphloridzin + O2
?
-
-
-
-
?
3-methoxyphenol + O2
?
-
-
-
-
?
3-methylcatechol + O2
3-methyl-o-benzoquinone + H2O
-
-
-
?
3-[2-(3,4-dihydroxyphenyl)ethylaminocarbonyl]-3-methyl-1-(4-acetylphenyl)triazene + O2
(2E)-3-(4-acetylphenyl)-N-[2-(3,4-dioxocyclohexa-1,5-dien-1-yl)ethyl]-1-methyltriaz-2-ene-1-carboxamide + H2O
-
-
-
-
?
3-[2-(3,4-dihydroxyphenyl)ethylaminocarbonyl]-3-methyl-1-(4-ethoxycarbonylphenyl)triazene + O2
ethyl 4-[(1E)-3-[[2-(3,4-dioxocyclohexa-1,5-dien-1-yl)ethyl]carbamoyl]-3-methyltriaz-1-en-1-yl]benzoate + H2O
-
-
-
-
?
3-[2-(3,4-dihydroxyphenyl)ethylaminocarbonyl]-3-methyl-1-(4-tolyl)triazene + O2
(2E)-N-[2-(3,4-dioxocyclohexa-1,5-dien-1-yl)ethyl]-1-methyl-3-(4-methylphenyl)triaz-2-ene-1-carboxamide + H2O
-
-
-
-
?
3-[2-(4-hydroxyphenyl)ethylaminocarbonyl]-3-methyl-1-(4-acetylphenyl)triazene + O2
(2E)-3-(4-acetylphenyl)-1-methyl-N-[2-(4-oxocyclohexa-1,5-dien-1-yl)ethyl]triaz-2-ene-1-carboxamide + H2O
-
-
-
-
?
3-[2-(4-hydroxyphenyl)ethylaminocarbonyl]-3-methyl-1-(4-cyanophenyl)triazene + O2
(2E)-3-(4-cyanophenyl)-1-methyl-N-[2-(4-oxocyclohexa-1,5-dien-1-yl)ethyl]triaz-2-ene-1-carboxamide + H2O
-
-
-
-
?
3-[2-(4-hydroxyphenyl)ethylaminocarbonyl]-3-methyl-1-(4-ethoxycarbonylphenyl)triazene + O2
ethyl 4-[(1E)-3-methyl-3-[[2-(4-oxocyclohexa-1,5-dien-1-yl)ethyl]carbamoyl]triaz-1-en-1-yl]benzoate + H2O
-
-
-
-
?
3-[2-(4-hydroxyphenyl)ethylaminocarbonyl]-3-methyl-1-(4-tolyl)triazene + O2
(2E)-1-methyl-3-(4-methylphenyl)-N-[2-(4-oxocyclohexa-1,5-dien-1-yl)ethyl]triaz-2-ene-1-carboxamide + H2O
-
-
-
-
?
4-bromophenol + O2
?
-
-
-
-
?
4-chlorocatechol + 1/2 O2
4-chlorocyclohexa-3,5-diene-1,2-dione + H2O
-
-
-
-
?
4-chlorophenol + O2
4-chloro-1,2-quinone + H2O
4-ethylcatechol + 1/2 O2
4-ethylcyclohexa-3,5-diene-1,2-dione + H2O
-
-
-
-
?
4-ethylresorcinol + O2
?
-
acts as enzyme substrate and inhibitor
-
-
?
4-hexylresorcinol + O2
?
-
-
-
-
?
4-hydroxyanisol + 1/2 O2
3,4-dihydoxyanisol + H2O
-
-
-
?
4-hydroxyanisole + O2
3,4-dihydoxyanisol + H2O
-
-
-
-
?
4-hydroxyanisole + O2
3-methoxycatechol + H2O
Mushroom
-
-
-
-
r
4-hydroxyanisole + O2
?
-
-
-
-
?
4-hydroxybenzaldehyde + 1/2 O2
3,4-dihydroxybenzaldehyde + H2O
-
-
-
?
4-hydroxybenzaldehyde + O2
?
-
-
-
-
?
4-hydroxybenzoic acid + O2 + AH2
3,4-dihydroxybenzoic acid + H2O + A
4-hydroxybenzyl alcohol + O2
?
4-hydroxybenzyl alcohol + O2 + AH2
3,4-dihydroxybenzyl alcohol + H2O + A
-
-
-
?
4-hydroxyphenyl acetic acid + O2
?
4-hydroxyphenyl propionic acid + O2
3,4-dihydroxyphenyl propionic acid + H2O
Mushroom
-
-
-
-
r
4-hydroxyphenyl propionic acid + O2
?
4-hydroxyphenylpropionic acid + O2
?
4-iodophenol + O2
?
-
-
-
-
?
4-methyl catechol + O2
4-methyl-o-benzoquinone + H2O
-
5% of the activity with L-dopa
-
-
?
4-methyl-catechol + O2
?
-
-
-
-
?
4-methylbenzene-1,2-diol + O2
?
-
-
-
-
?
4-methylcatechol + 1/2 O2
4-methyl-1,2-benzoquinone + H2O
4-methylcatechol + O2
4-cresol + H2O
-
-
-
-
r
4-methylcatechol + O2
4-methyl-1,2-benzoquinone + H2O
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
4-Methylphenol + O2
?
-
-
-
-
?
4-methylresorcinol + O2
?
-
acts as enzyme substrate and inhibitor
-
-
?
4-n-butylresorcinol + O2
?
-
-
-
-
?
4-nitrocatechol + 1/2 O2
4-nitrocyclohexa-3,5-diene-1,2-dione + H2O
-
-
-
-
?
4-nitrocatechol + O2
?
-
-
-
-
?
4-t-butylphenol + O2 + AH2
4-t-butyl 1,2-benzoquinone + H2O + A
-
-
-
?
4-tert-butylcatechol + 1/2 O2
4-(tert-butyl)benzo-1,2-quinone + H2O
4-tert-butylcatechol + 1/2 O2
4-tert-butylcyclohexa-3,5-diene-1,2-dione + H2O
-
-
-
-
?
4-tert-butylcatechol + O2
4-tert-butyl-o-benzoquinone + H2O
4-tert-butylcatechol + O2
?
4-tert-butylphenol + O2
4-tert-butyl 1,2-benzoquinone + H2O
-
-
-
?
4-tert-butylphenol + O2
?
-
-
-
-
?
4-tyrosol + O2
?
-
-
-
-
?
4-[(4-methylphenyl)azo]-1,2-benzendiol + 1/2 O2
4-[(E)-(4-methylphenyl)diazenyl]cyclohexa-3,5-diene-1,2-dione + H2O
4-[(4-methylphenyl)azo]-phenol + O2 + AH2
4-[(4-methylbenzo)azo]-1,2-benzendiol + H2O + A
5,6-dihydroxyindole + 1/2 O2
1H-indole-5,6-dione + H2O
-
-
-
-
?
adrenaline bitartrate + O2
?
-
-
-
-
?
alpha-arbutin + O2
?
-
alpha-arbutin also has a weaker inhibitory effect on the monophenolase activity of the enzyme, molecular docking, overview. The hydroxyl group establishes hydrogen bonds with the peroxide ion and polar contacts with a copper ion as well as with residues H259 and H263. The aromatic ring position cannot be stabilized by Pi-Pi-interactions
-
-
?
alpha-methyl-DL-tyrosine + O2 + AH2
N-methyl-DL-dopa + H2O + A
alpha-methyl-dopa + O2
alpha-methyldopaquinone + H2O
-
-
-
?
alpha-methyl-L-tyrosine + O2 + AH2
N-methyl-L-dopa + H2O + A
-
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
caffeic acid + O2
? + 2 H2O
caffeic acid + O2
caffeoyl quinone + H2O
catechin + O2
catechin-O-quinone + H2O
catechin dimer + O2
?
-
-
-
-
?
catechin trimer + O2
?
-
-
-
-
?
catechol + 1/2 O2
1,2 benzoquinone + H2O
-
-
-
-
?
catechol + 1/2 O2
1,2-benzoquinone + H2O
catechol + 1/2 O2
o-benzoquinone + H2O
-
PPO from butter lettuce shows a higher affinity to 4-methylcatechol than to catechol
-
-
?
catechol + O2
1,2-benzoquinone + H2O
chlorogenic acid + 1/2 O2
chlorogenoquinone + H2O
chlorogenic acid + O2
? + 2 H2O
chlorogenic acid + O2
chlorogenoquinone + H2O
Coke gallic acid + O2
?
-
-
-
-
?
D-ascorbic acid + O2
?
-
-
-
-
r
D-dopa + 1/2 O2
D-dopaquinone + H2O
D-dopa + 1/2 O2
dopaquinone + H2O
-
-
-
-
r
D-DOPA + O2
D-dopaquinone + H2O
D-dopa + O2
dopaquinone + H2O
D-Tyr + O2
D-dopa + H2O
-
-
-
?
D-tyrosine + L-dopa + O2
D-dopa + dopaquinone + H2O
D-tyrosine + O2
D-dopa + H2O
D-tyrosine + O2
dopaquinone + H2O
D-tyrosine + O2 + AH2
D-dopa + H2O + A
D-tyrosine + O2 + AH2
L-3,4-dihydroxyphenylalanine + H2O + A
-
-
-
-
?
deoxyarbutin + O2
?
oxytyrosinase is able to hydroxylate deoxyarbutin and finishes the catalytic cycle by oxidizing the formed o-diphenol to quinone, while the enzyme becomes deoxytyrosinase, which evolves to oxytyrosinase in the presence of oxygen. deoxyarbutin can alsio act as enzyme inhibitor. This compound is the only one described that does not release o-diphenol after the hydroxylation step. Oxytyrosinase hydroxylates the deoxyarbutin in ortho position of the phenolic hydroxyl group by means of an aromatic electrophilic substitution. As the oxygen orbitals and the copper atoms are not coplanar, but in axial/equatorial position, the concerted oxidation/reduction cannot occur and the release of a copper atom to bind again in coplanar position, enabling the oxidation/reduction or release of the o-diphenol from the active site to the medium. In the case of deoxyarbutin, the o-diphenol formed is repulsed by the water due to its hydrophobicity, and so can bind correctly and be oxidized to a quinone before being released
-
-
?
diphenol + O2
?
Helix vulgaris
-
-
-
-
r
DL-2-methyltyrosine + O2
?
-
-
-
-
?
DL-dopa + 1/2 O2
DL-dopaquinone + H2O
DL-dopa + 1/2 O2
dopaquinone + H2O
-
-
-
-
r
DL-DOPA + O2
DL-dopaquinone + H2O
-
78% activity compared to L-DOPA
-
-
?
DL-DOPA + O2
dopaquinone + H2O
DL-tyrosine + O2
DL-DOPA + H2O
-
20.6% activity compared to L-DOPA
-
-
?
DL-tyrosine + O2
dopaquinone + H2O
DL-tyrosine + O2 + AH2
DL-dopa + H2O + A
dopa + 1/2 O2
dopaquinone + H2O
Dopa + O2
dopaquinone + H2O
-
-
-
-
r
dopa methyl ester + O2
dopaquinone methyl ester + H2O
Mushroom
-
-
-
-
r
dopamine + 1/2 O2
dopamine quinone + H2O
dopamine + 1/2 O2
dopaminequinone + H2O
-
-
-
?
dopamine + O2
dopamine quinone + H2O
Mushroom
-
-
-
-
r
dopamine + O2
dopaquinone + H2O
-
-
-
-
?
epicatechin + O2
? + 2 H2O
-
-
-
?
epicatechin gallate + O2
?
-
-
-
-
?
epigallocatechin + O2
? + 2 H2O
-
-
-
?
epigallocatechin + O2
epigallocatechin-O-quinone + H2O
-
-
-
-
r
epigallocatechin gallate + O2
?
-
-
-
-
?
epigallocatechin gallate + O2
? + 2 H2O
-
-
-
?
esculetin + 1/2 O2
2H-chromene-2,6,7-trione + H2O
-
demonstration, that esculetin is no inhibitor, but a substrate of mushroom polyphenol oxidase (PPO) and horseradish peroxidase (POD)
-
-
?
esculetin + O2
?
-
-
-
-
?
ferulic acid + O2 + AH2
(2E)-3-(3,4-dihydroxy-5-methoxyphenyl)prop-2-enoic acid + H2O + A
gallate + O2
? + 2 H2O
-
-
-
-
?
gallic acid + 1/2 O2
5-hydroxy-3,4-dioxocyclohexa-1,5-diene-1-carboxylic acid + H2O
-
-
-
-
?
gamma-L-glutaminyl-3,4-dihydroxybenzene + O2
gamma-L-glutaminyl-3,4-benzoquinone + H2O
-
-
-
?
gamma-L-glutaminyl-4-hydroxybenzene + O2 + AH2
gamma-L-glutaminyl-3,4-dihydroxybenzene + H2O + A
-
-
-
?
glycyl-glycyl-L-tyrosine + O2
?
-
3.4fold higher activity compared to Tyr
-
-
?
glycyl-L-tyrosine + O2
?
-
2.9fold higher activity compared to Tyr
-
-
?
guaiacolum + O2
?
-
-
-
-
?
hydroquinone + O2
?
-
-
-
-
?
hydroquinone monomethylether + O2
quinone monomethylether
-
-
-
?
hydroxyhydroquinone + O2
2-hydroxy-p-benzoquinone + H2O
-
the oxidation of hydroxyhydroquinone by O2 catalyzed by tyrosinase occurs simultaneously with the non-enzymatic oxidation of hydroxyhydroquinone at pH 7.0, the identical isosbestic points indicating that there is a stoichiometric transformation from hydroxyhydroquinone to 2-hydroxy p-benzoquinone, a red p-quinone
-
-
?
L-3,4-dihydroxyphenylalanine + 1/2 O2
L-dopachrome + H2O
-
-
-
-
?
L-3,4-dihydroxyphenylalanine + 1/2 O2
L-dopaquinone + H2O
L-3-hydroxytyrosine + L-dopa + O2
?
L-adrenaline + O2
?
-
-
-
-
?
L-alpha-methyl tyrosine + O2
L-alpha-methyldopa + H2O
Mushroom
-
-
-
-
r
L-alpha-methyldopa + H2O
L-alpha-methyl tyrosine + O2
Mushroom
-
-
-
-
r
L-alpha-methyldopa + O2
L-alpha-methyldopaquinone + H2O
L-dopa + 1/2 O2
dopachrome + H2O
-
-
-
-
?
L-dopa + 1/2 O2
dopaquinone + H2O
Vibrio tyrosinaticus
-
-
-
-
r
L-dopa + 1/2 O2
L-dopachrome + H2O
-
-
-
-
?
L-dopa + 1/2 O2
L-dopaquinone + H2O
L-DOPA + O2
dopaquinone + H2O
L-DOPA + O2
L-dopachrome + H2O
-
-
-
?
L-Dopa + O2
L-dopaquinone + H2O
L-dopa methyl ester + O2
?
L-isoproterenol + O2
1-[1-hydroxy-2-(propan-2-ylamino)ethyl]-3,4-dioxocyclohexa-1,5-diene + H2O
Mushroom
-
-
-
-
r
L-Tyr + O2
L-Dopa + H2O
-
diphenolase activity
-
-
?
L-Tyr + O2 + AH2
L-dopa + H2O + A
L-tyrosine + H2O2
3,4-dihydroxy-L-phenylalanine
-
-
-
-
?
L-tyrosine + L-dopa + O2
L-dopa + dopaquinone + H2O
L-tyrosine + O2
dihydroxyphenylalanine quinone + H2O
-
-
-
?
L-tyrosine + O2
dopachrome + H2O
-
-
-
?
L-tyrosine + O2
dopaquinone + H2O
L-tyrosine + O2
L-DOPA + H2O
L-tyrosine + O2
L-dopaquinone + H2O
-
-
-
?
L-tyrosine + O2 + AH2
L-3,4-dihydroxyphenylalanine + H2O + A
L-tyrosine + O2 + AH2
L-dopa + H2O + A
L-tyrosine methyl ester + O2
?
L-tyrosine methyl ester + O2
L-DOPA methyl ester + H2O
-
-
-
?
L-tyrosine methyl ester + O2 + AH2
L-dopa methyl ester + H2O + A
-
-
-
-
?
larreatricin + O2
3'-hydroxy-larreatricin
3'-hydroxylation
-
-
?
larreatricin + O2
3-hydroxy-larreatricin
3-hydroxylation
-
-
?
methyl 3-hydroxy-L-tyrosinate + O2
?
-
-
-
-
r
methyl gallate + O2
methyl 5-hydroxy-3,4-dioxocyclohexa-1,5-diene-1-carboxylate + H2O
-
-
-
-
?
methylcatechol + O2
4-methyl-1,2-benzoquinone + H2O
-
-
-
-
?
methylgallate + O2
? + 2 H2O
-
-
-
-
?
monophenol + O2
o-diphenol + H2O
-
-
-
?
N-acetyl-3,4-dihydroxyphenethylamine + O2
?
-
-
-
-
?
N-acetyl-6-hydroxytryptophan + O2
?
-
-
-
?
N-acetyl-L-tyrosine + O2
N-acetyl-dopaquinone + H2O
-
-
-
?
N-acetyldopamine + 1/2 O2
N-acetyldopamine quinone + H2O
N-acetyldopamine quinone + O2
1,2-dehydro-N-acetyldopamine + H2O
-
enzyme has both o-diphenoloxidase and N-acetyldopamine quinone:N-acetyldopamine quinone methide isomerase activity
-
?
N-beta-alanyldopamine + 1/2 O2
N-beta-alanyldopamine quinone + H2O
-
-
-
?
N-formyl-L-tyrosine + O2
?
-
-
-
-
?
N-methyl-3,4-dihydroxyphenethylamine + O2
?
-
-
-
-
?
noradrenaline + O2
?
-
-
-
-
?
Norepinephrine + O2
?
-
-
-
-
?
o-diphenol + O2
o-quinone + H2O
o-methoxyphenol + O2 + AH2
1,2-dihydroxy-3-methoxybenzene + H2O + A
p-coumaric acid + O2
caffeic acid + H2O
p-coumaric acid + O2 + AH2
caffeic acid + H2O + A
p-cresol + O2
4-methyl-o-quinone + H2O
-
-
-
-
?
p-cresol + O2
4-methylpyrocatechol + H2O
p-cresol + O2 + AH2
4-methyl-o-quinone + H2O + A
-
-
-
?
p-cresol + O2 + AH2
4-methylcatechol + H2O + A
-
-
-
-
?
p-cresol + O2 + AH2
4-methylpyrocatechol + H2O + A
p-hydroquinone + O2
?
-
2% activity compared to catechol
-
-
?
p-hydroxybenzoic acid + O2
?
-
less than 1% activity compared to L-DOPA
-
-
?
p-tyrosol + O2
2-(3,4-dihydroxyphenyl)ethanol + H2O
p-tyrosol + O2 + AH2
2-(3,4-dihydroxyphenyl)ethanol + H2O + A
phaselic acid + 1/2 O2
(2S)-2-[[(2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)prop-2-enoyl]oxy]butanedioic acid + H2O
-
-
-
-
?
phenol + O2
catechol + H2O
Mushroom
-
-
-
-
r
phenol + O2 + AH2
catechol + H2O + A
phenol + O2 + AH2
o-dihydroxybenzene + H2O + A
phloretin + O2
?
-
the compound is a substrate and an inhibitor for tyrosinase
-
-
?
phloroglucinol + 1/2 O2
?
protocatechuic acid + 1/2 O2
3,4-dioxocyclohexa-1,5-diene-1-carboxylic acid + H2O
-
-
-
-
?
protocatechuic acid + O2
?
protocatechuic aldehyde + 1/2 O2
3,4-dioxocyclohexa-1,5-diene-1-carbaldehyde + H2O
-
-
-
-
?
protocatechuic aldehyde + O2
?
pyrocatechol + 1/2 O2
1,2-benzoquinone + H2O
pyrocatechol + O2
?
-
-
-
?
pyrogallate + O2
?
-
-
-
?
pyrogallate + O2
? + 2 H2O
-
-
-
-
?
pyrogallol + O2
? + 2 H2O
quinol + O2
quinone + H2O
-
-
-
?
resveratrol + O2
?
-
-
-
-
?
rhododendrol + O2
?
-
-
-
-
?
syringic acid + O2
?
-
-
-
-
?
tert-butylcatechol + 1/2 O2
4-(tert-butyl)benzo-1,2-quinone + H2O
-
hydrophobic substrate
-
-
?
trans-cinnamic acid + O2
?
tyramine + O2
4-(2-aminoethyl)cyclohexa-3,5-diene-1,2-dione + H2O
tyramine + O2
dopamine + H2O
tyrosine + O2
dopaquinone + H2O
tyrosine + O2 + AH2
dopa + H2O + A
-
-
-
-
?
tyrosine + O2 + AH2
L-dopa + H2O + A
-
-
-
-
?
tyrosol + O2
?
-
the compound is a substrate and an inhibitor for tyrosinase
-
-
?
vanillin + O2 + AH2
3,4-dihydroxy-5-methoxybenzaldehyde + H2O + A
-
-
-
-
?
additional information
?
-
(+)-catechin + O2

?
-
-
-
-
?
(+)-catechin + O2
?
-
-
-
-
?
(+)-catechin + O2
?
-
-
-
-
?
(+)-catechin + O2
?
-
-
-
-
?
(+)-catechin + O2
?
-
-
-
-
?
(+)-catechin + O2
?
Festuca sp.
-
-
-
-
?
(+)-catechin + O2
?
-
-
-
-
?
(+)-catechin + O2
?
Lolium sp.
-
-
-
-
?
(+)-catechin + O2
?
-
-
-
-
?
(+)-catechin + O2
?
-
-
-
-
?
(+)-catechin + O2
?
-
-
-
-
?
(+)-catechin + O2
?
-
60.8% activity compared to L-DOPA
-
-
?
(+)-catechin + O2
?
-
-
-
-
?
(+)-catechin + O2
?
-
-
-
-
?
(+)-catechin hydrate + 1/2 O2

?
-
-
-
?
(+)-catechin hydrate + 1/2 O2
?
-
-
-
-
?
(+)-catechin hydrate + 1/2 O2
?
-
-
-
?
(+)-catechin hydrate + 1/2 O2
?
-
-
-
-
?
(+)-catechin hydrate + 1/2 O2
?
-
-
-
-
?
(-)-epicatechin + 1/2 O2

?
-
-
-
?
(-)-epicatechin + 1/2 O2
?
-
the major endogenous polyphenol in litchi pericarp
-
-
?
(-)-epicatechin + 1/2 O2
?
-
-
-
-
?
(-)-epicatechin + 1/2 O2
?
-
-
-
?
(-)-epicatechin + 1/2 O2
?
-
-
-
-
?
(-)-epicatechin + 1/2 O2
?
-
-
-
-
?
(-)-epicatechin + 1/2 O2
?
-
-
-
?
(-)-epicatechin + O2

?
-
-
-
-
?
(-)-epicatechin + O2
?
-
-
-
-
?
(-)-epicatechin + O2
?
-
-
-
-
?
(-)-epicatechin + O2
?
-
-
-
-
?
(-)-epicatechin + O2
?
-
-
-
-
?
(-)-epicatechin + O2
?
Festuca sp.
-
-
-
-
?
(-)-epicatechin + O2
?
-
-
-
-
?
(-)-epicatechin + O2
?
Lolium sp.
-
-
-
-
?
(-)-epicatechin + O2
?
-
-
-
-
?
(-)-epicatechin + O2
?
-
-
-
-
?
(-)-epicatechin + O2
?
-
-
-
-
?
(-)-epicatechin + O2
?
-
-
-
-
?
(-)-epicatechin + O2
?
-
119% activity at 2.5 mM substrate concentration
-
-
?
(-)-epicatechin + O2
?
-
-
-
-
?
(R)-dopaxanthin + dehydroascorbic acid + O2

(R)-dopaxanthin quinone + L-ascorbic acid + H2O
-
-
-
-
?
(R)-dopaxanthin + dehydroascorbic acid + O2
(R)-dopaxanthin quinone + L-ascorbic acid + H2O
-
(R)-dopaxanthin is a pigment, the reaction rate on the (R)-isomer of dopaxanthin is 1.9fold lower than that for the (S)-isomer
quantitative product analysis
-
?
(R)-dopaxanthin + dehydroascorbic acid + O2
(R)-dopaxanthin quinone + L-ascorbic acid + H2O
-
-
-
-
?
(RS)-catechin + O2

?
-
isoenzymes 1-3, 96, 104, and 168% of activity with L-dopa respectively
-
-
?
(RS)-catechin + O2
?
-
83% of activity with L-dopa
-
-
?
2 4-methylcatechol + O2

2 4-methyl-1,2-benzoquinone + 2 H2O
-
-
-
-
?
2 4-methylcatechol + O2
2 4-methyl-1,2-benzoquinone + 2 H2O
-
-
-
?
2 4-methylcatechol + O2
2 4-methyl-1,2-benzoquinone + 2 H2O
high activity
-
-
?
2 4-methylcatechol + O2
2 4-methyl-1,2-benzoquinone + 2 H2O
-
-
-
-
?
2 4-methylcatechol + O2
2 4-methyl-1,2-benzoquinone + 2 H2O
-
best substrate
-
-
?
2 4-methylcatechol + O2
2 4-methyl-1,2-benzoquinone + 2 H2O
-
-
-
-
?
2 catechol + O2

2 1,2-benzoquinone + 2 H2O
-
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
-
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
51% activity compared to L-dopa
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
-
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
85% activity compared to L-dopa
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
-
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
92% activity compared to L-dopa
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
-
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
-
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
92% activity compared to L-dopa
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
-
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
-
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
high activity
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
-
-
-
?
2 catechol + O2
2 1,2-benzoquinone + 2 H2O
-
-
-
-
?
2 hydroquinone + O2

2 quinone + 2 H2O
Emerita asiatica
-
no activity with hydroquinone
-
-
?
2 hydroquinone + O2
2 quinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2

2 dopaquinone + 2 H2O
-
-
744014, 744483, 744486, 744488, 744490, 744491, 744495, 744511, 744669, 744671, 744676, 744818, 744819, 745086, 745095, 745130, 745133, 745138, 745139, 745406, 745819, 746193, 746346, 746498 -
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
best substrate
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
best substrate
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
best substrate
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
best substrate
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
Mushroom
-
-
-
-
r
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-dopa + O2
2 dopaquinone + 2 H2O
Vibrio tyrosinaticus
-
-
-
-
r
2 L-dopa + O2
2 dopaquinone + 2 H2O
-
-
-
-
?
2 L-tyrosine + O2

2 L-dopa
-
-
-
-
?
2 L-tyrosine + O2
2 L-dopa
-
-
-
?
2 L-tyrosine + O2
2 L-dopa
-
-
-
?
2-O-caffeoylhydroxycitric acid + O2

?
-
-
-
-
?
2-O-caffeoylhydroxycitric acid + O2
?
-
-
-
-
?
2-O-caffeoylhydroxycitric acid + O2
?
-
-
-
-
?
2-O-caffeoylhydroxycitric acid + O2
?
-
i.e., E-3-carboxy-2-(3-(3,4-dihydroxyphenyl)prop-2-enoyloxy)-3-hydroxypentanedioic acid
-
-
?
2-O-caffeoylhydroxycitric acid + O2
?
-
-
-
-
?
2-O-caffeoylhydroxycitric acid + O2
?
-
-
-
-
?
2-O-caffeoylhydroxycitric acid + O2
?
Festuca sp.
-
-
-
-
?
2-O-caffeoylhydroxycitric acid + O2
?
-
-
-
-
?
2-O-caffeoylhydroxycitric acid + O2
?
Lolium sp.
-
-
-
-
?
2-O-caffeoylhydroxycitric acid + O2
?
-
-
-
-
?
2-O-caffeoylhydroxycitric acid + O2
?
-
-
-
-
?
2-O-caffeoylhydroxycitric acid + O2
?
-
-
-
-
?
2-O-caffeoylhydroxycitric acid + O2
?
-
-
-
-
?
2-O-caffeoylhydroxycitric acid + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid + O2

?
-
-
-
-
?
2-O-caffeoylisocitric acid + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid + O2
?
Festuca sp.
-
-
-
-
?
2-O-caffeoylisocitric acid + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid + O2
?
Lolium sp.
-
-
-
-
?
2-O-caffeoylisocitric acid + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid 6-methyl ester + O2

?
-
-
-
-
?
2-O-caffeoylisocitric acid 6-methyl ester + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid 6-methyl ester + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid 6-methyl ester + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid 6-methyl ester + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid 6-methyl ester + O2
?
Festuca sp.
-
-
-
-
?
2-O-caffeoylisocitric acid 6-methyl ester + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid 6-methyl ester + O2
?
Lolium sp.
-
-
-
-
?
2-O-caffeoylisocitric acid 6-methyl ester + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid 6-methyl ester + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid 6-methyl ester + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid 6-methyl ester + O2
?
-
-
-
-
?
2-O-caffeoylisocitric acid 6-methyl ester + O2
?
-
-
-
-
?
3,4,5-trihydroxy-L-phenylalanine + O2

?
-
cytotoxicity of TOPA
-
-
?
3,4,5-trihydroxy-L-phenylalanine + O2
?
-
i.e. TOPA
-
-
?
3,4,5-trihydroxybenzoic acid + O2

?
-
trivial name gallic acid
-
-
?
3,4,5-trihydroxybenzoic acid + O2
?
-
trivial name gallic acid
-
-
?
3,4-dihydroxyphenylacetic acid + O2

?
-
12% of the activity with L-dopa
-
-
?
3,4-dihydroxyphenylacetic acid + O2
?
-
-
-
?
3,4-dihydroxyphenylacetic acid + O2
?
-
-
-
-
?
3,4-dihydroxyphenylacetic acid + O2
?
-
3-methylbenzothyazolinone hydrazone, MBTH, as chromophore coupling agent
-
-
?
3,4-dihydroxyphenylacetic acid + O2
?
-
-
-
?
4-chlorophenol + O2

4-chloro-1,2-quinone + H2O
-
-
-
-
?
4-chlorophenol + O2
4-chloro-1,2-quinone + H2O
-
91% of 4-chlorophenol is oxidized after 2 h by tyrosinase
4-chloro-1,2-quinone subsequently undergoes a nucleophilic substitution reaction at the chlorine atom by excess phenol to give the corresponding phenol-quinone adduct 4-(4-chlorophenoxy)cyclohexa-3,5-diene-1,2-dione
-
?
4-coumaric acid + O2

?
-
-
-
-
?
4-coumaric acid + O2
?
-
-
-
-
?
4-cresol + O2

?
-
root and pulp enzyme
-
-
?
4-cresol + O2
?
-
-
-
-
?
4-ethoxyphenol + O2

?
-
-
-
-
?
4-ethoxyphenol + O2
?
Mushroom
-
-
-
-
?
4-fluorophenol + O2

?
-
-
-
-
?
4-fluorophenol + O2
?
-
-
-
-
?
4-hydroxybenzoic acid + O2 + AH2

3,4-dihydroxybenzoic acid + H2O + A
-
50% of activity with L-dopa
-
?
4-hydroxybenzoic acid + O2 + AH2
3,4-dihydroxybenzoic acid + H2O + A
-
-
-
?
4-hydroxybenzyl alcohol + O2

?
-
-
-
-
?
4-hydroxybenzyl alcohol + O2
?
-
the compound is a substrate and an inhibitor for tyrosinase
-
-
?
4-hydroxyphenyl acetic acid + O2

?
-
-
-
-
?
4-hydroxyphenyl acetic acid + O2
?
Mushroom
-
-
-
-
?
4-hydroxyphenyl acetic acid + O2
?
-
-
-
-
?
4-hydroxyphenyl acetic acid + O2
?
-
-
-
-
?
4-hydroxyphenyl propionic acid + O2

?
-
-
-
-
?
4-hydroxyphenyl propionic acid + O2
?
-
-
-
-
?
4-hydroxyphenylpropionic acid + O2

?
-
85% activity compared to 3,4-dihydroxyhydrocinnamic acid
-
-
?
4-hydroxyphenylpropionic acid + O2
?
-
-
-
-
?
4-methoxyphenol + O2

?
-
-
-
-
?
4-methoxyphenol + O2
?
-
40% relative activity compared to L-DOPA, weak monophenolase activity
-
-
?
4-methylcatechol + 1/2 O2

4-methyl-1,2-benzoquinone + H2O
-
-
-
-
?
4-methylcatechol + 1/2 O2
4-methyl-1,2-benzoquinone + H2O
-
oxidation of the substrate with NaIO4 in CHCl3, and [P]CHCl3
-
-
?
4-methylcatechol + 1/2 O2
4-methyl-1,2-benzoquinone + H2O
-
-
-
-
?
4-methylcatechol + 1/2 O2
4-methyl-1,2-benzoquinone + H2O
-
-
-
-
?
4-methylcatechol + 1/2 O2
4-methyl-1,2-benzoquinone + H2O
-
diphenolic substrate
-
-
?
4-methylcatechol + 1/2 O2
4-methyl-1,2-benzoquinone + H2O
-
PPO from butter lettuce shows a higher affinity to 4-methylcatechol than to catechol
-
-
?
4-methylcatechol + 1/2 O2
4-methyl-1,2-benzoquinone + H2O
-
efficient diphenolic substrates for cherry PPO
-
-
?
4-methylcatechol + 1/2 O2
4-methyl-1,2-benzoquinone + H2O
-
best substrate
-
-
?
4-methylcatechol + 1/2 O2
4-methyl-1,2-benzoquinone + H2O
-
-
-
-
?
4-methylcatechol + O2

4-methyl-1,2-benzoquinone + H2O
-
good substrate
-
-
?
4-methylcatechol + O2
4-methyl-1,2-benzoquinone + H2O
-
-
-
-
?
4-methylcatechol + O2
4-methyl-1,2-benzoquinone + H2O
good substrate
-
-
?
4-methylcatechol + O2
4-methyl-1,2-benzoquinone + H2O
good substrate
-
-
?
4-methylcatechol + O2
4-methyl-1,2-benzoquinone + H2O
-
-
-
-
?
4-methylcatechol + O2
4-methyl-1,2-benzoquinone + H2O
-
-
-
-
?
4-methylcatechol + O2
4-methyl-1,2-benzoquinone + H2O
-
highest activity
-
-
?
4-methylcatechol + O2
4-methyl-1,2-benzoquinone + H2O
-
highest activity, 183% activity at 10 mM substrate concentration
-
-
?
4-methylcatechol + O2

4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
Mushroom
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
Mushroom
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
Mushroom
-
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
catecholase/cresolase activity ratio of 41
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
-
r
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2
4-methyl-o-benzoquinone + H2O
-
-
-
?
4-methylcatechol + O2

?
-
-
-
?
4-methylcatechol + O2
?
-
90% activity compared to 3,4-dihydroxyhydrocinnamic acid
-
-
?
4-methylcatechol + O2
?
-
-
-
-
?
4-methylcatechol + O2
?
-
-
-
?
4-tert-butylcatechol + 1/2 O2

4-(tert-butyl)benzo-1,2-quinone + H2O
-
-
-
?
4-tert-butylcatechol + 1/2 O2
4-(tert-butyl)benzo-1,2-quinone + H2O
-
-
-
-
?
4-tert-butylcatechol + O2

4-tert-butyl-o-benzoquinone + H2O
Mushroom
-
-
-
-
r
4-tert-butylcatechol + O2
4-tert-butyl-o-benzoquinone + H2O
-
-
-
-
r
4-tert-butylcatechol + O2

?
-
-
-
?
4-tert-butylcatechol + O2
?
-
-
-
?
4-tert-butylcatechol + O2
?
-
-
-
?
4-[(4-methylphenyl)azo]-1,2-benzendiol + 1/2 O2

4-[(E)-(4-methylphenyl)diazenyl]cyclohexa-3,5-diene-1,2-dione + H2O
-
-
-
-
?
4-[(4-methylphenyl)azo]-1,2-benzendiol + 1/2 O2
4-[(E)-(4-methylphenyl)diazenyl]cyclohexa-3,5-diene-1,2-dione + H2O
-
synthetic substrate
-
-
?
4-[(4-methylphenyl)azo]-phenol + O2 + AH2

4-[(4-methylbenzo)azo]-1,2-benzendiol + H2O + A
-
-
-
-
?
4-[(4-methylphenyl)azo]-phenol + O2 + AH2
4-[(4-methylbenzo)azo]-1,2-benzendiol + H2O + A
-
synthetic substrate
-
-
?
alpha-methyl-DL-tyrosine + O2 + AH2

N-methyl-DL-dopa + H2O + A
-
-
-
-
?
alpha-methyl-DL-tyrosine + O2 + AH2
N-methyl-DL-dopa + H2O + A
-
-
-
-
?
beta-arbutin + O2

?
-
-
-
?
beta-arbutin + O2
?
-
alpha-arbutin also has a weaker inhibitory effect on the monophenolase activity of the enzyme, molecular docking, overview. The hydroxyl group establishes hydrogen bonds with the peroxide ion and polar contacts with a copper ion as well as with residues H259 and H263. The aromatic ring position cannot be stabilized by Pi-Pi-interactions
-
-
?
caffeic acid + 1/2 O2

caffeoyl quinone + H2O
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
17% of activity with L-dopa
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
diphenolic caffeic acid is oxidized relatively fast by all tyrosinases, except only moderately by tyrosinase from Pycnoporus sanguineus
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
?
caffeic acid + 1/2 O2
caffeoyl quinone + H2O
-
-
-
-
?
caffeic acid + O2

?
-
-
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
-
22% activity compared to L-dopa
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
-
28% activity compared to L-dopa
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
-
27% activity compared to L-dopa
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
-
23% activity compared to L-dopa
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
-
-
-
?
caffeic acid + O2
?
-
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
Festuca sp.
-
-
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
Lolium sp.
-
-
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2
?
-
-
-
-
?
caffeic acid + O2

? + 2 H2O
-
-
-
-
?
caffeic acid + O2
? + 2 H2O
-
-
-
?
caffeic acid + O2
? + 2 H2O
-
-