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Disease on EC 1.14.16.4 - tryptophan 5-monooxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Habitual
Tryptophan hydroxylase gene polymorphism (A218C) and idiopathic recurrent miscarriage.
Acidosis
Changes in glucose do not alter baseline firing rate or chemosensitivity of serotonin neurons cultured from the medullary raphé.
Adenocarcinoma
Changes in serotonin dynamics in the gastrointestinal tract of colon-26 tumour-bearing mice: effects of cisplatin treatment.
Alopecia
Pteridin-dependent hydroxylases as autoantigens in autoimmune polyendocrine syndrome type I.
Alzheimer Disease
Allelic variation at the A218C tryptophan hydroxylase polymorphism influences agitation and aggression in Alzheimer's disease.
Brain-Specific Tryptophan Hydroxylase, TPH2, and 5-HTTLPR are Associated with Frontal Lobe Symptoms in Alzheimer's Disease.
Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease.
Evidence for decreased transport of tryptophan hydroxylase in Alzheimer's disease.
No association between tryptophan hydroxylase gene polymorphism and Alzheimer's disease.
Tyrosine hydroxylase, tryptophan hydroxylase, biopterin, and neopterin in the brains of normal controls and patients with senile dementia of Alzheimer type.
Arthritis, Rheumatoid
Decoy receptor 3 regulates the expression of tryptophan hydroxylase 1 in rheumatoid synovial fibroblasts.
Atherosclerosis
Chronic Intake of the Selective Serotonin Reuptake Inhibitor Fluoxetine Enhances Atherosclerosis.
Autoimmune Diseases
Autoantibodies to human tryptophan hydroxylase and aromatic L-amino acid decarboxylase.
Identification of tryptophan hydroxylase as an intestinal autoantigen.
Breast Neoplasms
Altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival.
Tryptophan hydroxylase 1 and 5-HT
Carcinogenesis
Immortalization of neuroendocrine pinealocytes from transgenic mice by targeted tumorigenesis using the tryptophan hydroxylase promoter.
Carcinoid Tumor
7-Hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumors.
Antiproliferative Effects of Telotristat Ethyl in Patients with Neuroendocrine Tumors: The TELEACE Real-World Chart Review Study.
CD8+ T cells against multiple tumor-associated antigens in peripheral blood of midgut carcinoid patients.
Changes in Weight Associated With Telotristat Ethyl in the Treatment of Carcinoid Syndrome.
Cystic fibrosis transmembrane conductance regulator modulates neurosecretory function in pulmonary neuroendocrine cell-related tumor cell line models.
Elevated aromatic-L-amino acid decarboxylase in human carcinoid tumors.
Gastroenteropancreatic Neuroendocrine Tumors.
Increased dopamine production in patients with carcinoid tumors.
Inhibition of Peripheral Synthesis of Serotonin as a New Target in Neuroendocrine Tumors.
Long-Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome.
Patient-Reported Symptom Experiences in Patients With Carcinoid Syndrome After Participation in a Study of Telotristat Etiprate: A Qualitative Interview Approach.
Properties of tryptophan hydroxylase from human carcinoid tumor.
Successful and unsuccessful approaches to imaging carcinoids: comparison of a radiolabelled tryptophan hydroxylase inhibitor with a tracer of biogenic amine uptake and storage, and a somatostatin analogue.
TELEPRO: Patient-Reported Carcinoid Syndrome Symptom Improvement Following Initiation of Telotristat Ethyl in the Real World.
Telotristat ethyl in carcinoid syndrome: safety and efficacy in the TELECAST phase 3 trial.
Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome.
Telotristat ethyl: a new option for the management of carcinoid syndrome.
Telotristat Ethyl: A Review in Carcinoid Syndrome Diarrhoea.
Telotristat Ethyl: First Global Approval.
Telotristat ethyl: proof of principle and the first oral agent in the management of well-differentiated metastatic neuroendocrine tumor and carcinoid syndrome diarrhea.
The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells.
Tryptophan hydroxylase and 5-hydroxytryptamine in carcinoids of the gastrointestinal tract.
Tryptophan hydroxylase antibodies used in the diagnosis of carcinoid.
Understanding the Patient Experience with Carcinoid Syndrome: Exit Interviews from a Randomized, Placebo-controlled Study of Telotristat Ethyl.
[Proceedings: Tryptophan hydroxylase inhibition as therapy for carcinoid tumors]
Carcinoma
7-Hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumors.
Cardiomyopathy, Dilated
Contribution of gene-modified mice and rats to our understanding of the cardiovascular pharmacology of serotonin.
Catalepsy
Activity of tryptophan hydroxylase in brain of hereditary predisposed to catalepsy rats.
Correlation between tryptophan hydroxylase activity in the brain and predisposition to pinch-induced catalepsy in mice.
Experimental studies on genetically determined predisposition to catatonia in rats as a model of schizophrenia.
Involvement of striatum serotonergic system in the expression of genetically defined catalepsy.
On the role of brain serotonin in expression of genetic predisposition to catalepsy in animal models.
[Changes in the serotonin system of the brains of rats genetically predisposed to catalepsy]
[The relation of tryptophan hydroxylase activity in the brain and the manifestation of catalepsy in mice]
Cholangiocarcinoma
Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growth.
Serotonin Pathway in Cancer.
Cholera
Immunoreactivity for the NMDA NR1 subunit in bulbospinal catecholamine and serotonin neurons of rat ventral medulla.
Origin of the serotonergic innervation to the rat dorsolateral hypothalamus: retrograde transport of cholera toxin and upregulation of tryptophan hydroxylase mRNA expression following selective nerve terminals lesion.
Serotonergic projections to the ventral respiratory column from raphe nuclei in rats.
Colitis
Alterations in melatonin and 5-HT signalling in the colonic mucosa of mice with dextran-sodium sulfate-induced colitis.
Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation.
Serotonin Has a Key Role in Pathogenesis of Experimental Colitis.
Colitis, Ulcerative
Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome.
Colorectal Neoplasms
Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation.
Cushing Syndrome
Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression.
Dandy-Walker Syndrome
Changes of neurotransmitters in the brainstem of patients with respiratory-pattern disorders during childhood.
Dementia
Brain-Specific Tryptophan Hydroxylase, TPH2, and 5-HTTLPR are Associated with Frontal Lobe Symptoms in Alzheimer's Disease.
Depression, Postpartum
Associations Between Variations in TPH1 , TPH2 and SLC6A4 Genes and Postpartum Depression: A Study in the Jordanian Population.
Diabetes Mellitus
[Changes in brain serotonin biosynthesis in rats with diabetes mellitus induced by streptozocin: effect of insulin treatment]
Diabetes Mellitus, Type 1
Inhibition and kinetic changes of brain tryptophan-5-hydroxylase during insulin-dependent diabetes mellitus in the rat.
Dyskinesias
Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia.
Encephalomyelitis
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.
Encephalomyelitis, Autoimmune, Experimental
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.
Enterocolitis
Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung's-associated enterocolitis.
Epilepsy
The ventrolateral medulla and medullary raphe in sudden unexpected death in epilepsy.
Tryptophan hydroxylase 2 (TPH2) gene polymorphisms and psychiatric comorbidities in temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Tryptophan hydroxylase 2 (TPH2) gene polymorphisms and psychiatric comorbidities in temporal lobe epilepsy.
Epileptic Syndromes
Neuropathology of early-infantile epileptic encephalopathy with suppression-bursts; comparison with those of early myoclonic encephalopathy and West syndrome.
Familial Primary Pulmonary Hypertension
Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension.
Fatty Liver
Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease.
Gastrointestinal Diseases
Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders.
Tryptophan hydroxylase autoantibodies and intestinal disease in autoimmune polyendocrine syndrome type 1.
Updates on the biology of serotonin and tryptophan hydroxylase.
Glioma
Serotonin in neuroblastoma x glioma NG108-15 hybrid cells.
Glucose Intolerance
Selective inhibition of intestinal 5-HT improves neurobehavioral abnormalities caused by high-fat diet mice.
Headache Disorders, Secondary
Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches.
Herpes Zoster
Superfluous expression of tryptophan hydroxylase in the zona incerta dopaminergic neurones.
Huntington Disease
Inhibition of tryptophan hydroxylase activity and decreased 5-HT1A receptor binding in a mouse model of Huntington's disease.
Hyperalgesia
Analgesic effects of electroacupuncture at ST25 and CV12 in a rat model of postinflammatory irritable bowel syndrome visceral pain.
Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain.
[Descending facilitation in chronic stress and chronic pain state]
Hyperhomocysteinemia
Maternal vitamin B6 deficient or supplemented diets on expression of genes related to GABAergic, serotonergic or glutamatergic pathways in hippocampus of rat dams and their offspring.
Hypersensitivity
Exendin-4, an analogue of glucagon-like peptide-1, attenuates hyperalgesia through serotonergic pathways in rats with neonatal colonic sensitivity.
SERT and TPH-1 mRNA expression are reduced in Irritable Bowel Syndrome patients irrespective of visceral sensitivity state in large intestine.
Hypertension
4-Chloro-DL-phenylalanine protects against monocrotaline?induced pulmonary vascular remodeling and lung inflammation.
Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension.
Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension.
Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.
Hypertension, Pulmonary
Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension.
Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension.
Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice.
Hyperthyroidism
Evidence that chronic apomorphine treatment enhances 5-hydroxytryptamine metabolism in brains of normal and neonatally hyperthyroid rats.
Influence of neonatal and adult hyperthyroidism on behavior and biosynthetic capacity for norepinephrine, dopamine and 5-hydroxytryptamine in rat brain.
Hypertrophy, Right Ventricular
4-Chloro-DL-phenylalanine protects against monocrotaline?induced pulmonary vascular remodeling and lung inflammation.
Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension.
Hypothyroidism
Effect of neonatal hypothyroidism on the serotonin system of the rat brain.
Effects of experimental hypothyroidism on 5-HT1A, 5-HT2A receptors, 5-HT uptake sites and tryptophan hydroxylase activity in mature rat brain1.
The effect of thyroid hormone on serotonergic neurones: depletion of serotonin in discrete brain areas of developing hypothyroid rats.
Infections
Acute nociceptive stimuli rapidly induce the activity of serotonin and noradrenalin neurons in the brain stem of awake mice.
Expression of tryptophan hydroxylase in gastric mucosa in symptomatic and asymptomatic Helicobacter pylori infection.
Liposomes with pH responsive 'on and off' switches for targeted and intracellular delivery of antibiotics.
Mast Cells and Serotonin Synthesis Modulate Chagas Disease in the Colon: Clinical and Experimental Evidence.
Reference gene selection for normalization of PCR analysis in chicken embryo fibroblast infected with H5N1 AIV.
RFX Transcription Factor DAF-19 Regulates 5-HT and Innate Immune Responses to Pathogenic Bacteria in Caenorhabditis elegans.
Influenza, Human
Lethal Avian Influenza A (H5N1) Virus Replicates in Pontomedullary Chemosensitive Neurons and Depresses Hypercapnic Ventilatory Response in Mice.
Intellectual Disability
Case Report: Whole Exome Sequencing Revealed Disease-Causing Variants in Two Genes in a Patient With Autism Spectrum Disorder, Intellectual Disability, Hyperactivity, Sleep and Gastrointestinal Disturbances.
The control of 5-hydroxytryptamine and dopamine synthesis in the brain: a theoretical approach.
Intestinal Diseases
Tryptophan hydroxylase autoantibodies and intestinal disease in autoimmune polyendocrine syndrome type 1.
Irritable Bowel Syndrome
Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome.
Isoform-Specific Substrate Inhibition Mechanism of Human Tryptophan Hydroxylase.
LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome.
Review article: intestinal serotonin signalling in irritable bowel syndrome.
SERT and TPH-1 mRNA expression are reduced in Irritable Bowel Syndrome patients irrespective of visceral sensitivity state in large intestine.
The Tryptophan Hydroxylase Inhibitor LX1031 Shows Clinical Benefit in Patients With Nonconstipating Irritable Bowel Syndrome.
TPH Gene Polymorphisms Are Associated With Disease Perception and Quality of Life in Women With Irritable Bowel Syndrome.
[Effects of baldrinal of Valeriana jatamansi on expression of CRF, TPH1 mRNA and 5-HT in rats with irritable bowel syndrome].
[Moxibustion relieves abdominal hypersensitivity and diarrhea by regulating colonic 5-hydroxytryptamine signaling pathway in rats with diarrhea type irritable bowel syndrome].
Learning Disabilities
[Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder with or without learning disorder]
Leukemia
Cytotoxic compounds from the leaves of Garcinia polyantha.
Flavanocoumarins from Guazuma ulmifolia bark and evaluation of their affinity for STAT1.
Rapid turnover of tryptophan hydroxylase in serotonin producing cells: demonstration of ATP-dependent proteolytic degradation.
Leukocytosis
Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice.
Liver Diseases
Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease.
Lung Diseases
Sicilian family with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and lethal lung disease in one of the affected brothers.
Malnutrition
Early nutritional changes modify the kinetics and phosphorylation capacity of tryptophan-5-hydroxylase.
Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition.
[Intrauterine malnutrition. II. L-tryptophan, tryptophan-5-hydroxylase and serotonin in the brain of rats]
Mastocytoma
Characterization and chromosomal mapping of a cDNA encoding tryptophan hydroxylase from a mouse mastocytoma cell line.
Characterization of yellowfin tuna (Thunnus albacares, Scombroidei) tryptophan hydroxylase.
Immunohistochemical localization of tryptophan hydroxylase in the human and rat gastrointestinal tracts.
Inhibition of tryptophan hydroxylase by (R)- and (S)-1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines (salsolinols).
Isolation and structural characterization of the murine tryptophan hydroxylase gene.
Rapid turnover of tryptophan hydroxylase in serotonin producing cells: demonstration of ATP-dependent proteolytic degradation.
Tryptophan 5-monooxygenase from mouse mastocytoma clone P815.
Tryptophan 5-monooxygenase from mouse mastocytoma P815. A simple purification and general properties.
Tryptophan 5-monooxygenase from mouse mastocytoma: high-performance liquid chromatography assay.
Tryptophan hydroxylase from mouse mastocytoma P-815. Reversible activation by ethylenediaminetetraacetate.
Melanoma
Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells.
Melanoma, Amelanotic
Serotoninergic system in hamster skin.
Memory Disorders
Serotonin Transporter and Tryptophan Hydroxylase Gene Variations Mediate Working Memory Deficits of Cocaine Users.
Metabolic Diseases
Deficiency of tyrosine hydroxylase or tryptophan hydroxylase: a possible cause of two hypothetical metabolic diseases.
Metabolic Syndrome
Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression.
Migraine Disorders
A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.
Functional gene variants of the serotonin-synthesizing enzyme tryptophan hydroxylase 2 in migraine.
Mechanisms of pain modulation by sex hormones in migraine.
The A218C polymorphism of tryptophan hydroxylase gene and migraine.
Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches.
Mucocutaneous Lymph Node Syndrome
Involvement of tryptophan hydroxylase 2 (TPH2) gene polymorphisms in susceptibility to coronary artery lesions in Korean children with Kawasaki disease.
Myoclonus
Post-hypoxic intention myoclonus treated with 5-hydroxy-tryptophan and an extracerebral decarboxylase inhibitor.
Tryptamine-induced myoclonus in guinea-pigs pretreated with a monoamine oxidase inhibitor indicates pre- and post-synaptic actions of tryptamine upon central indoleamine systems.
Narcolepsy
Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy.
Neoplasm Metastasis
The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells.
Tryptophan hydroxylase and 5-hydroxytryptamine in carcinoids of the gastrointestinal tract.
Neoplasms
4-Chloro-DL-phenylalanine protects against monocrotaline?induced pulmonary vascular remodeling and lung inflammation.
Analgesic activity of cynaropicrinon on post-inflammatory irritable bowel syndrome visceral hypersensitivity in a rat model.
Changes in serotonin dynamics in the gastrointestinal tract of colon-26 tumour-bearing mice: effects of cisplatin treatment.
Comparisons of tryptophan hydroxylase from a malignant murine mast cell tumor and rat mesencephalic tegmentum.
Elevated aromatic-L-amino acid decarboxylase in human carcinoid tumors.
Gastrointestinal and metabolic function in patients with the carcinoid syndrome.
Histological features and expression of enzymes implicated in melatonin synthesis in pineal parenchymal tumours and in cultured tumoural pineal cells.
Induction of tryptophan hydroxylase in the liver of s.c. tumor model of prostate cancer.
Malignant melanoma producing serotonin.
Methylenedioxymethamphetamine-induced suppression of interleukin-1beta and tumour necrosis factor-alpha is not mediated by serotonin.
Principal component analysis, hierarchical clustering, and decision tree assessment of plasma mRNA and hormone levels as an early detection strategy for small intestinal neuroendocrine (carcinoid) tumors.
Selection of reference genes for quantitative real-time PCR analysis in canine mammary tumors using the GeNorm algorithm.
Serotonin Pathway in Cancer.
Successful and unsuccessful approaches to imaging carcinoids: comparison of a radiolabelled tryptophan hydroxylase inhibitor with a tracer of biogenic amine uptake and storage, and a somatostatin analogue.
Tryptophan hydroxylase 1 and 5-HT
Tryptophan hydroxylase and 5-hydroxytryptamine in carcinoids of the gastrointestinal tract.
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.
Tryptophan Metabolism as Source of New Prognostic Biomarkers for FAP Patients.
Update on management of midgut neuroendocrine tumors.
Neuroblastoma
Serotonin in neuroblastoma x glioma NG108-15 hybrid cells.
Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells.
Neuroendocrine Tumors
Antiproliferative Effects of Telotristat Ethyl in Patients with Neuroendocrine Tumors: The TELEACE Real-World Chart Review Study.
Changes in Weight Associated With Telotristat Ethyl in the Treatment of Carcinoid Syndrome.
Efficacy of the tryptophan hydroxylase inhibitor telotristat on growth and serotonin secretion in 2D and 3D cultured pancreatic neuroendocrine tumor cells.
Serotonin Pathway in Cancer.
Tryptophan hydroxylase antibodies used in the diagnosis of carcinoid.
Neuroinflammatory Diseases
Beneficial Effects of Exercise on Depression and Anxiety During the Covid-19 Pandemic: A Narrative Review.
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.
Obesity
Altered intestinal neuroendocrine gene expression in humans with obesity.
High fat diet leads to tissue specific changes reflecting risk factors for diseases in DBA/2J mice.
Increased binding at 5-HT(1A), 5-HT(1B), and 5-HT(2A) receptors and 5-HT transporters in diet-induced obese rats.
Investigating the complex interplay between genotype and high-fat-diet feeding in the lactating mammary gland using the Tph1 and Ldlr knockout models.
Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease.
Properties of myenteric neurons and mucosal functions in the distal colon of diet-induced obese mice.
Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity.
Osteoporosis
Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis.
Ursolic acid derivatives as bone anabolic agents targeted to tryptophan hydroxylase 1 (Tph-1).
Paralysis
Tryptophan hydroxylase activity in the brains of controls and parkinsonian patients.
Parkinson Disease
Dopaminergic transplants alter in vivo activity of tryptophan hydroxylase in the striatum in a rat model of Parkinson's disease.
Involvement of medullary serotonergic groups in multiple system atrophy.
Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinson's disease.
Tryptophan hydroxylase activity in the brains of controls and parkinsonian patients.
Tryptophan hydroxylase type 2 variants modulate severity and outcome of addictive behaviors in Parkinson's disease.
Phenylketonurias
Inherited disorders affecting dopamine and serotonin: critical neurotransmitters derived from aromatic amino acids.
The control of 5-hydroxytryptamine and dopamine synthesis in the brain: a theoretical approach.
The effect of plasma valine, isoleucine and leucine on the control of the flux through tyrosine- and tryptophan-hydroxylase in the brain.
Pheochromocytoma
"7-tetrahydrobiopterin," a naturally occurring analogue of tetrahydrobiopterin, is a cofactor for and a potential inhibitor of the aromatic amino acid hydroxylases.
Increased dopamine production in patients with carcinoid tumors.
Pneumonia
4-Chloro-DL-phenylalanine protects against monocrotaline?induced pulmonary vascular remodeling and lung inflammation.
Polyendocrinopathies, Autoimmune
APECED syndrome in childhood: clinical spectrum is enlarging.
Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systems.
Gastrointestinal immunity against tryptophan hydroxylase-1, aromatic L-amino-acid decarboxylase, AIE-75, villin and Paneth cells in APECED.
Serotonin and tryptophan metabolites, autoantibodies and gut microbiome in APECED.
Sicilian family with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and lethal lung disease in one of the affected brothers.
Premature Ejaculation
Association Between Lifelong Premature Ejaculation and Polymorphism of Tryptophan Hydroxylase 2 Gene in the Han Population.
Premenstrual Dysphoric Disorder
Serotonin transporter, tryptophan hydroxylase, and monoamine oxidase A gene polymorphisms in premenstrual dysphoric disorder.
Prostatic Neoplasms
Induction of tryptophan hydroxylase in the liver of s.c. tumor model of prostate cancer.
Serotonin synthesis and metabolism-related molecules in a human prostate cancer cell line.
protein acetyllysine n-acetyltransferase deficiency
Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity.
Pulmonary Arterial Hypertension
4-Chloro-DL-phenylalanine protects against monocrotaline?induced pulmonary vascular remodeling and lung inflammation.
Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension.
Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension.
Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.
Pulmonary Disease, Chronic Obstructive
Activation of the Serotonin Pathway is Associated with Poor Outcome in COPD Exacerbation: Results of a Long-Term Cohort Study.
Dysregulation of the Tryptophan Pathway Evidences Gender Differences in COPD.
Rabies
Localization of Serotoninergic Neurons that Participate in Regulating Diaphragm Activity in the Cat.
Scoliosis
Association study of single nucleotide polymorphism in tryptophan hydroxylase 1 gene with adolescent idiopathic scoliosis: A meta-analysis.
Association study of tryptophan hydroxylase 1 and arylalkylamine N-acetyltransferase polymorphisms with adolescent idiopathic scoliosis in Han Chinese.
Seizures
Experimental studies on genetically determined predisposition to catatonia in rats as a model of schizophrenia.
Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise.
Shy-Drager Syndrome
Tryptophan hydroxylase activity in the brains of controls and parkinsonian patients.
Sleep Deprivation
Increased brain serotonin metabolism during rebound sleep in sleep-deprived rats.
Sleep Initiation and Maintenance Disorders
Association of Tryptophan Hydroxylase-2 Gene rs4290270 with Primary Insomnia and Depressive Symptoms in a Chinese Han Population.
Reversibility of para-chlorophenylalanine-induced insomnia by intrahypothalamic microinjection of L-5-hydroxytryptophan.
Spinal Cord Injuries
Synthesis, transport and metabolism of serotonin formed from exogenously applied 5-HTP after spinal cord injury in rats.
Starvation
Serotonin signaling mediates protein valuation and aging.
Steatorrhea
Gastrointestinal and metabolic function in patients with the carcinoid syndrome.
Striatonigral Degeneration
Tryptophan hydroxylase activity in the brains of controls and parkinsonian patients.
Stroke
LIM kinase inhibitor T56-LIMKi protects mouse brain from photothrombotic stroke.
Stupor
Behavioral and neurochemical effects induced by subchronic combined exposure to toluene at 40 ppm and noise at 80 dB-A in rats.
Behavioral and neurochemical effects induced by subchronic exposure to 40 ppm toluene in rats.
Supranuclear Palsy, Progressive
Tryptophan hydroxylase activity in the brains of controls and parkinsonian patients.
Temporomandibular Joint Disorders
Association between tryptophan hydroxylase gene polymorphism and painful non-osseous temporomandibular disorders.
Teratoma
Neurochemical studies in a mouse teratoma with neuroepithelial differentiation. Presence of cyclic AMP, serotonin and enzymes of the serotonergic, adrenergic and cholinergic systems.
Tetanus
Partial Raphe Dysfunction in Neurotransmission Is Sufficient to Increase Mortality after Anoxic Exposures in Mice at a Critical Period in Postnatal Development.
Stereotaxic injection of tetanus toxin in rat central nervous system causes alteration in normal levels of monoamines.
Thromboembolism
Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase.
Thrombosis
Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase.
Tic Disorders
Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population.
Tourette Syndrome
Role of the novel tryptophan hydroxylase-2 gene in Tourette syndrome.
Tremor
Evidence for the involvement of central serotonergic mechanisms in cholinergic tremor induced by tacrine in Balb/c mice.
Serotonin synthesis inhibition in olivo-cerebellar system attenuates harmaline-induced tremor in Swiss albino mice.
Triple Negative Breast Neoplasms
Up-regulation of cathepsin S expression by HSP90 and 5-HT7 receptor-dependent serotonin signaling correlates with triple negativity of human breast cancer.
tryptophan 5-monooxygenase deficiency
Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension.
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan.
Poricoic acid A as a modulator of TPH-1 expression inhibits renal fibrosis via modulating protein stability of ?-catenin and ?-catenin-mediated transcription.
Role of brain cytochrome P450 (CYP2D) in the metabolism of monoaminergic neurotransmitters.
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.
Vitiligo
Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: epidermal H2O2/ONOO--mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low serotonin and melatonin levels.