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EC Tree
IUBMB CommentsRequires Fe2+. The enzyme has been characterized from the leaves of the plant Tecoma stans (Yellow Bells).
The expected taxonomic range for this enzyme is: Tecoma stans
Synonyms
anthranilate hydroxylase,
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anthranilate 3-hydroxylase
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anthranilate hydroxylase
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anthranilic acid hydroxylase
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anthranilic hydroxylase
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oxygenase, anthranilate 3-mono-
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anthranilate + tetrahydrobiopterin + O2 = 3-hydroxyanthranilate + dihydrobiopterin + H2O
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anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
Requires Fe2+. The enzyme has been characterized from the leaves of the plant Tecoma stans (Yellow Bells).
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anthranilate + tetrahydrofolic acid + O2
3-hydroxyanthranilate + dihydrofolic acid + H2O2
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specific for anthranilate, the optimum concentration is 0.5 mM, tetrahydrofolic acid is the most active electron donor when tested alone
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additional information
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phenylalanine, benzoic acid, acetanilide, tryptophan, kynurenine and cinnamic acid do not serve as substrates
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tetrahydrofolic acid
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absolute requirement
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Fe3+
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activator, required for the reaction
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1,10-phenanthroline
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74.2% inhibition at 0.5 mM
2,2'-dipyridyl
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97.4% inhibition, reversed by Fe3+
2,3-Dimercaptopropanol
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Ag+
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100% inhibition at 0.5 mM
aminopterin
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100% inhibition at 0.5 mM, 78.4% inhibition at 0.2 mM
anthranilic acid
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above 1 mM
Co2+
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62.4% inhibition at 0.5 mM
Cu2+
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77% inhibition at 0.5 mM
cysteine
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91.9% inhibition at 0.5 mM
glutathione
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86.8% inhibition at 0.5 mM
Hg2+
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97% inhibition at 0.5 mM
iodoacetate
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57% inhibition at 0.5 mM
p-chloromercuribenzoate
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slight at 0.5 mM
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NADH
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increases activity
NADPH
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increases activity
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3.6 - 6.2
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about 50% of activity maximum at pH 3.6 and pH 6.2
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brenda
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brenda
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using fractional precipitation with acetone and adsorption on DEAE-cellulose
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Nair, P.M.; Vaidyanathan, C.S.
Anthranilic acid hydroxylase from Tecoma stans
Biochim. Biophys. Acta
110
521-531
1965
Tecoma stans
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brenda
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1.14.16.3 anthranilate 3-monooxygenase
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