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IUBMB CommentsA cytochrome P-450 (heme-thiolate) protein involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.
The expected taxonomic range for this enzyme is: Streptomyces carzinostaticus
Reaction Schemes
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2
reduced ferredoxin [iron-sulfur] cluster
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2
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=
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2
oxidized ferredoxin [iron-sulfur] cluster
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Synonyms
ncsb3, more
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EC 1.14.99.49
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formerly
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NcsB3
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2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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2-hydroxy-5-methyl-1-naphthoate,reduced ferredoxin:oxygen oxidoreductase (7-hydroxylating)
A cytochrome P-450 (heme-thiolate) protein involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.
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2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
Substrates: the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin
Products: -
?
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
Substrates: -
Products: -
?
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
Substrates: the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin
Products: -
?
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
Substrates: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
Substrates: the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin
Products: -
?
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
Substrates: the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin
Products: -
?
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cytochrome P-450
a heme-thiolate protein
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SwissProt
brenda
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SwissProt
brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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NCSB3_STRCZ
410
0
45493
Swiss-Prot
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heterologous expression of the gene together with ncsB and ncsB1 in Streptomyces lividans TK24
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Hang, V.T.T.; Oh, T.J.; Yamaguchi, T.; Sohng, J.K.
In vivo characterization of NcsB3 to establish the complete biosynthesis of the naphthoic acid moiety of the neocarzinostatin chromophore
FEMS Microbiol. Lett.
311
119-125
2010
Streptomyces carzinostaticus (Q84HB6), Streptomyces carzinostaticus, Streptomyces carzinostaticus ATCC 15944 (Q84HB6)
brenda
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