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Information on EC 1.14.15.30 - 3-ketosteroid 9alpha-monooxygenase

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IUBMB Comments
The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It forms a two-component system with a ferredoxin reductase (KshB). The enzyme contains a Rieske-type iron-sulfur center and non-heme iron. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
ksha2, ksha1, kshab, ksha5, ksha3, 3-ketosteroid-9alpha-hydroxylase, 3-ketosteroid 9-alpha-hydroxylase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
androsta-1,4-diene-3,17-dione + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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