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Information on EC 1.14.15.26 - toluene methyl-monooxygenase

for references in articles please use BRENDA:EC1.14.15.26
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IUBMB Comments
The enzyme, characterized from several Pseudomonas strains, catalyses the first step in the degradation of toluenes and xylenes. It has a broad substrate specificity and is also active with substituted compounds, such as chlorotoluenes. The electrons are provided by a reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase) that transfers electrons from NADH via FAD and an [2Fe-2S] cluster. The enzyme can also act on its products, producing gem-diols that spontaneously dehydrate to form aldehydes.
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The expected taxonomic range for this enzyme is: Pseudomonas
Reaction Schemes
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2
reduced ferredoxin [iron-sulfur] cluster
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2
=
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2
oxidized ferredoxin [iron-sulfur] cluster
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+
+
2
reduced ferredoxin [iron-sulfur] cluster
+
2
=
+
2
oxidized ferredoxin [iron-sulfur] cluster
+
+
+
2
reduced ferredoxin [iron-sulfur] cluster
+
2
=
+
2
oxidized ferredoxin [iron-sulfur] cluster
+
Synonyms
ntnM, xylM, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
m-xylene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = 3-methylbenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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(3)
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p-xylene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = 4-methylbenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
(2)
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toluene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = benzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
(1)
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