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Information on EC 1.14.14.75 - fenbendazole monooxygenase (4'-hydroxylating)

for references in articles please use BRENDA:EC1.14.14.75
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IUBMB Comments
CYP2C19 is microsomal cytochrome P-450 monooxygenase that catalyses the hydroxylation of the benzene ring of fenbendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes. This activity is also carried out by CYP2J2. cf. EC 1.14.14.74, albendazole monooxygenase (hydroxylating). CYP2C19 does not act on albendazole.
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The expected taxonomic range for this enzyme is: Homo sapiens
Synonyms
CYP2C19, CYP2J2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
fenbendazole + [reduced NADPH-hemoprotein reductase] + O2 = 4'-hydroxyfenbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
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