Disease on EC 1.14.14.73 - albendazole monooxygenase (sulfoxide-forming)
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albendazole monooxygenase (sulfoxide-forming) deficiency
Inducible CYP2J2 and Its Product 11,12-EET Promotes Bacterial Phagocytosis: A Role for CYP2J2 Deficiency in the Pathogenesis of Crohn's Disease?
Alzheimer Disease
CYP2J2 rs890293 polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese Han population.
Alzheimer Disease
Gene- gene interaction between CYP2J2 and PPAR -? gene on late-onset Alzheimer's disease in the eastern Chinese Han population.
Aortic Aneurysm, Abdominal
CYP2J2 Overexpression Increases EETs and Protects against Angiotensin II-Induced Abdominal Aortic Aneurysm in Mice.
Arrhythmias, Cardiac
CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy.
Asthma
Promoter polymorphism G-50T of a human CYP2J2 epoxygenase gene is associated with common susceptibility to asthma.
Atherosclerosis
CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study.
Atherosclerosis
CYP2J2 Overexpression Increases EETs and Protects Against HFD-induced Atherosclerosis in ApoE-/- Mice.
Atherosclerosis
CYP2J2 participates in atherogenesis by mediating cell proliferation, migration and foam cell formation.
Brain Infarction
Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.
Brain Ischemia
Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.
Breast Neoplasms
Activation of ALDH1A1 in MDA-MB-468 breast cancer cells that over-express CYP2J2 protects against paclitaxel-dependent cell death mediated by reactive oxygen species.
Breast Neoplasms
Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.
Breast Neoplasms
Impact of gene polymorphisms in drug-metabolizing enzymes and transporters on trough concentrations of rivaroxaban in patients with atrial fibrillation.
Breast Neoplasms
In-Depth Characterization of EpiIntestinal Microtissue as a Model for Intestinal Drug Absorption and Metabolism in Human.
Carcinogenesis
A molecular design strategy to construct the near-infrared fluorescent probe for selectively sensing human cytochrome P450 2J2.
Carcinoma
CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma.
Carcinoma
Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors.
Carcinoma
Expression of cytochrome P450 arachidonic acid epoxygenase 2J2 in human tumor tissues and cell lines.
Carcinoma
Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells.
Carcinoma
The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation.
Carcinoma
The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells.
Carcinoma, Hepatocellular
6,8-Diprenylorobol Induces Apoptosis in Human Hepatocellular Carcinoma Cells via Activation of FOXO3 and Inhibition of CYP2J2.
Carcinoma, Hepatocellular
CYP2J2 promotes the development of hepatocellular carcinoma by increasing the EETs production to improve HIF-1? stability.
Carcinoma, Hepatocellular
Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation.
Carcinoma, Hepatocellular
Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells.
Carcinoma, Hepatocellular
Role of cytochrome P450 2J2 on cell proliferation and resistance to an anticancer agent in hepatocellular carcinoma HepG2 cells.
Carcinoma, Squamous Cell
The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells.
Cardiomegaly
Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice.
Cardiomegaly
CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPK?2 and enhancing nuclear translocation of Akt1.
Cardiomegaly
CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy.
Cardiomegaly
Epoxyeicosatrienoic acid prevents maladaptive remodeling in pressure overload by targeting calcineurin/NFAT and Smad-7.
Cardiomyopathies
CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes.
Cardiotoxicity
Activity, Inhibition and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes.
Cardiotoxicity
CYP2J2 Expression in Adult Ventricular Myocytes Protects Against Reactive Oxygen Species Toxicity.
Cardiotoxicity
Overexpression of CYP2J2 Provides Protection against Doxorubicin Induced Cardiotoxicity.
Cardiovascular Diseases
Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study.
Cardiovascular Diseases
CYP2J2 epoxygenase membrane anchor plays an important role in facilitating electron transfer from CPR.
Cardiovascular Diseases
Regulation of CYP2J2 and EET Levels in Cardiac Disease and Diabetes.
Cardiovascular Diseases
The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases.
Colitis, Ulcerative
Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression.
Colitis, Ulcerative
Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis.
Colorectal Neoplasms
Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling.
Coronary Artery Disease
A novel polymorphism of the CYP2J2 gene is associated with coronary artery disease in Uygur population in China.
Coronary Artery Disease
Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease.
Coronary Artery Disease
Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease.
Coronary Artery Disease
Gender-Specific Effect of CYP2C8*3 on the Risk of Essential Hypertension in Bulgarian Patients.
Coronary Artery Disease
Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease.
Coronary Artery Disease
Research/review: Insights into the mutation-induced dysfunction of arachidonic acid metabolism from modeling of human CYP2J2.
Coronary Artery Disease
Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.
Coronary Artery Disease
Role of cytochrome epoxygenase (CYP2J2) in the pathophysiology of coronary artery disease in South Indian population.
Coronary Artery Disease
Structural basis for the mutation-induced dysfunction of human CYP2J2: a computational study.
Coronary Disease
CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study.
Coronary Disease
The -50G>T polymorphism in the promoter of the CYP2J2 gene in coronary heart disease: the Ludwigshafen Risk and Cardiovascular Health study.
Coronary Disease
The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins.
Crohn Disease
Inducible CYP2J2 and Its Product 11,12-EET Promotes Bacterial Phagocytosis: A Role for CYP2J2 Deficiency in the Pathogenesis of Crohn's Disease?
Diabetes Mellitus, Type 2
Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History.
Diabetic Cardiomyopathies
Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice.
Diabetic Nephropathies
Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice.
Diabetic Nephropathies
Genetics Variants in the Epoxygenase Pathway of Arachidonic Metabolism Are Associated with Eicosanoids Levels and the Risk of Diabetic Nephropathy.
Diabetic Nephropathies
The Human Genetic Variants CYP2J2 rs2280275 and EPHX2 rs751141 and Risk of Diabetic Nephropathy in Egyptian Type 2 Diabetic Patients.
Dyslipidemias
CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPAR?.
Essential Hypertension
A common polymorphism G-50T in cytochrome P450 2J2 gene is associated with increased risk of essential hypertension in a Russian population.
Essential Hypertension
Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension.
Essential Hypertension
Gender-Specific Effect of CYP2C8*3 on the Risk of Essential Hypertension in Bulgarian Patients.
Glaucoma
The effects of endothelium-specific CYP2J2 overexpression on the attenuation of retinal ganglion cell apoptosis in a glaucoma rat model.
Glioma
Berberine Induces CYP2J2 Expression in Human U251 Glioma Cells via Regulation of Peroxisome Proliferator-Activated Receptor Alpha.
Glioma
Targeting CYP2J2 to Enhance the Anti-Glioma Efficacy of Cannabinoid Receptor 2 Stimulation by Inhibiting the Pro-Angiogenesis Function of M2 Microglia.
Glucose Intolerance
CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue.
Heart Failure
CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPK?2 and enhancing nuclear translocation of Akt1.
Heart Failure
CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes.
Heart Failure
CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure.
Heart Failure
Endothelium-specific CYP2J2 overexpression improves cardiac dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling.
Heart Failure
Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-?-induced injury.
Hematologic Diseases
CYP2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth.
Hematologic Neoplasms
Cytochrome P450 2J2, a new key enzyme in cyclophosphamide bioactivation and a potential biomarker for hematological malignancies.
Hyperemia
Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice.
Hyperhomocysteinemia
Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation.
Hyperlipidemias
CYP2J2 overexpression ameliorates hyperlipidemia via increased fatty acid oxidation mediated by the AMPK pathway.
Hypertension
A common polymorphism G-50T in cytochrome P450 2J2 gene is associated with increased risk of essential hypertension in a Russian population.
Hypertension
A comprehensive study revealed SNP-SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk.
Hypertension
CYP2J2 -50 G/T and ADRB2 G46A Gene Polymorphisms in Saudi Subjects with Hypertension.
Hypertension
Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension.
Hypertension
Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?
Hypertension
OS066. Intrauterine CYP2J2 expression and circulatingepoxyeicosatrienoic acid levels in preeclampsia.
Hypertension
Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension.
Hypertension
Structural basis for the mutation-induced dysfunction of human CYP2J2: a computational study.
Hypertension, Pulmonary
Gene Delivery of a Cytochrome P450 Epoxygenase Ameliorates Monocrotaline-induced Pulmonary Artery Hypertension in Rats.
Infarction, Middle Cerebral Artery
Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium.
Infections
CYP2J2 participates in atherogenesis by mediating cell proliferation, migration and foam cell formation.
Insulin Resistance
Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice.
Insulin Resistance
CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue.
Insulin Resistance
CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPAR?.
Insulin Resistance
Endothelium-specific CYP2J2 overexpression attenuates age-related insulin resistance.
Insulin Resistance
Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History.
Ischemic Stroke
Association of CYP2J2 gene polymorphisms with ischemic stroke and stroke subtypes in Chinese population.
Ischemic Stroke
Cerebral Small Vessel Disease is Associated with Genetic Variations in CYP2J.
Ischemic Stroke
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
Kidney Failure, Chronic
Delivery of AAV2-CYP2J2 protects remnant kidney in the 5/6 nephrectomized rat via inhibition of apoptosis and fibrosis.
Leukemia
CYP2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth.
Leukemia
The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases.
Liver Diseases
CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice.
Macular Degeneration
Associations between CYP2J2 (-76G>T) rs890293 polymorphism and age-related macular degeneration.
Myocardial Infarction
Association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms with myocardial infarction in South Indian population.
Myocardial Infarction
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
Myocardial Infarction
Haplotype analysis of the CYP2J2 gene associated with myocardial infarction in a Chinese Han population.
Myocardial Infarction
The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile.
Neoplasm Metastasis
CYP2J2 promotes the development of hepatocellular carcinoma by increasing the EETs production to improve HIF-1? stability.
Neoplasm Metastasis
Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling.
Neoplasms
A molecular design strategy to construct the near-infrared fluorescent probe for selectively sensing human cytochrome P450 2J2.
Neoplasms
Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.
Neoplasms
Altered expression of cytochrome P450 enzymes involved in metabolism of androgens and vitamin D in the prostate as a risk factor for prostate cancer.
Neoplasms
Comparative Analysis of Peritoneum and Tumor Eicosanoids and Pathways in Advanced Ovarian Cancer.
Neoplasms
CYP epoxygenase derived EETs: from cardiovascular protection to human cancer therapy.
Neoplasms
CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma.
Neoplasms
CYP2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth.
Neoplasms
Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors.
Neoplasms
Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance.
Neoplasms
Cytochrome P450 Epoxygenase 2J2 Protects Against Lung Ischemia/Reperfusion Injury by Activating the P13K/Akt/GSK-3-?/NF-kB Signaling Pathway During Deep Hypothermic Low Flow in Mice.
Neoplasms
Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.
Neoplasms
Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.
Neoplasms
Epoxyeicosatrienoic Acids Attenuate Reactive Oxygen Species level, Mitochondrial Dysfunction, Caspase Activation and Apoptosis in Carcinoma Cells Treated with Arsenic Trioxide.
Neoplasms
Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-?-induced injury.
Neoplasms
Expression of cytochrome P450 arachidonic acid epoxygenase 2J2 in human tumor tissues and cell lines.
Neoplasms
Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling.
Neoplasms
Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation.
Neoplasms
Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells.
Neoplasms
Inhibition and inactivation of human CYP2J2: Implications in cardiac pathophysiology and opportunities in cancer therapy.
Neoplasms
Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2.
Neoplasms
OS066. Intrauterine CYP2J2 expression and circulatingepoxyeicosatrienoic acid levels in preeclampsia.
Neoplasms
Plant natural product plumbagin presents potent inhibitory effect on human cytochrome P450 2J2 enzyme.
Neoplasms
Role of cytochrome P450 2J2 on cell proliferation and resistance to an anticancer agent in hepatocellular carcinoma HepG2 cells.
Neoplasms
Selective Inhibitors of CYP2J2 Related to Terfenadine Exhibit Activity Strongly against Human Cancers in vitro and in vivo.
Neoplasms
The development of novel cytochrome P450 2J2 (CYP2J2) inhibitor and the underlying interaction between inhibitor and CYP2J2.
Neoplasms
The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation.
Neoplasms
The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases.
Neoplasms
The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells.
Non-alcoholic Fatty Liver Disease
CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice.
Obesity
CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue.
Obesity
Endothelium-specific CYP2J2 overexpression attenuates age-related insulin resistance.
Obesity
Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History.
Obesity, Maternal
Role of pregnancy and obesity on vitamin D status, transport, and metabolism in baboons.
Pre-Eclampsia
Increased epoxyeicosatrienoic acids and reduced soluble epoxide hydrolase expression in the preeclamptic placenta.
Pre-Eclampsia
OS066. Intrauterine CYP2J2 expression and circulatingepoxyeicosatrienoic acid levels in preeclampsia.
Proteinuria
Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.
Psoriasis
Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study.
Pulmonary Disease, Chronic Obstructive
Expression of cytochrome P450 mRNAs in Type II alveolar cells from subjects with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population.
Reperfusion Injury
Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids.
Squamous Cell Carcinoma of Head and Neck
The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells.
Stroke
Association of CYP2J2 gene polymorphisms with ischemic stroke and stroke subtypes in Chinese population.
Stroke
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
Triple Negative Breast Neoplasms
Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.
Varicose Veins
Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis.
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