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Information on EC 1.14.14.29 - 25/26-hydroxycholesterol 7alpha-hydroxylase

for references in articles please use BRENDA:EC1.14.14.29

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IUBMB Comments

A P-450 (heme-thiolate) protein. Unlike EC 1.14.14.26, 24-hydroxycholesterol 7α-monooxygenase, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25-epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent . The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase.

The enzyme appears in viruses and cellular organisms

Synonyms
cyp7b1, cyp7b, cholesterol 25-hydroxylase, oxysterol 7alpha-hydroxylase, oxysterol 7 alpha-hydroxylase, cypb1, cyp7b1 oxysterol 7alpha-hydroxylase, cytochome p450 7b1, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(25R)-cholest-5-ene-3beta,26-diol + [reduced NADPH-hemoprotein reductase] + O2 = (25R)-cholest-5-ene-3betA,7alpha,26-triol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
cholest-5-ene-3beta,25-diol + [reduced NADPH-hemoprotein reductase] + O2 = cholest-5-ene-3beta,7alpha,25-triol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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