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Information on EC 1.14.14.22 - dibenzothiophene sulfone monooxygenase

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IUBMB Comments
This bacterial enzyme catalyses a step in the desulfurization pathway of dibenzothiophenes. The enzyme forms a two-component system with a dedicated NADH-dependent FMN reductase (EC 1.5.1.42) encoded by the dszD gene, which also interacts with EC 1.14.14.21, dibenzothiophene monooxygenase. The flavin-N5-oxide that is formed by the enzyme reacts spontaneously with NADH to give oxidized flavin, releasing a water molecule.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
dbt sulfone monooxygenase, dibenzothiophene sulfone monooxygenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dibenzothiophene-5,5-dioxide + FMNH2 + NADH + O2 = 2'-hydroxybiphenyl-2-sulfinate + H2O + FMN + NAD+ + H+
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overall reaction
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dibenzothiophene-5,5-dioxide + FMNH2 + O2 = 2'-hydroxybiphenyl-2-sulfinate + FMN-N5-oxide
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(1a)
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FMN-N5-oxide + NADH = FMN + H2O + NAD+ + H+
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(1c), spontaneous
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