Disease on EC 1.14.14.19 - steroid 17alpha-monooxygenase and Organism(s) Homo sapiens
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17alpha-hydroxyprogesterone deacetylase deficiency
A 5'-splice site mutation in the cytochrome P450 steroid 17alpha-hydroxylase gene in 17alpha-hydroxylase deficiency.
17alpha-hydroxyprogesterone deacetylase deficiency
A complex heterozygous mutation of His373Leu and Asp487-Ser488-Phe489 deletion in human cytochrome P450c17 causes 17alpha-hydroxylase/17,20-lyase deficiency in three Chinese sisters.
17alpha-hydroxyprogesterone deacetylase deficiency
CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding.
17alpha-hydroxyprogesterone deacetylase deficiency
Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency.
17alpha-hydroxyprogesterone deacetylase deficiency
Distinctive profile of the 17-hydroxylase and 17,20-lyase activities revealed by urinary steroid metabolomes of patients with CYP17 deficiency.
17alpha-hydroxyprogesterone deacetylase deficiency
New compound heterozygous mutation in the CYP17 gene in a 46,XY girl with 17 alpha-hydroxylase/17,20-lyase deficiency.
17alpha-hydroxyprogesterone deacetylase deficiency
Novel CYP17A1 mutation in a Japanese patient with combined 17alpha-hydroxylase/17,20-lyase deficiency.
Addison Disease
Three new Brazilian cases of 17?-hydroxylase deficiency: clinical, molecular, hormonal, and treatment features.
Adenoma
High expression of cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome associated with high secretion of adrenal androgens.
Adenoma
In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome.
Adenoma
Mechanism of abnormal production of adrenal androgens in patients with adrenocortical adenomas and carcinomas.
Adrenal Hyperplasia, Congenital
17?-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS.
Adrenal Hyperplasia, Congenital
Male pseudohermaphroditism as a cause of secondary hypertension: a case report.
Adrenal Hyperplasia, Congenital
Steroid 17alpha-hydroxylase deficiency: functional characterization of four mutations (A174E, V178D, R440C, L465P) in the CYP17A1 gene.
Adrenal Hyperplasia, Congenital
The Glu331del mutation in the CYP17A1 gene causes atypical congenital adrenal hyperplasia in a 46,XX female.
Adrenal Hyperplasia, Congenital
Two rare forms of congenital adrenal hyperplasia, 11? hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations.
Adrenocortical Adenoma
High expression of cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome associated with high secretion of adrenal androgens.
Adrenocortical Adenoma
In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome.
Adrenocortical Adenoma
Mechanism of abnormal production of adrenal androgens in patients with adrenocortical adenomas and carcinomas.
Adrenocortical Carcinoma
In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: a novel mechanism of action?
Antley-Bixler Syndrome Phenotype
Abnormal steroidogenesis in three patients with Antley-Bixler syndrome: apparent decreased activity of 17alpha-hydroxylase, 17,20-lyase and 21-hydroxylase.
Antley-Bixler Syndrome Phenotype
Homozygous mutation G539R in the gene for P450 oxidoreductase in a family previously diagnosed as having 17,20-lyase deficiency.
aromatase deficiency
Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic.
Breast Neoplasms
A population pharmacokinetic analysis of the oral CYP17 lyase and androgen receptor inhibitor seviteronel in patients with advanced/metastatic castration-resistant prostate cancer or breast cancer.
Breast Neoplasms
CYP17 5'-UTR MspA1 polymorphism and the risk of premenopausal breast cancer in a German population-based case-control study.
Breast Neoplasms
CYP17 genotype modifies the association between lignan supply and premenopausal breast cancer risk in humans.
Breast Neoplasms
Cytochrome P450c17alpha gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations.
Breast Neoplasms
Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.
Breast Neoplasms
Genetic modeling of estrogen metabolism as a risk factor of hormone-dependent disorders.
Breast Neoplasms
Genetic modelling of the estrogen metabolism as a risk factor of hormone-dependent disorders.
Breast Neoplasms
Metabolism of pregnenolone by human breast cancer. Evidence for 17 alpha-hydroxylase and 17,20-lyase.
Breast Neoplasms
The CYP17A1 -34T > C polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Breast Neoplasms
The risk of breast cancer associated with dietary lignans differs by CYP17 genotype in women.
Carcinoma
Mechanism of abnormal production of adrenal androgens in patients with adrenocortical adenomas and carcinomas.
Cholera
Loss of expression of a differentiated function gene, steroid 17 alpha-hydroxylase, as adrenocortical cells senescence in culture.
Cryptorchidism
A single amino acid substitution in the putative redox partner-binding site of P450c17 as cause of isolated 17,20-lyase deficiency.
Cushing Syndrome
High expression of cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome associated with high secretion of adrenal androgens.
Cushing Syndrome
In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome.
Diabetes Mellitus
Decreased steroidogenic enzyme 17,20-lyase and increased 17-hydroxylase activities in type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Decreased steroidogenic enzyme 17,20-lyase and increased 17-hydroxylase activities in type 2 diabetes mellitus.
Disorder of Sex Development, 46,XY
Production of male pseudohermaphroditism in rats by two new inhibitors of steroid 17alpha-hydroxylase and C 17-20 lyase.
Disorders of Sex Development
Isolated 17,20-lyase deficiency due to the cytochrome b5 mutation W27X.
Disorders of Sex Development
Isolated 17,20-Lyase Deficiency in a CYB5A Mutated Female With Normal Sexual Development and Fertility.
Disorders of Sex Development
Male pseudohermaphroditism as a cause of secondary hypertension: a case report.
Dyskinesias
Interactive effect of cytochrome P450 17alpha-hydroxylase and dopamine D3 receptor gene polymorphisms on abnormal involuntary movements in chronic schizophrenia.
Endometriosis
Cytochrome P450c17alpha 5'-untranslated region *T/C polymorphism in endometriosis.
Endometriosis
Estrogen receptor alpha dinucleotide repeat and cytochrome P450c17alpha gene polymorphisms are associated with susceptibility to endometriosis.
Endometriosis
Genetic polymorphisms of cytochrome P450cl7alpha (CYP17) and progesterone receptor genes (PROGINS) in the assessment of endometriosis risk.
Fetal Growth Retardation
A polymorphism in the CYP17 gene and intrauterine fetal growth restriction.
Gonadal Dysgenesis
Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases.
Gynecomastia
CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding.
Hepatitis C
Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients.
Hepatitis C, Chronic
Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients.
Herpes Zoster
A homodimer model can resolve the conundrum as to how cytochrome P450 oxidoreductase and cytochrome b5 compete for the same binding site on cytochrome P450c17.
Herpes Zoster
Fetal programming of adrenal androgen excess: lessons from a nonhuman primate model of polycystic ovary syndrome.
Herpes Zoster
Gender and gonadal status differences in zona reticularis expression in marmoset monkey adrenals: Cytochrome b5 localization with respect to cytochrome P450 17,20-lyase activity.
Herpes Zoster
Human adrenal corticocarcinoma NCI-H295R cells produce more androgens than NCI-H295A cells and differ in 3beta-hydroxysteroid dehydrogenase type 2 and 17,20 lyase activities.
Herpes Zoster
Role of cytochrome b5 in the modulation of the enzymatic activities of cytochrome P450 17?-hydroxylase/17,20-lyase (P450 17A1).
Hirsutism
Adrenal androgen excess in women: lack of a role for 17-hydroxylase and 17,20-lyase dysregulation.
Hyperaldosteronism
Congenital adrenal hyperplasia causing hypertension: an illustrative review.
Hyperandrogenism
Enzymatic activities of P450c17 stably expressed in fibroblasts from patients with the polycystic ovary syndrome.
Hyperandrogenism
Oxidative stress increases the 17,20-lyase-catalyzing activity of adrenal P450c17 through p38? in the development of hyperandrogenism.
Hyperkalemia
DELAYED DIAGNOSIS OF A 17-HYDROXYLASE/17,20-LYASE DEFICIENT CASE PRESENTED WITH 46,XY FEMALE: LOW NORMAL POTASSIUM CAN ALERT CLINICIAN.
Hypertension
17-alpha-Hydroxylase deficiency: a case report with clinical and molecular analysis.
Hypertension
17-hydroxylase/17,20-lyase deficiency due to a R96Q mutation causing hypertension and poor breast development.
Hypertension
17?-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS.
Hypertension
A rare cause of congenital adrenal hyperplasia: Clinical and genetic findings and follow-up characteristics of six patients with 17- hydroxylase deficiency and two novel mutations.
Hypertension
Association of the CYP17 and CYP19 gene polymorphisms in women with polycystic ovary syndrome from Punjab, Pakistan.
Hypertension
Common variant rs11191548 near the CYP17A1 gene is associated with hypertension and the serum 25(OH) D levels in Han Chinese.
Hypertension
DELAYED DIAGNOSIS OF A 17-HYDROXYLASE/17,20-LYASE DEFICIENT CASE PRESENTED WITH 46,XY FEMALE: LOW NORMAL POTASSIUM CAN ALERT CLINICIAN.
Hypertension
Fertility in patients with genetic deficiencies of cytochrome P450c17 (CYP17A1): combined 17-hydroxylase/17,20-lyase deficiency and isolated 17,20-lyase deficiency.
Hypertension
Genotypic Sex and Severity of the Disease Determine the Time of Clinical Presentation in Steroid 17?-Hydroxylase/17,20-Lyase Deficiency.
Hypertension
Identification of a homozygous c.1039C>T (p.R347C) variant in CYP17A1 in a 67-year-old female patient with partial 17?-hydroxylase/17,20-lyase deficiency.
Hypertension
Identifying a novel mutation of CYP17A1 gene from five Chinese 17?-hydroxylase/17, 20-lyase deficiency patients.
Hypertension
Male pseudohermaphroditism as a cause of secondary hypertension: a case report.
Hypertension
Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases.
Hypertension
Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic.
Hypertension
Subtle 17alpha-hydroxylase/17,20-lyase deficiency with homozygous Y201N mutation in an infertile woman.
Hypertension
Three new Brazilian cases of 17?-hydroxylase deficiency: clinical, molecular, hormonal, and treatment features.
Hypoaldosteronism
Congenital adrenal hyperplasia causing hypertension: an illustrative review.
Hypogonadism
Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction.
Hypogonadism
Isolated 17,20-lyase (desmolase) deficiency in a 46,XX female presenting with delayed puberty.
Hypogonadism
Isolated 17,20-Lyase Deficiency in a CYB5A Mutated Female With Normal Sexual Development and Fertility.
Hypogonadism
Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases.
Hypogonadism
Three new Brazilian cases of 17?-hydroxylase deficiency: clinical, molecular, hormonal, and treatment features.
Hypokalemia
17?-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS.
Hypokalemia
DELAYED DIAGNOSIS OF A 17-HYDROXYLASE/17,20-LYASE DEFICIENT CASE PRESENTED WITH 46,XY FEMALE: LOW NORMAL POTASSIUM CAN ALERT CLINICIAN.
Hypokalemia
Fertility in patients with genetic deficiencies of cytochrome P450c17 (CYP17A1): combined 17-hydroxylase/17,20-lyase deficiency and isolated 17,20-lyase deficiency.
Hypokalemia
Identification of a homozygous c.1039C>T (p.R347C) variant in CYP17A1 in a 67-year-old female patient with partial 17?-hydroxylase/17,20-lyase deficiency.
Hypokalemia
Identifying a novel mutation of CYP17A1 gene from five Chinese 17?-hydroxylase/17, 20-lyase deficiency patients.
Hypokalemia
Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic.
Hypokalemia
Two rare forms of congenital adrenal hyperplasia, 11? hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations.
Hypospadias
CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding.
Infections
17?-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS.
Infections
Enzymatic activities of P450c17 stably expressed in fibroblasts from patients with the polycystic ovary syndrome.
Infertility
A rare enzymatic defect, true isolated 17,20-lyase deficiency leading to endocrine disorders and infertility: case report.
Infertility
Association of the CYP17 and CYP19 gene polymorphisms in women with polycystic ovary syndrome from Punjab, Pakistan.
Infertility
Haploinsufficiency of cytochrome P450 17alpha-hydroxylase/17,20 lyase (CYP17) causes infertility in male mice.
Infertility
Isolated 17,20-Lyase Deficiency in a CYB5A Mutated Female With Normal Sexual Development and Fertility.
Insulin Resistance
Enzymatic activities of P450c17 stably expressed in fibroblasts from patients with the polycystic ovary syndrome.
Insulin Resistance
No association between CYP17 -34T/C polymorphism and insulin resistance in Thai polycystic ovary syndrome.
Insulin Resistance
The treatment of insulin resistance does not improve adrenal cytochrome P450c17alpha enzyme dysregulation in polycystic ovary syndrome.
Leiomyoma
A possible role of the cytochrome P450c17alpha gene (CYP17) polymorphism in the pathobiology of uterine leiomyomas from black South African women: a pilot study.
Leiomyoma
Association of the CYP17 gene polymorphism with risk for uterine leiomyoma in Brazilian women.
Leiomyoma
Genotype distribution of estrogen receptor-alpha, catechol-O-methyltransferase, and cytochrome P450 17 gene polymorphisms in Caucasian women with uterine leiomyomas.
Liver Diseases
Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients.
Liver Neoplasms
Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients.
Methemoglobinemia
Isolated 17,20-Lyase Deficiency in a CYB5A Mutated Female With Normal Sexual Development and Fertility.
Neoplasms
Adrenocortical carcinoma manifesting pure primary aldosteronism: a case report and analysis of steroidogenic enzymes.
Neoplasms
Cytochrome b5 expression in gonadectomy-induced adrenocortical neoplasms of the domestic ferret (Mustela putorius furo).
Neoplasms
HPLC-RIA analysis of steroid hormone profile in a virilizing stromal tumor of the ovary.
Neoplasms
In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome.
Neoplasms
Metabolism of pregnenolone by human breast cancer. Evidence for 17 alpha-hydroxylase and 17,20-lyase.
Neoplasms
Mouse strain susceptibility to gonadectomy-induced adrenocortical tumor formation correlates with the expression of GATA-4 and luteinizing hormone receptor.
Neoplasms
Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys.
Neoplasms
Tumor necrosis factor alpha, CYP 17, urokinase, and interleukin 10 gene polymorphisms in postmenopausal women: correlation to bone mineral density and susceptibility to osteoporosis.
Osteoporosis
Polymorphisms in the P450 c17 (17-hydroxylase/17,20-Lyase) and P450 c19 (aromatase) genes: association with serum sex steroid concentrations and bone mineral density in postmenopausal women.
Osteoporosis
Tumor necrosis factor alpha, CYP 17, urokinase, and interleukin 10 gene polymorphisms in postmenopausal women: correlation to bone mineral density and susceptibility to osteoporosis.
Ovarian Cysts
17?-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS.
Ovarian Cysts
Deficiency of 17,20-lyase causing giant ovarian cysts in a girl and a female phenotype in her 46,XY sister: case report.
Ovarian Cysts
Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases.
Ovarian Hyperstimulation Syndrome
Ovarian hyperstimulation syndrome with low oestradiol in non-classical 17 alpha-hydroxylase, 17,20-lyase deficiency: what is the role of oestrogens?
Pediatric Obesity
Peer group normalization and urine to blood context in steroid metabolomics: the case of CAH and obesity.
Pituitary ACTH Hypersecretion
Ketoconazole and plasma and urine steroid levels in Cushing's disease.
Polycystic Ovary Syndrome
17-Hydroxyprogesterone responses to gonadotrophin-releasing hormone agonist buserelin and adrenocorticotrophin in polycystic ovary syndrome: investigation of adrenal and ovarian cytochrome P450c17alpha dysregulation.
Polycystic Ovary Syndrome
Alternate pathway 17,20-lyase enzyme activity in the adrenals is enhanced in patients with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Differential activity of the cytochrome P450 17alpha-hydroxylase and steroidogenic acute regulatory protein gene promoters in normal and polycystic ovary syndrome theca cells.
Polycystic Ovary Syndrome
Dysregulation of cytochrome P450 17alpha-hydroxylase messenger ribonucleic acid stability in theca cells isolated from women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Genetic modelling of the estrogen metabolism as a risk factor of hormone-dependent disorders.
Polycystic Ovary Syndrome
Increased cytochrome P450 17alpha-hydroxylase promoter function in theca cells isolated from patients with polycystic ovary syndrome involves nuclear factor-1.
Polycystic Ovary Syndrome
No association between CYP17 -34T/C polymorphism and insulin resistance in Thai polycystic ovary syndrome.
Polycystic Ovary Syndrome
Ovarian steroidogenic responses to gonadotropin-releasing hormone agonist testing with nafarelin in hirsute women with adrenal responses to adrenocorticotropin suggestive of 3 beta-hydroxy-delta 5-steroid dehydrogenase deficiency.
Polycystic Ovary Syndrome
Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases.
Polycystic Ovary Syndrome
Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome.
Polycystic Ovary Syndrome
The treatment of insulin resistance does not improve adrenal cytochrome P450c17alpha enzyme dysregulation in polycystic ovary syndrome.
Primary Ovarian Insufficiency
Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases.
Prostatic Diseases
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.
Prostatic Hyperplasia
Inhibition of androgen synthesis by 22-hydroximino-23,24-bisnor-4-cholen-3-one.
Prostatic Hyperplasia
Shorter CAG repeats in androgen receptor and non-GG genotypes in prostate-specific antigen loci are associated with decreased risk of benign prostatic hyperplasia and prostate cancer.
Prostatic Neoplasms
4-pregnene-3-one-20 beta-carboxaldehyde: a potent inhibitor of 17 alpha-hydroxylase/C17,20-lyase and of 5 alpha-reductase.
Prostatic Neoplasms
A population pharmacokinetic analysis of the oral CYP17 lyase and androgen receptor inhibitor seviteronel in patients with advanced/metastatic castration-resistant prostate cancer or breast cancer.
Prostatic Neoplasms
Assessment of cytochrome P450-mediated drug-drug interaction potential of orteronel and exposure changes in patients with renal impairment using physiologically based pharmacokinetic modeling and simulation.
Prostatic Neoplasms
Association of a CYP17 polymorphism with overall survival in Caucasian patients with androgen-independent prostate cancer.
Prostatic Neoplasms
Association of the CYP17 gene polymorphism with the risk of prostate cancer: a meta-analysis.
Prostatic Neoplasms
Commentary on "Comparison of abiraterone acetate versus ketoconazole in patients with metastatic castration resistant prostate cancer refractory to docetaxel." Peer A, Gottfried M, Sinibaldi V, Carducci MA, Eisenberger MA, Sella A, Leibowitz-Amit R, Berger R, Keizman D, Department of Oncology, Rambam Medical Center, Haifa, Israel.: Prostate 2014 Apr;74(4):433-40; doi:10.1002/pros.22765. [Epub 2013 Dec 11].
Prostatic Neoplasms
Comparison of abiraterone acetate versus ketoconazole in patients with metastatic castration resistant prostate cancer refractory to docetaxel.
Prostatic Neoplasms
Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.
Prostatic Neoplasms
Homology modelling of the enzyme P450 17 alpha-hydroxylase/17,20-lyase--a target for prostate cancer chemotherapy--from the crystal structure of P450BM-3.
Prostatic Neoplasms
Imidazole substituted biphenyls: a new class of highly potent and in vivo active inhibitors of P450 17 as potential therapeutics for treatment of prostate cancer.
Prostatic Neoplasms
Inhibition of aromatase (P450Arom) by some 1-(benzofuran-2-ylmethyl)imidazoles.
Prostatic Neoplasms
Inhibition of CYP 17, a new strategy for the treatment of prostate cancer.
Prostatic Neoplasms
Inhibition of p450 17 as a new strategy for the treatment of prostate cancer.
Prostatic Neoplasms
Linkage and association of CYP17 gene in hereditary and sporadic prostate cancer.
Prostatic Neoplasms
Orteronel plus prednisone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (ELM-PC 4): a double-blind, multicentre, phase 3, randomised, placebo-controlled trial.
Prostatic Neoplasms
Pharmacokinetics and Urinary Excretion Mechanism of Orteronel (TAK-700), A Novel 17,20-Lyase Inhibitor, in Animals.
Prostatic Neoplasms
Phase 1/2 study of orteronel (TAK-700), an investigational 17,20-lyase inhibitor, with docetaxel-prednisone in metastatic castration-resistant prostate cancer.
Prostatic Neoplasms
Phase 2 Study of Seviteronel (INO-464) in Patients With Metastatic Castration-Resistant Prostate Cancer After Enzalutamide Treatment.
Prostatic Neoplasms
Phase I Study of Seviteronel, a Selective CYP17 Lyase and Androgen Receptor Inhibitor, in Men with Castration-Resistant Prostate Cancer.
Prostatic Neoplasms
Phase I/II Trial of Orteronel (TAK-700)--an Investigational 17,20-Lyase Inhibitor--in Patients with Metastatic Castration-Resistant Prostate Cancer.
Prostatic Neoplasms
Pyridyl substituted benzocycloalkenes: new inhibitors of 17 alpha-hydroxylase/17,20-lyase (P450 17 alpha).
Prostatic Neoplasms
Structural and Functional Evaluation of Clinically-Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1 (CYP17A1).
Prostatic Neoplasms
Synthesis of hydroxy derivatives of highly potent non-steroidal CYP 17 inhibitors as potential metabolites and evaluation of their activity by a non cellular assay using recombinant human enzyme.
Prostatic Neoplasms
Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer.
Prostatic Neoplasms
Targeting the Adrenal Gland in Castration-Resistant Prostate Cancer: A Case for Orteronel, a Selective CYP-17 17,20-Lyase Inhibitor.
Prostatic Neoplasms
[Inhibitors of androgen and estrogen biosynthesis in castration-resistant prostate cancer].
Puberty, Delayed
17?-Hydroylase/17,20-lyase deficiency related to P.Y27*(c.81C>A) mutation in CYP17A1 gene.
Puberty, Delayed
Isolated 17,20-lyase (desmolase) deficiency in a 46,XX female presenting with delayed puberty.
Sexual Infantilism
Fertility in patients with genetic deficiencies of cytochrome P450c17 (CYP17A1): combined 17-hydroxylase/17,20-lyase deficiency and isolated 17,20-lyase deficiency.
Sexual Infantilism
Identification of a homozygous c.1039C>T (p.R347C) variant in CYP17A1 in a 67-year-old female patient with partial 17?-hydroxylase/17,20-lyase deficiency.
Sexual Infantilism
Male pseudohermaphroditism as a cause of secondary hypertension: a case report.
Sexual Infantilism
Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic.
Starvation
Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells.
steroid 11beta-monooxygenase deficiency
Two rare forms of congenital adrenal hyperplasia, 11? hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations.
steroid 17alpha-monooxygenase deficiency
17-hydroxylase/17,20-lyase deficiency due to a R96Q mutation causing hypertension and poor breast development.
steroid 17alpha-monooxygenase deficiency
17alpha-hydroxylase/17,20-lyase deficiency as a model to study enzymatic activity regulation: role of phosphorylation.
steroid 17alpha-monooxygenase deficiency
A case of male pseudohermaphroditism due to 17 alpha-hydroxylase deficiency and hormonal profiles in the nuclear family.
steroid 17alpha-monooxygenase deficiency
A novel mutation in CYP17A1 gene leads to congenital adrenal hyperplasia: A case report.
steroid 17alpha-monooxygenase deficiency
A rare cause of congenital adrenal hyperplasia: Clinical and genetic findings and follow-up characteristics of six patients with 17- hydroxylase deficiency and two novel mutations.
steroid 17alpha-monooxygenase deficiency
A rare enzymatic defect, true isolated 17,20-lyase deficiency leading to endocrine disorders and infertility: case report.
steroid 17alpha-monooxygenase deficiency
A review of the literature on common CYP17A1 mutations in adults with 17-hydroxylase/17,20-lyase deficiency, a case series of such mutations among Koreans and functional characteristics of a novel mutation.
steroid 17alpha-monooxygenase deficiency
A single amino acid substitution in the putative redox partner-binding site of P450c17 as cause of isolated 17,20-lyase deficiency.
steroid 17alpha-monooxygenase deficiency
A single-amino-acid in-frame deletion in CYP17A1 results in combined 17-hydroxylase and 17,20-lyase deficiency in an Iranian family despite the protein mutation site.
steroid 17alpha-monooxygenase deficiency
Apparent pregnene hydroxylation deficiency (APHD): seeking the parentage of an orphan metabolome.
steroid 17alpha-monooxygenase deficiency
Clinical, Molecular, Functional, and Structural Characterization of CYP17A1 Mutations in Brazilian Patients with 17-Hydroxylase Deficiency.
steroid 17alpha-monooxygenase deficiency
CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding.
steroid 17alpha-monooxygenase deficiency
Defects of the testosterone biosynthetic pathway in boys with hypospadias.
steroid 17alpha-monooxygenase deficiency
DELAYED DIAGNOSIS OF A 17-HYDROXYLASE/17,20-LYASE DEFICIENT CASE PRESENTED WITH 46,XY FEMALE: LOW NORMAL POTASSIUM CAN ALERT CLINICIAN.
steroid 17alpha-monooxygenase deficiency
Diagnosis and treatment of 17-hydroxylase deficiency.
steroid 17alpha-monooxygenase deficiency
Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency.
steroid 17alpha-monooxygenase deficiency
Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20-lyase deficiency.
steroid 17alpha-monooxygenase deficiency
Fertility in patients with genetic deficiencies of cytochrome P450c17 (CYP17A1): combined 17-hydroxylase/17,20-lyase deficiency and isolated 17,20-lyase deficiency.
steroid 17alpha-monooxygenase deficiency
Homozygous mutation G539R in the gene for P450 oxidoreductase in a family previously diagnosed as having 17,20-lyase deficiency.
steroid 17alpha-monooxygenase deficiency
Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells.
steroid 17alpha-monooxygenase deficiency
Isolated 17,20-lyase (desmolase) deficiency in a 46,XX female presenting with delayed puberty.
steroid 17alpha-monooxygenase deficiency
Isolated 17,20-lyase deficiency due to the cytochrome b5 mutation W27X.
steroid 17alpha-monooxygenase deficiency
Isolated 17,20-Lyase Deficiency in a CYB5A Mutated Female With Normal Sexual Development and Fertility.
steroid 17alpha-monooxygenase deficiency
MECHANISMS IN ENDOCRINOLOGY: Rare defects in adrenal steroidogenesis.
steroid 17alpha-monooxygenase deficiency
Metabolic evidence for impaired 17alpha-hydroxylase activity in a kindred bearing the E305G mutation for isolate 17,20-lyase activity.
steroid 17alpha-monooxygenase deficiency
Molecular basis of 17?-hydroxylase/17,20-lyase deficiency.
steroid 17alpha-monooxygenase deficiency
Molecular basis of apparent isolated 17,20-lyase deficiency: compound heterozygous mutations in the C-terminal region (Arg(496)----Cys, Gln(461)----Stop) actually cause combined 17 alpha-hydroxylase/17,20-lyase deficiency.
steroid 17alpha-monooxygenase deficiency
Ovarian hyperstimulation syndrome with low oestradiol in non-classical 17 alpha-hydroxylase, 17,20-lyase deficiency: what is the role of oestrogens?
steroid 17alpha-monooxygenase deficiency
Pitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency.
steroid 17alpha-monooxygenase deficiency
Puberty in a case with novel 17-hydroxylase mutation and the putative role of estrogen in development of pubic hair.
steroid 17alpha-monooxygenase deficiency
Six new cases confirm the clinical molecular profile of complete combined 17?-hydroxylase/ 17,20-lyase deficiency in Brazil.
steroid 17alpha-monooxygenase deficiency
Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic.
steroid 17alpha-monooxygenase deficiency
Steroid 17alpha-hydroxylase deficiency: first Australian case report.
steroid 17alpha-monooxygenase deficiency
Steroid 17alpha-hydroxylase deficiency: functional characterization of four mutations (A174E, V178D, R440C, L465P) in the CYP17A1 gene.
steroid 17alpha-monooxygenase deficiency
Structural characterization of normal and mutant human steroid 17 alpha-hydroxylase genes: molecular basis of one example of combined 17 alpha-hydroxylase/17,20 lyase deficiency.
steroid 17alpha-monooxygenase deficiency
Subnormal cortisol response to adrenocorticotropin in isolated partial 17,20-lyase deficiency.
steroid 17alpha-monooxygenase deficiency
Subtle 17alpha-hydroxylase/17,20-lyase deficiency with homozygous Y201N mutation in an infertile woman.
steroid 17alpha-monooxygenase deficiency
The genetic and functional basis of isolated 17,20-lyase deficiency.
steroid 17alpha-monooxygenase deficiency
Towards a unifying mechanism for CYP17 mutations that cause isolated 17,20-lyase deficiency.
steroid 17alpha-monooxygenase deficiency
Two novel heterozygous mutations in the CYP17A1 gene in a Chinese patient with 17?-hydroxylase 17,20-lyase deficiency.
steroid 17alpha-monooxygenase deficiency
Two rare forms of congenital adrenal hyperplasia, 11? hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations.
steroid 17alpha-monooxygenase deficiency
[Clinical and genetic analysis of a patient with 17-hydroxylase/17,20-lyase deficiency].
steroid 21-monooxygenase deficiency
The activities of 5?-reductase and 17,20-lyase determine the direction through androgen synthesis pathways in patients with 21-hydroxylase deficiency.
Wilms Tumor
New frontiers on the molecular underpinnings of hypospadias according to severity.