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Information on EC 1.14.14.175 - ferruginol synthase

for references in articles please use BRENDA:EC1.14.14.175

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IUBMB Comments

A cytochrome P-450 (heme thiolate) enzyme found in some members of the Lamiaceae (mint family). The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant.

The enzyme appears in viruses and cellular organisms

Synonyms
cyp76ah1, cyp76ah24, cyp76ah4, ferruginol synthase, miltiradiene oxidase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
abieta-8,11,13-triene + [reduced NADPH-hemoprotein reductase] + O2 = ferruginol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
carnosate bioynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links